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| 1 | Quantitative Assessment of Impacts of Regional Climate and Human Activities on Saline-alkali Land Changes:A Case Study of Qian'an County,Jilin Province显示文摘Interdecadal and interannual variations of saline-alkali land area in Qian′an County, Jilin Province, China were comprehensively analyzed in this paper by means of satellite remote sensing interpretation, field flux observations and regional climate diagnosis.The results show that on the interannual scale, the impact of climate factors accounts for 71.6% of the total variation of the saline-alkali land area, and that of human activities accounts for 28.4%.Therefore the impact of climate factors is obviously greater than that of human activities.On the interdecadal scale, the impact of climate factors on the increase of the saline-alkali land area accounts for 43.2%, and that of human activities accounts for 56.8%.The impact of human activities on the variation of saline-alkali land area is very clear on the interdecadal scale, and the negative impact of human activities on the environment should not be negligible.Besides, changes in the area of heavy saline-alkali land have some indication for development of saline-alkali land in Qian′an County. | LIAN Yi WANG Jie TU Gang REN Hongling SHEN Baizhu ZHI Keguang LI Shangfeng GAO Zongting | 2010 | Chinese Geographical Science2010，20，1： | 3 |
| 2 | BYSL contributes to tumor growth by cooperating with the mTORC2 complex in gliomas显示文摘Objective:BYSL,which encodes the Bystin protein in humans,is upregulated in reactive astrocytes following brain damage and/or inflammation.We aimed to determine the role and mechanism of BYSL in glioma cell growth and survival.Methods:BYSL expression in glioma tissues was measured by quantitative real-time PCR,Western blot,and immunohistochemistry.In vitro assays were performed to assess the role of BYSL in cell proliferation and apoptosis.Protein interactions and co-localization were determined by co-immunoprecipitation and double immunofluorescence.The expression and activity of the AKT/m TOR signaling molecules were determined by Western blot analysis,and the role of BYSL in glioma growth was confirmed in an orthotopic xenograft model.Results:The BYSL m RNA and protein levels were elevated in glioma tissues.Silencing BYSL inhibited glioma cell proliferation,impeded cell cycle progression,and induced apoptosis,whereas overexpressing BYSL protein led to the opposite effects.We identified a complex consisting of BYSL,RIOK2,and m TOR,and observed co-localization and positive correlations between BYSL and RIOK2 in glioma cells and tissues.Overexpressing BYSL or RIOK2 increased the expression and activity of AKT/m TOR signaling molecules,whereas downregulation of BYSL or RIOK2 decreased the activity of AKT/m TOR signaling molecules.Silencing BYSL or RIOK2 decreased the growth of the tumors and prolonged the lifespan of the animals in an orthotopic xenograft model.Conclusions:High expression of BYSL in gliomas promoted tumor cell growth and survival both in vitro and in vivo.These effects could be attributed to the association of BYSL with RIOK2 and m TOR,and the subsequent activation of AKT signaling. | Shangfeng Gao Zhuang Sha Junbo Zhou Yihao Wu Yunnong Song Cheng Li Xuejiao Liu Tong Zhang Rutong Yu | 2021 | Cancer Biology & Medicine2021，18，1： | 3 |
| 3 | CsPb(I_(x)Br_(1-x))_(3) solar cells显示文摘Owing to its nice performance, low cost, and simple solution-processing, organic-inorganic hybrid perovskite solar cell(PSC) becomes a promising candidate for next-generation high-efficiency solar cells.The power conversion efficiency(PCE) has boosted from 3.8% to 25.2% over the past ten years. Despite the rapid progress in PCE, the device stability is a key issue that impedes the commercialization of PSCs. Recently, all-inorganic cesium lead halide perovskites have attracted much attention due to their better stability compared with their organic-inorganic counterpart. In this progress report, we summarize the properties of CsPb(IxBr1-x)3 and their applications in solar cells. The current challenges and corresponding solutions are discussed. Finally, we share our perspectives on CsPb(IxBr1-x)3 solar cells and outline possible directions to further improve the device performance. | Xue Jia Chuantian Zuo Shuxia Tao Kuan Sun Yixin Zhao Shangfeng Yang Ming Cheng Mingkui Wang Yongbo Yuan Junliang Yang Feng Gao Guichuan Xing Zhanhua Wei Lijun Zhang Hin-Lap Yip Mingzhen Liu Qing Shen Longwei Yin Liyuan Han Shengzhong Liu Lianzhou Wang Jingshan Luo Hairen Tan Zhiwen Jin Liming Ding | 2019 | Science Bulletin2019，64，20： | 2 |
| 4 | Effect of heat treatment on the structure and properties of poly(2,6- benzothiazole) (ABPBT) and poly(2,5-benzoxazole) (ABPBO) 显示文摘 | Wang Shangfeng Gao Bingbao Lu Zhibao et a l | 2000 | Journal of Materials Science2000，35，23： | 1 |
| 5 | ZNF3 regulates proliferation,migration and invasion through MMP1 and TWIST in colorectal cancer显示文摘Colorectal cancer(CRC)is a malignant tumor with a high incidence and mortality worldwide.Currently,the underlying molecular mechanisms of CRC are still unclear.Zinc finger protein 3(ZNF3)is a zinc-finger transcription factor that has been reported as a candidate for breast cancer prognosis,suggesting its involvement in the regulation of tumorigenesis.However,the association between ZNF3 and CRC remains unknown.To investigate the role of ZNF3 in CRC,we first analyze the correlation between ZNF3 expression and CRC,and the results demonstrate that ZNF3 is highly expressed in CRC tissue and cells,which is associated with the age of CRC patients.In vitro studies show that ZNF3 overexpression promotes CRC cell migration.Compared to control cells,knockdown of ZNF3 markedly suppresses CRC cell proliferation,migration and invasion and promotes G0/G1 phase cell cycle arrest.The expressions of the EMT-related markers TWIST and MMP1 are significantly decreased when ZNF3 is silenced.Additionally,overexpression of MMP1 and TWIST exacerbates CRC cell proliferation,accelerates the S phase cell cycle in ZNF3-knockdown SW480 cells,and increases cell migration and invasion through Transwell chambers.These data suggest that ZNF3 is involved in cellular proliferation,migration and invasion by regulating MMP1 and TWIST in CRC cells. | Le Du Ning Liu Jianfeng Jin Meng Cao Yuantian Sun Xinzheng Gao Banzhan Ruan Shangfeng Yang Dongsheng Ge Yingzhuan Ye Yinxi Zhou Erfei Chen Jin Yang | 2022 | Acta Biochimica et Biophysica Sinica2022，54，12： | 1 |
| 6 | Developmental expression of CAPON and Dexras1 in spinal cord of rats显示文摘To study the expression of the carboxy-ter-minal PSD-95/DLG/ZO-1 ligand of nNOS(CAPON)and Dexras1 mRNA during development in the spinal cord of rats,real-time polymerase chain reaction(Real-time PCR),as a quantitative method,was used to study the developmental expression of CAPON and Dexras1 mRNA level in the spinal cord.The spatial expression of CAPON and Dexras1 mRNA was examined by a com-bination of in situ hybridization(ISH)and immunofluor-escence.During the development of the spinal cord,CAPON mRNA was expressed in low levels from embryo day 14 to day 18.At postnatal day 1,it reached the peak and was expressed in the part which will become the dor-sal horn when mature.It then decreased gradually until postnatal week 12,when it presented in the ventral horn.At embryo day 14,Dexras1 mRNA was expressed at low levels,increased during embryo day 16 to day 18 and peaked at postnatal day 1.Spatiotemporal expression of Dexras1 mRNA was similar to CAPON as confirmed by correlation analysis and colocalization.CAPON and neuronal nitric oxide synthase(nNOS)was expressed within the same cells of the dorsal horn at postnatal day 1 but had different subcellular localizations.Co-express-ion of CAPON and Dexras1 mRNA in myeloid tissue during development process of rat indicates that the adaptor protein,CAPON may play a probable role in differentiation of neurons,synaptic plasticity and synap-togenesis by regulating nNOS to activate Dexras1. | Xin LI Chun CHENG Jian ZHAO Mengling CHEN Shuqiong NIU Shangfeng GAO Aiguo SHEN | 2008 | Frontiers of Medicine2008，2，1： | 0 |
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