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| 1 | Structure of MERS-CoV spike receptor-binding domain complexed with human receptor DPP4显示文摘最近的尖铁 glycoprotein (S) 鉴别中东呼吸症候群 coronavirus (MERS-CoV ) 指向细胞的受体, dipeptidyl peptidase 4 (DPP4 ) 。顺序比较和当模特儿的分析在病毒的尖铁上揭示了一个通常认为的受体绑定领域(RBD ) ,它调停这个相互作用。我们报导 3.0 Å MERS-CoV RBD 的决定水晶结构跳了到人的 DPP4 的细胞外的领域。我们的结果证明 MERS-CoV RBD 由一个核心和受体绑定子域组成。受体绑定子域与 DPP4 β 交往;推进器然而并非它的内在的 hydrolase 领域。MERS-CoV RBD 和相关 SARS-CoV RBD 分享他们的核心子域的结构的类似的高度,但是在受体绑定子域是尤其是分叉的。Mutagenesis 研究在为到 DPP4 和入口的病毒的绑定是批评的进目标房间的受体绑定子域识别了几关键残余。在在 MERS-CoV RBD 和 DPP4 之间的接口的原子细节提供病毒和受体相互作用的结构的理解,它能对 MERS-CoV 感染指导治疗学和疫苗的开发。 | Nianshuang Wang Xuanling Shi Liwei Jiang Senyan Zhang Dongli Wang Pei Tong Dongxing Guo Lili Fu Ye Cui Xi Liu Kelly C Arledge Ying-Hua Chen Linqi Zhang Xinquan Wang | 2013 | Cell Research2013，23，8： | 26 |
| 2 | Dynamic tubulation of mitochondria drives mitochondrial network formation显示文摘 | Chong Wang Wanqing Du Qian Peter Su Mingli Zhu Peiyuan Feng Ying Li Yichen Zhou Na Mi Yueyao Zhu Dong Jiang Senyan Zhang Zerui Zhang Yujie Sun Li Yu | 2015 | Cell Research2015，25，10： | 8 |
| 3 | Configuration synthesis of machining centres with tool change mechanisms显示文摘 | Fu Chen Hong Senyan | 1999 | International Journal of Machine Tools & Manufacture1999，62，39： | 1 |
| 4 | Structural insights into the as- sembly and activation of IL-113 with its receptor显示文摘 | Dongli W Senyan Z Liang L | 2010 | Nature Immu- nology2010，10，1038： | 1 |
| 5 | Predicting vehicle fuel consumption patterns using floating vehicle data显示文摘The status of energy consumption and air pollution in China is serious. It is important to analyze and predict the different fuel consumption of various types of vehicles under different influence factors. In order to fully describe the relationship between fuel consumption and the impact factors, massive amounts of floating vehicle data were used.The fuel consumption pattern and congestion pattern based on large samples of historical floating vehicle data were explored, drivers' information and vehicles' parameters from different group classification were probed, and the average velocity and average fuel consumption in the temporal dimension and spatial dimension were analyzed respectively.The fuel consumption forecasting model was established by using a Back Propagation Neural Network. Part of the sample set was used to train the forecasting model and the remaining part of the sample set was used as input to the forecasting model. | Yiman Du Jianping Wu Senyan Yang Liutong Zhou | 2017 | Journal of Environmental Sciences2017，29，9： | 1 |
| 6 | Study on the tourism contracts显示文摘 | Sun SenYan | 1999 | Dong-wu Law lournal1999，，1： | 1 |
| 7 | Identification of two AFLP markers linked to bacterial wilt resistance in tomato and conversion to SCAR markers显示文摘 | Miao Lixiang Shou Senyan Cai Jiayan | 2009 | Melecular Biology Reports2009，36，3： | 1 |
| 8 | p55PIK-PI3K stimulates angiogenesis in colorectal cancer cell by activating NF-κB pathway显示文摘 | Guihua Wang Cheng Chen Rui Yang Xiaonian Cao Senyan Lai Xuelai Luo Yongdong Feng Xianmin Xia Jianping Gong Junbo Hu | 2013 | Angiogenesis2013，，3： | 1 |
| 9 | Autotoxic potential of cucurbit crops显示文摘 | Yu Jingquan Shou Senyan Qian Yarong | | 0，，： | 1 |
| 10 | 驱动蛋白介导自噬性溶酶体出管显示文摘本研究通过在体外重构自噬性溶酶体出管的单分子研究体系,详细解析了驱动蛋白KIF5B介导自噬性溶酶体出管再生的分子机制。 | Wanqing Du Qian Peter Su Yang Chen Yueyao Zhu Dong Jiang Yueguang Rong Senyan Zhang Yixiao Zhang He Ren Chuanmao Zhang Xinquan Wang Ning Gao Yanfeng Wang Lingfei Sun 孙育杰 俞立 | 2017 | 科学新闻2017，19，4： | 0 |
| 11 | Thiol-mediated transportation pathway:an approach for improving tumor penetration of nanomedicines in vivo显示文摘Abnormal tumor microenvironment imposes barriers to tumor penetration of nanomedicine,which remains a major challenge for effective anti-tumor.Herein,we present disulfide-based nanoparticles that actively penetrate deep tumors in vivo through a thiol-mediated transportation pathway.To achieve active tumor accumulation in vivo,disulfide-based nanoparticles are modified with folic acid units(FA-DBNPs).It is gratifying that FA-DBNPs still enter cells via the thiol-mediated pathway,which facilitates transcellular transportation and tumor penetration both in vitro and in vivo.Besides,FA-DBNPs exhibit GSH concentration-dependent depolymerization characterization,indicating that the GSH level in tumor tissues regulates the penetration depth of FA-DBNPs.Benefiting from these advantages,FA-DBNPs showed potent anti-tumor activity in mouse models,leading to the significant regression of tumors.The current study lays a foundation that thiol-mediated transportation is a promising approach in nanomedicine design for solid tumor therapy. | Junjie Zhang Weican Sun Xing Wang Senyan Chen Jingying Li Huanghao Yang | 2024 | Science China Chemistry2024，67，1： | 0 |
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