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| 1 | Identification of immunodominant linear B-cell epitopes within the major outer membrane protein of Chlamydia trachomatis显示文摘Chlamydia trachomatis 是最流行的性播送的病原体之一。Chlamydial 主要的外部膜蛋白质(MOMP ) 能在鼠科的模型导致强壮的细胞、体液的有免疫力的回答并且被认为是一个潜在的疫苗的候选人。在这份报告, MOMP 的氨基酸顺序用帮助计算机的技术被分析扫描 B 房间 epitopes,和三可能的线性 B 房间 epitopes 肽(VLKTDVNKE, TKDASIDYHE, TRLIDERAAH ) 与高预言的 antigenicity 和高度,保存被调查。为各潜在的 epitope 编码区域的 DNA 被克隆进 pET32a (+) 并且在 Escherichia coli 表示了为 Trx-His-tag 熔化蛋白质。熔化蛋白质被 Ni-NTA agarose 祷告净化并且由 SDS 页和西方的污点分析列在后面。我们与这三熔化蛋白质使老鼠免疫。从使免疫的老鼠包含 anti-epitope 抗体的 sera 能认出 C。在 ELISA 的 trachomatis serovars D 和 E。这些熔化蛋白质的 Antisera 在 serovar E 的侵略上显示了禁止的效果由在 vitro 中立化试金。另外,浆液从恢复健康的 C 取样。感染 trachomatis 的病人与由西方的污点试金的 epitope 熔化蛋白质是反应的。我们的结果证明生物信息的分析选择的 epitope 序列是高度保存的 C。trachomatis MOMP B 房间 epitopes,并且能是子单元疫苗的发展的好候选人,它能在临床的诊断被使用。 | Shanli Zhu Jun Chen Meixia Zheng Wenci Gong Xiangyang Xue Wenshu Li Lifang Zhang | 2010 | Acta Biochimica et Biophysica Sinica2010，42，11： | 11 |
| 2 | Expression of HPV6b L1/EBV LMP2 multiepitope and immunogenicity in mice显示文摘人的乳头状瘤病毒(HPV ) 专业衣壳蛋白质 L1 是为 epitopes 的交货的重要车辆。调查包含 EpsteinBarr 的 multiepitope 的 hybridized HPV6b L1 的表示和 immunogenicity 病毒(EBV ) 潜伏膜蛋白质 2 (LMP2 ) ,包含哺乳动物的 codon 优化 HPV6b L1 基因和 EBV LMP2 multiepitope 的 recombinant plasmid pcDNA3.1 (+) 被构造。包含 T 房间和 B 房间 epitope 富有的肽的 EBV LMP2 multiepitope 被插入到 HPV6b 编码 L1 顺序的 C 终端。构造 plasmid 在由酶限制试金和 DNA 验证了以后,定序是进 COS-7 房间的 transfected。在 COS-7 房间的妄想的基因的表示被 RT-PCR,西方的污点分析和 immunofluorescence 试金证实。结果在 transfected COS-7 房间在 mRNA 和蛋白质层次两个都揭示了妄想的 HPV6b L1/EBV LMP2 multiepitope 基因的成功的表示。在老鼠的肌内的管理能对 HPV6b 得到不仅抗体 L1 像病毒的粒子和 EBV LMP2,而且对 EBV LMP2 epitopes 的细胞毒素的 T 淋巴细胞活动。现在的结果证实那 HPV L1 蛋白质是潜在的作为 immunogen 把 EBV LMP2 的 multiepitope 送到 MHC 一级和班 II 小径,扩大象交货车辆的 HPV L1 的使用。 | Shanli Zhu Xiangyang Xue Jianxiao Liu Lijun Lu Pengyun Zhao Jia Wang WenShu Li Lifang Zhang | 2010 | Acta Biochimica et Biophysica Sinica2010，42，8： | 4 |
| 3 | Geochronology and Geochemical Characteristics of Intrusion in the Jinchangliang Gold Deposit,Inner Mongolia and Their Tectonic Significance显示文摘Discovered and mined in recent years, the Jinchangliang gold deposit has not yet been studied in its genetic type. In this paper, the geological features of ore deposit, S isotopic composition, metallogenic age and elements geochemical of the granite closely related to mineralization were discussed. The results of the geological features of ore deposit and S isotopic composition show that ore-bearing hydrothermal solution was closely related with the intrusion of magmatic. The granite is characteristic of high silica SiO_2=72.38%–72.98%, high aluminum and Al_2O_3=14.22%–14.35%, low calcium CaO=0.16% –0.26%, and low value of FeOT/MgO(6.86–7.73), and rich in alkalis Na_2O+K_2O=9.11%–9.24%, suggesting that it is high-K calc-alkaline, highly fractionated, weak aluminum A-type granite. The REE patterns are inclined to right and show intense fractionation between LREE and HREE, without obvious negative Eu anomaly(δEu=0.80–0.84). The primitive mantle-normalized spidergrams are characterized by depletion of Ba, U, Ta, Nb, Zr, Ti and P, which implies that the granite has the characteristics of the crust-mantle mixing. S isotopes also indicate that the material source of gold deposit is closely related to the granite rocks. The LA-ICP-MS Zircon UPb age of the Damiao rock mass medium-fine grained monzogranite(belonging to the early IndoChina) is(245±1) Ma. It shows that Jinchangliang gold deposit was not formed in Yanshanian, but the early Indo-China. Specifically speaking, the deposit was formed in the collision stage of the North China plate and the Siberian plate. | SUN Zhenjun SUN Guosheng YU Henan TIAN Yi LIU Shanli XIANG Zhu MENG Jian XUE Huaiyu LU Lina | 2015 | Acta Geologica Sinica(English Edition)2015，89，6： | 4 |
| 4 | Construction of van der Waals substrates for largely mismatched heteroepitaxy systems using first principles显示文摘The high density of defects induced by large strains in largely mismatched heteroepitaxy systems, such as AlN and GaN, because of the large lattice and thermal mismatch between substrates and epilayers is the bottleneck problem. Graphene-assisted van der Waals(vdW) heteroepitaxy offers a new opportunity to resolve this problem. However, it suffers from the difficulty of nucleation. Here we theoretically assess the effects of five 2D materials for vdW heteroepitaxy of AlN and GaN, including graphene, hBN, MoS2, gC3N, and gC3N4, and provide physical insights using first-principle calculations. MoS2 and gC3N exhibit significant potential to overcome the shortcomings of graphene owing to their appropriate binding strengths and Al(or Ga)diffusion barriers. Moreover, the interface behavior between the epilayers and the substrates are carefully analyzed. Our findings are helpful not only for obtaining high-quality AlN and GaN films but also for developing new criterions to discover effective 2D materials for vdW heteroepitaxy. | ZhiMing Shi XiaoJuan Sun YuPing Jia XinKe Liu ShanLi Zhang ZhanBin Qi DaBing Li | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，12： | 3 |
| 5 | Polarization-enhanced AlGaN solar-blind ultraviolet detectors显示文摘AlGaN solar-blind ultraviolet detectors have great potential in many fields,although their performance has not fully meet the requirements until now.Here,we proposed an approach to utilize the inherent polarization effect of AlGaN to improve the detector performance.AlGaN heterostructures were designed to enhance the polarization field in the absorption layer,and a high built-in field and a high electron mobility conduction channel were formed.As a result,a high-performance solar-blind ultraviolet detector with a peak responsivity of 1.42 A/W at 10 V was achieved,being 50 times higher than that of the nonpolarization-enhanced one.Moreover,an electron reservoir structure was proposed to further improve the performance.A higher peak responsivity of 3.1 A/W at30 V was achieved because the electron reservoir structure could modulate the electron concentration in the conduction channel.The investigation presented here provided feasible approaches to improve the performance of the AlGaN detector by taking advantage of its inherent property. | Ke Jiang Xiaojuan Sun Zi-Hui Zhang Jianwei Ben Jiamang Che Zhiming Shi Yuping Jia Yang Chen Shanli Zhang Wei Lv Dabing Li | 2020 | Photonics Research2020，8，7： | 3 |
| 6 | Activities of principal photosynthetic enzymes in green macroalga Ulva linza:functional implication of C_4 pathway in CO_2 assimilation显示文摘The green-tide-forming macroalga Ulva linza was profiled by transcriptome sequencing to ascertain whether the alga carries both C3 and C4 photosynthesis genes.The key enzymes involved in C4 metabolism including pyruvate orthophosphate dikinase(PPDK),phosphoenolpyruvate carboxylase(PEPC),and phosphoenolpyruvate carboxykinase(PCK) were found.When measured under normal and different stress conditions,expression of rbcL was higher under normal conditions and lower under the adverse conditions,whereas that of PPDK was higher under some adverse conditions,namely desiccation,high salinity,and low salinity.Both ribulose-1,5-biphosphate carboxylase(RuBPCase) and PPDK were found to play a role in carbon fixation,with significantly higher PPDK activity across the stress conditions.These results suggest that elevated PPDK activity alters carbon metabolism in U.linza leading to partial operation of the C4 carbon metabolism,a pathway that,under stress conditions,probably contributes to the hardy character of U.linza and thus to its wide distribution. | XU JianFang ZHANG XiaoWen YE NaiHao ZHENG Zhou MOU ShanLi DONG MeiTao XU Dong MIAO JinLai | 2013 | Science China(Life Sciences)2013，56，6： | 2 |
| 7 | Electroacupuncture enhances hippocampal NSCs proliferation in cerebral ischemia-reperfusion injured rats via activation of notch signaling pathway显示文摘 | Jing Tao Bin Chen Yanling Gao Shanli Yang Jia Huang Xin Jiang Yayin Wu Jun Peng Zhenfeng Hong Lidian Chen | 2014 | International Journal of Neuroscience2014，，3： | 2 |
| 8 | Epstein-Barr 病毒的从潜伏的膜蛋白质 2 的重叠 epitopes (LMP2 ) 的空想地熔化的抗原富人作为一支潜在的疫苗和诊断代理人显示文摘Epstein-Barr 病毒(EBV ) 在全世界是流行的并且在人与几恶意的疾病被联系。(LMP2 ) 潜伏的膜蛋白质 2 在联系 EBV 的 tumors; 的致病 EBV 起一个关键作用;因此, LMP2 被认为是一个潜在的 immunodiagnostic 和 immunotherapeutic 目标。multi-epitope-based 抗原是为治疗学的疫苗的一种有希望的选择并且如此的恶意诊断。在这研究,我们系统地屏蔽了细胞毒素的 T 淋巴细胞(CTL ) ,助手 T 房间(Th ) 和在用生物信息学的 EBV-LMP2 以内的 B 房间 epitopes。基于屏幕,在 T 房间和 B 房间的重叠 epitopes 的二个肽富人被选择构造为叫作 EBV-LMP2m 的妄想的 multi-epitope 蛋白质包含顺序的 plasmid,它 LMP2aa195~232 和 LMP2aa419~436 是镇静的。EBV-LMP2m 蛋白质在 E 被表示。在原核生物的 codon 优化以后的 coli BL21 (DE3 ) 。在 BALB/c 老鼠的净化的妄想的抗原的接种在阴道粘液而且特定的 CTL 回答在浆液和能分泌的 IgA 导致了特定的 IgG 的高水平不仅。由把净化的 EBV-LMP2m 用作抗原,在 202 鼻咽的癌(NPC ) 的浆液标本的特定的 IgG 的存在病人们有效地与 52.84 % 被检测;敏感和 95.40 %特性,基于 VCA-IgA 在传统的察觉方法上代表改进, 60.53 %敏感和 76.86 %特性) 。上述结果显示 EBV-LMP2m 可以为 NPC 病人为联系 EBV 的肿瘤而且一个诊断代理人被用作潜在的目标抗原不仅。 | Xiaoyun Lin Shao Chen Xiangyang Xue Lijun Lu Shanli Zhu Wenshu Li Xiangmin Chen Xiaozhi Zhong Pengfei Jiang Torsoo Sophia Sename Yi Zheng Lifang Zhang | 2016 | Cellular & Molecular Immunology2016，13，4： | 2 |
| 9 | A multi-epitope vaccine based on Chlamydia trachomatis major outer membrane protein induces specific immunity in mice显示文摘我们评估了包括主要的外部膜蛋白质(MOMP ) 的一支候选人疫苗的 immunogenicity 和功效 multi-epitopeof Chlamydia trachomatis。从包含多重 T 房间和 B 房间 epitopes 的 MOMP 导出的 multi-epitope 的短基因是人工地,包含 codon 的 synthesized.The recombinant plasmid pET32a (+) 优化了 MOMP multi-epitope 基因被构造。在 Escherichia coli 的 fusionprotein Trx-His-MOMP multi-epitope 的表示被钠 dodecyl sulfatepolyacrylamide 胶化电气泳动和西方的污点分析证实。Balb/c 老鼠是 inoculatedwith 皮下地,三与 2 星期的间隔预定的净化的熔化蛋白质。结果出现了 MOMP multi-epitopeelicited 不仅对 C 的强壮的体液的有免疫力的回答。由显著地产生特定的抗体(IgG1 和 IgG2a ) 的高水平的 trachomatis,而且由 inducingrobust 的细胞的有免疫力的回答在老鼠的细胞毒素的 T 淋巴细胞回答。而且, MOMP multi-epitope 实质地告知 IFN- 的分泌物,表明这支疫苗能导致强壮的 Th1 回答。最后,老鼠与 C 的 MOMP multi-epitope displayeda 减小种牛痘。在 chlamydial 挑战和感染的 C 的一个加速的清理之上流的 trachomatis。trachomatis。在结论, MOMP multi-epitope 疫苗可以对 C 为有效预防 andtherapeutic 疫苗的发展有潜力。trachomatis 感染。 | Jianxin Tu B ailong Hou Bingbing Wang Xiaoyun Lin Wenci Gong Haiyan Dong Shanli Zhu Shao Chen Xiangyang Xue Kong-Nan Zhao Lifang Zhang | 2014 | Acta Biochimica et Biophysica Sinica2014，46，5： | 1 |
| 10 | Recent advances in study on transgenic plants for salt tolerance显示文摘 | Zhao Fengyun Guo Shanli Wang Zenglan | 2003 | Journal of Plant Physiology and Molecular Biology2003，29，3： | 1 |
| 11 | Lie triple derivations of nest algebras on Banach spaces显示文摘 | Sun Shanli Ma Xuefeng | 2012 | Linear Algebra and its Applications2012，436，： | 1 |
| 12 | Re- moval of 3-Chlorophenol from Water Using Rice-Straw- Based Carbon 显示文摘 | Wang Shanli Tzou Yu Min Lu Yi Hsien | 2007 | J Hazard Mater2007，147，12： | 1 |
| 13 | Perspectives on the sequence stratigraphy of continental strata显示文摘 | Shanly K W McCabe P S | 1994 | AAPG Bulletin1994，74，4： | 1 |
| 14 | Weighted composition operator between different weighted Bloch type spaces显示文摘 | Ye Shanli | 2007 | Acta Math Sinica:Chinese Set2007，50，4： | 1 |
| 15 | The contribution of photoinduced charge-transfer enhancement to the SERS of uranyl(Ⅵ) in a uranyl-Ag_2O complex显示文摘Charge-transfer(CT) is an important enhancement mechanism in the field of surface-enhanced Raman scattering(SERS) that typically increases the Raman intensity of molecules by as much as 10–100 times.Herein, a low-cost Ag_2O aggregates substrate was prepared via a facile chemical precipitation method,and the calculated CT-based enhancement factor of the uranyl ions adsorbed on it reached as high as 10~5, a metal-comparable value. The efficient photoinduced CT process from the valence band of Ag_2O to the LUMO of uranyl ions under appropriate excitation sources resulted in the repulsion of the axial oxygen atoms of the O=U=O bond, which enhanced its polarizability, creating a more intense Raman mode. To the best of our knowledge, this study firstly reports such a strong photoinduced CT enhancement of uranyl ions, with concentrations of 10^(-8) mol L^(-1) or lower being detected using this Ag_2O substrate. Most importantly, this research has shown that the photoinduced CT enhancement also contributes to the SERS of uranyl ions on pure Ag substrates which have often been ascribed to the electromagnetic enhancement in previous studies. In addition, Ag_2O can be used to selectively detect uranyl ions without interference from many other molecules or ions because of the energy matching rule of the photoinduced CT process, which was readily available for uranyl detection in the environmental aqueous solution. | Shaofei Wang Shanli Yang Haoxi Wu Jiaolai Jiang Lang Shao Yiming Ren Yingru Li Chuanhui Liang Mingfu Chu Xiaolin Wang | 2019 | Science Bulletin2019，64，5： | 1 |
| 16 | Evidence for an association between thyroid-stimulation hormone and insulin-like growth factor 1 receptors:A tale of two antigens implicated in Graves'disease显示文摘 | Shanli Tsui Vibha Naik Neil Hoa | 2008 | The Journal of Immunology2008，181，6： | 1 |
| 17 | Detection of two exogenous genes in transgenie cattle by loop-mediated isothermal amplification 显示文摘 | Zhai Shanli Liu Chuxin Zhang Qingde | 2012 | Transgenic Res2012，21，6： | 1 |
| 18 | Clinical characteristics and long-term postoperative results of infantile esotropia显示文摘 | Shanly Y Prager TC Mazow ML | 1994 | Am J Ophthalmol1994，117，2： | 1 |
| 19 | 显示文摘 | Sung Hyun Lee a Akhlesh Gupta a ShanLi Wang a | 2005 | Solar Energy Materials & Solar Cells2005，5，86： | 1 |
| 20 | Effect of green tea catechins on the postprandial glycemic response to starches differing in amylase content显示文摘 | LIU Jie WANG Mingzhu PENG Shanli | 2011 | Journal of Agricultural and Food Chemistry2011，59，9： | 1 |
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