|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | The endoplasmic reticulum-associated degradation is necessary for plant salt tolerance显示文摘真核细胞的有机体有允许错误褶层或 unassembled 蛋白质在 endoplasmic 蜂窝胃被保留的质量控制的机制(嗯) 并且随后由嗯联系降级(ERAD ) 降级了。ERAD 小径很好在酵母和哺乳动物被学习;然而,植物 ERAD 的生物功能没被报导。通过分子、细胞的生物途径,我们发现 ERAD 是必要的让植物克服盐应力。在蛋白质在植物房间增加了的盐处理 ubiquitinated 之上,特别展开了快速在 ER 积累了并且随后导致了的蛋白质嗯压力回答。在 ERAD 小径的 HRD1/HRD3 建筑群的 HRD3A 的缺点导致了展开的蛋白质反应(UPR ) 的改变,腌的增加的植物敏感,和在植物房间的 ERAD 底层的保留。而且,我们证明从 ER 的那个 Ca 2+ 版本涉及 UPR 的举起,反应的氧种类(ROS ) 参与 ERAD 相关的植物盐反应小径。 | Lijing Liu Feng Cui Qingliang Li Bojiao Yin Huawei Zhang Baoying Lin Zaorong Wu Ran Xia Sanyuan Tang Qi Xie | 2011 | Cell Research2011，21，6： | 19 |
| 2 | Control of Bird Feeding Behavior by Tannin1 through Modulating the Biosynthesis of Polyphenols and Fatty Acid-Derived Volatiles in Sorghum显示文摘Bird predation during seed maturation causes great loss to agricultural production.In this study,through GWAS analysis of a large-scale sorghum germplasm diversity panel,we identified that Tannin1,which encodes a WD40 protein functioning in the WD40/MYB/bHLH complex,controls bird feeding behavior in sorghum.Metabolic profiling analysis showed that a group of sorghum accessions preferred by birds contain mutated tan1-a/b alleles and accumulate significantly lower levels of anthocyanins and condensed tannin compounds.In contrast,a variety of aromatic and fatty acid-derived volatiles accumulate at significantly higher levels in these bird-preference accessions.We subsequently conducted both sparrow feeding and sparrow volatile attractant assays,which confirmed,respectively,the antifeedant and attractant functions of these differentially accumulated metabolites.In addition,the connection between the biosynthesis pathway of anthocyanin and proanthocyanidin and the pathway of fatty acid–derived volatile biosynthesis was demonstrated by discovering that Tannin1 complex modulates fatty acid biosynthesis by regulating the expression of SbGL2 in sorghum,thus affecting the accumulation of fatty acid-derived volatiles.Taken together,our study identified Tannin1 as the gene underlying the major locus controlling bird feeding behavior in sorghum,illustrating an example of the identification of an ecologically impactful molecular mechanism from field observation and providing significant insights into the chemistry of bird–plant ecological interactions. | Peng Xie Jiayang Shi Sanyuan Tang Chengxuan Chen Aimal Khan Fengxia Zhang Ying Xiong Chao Li Wei He Guodong Wang Fumin Lei Yaorong Wu Qi Xie | 2019 | Molecular Plant2019，12，10： | 8 |
| 3 | A composite insulation structure for silicon-based planar neuroprobes显示文摘Silicon-based planar neuroprobes are composed of silicon substrate,conducting layer,and insulation layers of SiO 2 or SiN membrane.The insulation layer is very important because it affects many key parameters of neuprobes,like impedance,SNR(signal noise ratio),reliability,etc.Monolayer membrane of SiO 2 or SiN are not good choices for insulation layer,since defects and residual stress in these layers can induce bad passivation.In this paper a composite insulation structure is studied,with thermal SiO 2 as the lower insulation layer and with multilayer membrane composed of PECVD SiO 2 and SiN as the upper insulation layer.This structure not only solves the problem of residual stress but also ensures a good probe passivation.So it's a good choice for insulation layer of neuroprobes. | ZHAO Hui PEI WeiHua CHEN SanYuan GUI Qiang TANG RongYu GUO Kai CHEN HongDa | 2012 | Science China(Technological Sciences)2012，55，9： | 2 |
| 4 | 32-site microelectrode modified with Pt black for neural recording fabricated with thin-film silicon membrane显示文摘Multi-electrode array is an important tool in the study of neural-network,cognition,remembrance,as well as brain-computer-interface,etc.Fork-like 32-site microelectrodes are developed with silicon.By use of integrated circuit technology,the length of the electrodes,the area of the recording sites,as well as the spaces between the sites are closely controlled.SiO2/SiNx/SiO2composite dielectric membrane and Pt black are introduced to improve the characteristics of the electrodes.The whole thickness of the thin-film probe was 21μm.By combining the modifying process with the micro-fabrication method,this kind of silicon based microelectrode satisfies high-density recording and the performance characterization is evaluated by test in vitro and in vivo. | CHEN SanYuan PEI WeiHua ZHAO Hui GUI Qiang TANG RongYu CHEN YuanFang FANG XiaoLei HONG Bo GAO XiaoRong CHEN HongDa | 2014 | Science China(Information Sciences)2014，57，5： | 2 |
| 5 | Creation of fragrant sorghum by CRISPR/Cas9显示文摘Sorghum,the fifth largest cereal crop,has high value as a staple food and raw material for liquor and vinegar brewing.Due to its high biomass and quality,it is also used as the second most planted silage resource.No fragrant sorghums are currently on the market.Through CRISPR/Cas9-mediated knockout of Sb BADH2,we obtained sorghum lines with extraordinary aromatic smell in both seeds and leaves.Animal feeding experiments showed that fragrant sorghum leaves were attractable.We believe this advantage will produce great value in the sorghum market for both grain and whole biomass forage. | Dan Zhang Sanyuan Tang Peng Xie Dekai Yang Yaorong Wu Shujing Cheng Kai Du Peiyong Xin Jinfang Chu Feifei Yu Qi Xie | 2022 | Journal of Integrative Plant Biology2022，64，5： | 1 |
| 6 | A large insert Thellungiella halophila BIBAC library for genomics and identification of stress tolerance genes显示文摘 | Weiquan Wang Yaorong Wu Yin Li Jiaying Xie Zhonghui Zhang Zhiyong Deng Yiyue Zhang Cuiping Yang Jianbin Lai Huawei Zhang Hongyan Bao Sanyuan Tang Chengwei Yang Peng Gao Guixian Xia Huishan Guo Qi Xie | 2010 | Plant Molecular Biology (-)2010，，1： | 1 |
| 7 | An efficient sys- tem to detect protein ubiquitination by agroinfiltration in Nico- tiana benthamiana显示文摘 | Liu Lijing Zhang Yiyue Tang Sanyuan | 2010 | The Plant Journal2010，61，5： | 1 |
| 8 | miR-185 is an independent prognosis factor and suppresses tumor metastasis in gastric cancer显示文摘 | Zhiqin Tan Hao Jiang Youhua Wu Liming Xie Wenxiang Dai Hailin Tang Sanyuan Tang | 2014 | Molecular and Cellular Biochemistry . 2014 (1-2)2014，，1： | 1 |
| 9 | Fabrication of strongly adherent platinum black coatings on microelectrodes array显示文摘Platinum black coating can effectively improve the performance of MEAs(microelectrodes array)in neural signal transduction,though its lack of adhesion strength and durability tampers its usage in long term experiments.Here a new method of composite electrodeposition provides highly adhesive platinum black coating that enables MEAs for a month’s long task and repeatable utilization.The new method was compared with present techniques on multiple aspects,e.g.actual surface area,surface morphology,interfacial impedance,durability and real application tests.Results show that the new composite coating provides greatly improved durability without compromising its performances.Neural cells were cultured on these MEAs for 40 days in vitro and spontaneous action potentials with high signal/noise ratio were recorded.Theoretical model and simulation provided preliminary understanding on the mechanism of this strengthened platinum black coating. | TANG RongYu PEI WeiHua CHEN SanYuan ZHAO Hui CHEN YuanFang HAN Yao WANG ChunLan CHEN HongDa | 2014 | Science China(Information Sciences)2014，57，4： | 0 |
| 10 | TRIM-9 functions in the UNC-6/UNC-40 pathway to regulate ventral guidance显示文摘分成三部分的主题(修剪) 家庭蛋白质是戒指手指包含域,多域蛋白质在许多生物过程含有。包括 TRIM-9, MID1 和 MID2,整齐的蛋白质的 TRIM-9/C-I 亚科的成员有 neuronal 功能并且与神经病学的疾病被联系。为了探索 C-I 的功能是否整修蛋白质,在无脊椎动物被保存,我们分析了 Caenorhabditis elegans 和果蝇 trim-9 异种。C。elegans trim-9 异种在雌雄同体的腹的指导展出缺点特定的神经原(HSN ) 和触摸神经原 AVM。进一步基因的分析显示 TRIM-9 参予 UNC-6-UNC-40 吸引力小径。UNC-40 的不对称的分发在 trim-9 异种在 HSN 开发期间是正常的。然而, MIG-10 的不对称的本地化, UNC-40 的一个下游的受动器,在 trim-9 异种被废除。这些结果建议 TRIM-9 工作在 UNC-40 小径的 MIG-10 在上游。而且,我们证明在 vitro 的 TRIM-9 展览 E3 ubiquitin ligase 活动和这项活动为在 vivo 的 TRIM-9 功能是重要的。另外,我们发现果蝇 trim-9 为一组感觉神经原轴突的中线吸引力被要求。Netrin/UNC-6 受体的在表示上穿破在 trim-9 异种压制指导缺点。我们的学习在 UNC-40/Frazzled-mediated UNC-6/Netrin 吸引力小径揭示 TRIM-9 的 evolutionarily 保存的功能。 | Song Song Qinglan Ge Jinbo Wang Haiyang Chen Sanyuan Tang Junfeng Bi Xia Li Qi Xie Xun Huang | 2011 | Journal of Genetics and Genomics2011，38，1： | 0 |
| 11 | 黄酮类化合物紫花牡荆素通过内质网应激上调死亡受体5促进TRAIL诱导的结肠癌细胞凋亡(英文)显示文摘Objective:The aim of this study was to explore the mechanisms by which the flavonoid casticin enhances tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in colon cancer cells. Methods:Human colon cancer HT-29 cells were treated with TRAIL or casticin. Cytotoxicity was examined by MTT assay, and apoptosis determined by morphological observation and flow cytometric analysis. Death receptor 5 (DR5), DR4, and endoplasmic reticulum (ER) stress response markers, including glucose regulating protein 78 (GRP78), activating transcription factor 4 (ATF4) and CHOP (CCAAT/enhancer binding protein homologous protein), were examined with western blot. Small interfering RNA (siRNA) transfection was employed to knock down CHOP. Results:HT-29 cells were resistance to TRAIL-induced apoptosis, but casticin, at subtoxic concentrations, potentiated HT-29 cells to TRAIL-induced apoptosis. Casticin up-regulated the expression of DR5 time-and dose-dependent manners, but had no effect on the expression of DR4. Also, casticin increased the levels of ER stress response markers (GRP78, ATF4 and CHOP) in a similar way to DR5. Knockdown of CHOP by specific siRNA, or salubrinal, an ER stress inhibitor, abolished the up-regulation of DR5 and enhancement of TRAIL-induced apoptosis by casticin. Conclusion:Casticin enhances TRAIL-induced apoptosis of colon cancer cells by ER stress-mediated up-regulation of DR5. | Sanyuan Tang Guangjin Yuan Zhengyang Yu Leilan Yin Hao Jiang | 2013 | The Chinese-German Journal of Clinical Oncology2013，12，6： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员