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| 1 | Analysis of In-hospital Neonatal Death in the Tertiary Neonatal Intensive Care Unit in China: A Multicenter Retrospective Study显示文摘 | Chen-Hong Wang Li-Zhong Du Xiao-Lu Ma Li-Ping Shi Xiao-Mei Tong Hong Liu Guo-Fang Ding Bin Yi Xin-Nian Pan Dan-Ni Zhong Ling Liu Mei Li Cui-Qing Li Shi-Wen Xia Hong-Yun Wang Ling He Kun Liang Xiao-Yu Zhou Shu-Ping Han Qin Lyu Yin-Ping Qiu Ruo-Bing Shan De-Zhi Mu Xiao-Hong Liu Si-Qi Zhuang Jing Guo Li Liu Jia-Jun Zhu Hong Xiong | 2016 | Chinese Medical Journal2016，，22： | 8 |
| 2 | Tumor-expressed B7-H3 mediates the inhibition of antitumor T-cell functions in ovarian cancer insensitive to PD-1 blockade therapy显示文摘Although PD-L1/PD-1 blockade therapy has been approved to treat many types of cancers,the majority of patients with solid tumors do not respond well,but the underlying reason remains unclear.Here,we studied ovarian cancer(OvCa),a tumor type generally resistant to current immunotherapies,to investigate PD-1-independent immunosuppression.We found that PD-L1 was not highly expressed in the tumor microenvironment(TME)of human OvCa.Instead,B7-H3,another checkpoint molecule,was highly expressed by both tumor cells and tumor-infiltrating antigen-presenting cells(APCs),which correlated with T-cell exhaustion in patients.Using ID8 OvCa mouse models,we found that B7-H3 expressed on tumor cells,but not host cells,had a dominant role in suppressing antitumor immunity.Therapeutically,B7-H3 blockade,but not PD-1 blockade,prolonged the survival of ID8 tumorbearing mice.Collectively,our results demonstrate that tumor-expressed B7-H3 inhibits the function of CD8^(+)T cells and suggest that B7-H3 may be a target in patients who are not responsive to PD-L1/PD-1 inhibition,particularly OvCa patients. | Dongli Cai Jiaming Li Dingfeng Liu Shanjuan Hong Qin Qiao Qinli Sun Pingping Li Nanan Lyu Tiantian Sun Shan Xie Li Guo Ling Ni Liping Jin Chen Dong | 2020 | Cellular & Molecular Immunology2020，17，3： | 8 |
| 3 | Overexpression of SIRT1 is a poor prognostic factor for advanced colorectal cancer显示文摘 | Jiang Kewei Lyu Liang Shen Zhanlong Zhang Jizhun Zhang Hui Dong Jianqiang Yan Yichao Liu Fangfang Wang Shan | 2014 | Chinese Medical Journal2014，，11： | 5 |
| 4 | Preparation of Titanium-silphenylene-siloxane Hybrid Polymers with High Refractive Index,Transmittance,and Thermal Stability显示文摘Vinyl-containingtitanium-silphenylene-sioxane oligomers(O1,O2,O3,andO4)withdifferent molar ratios of titanium to silicon were successfully synthesized in high yields by nonhydrolytic sol-gel reaction,and the obtained four oligomers were further crosslinked with methylphenyl hydro-silicone oil(4)to form corresponding polymers(P1,P2,P3,and P4)by hydrosilylation reaction.Their structures were characterized with spectroscopic characterization techniques including FTIR,1H-NMR,and Raman spectroscopy.The effect of titanium element on crosslinking behavior,thermal resistance,refractive index,transparency,thermal aging stability,glass transition temperature,and surface properties of the polymers were studied.Compared with titanium-free polymer P1,the thermal resistance,refractive index,and thermal aging stability of titanium-silphenylene-siloxane polymers(P2,P3,and P4)were significantly improved.The titanium-silphenylene-siloxane polymers achieved a high refractive index(n=1.580-1.584)and thermostability(Tsd>500℃).In thermal aging,the polymers exhibited superior performances with high optical transparency(~90%at 450 nm)and exhibited high thermal stability(~84%at 450 nm after thermal aging at 150℃for 120 h).These data indicate that the polymers have potential application in optical materials such as LED encapsulants. | Dong Zhao Shu-Xi Shan Meng Zhang Xiao-A Zhang Sheng-Ling Jiang Ya-Fei Lyu | 2020 | Chinese Journal of Polymer Science2020，38，9： | 5 |
| 5 | Visceral Leishmaniasis--China,2015−2019显示文摘What is already known about this topic?Visceral leishmaniasis(VL)is an important vectorborne disease in rural areas of western China.The spreading of VL made its prevention and control become more complicated.What is added by this report?The number of VL cases decreased from 2015(n=498)to 2019(n=166).However,the mountain-type zoonotic visceral leishmaniasis(MT-ZVL)cases increased from 2015(n=82,16.5%)to 2019(n=122,73.5%).In addition,both number and proportion of imported cases increased from 2015(n=18,3.6%)to 2019(n=41,24.7%).The re-emergence of MT-ZVL was considerable;13 historically-endemic counties reported 48 indigenous cases.Infants and young children were the high risk population of VL(848,62.4%)followed by farmers(303,22.3%).What are the implications for public health practice?Both MT-ZVL and imported cases showed an increasing trend in China.Therefore,two actions are needed to control VL:1)to prevent re-emergence and spreading of MT-ZVL;and 2)to ensure timely diagnosis and appropriate treatment to avoid fatal VL cases,especially in non-endemic areas. | Zhengbin Zhou Shan Lyu Yi Zhang Yuanyuan Li Shizhu Li Xiao-nong Zhou | 2020 | China CDC weekly2020，2，33： | 4 |
| 6 | Effect of Alemtuzumab on Intestinal Intraepithelial Lymphocytes and Intestinal Barrier Function in Cynomolgus Model显示文摘 | Lin-Lin Qu Ya-Qing Lyu Hai-Tao Jiang Ting Shan Jing-Bin Zhang Qiu-Rong Li Jie-Shou Li | 2015 | Chinese Medical Journal2015，，5： | 3 |
| 7 | Experimental study of single-row chevron-jet impingement heat transfer on concave surfaces with different curvatures显示文摘To address the curvature effect on single-row chevron-nozzle jet impingement heat transfer on concave surface,a series of experiments are conducted in the present investigation.Four concave surfaces including one semi-cylindrical concave surface and three parabolic concave surfaces with different width-to-depth ratios are tested under three typical Reynolds numbers(Re=5000,10000 and 15000)and several dimensionless nozzle-to-surface distances ranging from 1 to 8.The results show that the concave curvature has a clear impact on chevron-nozzle jet impingement heat transfer,tightly dependent on jet Reynolds number and impinging distance.In general,the semicylindrical concave surface produces the highest longitudinally-averaged Nusselt number at the leading line of concave surface.Under a low jet Reynolds number,the parabolic concave surface with a highly curved curvature produces higher longitudinally-averaged Nusselt number at the leading line and more uniform longitudinally-averaged Nusselt number distribution along the curvilinear direction.However,the longitudinally-averaged Nusselt number at the leading line of concave surface is the lowest for the highly curved surface under a high jet Reynolds number and large impinging distance.In comparison with the round-nozzle,chevron nozzle plays a more significant role on improving jet impingement heat transfer at small impinging distances. | Yuanwei LYU Jingzhou ZHANG Xichen LIU Yong SHAN | 2019 | Chinese Journal of Aeronautics2019，32，10： | 3 |
| 8 | Environmental Monitoring of A Laboratory for New Coronavirus Nucleic Acid Testing显示文摘The coronavirus disease 2019(COVID-19) is an infection of the respiratory tract which first broke out in Wuhan, China, in December 2019. The etiologic agent of this disease was identified as a betacoronavirus related to severe acute respiratory syndrome coronavirus(SARS-CoV). Thus, the International Committee on Virus Classification named the new coronavirus severe acute respiratory syndrome coronavirus-2(SARS-CoV-2)[1]. | NING Pei Yong YU Ai Ping WANG Yuan GUO Li Ru SHAN Dan KONG Mei YU Ling Qi LYU Li Kun ZOU Ming SU Xu FEI Chun Nan ZHOU Yu Hui WANG Bai Qi | 2020 | Biomedical and Environmental Sciences2020，33，10： | 2 |
| 9 | A Simple, Low-cost Method to Fabricate Drag-reducing Coatings on a Macroscopic Model Ship显示文摘 | WANG Zhipeng ZHANG Songsong GAO Shan OUYANG Xiao LI Jie LI Rui WEI Hao SHUAI Zhijun LI Wanyou LYU Shanshan | 2018 | Chemical Research in Chinese Universities2018，34，4： | 2 |
| 10 | Prediction of cutting forces in ball-end milling of 2.5D C/C composites显示文摘Machining of carbon/carbon(C/C) composite materials is difficult to carry out due to its high specific stiffness,brittleness,anisotropic,non-homogeneous and low thermal conductivity,which can result in tear,burr,poor surface quality and rapid wear of cutters.Accurate and fast prediction of cutting forces is important for milling C/C composite materials with high quality.This paper presents an alternative cutting force model involving the influences of the directions of fiber.Based on the calculated and experimental results,the cutting forces' coefficients of 2.5D C/C composites are evaluated using multiple linear regression method.Verification experiment has been carried out through a group of orthogonal tests.Results indicate that the proposed model is reliable and can be used to predict the cutting forces in ball-end milling of 2.5D C/C composites. | Shan Chenwei Wang Xiao Yang Xuanxuan Lyu Xiaobo | 2016 | Chinese Journal of Aeronautics2016，29，3： | 2 |
| 11 | Genome and Comparative Transcriptomics of African Wild Rice Oryza Iongistaminata Provide Insights into Molecular Mechanism of Rhizomatousness and Self-Incompatibility显示文摘Dear Editor, Oryza Iongistaminata is an African wild rice species with AA genome type possessing special traits that are highly valued for improving cultivated rice,such as strong resistance to biotic and abiotic stresses (Song et al.,1995) for improving resistance of cultivars,rhizomatousness for perennial breeding (Glover et al.,2010),and self-incompatibility (SI) for new ways to produce hybrid seeds (Ghesquiere,1986).Deciphering the genome of O.longistaminata will be the key to uncovering the mechanism of these hallmark traits and improving cultivated rice. | Yesheng Zhang Shilai Zhang Hui Liu Binying Fu Lijuan Li Min Xie Yue Song Xin Li Jing Cai Wenting Wan Ling Kui Hui Huang Jun Lyu Yang Dong Wensheng Wang Liyu Fluang Jing Zhang Qinzhong Yang Qinfi Shan Qiong Li Wangqi Huang Dayun Tao Muhua Wang Mingsheng Chen Yeisoo Yu Rod A. Wing Wen Wang Fengyi Hu | 2015 | Molecular Plant2015，8，11： | 1 |
| 12 | Rationale,design,and baseline characteristics of Chinese registry in early detection and risk stratification of coronary plaques(C-STRAT)study显示文摘To the Editor:Coronary computed tomographic angiography(CCTA)has been considered as one of the most important noninvasive imaging modalities in diagnosing coronary artery disease(CAD).[1]Modern scanner of CCTA can provide precise coronary atherosclerotic plaque information,showing improved diagnostic accuracy and sensitivity for identifying obstructive CAD with a preferable temporal and spatial resolution.Several studies have demonstrated the prognosis value of CCTA for the prediction of future adverse CAD events. | Jun-Jie Yang Dong-Kai Shan Lei Xu Jun-Fu Liang Zhao-Qian Wang Mei Zhang Min Li Wen-Jie Yang Jian-Rong Xu Yong-Gao Zhang Li-Ming Xia Li-Hua Wang Hong-Jie Hu Zhi-Gang Yang Tao Li Qi Tian Xu-Dong Lyu Yun-Dai Chen | 2021 | Chinese Medical Journal2021，，7： | 1 |
| 13 | Enhanced 1.54-μm photo-and electroluminescence based on a perfluorinated Er(Ⅲ) complex utilizing an iridium(Ⅲ) complex as a sensitizer显示文摘Advanced 1.5-μm emitting materials that can be used to fabricate electrically driven light-emitting devices have the potential for developing cost-effective light sources for integrated silicon photonics.Sensitized erbium(Er^(3+))in organic materials can give bright 1.5-μm luminescence and provide a route for realizing 1.5-μm organic light emitting diodes(OLEDs).However,the Er3+electroluminescence(EL)intensity needs to be further improved for device applications.Herein,an efficient 1.5-μm OLED made from a sensitized organic Er3+co-doped system is realized,where a“traditional”organic phosphorescent molecule with minimal triplet–triplet annihilation is used as a chromophore sensitizer.The chromophore provides efficient sensitization to a co-doped organic Er^(3+) complex with a perfluorinatedligand shell.The large volume can protect the Er^(3+) 1.5-μm luminescence from vibrational quenching.The average lifetime of the sensitized Er^(3+) 1.5-μm luminescence reaches ~0.86 ms,with a lifetime component of 2.65 ms,which is by far the longest Er^(3+) lifetime in a hydrogen-abundant organic environment and can even compete with that obtained in the fully fluorinated organic Er^(3+) system.The optimal sensitization enhances the Er^(3+) luminescence by a factor of 1600 even with a high concentration of the phosphorescent molecule,and bright 1.5-μm OLEDs are obtained. | Hong-Fei Li Xiao-Qi Liu Chen Lyu Jelena Gorbaciova Li-Li Wen Guo-Gang Shan Peter B.Wyatt Huan-Qing Ye William P.Gillin | 2020 | Light(Science & Applications)2020，9，1： | 1 |
| 14 | Carbon sequestration and emissions mitigation in paddy fields based on the DNDC model: A review显示文摘The DeNitrification–DeComposition(DNDC)model is a process model with a series of carbon and nitrogen biogeochemistry in agro-ecosystems.It incorporates the driving factors of the ecological environment and aims to simulate the carbon and nitrogen cycle in the terrestrial ecosystem.Furthermore,the model can be applied effectively in a paddy ecosystem.Based on an investigation and literature review,this study summarized and analyzed the impact of agricultural practices such aswatermanagement,fertilizer application,and strawincorporation on greenhouse gas emissions and soil carbon storage.After years of improvement,the DNDC model can presently be used effectively to evaluate the carbon sequestration and emissions mitigation potential of various agricultural practices.However,the related details of scientific processes of agricultural management,such as biochar incorporation and plastic mulching in paddy fields,should be added or modified and combined with experimental cases of actual agricultural practices to complete the calibration of the model,provide theoretical support for its promotion,and establish a reliable method of evaluating carbon sequestration and emissions mitigation in paddy fields. | Shan Yin Xianxian Zhang Junyao Lyu Yuee Zhi Feng Chen Longqin Wang Chunjiang Liu Sheng Zhou | 2020 | Artificial Intelligence in Agriculture2020，，1： | 1 |
| 15 | Insights into the mechanism of Sub3 inhibiting Fusarium moniliforme infection in maize显示文摘Fusarium moniliforme(F.moniliforme) and its secondary metabolite fumonisin pose a severe threat to food safety,and searching for effective antimicrobial agents is a focus of current research.In this study,the secondary structure of Sub3 was analyzed by circular dichroism,meanwhile,the inhibition rate of Sub3 against spores,mycelia of F.moniliforme and infected maize was studied.To explore the possible inhibition mechanisms,morphological and structural changes of spores treated with Sub3 at0,1/2 MIC(minimum inhibitory concentration) and MIC were observed by scanning electron microscopy and transmission electron microscopy;the cell wall integrity,membrane integrity,reactive oxygen species,mitochondrial membrane potential,ATP synthase activity,redox reactions,and the nuclear damage of F.moniliforme were also investigated.The results showed that Sub3 was mostly in the state of random in deionized water,while mainly showed the β-sheet structure in the hydrophobic environment of 50% Trifluoroethanol(TFE) solution,indicating that Sub3 might generate partial structure deformation when acting on the cell membrane;and its MIC on F.moniliforme spores was 0.2 g/L.Under the 1/2 MIC and MIC,the inhibition rates of Sub3 against F.moniliforme infected maize were 34.3% and75.6%,respectively.The results of inhibition mechanisms revealed that the defective pathogenicity of F.moniliforme caused by Sub3 was attributed to damages on both the cell wall and the cell membrane,which might upset balance of intracellular redox system and mitochondrial energy metabolism and trigger nucleus damage,ultimately leading to cell death.Meanwhile,Sub3 could diminished ATP synthase enzyme activity in a dose-dependent manner.The results provided direct evidence for inhibition of F.moniliforme infection of maize by Sub3,and useful knowledge applicable for food preservation. | Haojie Yang Wei Zhang Pingping Tian Bangbang Li Shan Wei Shuaibing Zhang Na Li Yangyong Lyu Yuansen Hu | 2022 | Grain & Oil Science and Technology2022，5，1： | 1 |
| 16 | Projecting the proliferation risk of Oncomelania hupensis in China driven by SSPs:A multi-scenario comparison and integrated modeling study显示文摘Climate change has been known to cause variations in the geographically suitable areas for the schistosome-transmitting Oncomelania hupensis(O.hupensis).The spread of snails not only depends on the degree of warming but also on the socioeconomic development of the next few decades.Shared socioeconomic pathways(SSPs)published by CMIP6 consider carbon emission pathways as well as influences of distinct types of social development and land use on the regional climate,providing the possibility to accurately evaluate the impact of socioeconomic development and climate variation on the spread of O.hupensis.This study employed SSP126,SSP245,SSP370,and SSP585 and the correlative approach to explore the impacts of climate change and socioeconomic development on the potential diffusion areas for O.hupensis in China.The results exhibited strong evidence that O.hupensis will spread in the north of the middle and lower reaches of the Yangtze River and disappear from a small part of its current southern habitat,whereas in Sichuan and Yunnan,O.hupensis may spread slightly to the southeast.The projection also demonstrated that fossil fuel-driven development(SSP585)will be more conducive to the spread of O.hupensis breeding sites in the 2030s,whereas the continuous increase in snail breeding habitats under the regional rivalry path(SSP370)may lead to great challenges in snail control in the long term(2020-2080). | Yan-Feng GONG Xiao-Kang HU Yu-Wan HAO Zhuo-Wei LUO Jia-Xin FENG Jing-Bo XUE Zhao-Yu GUO Yin-Long LI Li-Juan ZHANG Shang XIA Shan LYU Jing XU Shi-Zhu LI | 2022 | Advances in Climate Change Research2022，13，2： | 1 |
| 17 | PolyvasculaR Evaluation for Cognitive Impairment and vaScular Events (PRECISE)-a population-based prospective cohort study: rationale, design and baseline participant characteristics显示文摘Background and purpose Cardiovascular diseases and dementia are two major diseases in the elderly.Atherosclerosis is associated with future vascular events and cognitive impairment.The PolyvasculaR Evaluation for Cognitive Impairment and vaScular Events(PRECISE)study is a population-based prospective cohort study with comprehensive evaluation of multiterritorial artery stenosis and plaque using advanced vascular imaging techniques and prospective collection of vascular events and cognitive assessments.Methods Between May 2017 and September 2019,the PRECISE study enrolled 3067 community-dwelling adults with ages between 50 and 75 years cluster sampled from six villages and four communities of Lishui city in China.Data are collected in face-to face interviews at baseline,2-year and 4-year follow-up visits.Brain MRI including high-resolution sequences for intracranial and carotidal arteries and CT angiography for thoracoabdominal arteries were performed at baseline and will be rescanned after 4 years.Cardiovascular/cerebrovascular events and cognitive assessment will be prospectively collected after the enrollment.Blood and urine samples were collected and biomarkers were tested at baseline.Results A total of 3067 subjects were enrolled,among which 53.5%were female with an average age of 61.2±6.7 years.Among them,2.8%,8.1%,43.1%and 21.6%had a history of stroke,coronary heart diseases,hypertension and diabetes mellitus,respectively.Conclusions The PRECISE study is a population-based prospective cohort study with comprehensive evaluation of atherosclerotic stenosis and plaque using advanced vascular imaging techniques.Data from this cohort provide us an opportunity to precisely evaluate polyvascular atherosclerosis and its association with future vascular events and cognitive impairment. | Yuesong Pan Jing Jing Xueli Cai Yilong Wang Suying Wang Xia Meng Chunlai Zeng Jiong Shi Jiansong Ji Jinxi Lin Lingchun Lyu Zhe Zhang Lerong Mei Shiping Li Shan Li Wanlin Zhu Hao Li Tiemin Wei Yongjun Wang | 2021 | Stroke & Vascular Neurology2021，6，1： | 1 |
| 18 | Numerical investigation on flow mechanism in a supersonic fluidic oscillator显示文摘A type of supersonic fluidic oscillator is proposed and its ability to generate pulsating supersonic jet is proved in this paper.Unsteady two-dimensional numerical simulations reveal that the fluid transforms from subsonic to supersonic condition in the mixing chamber of oscillator after the supplied flow pressure increases from 1.1×105 Pa to 5.0×105 Pa.When the supersonic flow is formed inside the oscillator,the wall-attached flow represents expansion wave and compression wave alternately.The oscillating frequency will saturate to a certain value with the increase of supplied pressure.Examination of the internal fluid dynamics indicates that the flow direction inside the FeedBack Channel(FBC)is related to the change of the local pressure at the inlet and the outlet of the feedback channel.The vortices produced in the mixing chamber present different distribution characteristics with the change of the fluid’s direction in the FBC.The sweeping jet is divided into two jets with varying flow rate over time by the splitter.In the end of two channels,two jets are accelerated above sound speed by convergent-divergent nozzle.Therefore,pulsating supersonic jets are produced at two outlets for this type of fluidic oscillator. | Yongjun SANG Yong SHAN Jingzhou ZHANG Xiaoming TAN Yuanwei LYU | 2021 | Chinese Journal of Aeronautics2021，34，5： | 1 |
| 19 | Anti-fungal properties of Puroindoline A against Aspergillus glaucus显示文摘Aspergillus glaucus can grow in low moisture grain,and is one of the main fungi responsible for agricultural product losses.Puroindoline A(PINA)is a tryptophan-rich alkaline adiponectin that can effectively inhibit numerous plant bacteria and fungi.However,the mechanism of PINA against A.glaucus remains unclear.Herein,we found that recombinant PINA(rPINA)could inhibit A.glaucus mycelia growth on salt Czapek dox agar(SCDA)medium and spore germination on Czapek dox(CD)medium.Scanning electron microscopy revealed that incomplete morphological characteristics of both A.glaucus spores and mycelia occurred following rPINA treatment.Laser scanning confocal microscopy(LSCM)showed that rPINA could enter the interior of spores.Flow cytometry and propidium iodide(PI)staining illustrated membranes of spores were severely damaged,especially after treatment with 0.9 mg/mL rPINA for 12 h,and spores with intact membranes were reduced by 30.7%.Additionally,rPINA reduced the mitochondrial membrane potential(MMP)by 5,5′,6,6′-tetrachlorr-1,1′,3,3′-tetraethyl-imidacarbocyanine iodide(JC-1)staining,and caused DNA damage by 4′,6-diamidino-2-phenylindole(DAPI)staining.These results indicated that rPINA may damage cell membranes and DNA structure and reduceMMP,thereby inhibiting the growth of A.glaucus.The antifungal mechanism has been demonstrated in this study,and results show that rPINA has application potential in preventing postharvest loss in the agricultural industry. | Wenjing Yuan Pingping Tian Ang Lyu Yangyong Lyu Wei Zhang Shan Wei Yuansen Hu | 2020 | Grain & Oil Science and Technology2020，3，1： | 0 |
| 20 | Cu-DNAzyme facilitates highly sensitive immunoassay显示文摘Fast and sensitive antigen detection is important in biomedical research and development. Despite, being invented 48 years ago, the enzyme-linked immunosorbent assay(ELISA) remains one of the most successful and widely employed bioanalytical techniques in research and clinical diagnostics due to its reliability and simplistic design. Recently, nanotechnology has offered efficient signal reporting. In spite of some improvements in these systems, there are typically increased material costs involved and the need for expensive equipment or complicated chemical processes, thus negating any possible benefits over ELISA. Herein, we communicate a simple Cu-DNAzyme system for signal transduction of a CuO nanoparticle-labeled immunoassay. The reported immunoassay amplifies signal generation similar to traditional ELISA and is fast, simple, cost-effective, and sensitive, holding promise for biomedical applications and point-of-care testing. | Zhi Shan Mingsheng Lyu Dennis Curry David Oakley Ken Oakes Xu Zhang | 2019 | Chinese Chemical Letters2019，30，9： | 0 |
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