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| 1 | The wonders of BMP9:From mesenchymal stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism to regenerative medicine显示文摘Although bone morphogenetic proteins(BMPs)initially showed effective induction of ectopic bone growth in muscle,it has since been determined that these proteins,as members of the TGF-b superfamily,play a diverse and critical array of biological roles.These roles include regulating skeletal and bone formation,angiogenesis,and development and homeostasis of multiple organ systems.Disruptions of the members of the TGF-b/BMP superfamily result in severe skeletal and extra-skeletal irregularities,suggesting high therapeutic potential from understanding this family of BMP proteins.Although it was once one of the least characterized BMPs,BMP9 has revealed itself to have the highest osteogenic potential across numerous experiments both in vitro and in vivo,with recent studies suggesting that the exceptional potency of BMP9 may result from unique signaling pathways that differentiate it from other BMPs.The effectiveness of BMP9 in inducing bone formation was recently revealed in promising experiments that demonstrated efficacy in the repair of critical sized cranial defects as well as compatibility with bone-inducing bio-implants,revealing the great translational promise of BMP9.Furthermore,emerging evidence indicates that,besides its osteogenic activity,BMP9 exerts a broad range of biological functions,including stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism.This review aims to summarize our current understanding of BMP9 across biology and the body. | Sami Mostafa Mikhail Pakvasa Elam Coalson Allen Zhu Alex Alverdy Hector Castillo Jiaming Fan Alex Li Yixiao Feng Di Wu Elliott Bishop Scott Du Mia Spezia Alissa Li Ofir Hagag Alison Deng Winny Liu Mingyang Li Sherwin S·Ho Aravind Athiviraham Michael J·Lee Jennifer Moriatis Wolf Guillermo A·Ameer Hue H·Luu Rex C·Haydon Jason Strelzow Kelly Hynes Tong-Chuan He Russell R·Reid | 2019 | Genes & Diseases2019，6，3： | 15 |
| 2 | Identification of proteins involved in lignocellulose degradation using in gel zymogram analysis combined with mass spectroscopy-based peptide analysis of gut proteins from larval Asian Ionghorned beetles, Anoplophora glabripennis显示文摘 | Scott M. Geib Ming Tien Kelli Hoover | 2010 | Insect Science2010，17，3： | 5 |
| 3 | Reduction in endotoxemia, oxidative and inflammatory stress, and insulin resistance after Roux-en-Y gastric bypass surgery in patients with morbid obesity and type 2 diabetes mellitus显示文摘 | Scott V. Monte Joseph A. Caruana Husam Ghanim Chang Ling Sia Kelly Korzeniewski Jerome J. Schentag Paresh Dandona | 2012 | Surgery2012，，4： | 2 |
| 4 | Person, Process, Choice:the Psychology of New Venture Creation Kelly G Shaver显示文摘 | Shaver Kelly C L Scott Linda R | 1991 | Entrepreneurship: Theory&Practice1991，，2： | 1 |
| 5 | 原发性免疫缺陷病患者肿瘤发生情况:美国免疫缺陷网络注册患者肿瘤发病率分析显示文摘研究背景评估了在美国免疫缺陷网络(USIDNET)注册的原发性免疫缺陷病(PIDDs)患者的总体和器官特异性肿瘤发病率,并与监测、流行病学和最终结果项目(SEER)数据库中经年龄校正的人群的肿瘤发病率进行比较。目的假设PIDD患者由于免疫功能受损,肿瘤发病率会增加。方法将2003年至2015年在USIDNET注册中心注册的PIDD (n=3658)患者的总体和器官特异性肿瘤发病率进行评估,并与SEER数据库中经年龄校正的人群发病率进行比较。结果与年龄相匹配的SEER人群相比,观察到PIDD患者罹患肿瘤的相对危险率为1. 42倍(P<0. 001)。PIDD的男性患癌症的风险是年龄校正的男性人群的1. 91倍(P<0. 001),而PIDD女性患者的总体肿瘤发病率与经年龄校正的女性人群相比并无差异。对SEER数据库中最常见的4个恶性肿瘤——肺癌、结肠癌、乳腺癌和前列腺癌的发病率进行分析,PIDD患者中这些肿瘤的发病没有显著增加。男性和女性PIDD患者的淋巴瘤发病率均显著增加(男性10倍,P<0. 001;女性8. 34倍,P<0. 001)。结论 PIDD患者的肿瘤发病率较高。在特定的PIDD人群中淋巴瘤发病率的增高是导致总体肿瘤发病率提高的主要原因,而常见的实体肿瘤的风险没有增加。这些数据表明免疫系统在预防特定肿瘤方面有一定的作用。 | Paul C.Mayor Kevin H.Eng Kelly L.Singel Scott I.Abrams Kunle Odunsi Kirsten B.Moysich Ramsay Fuleihan Elizabeth Garabedian Patricia Lugar Hans D.Ochs Francisco A.Bonilla Rebecca H.Buckley Kathleen E.Sullivan Zuhair K.Ballas Charlotte Cunningham-Rundles Brahm H.Segal 白炜 曾小峰 | 2018 | 中华临床免疫和变态反应杂志2018，12，2： | 1 |
| 6 | Mitochondrial Polymorphisms Significantly Reduce the Risk of Parkinson Disease显示文摘 | Joelle M. van der Walt Kristin K. Nicodemus Eden R. Martin William K. Scott Martha A. Nance Ray L. Watts Jean P. Hubble Jonathan L. Haines William C. Koller Kelly Lyons Rajesh Pahwa Matthew B. Stern Amy Colcher Bradley C. Hiner Joseph Jankovic William G. | 2003 | The American Journal of Human Genetics2003，，4： | 1 |
| 7 | The Swift Ultra-Violet/Optical Telescope显示文摘 | Peter W. A. Roming Thomas E. Kennedy Keith O. Mason John A. Nousek Lindy Ahr Richard E. Bingham Patrick S. Broos Mary J. Carter Barry K. Hancock Howard E. Huckle S D. Hunsberger Hajime Kawakami Ronnie Killough T Scott Koch Michael K. Mclelland Kelly Smith | 2005 | Space Science Reviews (-)2005，，3： | 1 |
| 8 | Debris from Cobalt-Chrome Cable May Cause Acetabular Loosening显示文摘 | Kelly Scott S Johnston R C | 1992 | Clin Orthop1992，285，： | 1 |
| 9 | Polymerization of Cyclopentene Using Metallocene Catalysts: Competitive Cis- and Trans-1,3 Insertion Mechanisms显示文摘 | Mark Kelly W Wang Shaotian Scott Collins | 1997 | Maeromole- cules1997，30，11： | 1 |
| 10 | Tetracycline resistome of the organic pig gut 显示文摘 | Kazimierczak K A Scott K P Kelly D | 2009 | Applied andEnvironmental Microbiology2009，75，6： | 1 |
| 11 | Effect of cortisol on the physiology of cultured pavement cell epithelia from freshwater trout gills显示文摘 | KELLY Scott P WOOD Chris M | 2001 | Am J Physiol Regulatory Integrative Comp Physiol2001，，281： | 1 |
| 12 | Effects of cortisol and prolactin on Na^+ and Cl-transport in cultured branchial epithelia from FW rainbow trout显示文摘 | ZHOU Bingsheng KELLY Scott P IANOWSKI Juan P | 2003 | Am J Physiol Regul Integr Comp Physiol2003，，285： | 1 |
| 13 | Laparoscopic sleeve gastrec- tomy in patients with preexisting gastroesophageal reflux disea- seA national analysis 显示文摘 | Cecily ED Kelly B Scott RS | 2014 | JAMA Surg2014，149，4： | 1 |
| 14 | Effects of salinity and nutritional status on growth and metabolism of Spams sarba in a closed seawater system显示文摘 | Norman Y.S. Woo Scott P. Kelly | 1995 | Aquaculture1995，，1： | 1 |
| 15 | Ethnic differences in cytokine gene polymorphisms: potential implications for cancer development显示文摘 | Jovanny Zabaleta Barbara G. Schneider Kelli Ryckman Pleasant F. Hooper M. Constanza Camargo M. Blanca Piazuelo Rosa A. Sierra Elizabeth T. H. Fontham Pelayo Correa Scott M. Williams Augusto C. Ochoa | 2008 | Cancer Immunology Immunotherapy2008，，1： | 1 |
| 16 | Late Effects of Early Surgery on Lipoma and Lipomeningocele in Children Less Than 1 Year Old显示文摘 | Nihat Satar Stuart B. Bauer R. Michael Scott Jeremy Shefner Mary Kelly Mary Darbey | 1997 | The Journal of Urology1997，，4： | 1 |
| 17 | Analysis of a Physician Tool for Evaluating Dysphagia on an Inpatient Stroke Unit: The Modified Mann Assessment of Swallowing Ability显示文摘 | Nader Antonios Giselle Carnaby-Mann Michael Crary Leslie Miller Holly Hubbard Kelly Hood Raam Sambandam Andrew Xavier Scott Silliman | 2010 | Journal of Stroke and Cerebrovascular Diseases2010，，1： | 1 |
| 18 | Self-Handicapping and the Five Factor Model of Personality: Mediation Be-tween Neuroticism and Conscientiousness 显示文摘 | SCOTT R R KELLI E C MARCUS K R | 2002 | Personality and Individual Differences2002，32，： | 1 |
| 19 | Risk Assessment Using a Novel Score to Predict Anastomotic Leak and Major Complications after Oesophageal Resection显示文摘 | Fergus Noble Nathan Curtis Scott Harris Jamie Kelly Ian Bailey James Byrne Timothy Underwood | 2012 | Journal of Gastrointestinal Surgery2012，，6： | 1 |
| 20 | Specialized staff and equipment for weight loss Surgery patients:Best practice guideline显示文摘 | Anthony D whittemore John Kelly Scott shikora | 2005 | Obesity Research2005，13，2： | 1 |
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