|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | A multicenter,retrospective.epidemiologic survey of the clinical features and management of bone metastatic disease in China显示文摘Background:Bone metastases are common in patients with advanced cancer.Bisphosphonates(BPs) could prevent or delay the development of skeleton-related events(SREs).The present study aimed to identify the clinical features of and treatment strategies for Chinese patients with bone metastases.Methods:Consecutive cancer patients who had bone metastases and received BP treatment were enrolled.A questionnaire was developed to collect the patients' clinical data,as well as information on the diagnosis and management of bone metastases.Physicians' awareness of the guidelines and knowledge of the application of BP were also assessed.Results:A total of 3223 patients with lung cancer(36.5%),breast cancer(30.9%),prostate cancer(8.5%),and gastrointestinal cancer(5.7%) were included in this study.The sites of bone metastases were the thoracic spine(56.0%),lumbar spine(47.1%),ribs(32.6%),and pelvis(23.2%).The SRE frequency was the highest in patients with multiple myeloma(36.6%),followed by those with lung cancer(25.9%),breast cancer(20.2%),prostate cancer(18.2%),and gastrointestinal cancer(17.3%).Irradiation to the bone was the most frequent SRE(58%in lung cancer patients,45%in breast cancer patients,and 48%in prostate cancer patients).Our survey also showed that 45.5%of patients received BP within 3 months after their diagnosis of bone metastases,whereas the remaining 54.5%of patients did not receive BP treatment until at least 3 months after their diagnosis of bone metastases.The SRE frequency in the former group was significantly lower than that in the latter group(4.0%vs.42.3%,P < 0.05).In patients with more than 6 months of continuous BP treatment,the mean time to the first SRE was significantly longer than that in patients with less than 6 months of continuous BP treatment(7.2 vs.3.4 months,P < 0.05).In addition,12.2%of the physicians were not aware of the efficacy of BP in preventing and delaying SRE.Only half(52.3%) of the physicians agreed that the BP treatment should persist for at least 6 months unless it was intolerable.Conclusions:Our study suggested that prompt and persistent BP treatment was associated with a reduced risk of SREs.However,our survey also revealed that the proper application of BP was not as common as expected in China. | Yunpeng Yang Yuxiang Ma Jin Sheng Yan Huang Yuanyuan Zhao Wenfeng Fang Shaodong Hong Ying Tian Cong Xue Li Zhang | 2016 | Chinese Journal of Cancer2016，35，5： | 13 |
| 2 | Low-frequency E-field Detection Array(LFEDA)-Construction and preliminary results显示文摘In recent years, locating total lightning at the VLF/LF band has become one of the most important directions in lightning detection. The Low-frequency E-field Detection Array(LFEDA) consisting of nine fast antennas was developed by the Chinese Academy of Meteorological Sciences in Guangzhou between 2014 and 2015. This paper documents the composition of the LFEDA and a lightning-locating algorithm that applies to the low-frequency electric field radiated by lightning pulse discharge events(LPDEs). Theoretical simulation and objective assessment of the accuracy and detection efficiency of LFEDA have been done using Monte Carlo simulation and artificial triggered lightning experiment, respectively. The former results show that having a station in the network with a comparatively long baseline improves both the horizontal location accuracy in the direction perpendicular to the baseline and the vertical location accuracy along the baseline. The latter results show that detection efficiencies for triggered lightning flashes and return strokes are 100% and 95%, respectively. The average planar location error for return strokes of triggered lightning flashes is 102 m. By locating LPDEs in thunderstorms, we find that LPDEs are consistent with convective regions as indicated by strong reflectivity columns, and present a reasonable distribution in the vertical direction.In addition, the LFEDA can reveal an image of lightning development through mapping the channels of lightning. Based on three-dimensional locations, the vertical propagation speed of the preliminary breakdown and the changing trend of the leader's speed in an intra-cloud and a cloud-to-ground flash are investigated. The research results show that the LFEDA has the capability for three-dimensional location of lightning, which provides a new technique for researching lightning development characteristics and thunderstorm electricity. | SHI DongDong ZHENG Dong ZHANG Yang ZHANG YiJun HUANG ZhiGang LU WeiTao CHEN ShaoDong YAN Xu | 2017 | Science China Earth Sciences2017，60，10： | 10 |
| 3 | Development of Application of RE Polishing Materials显示文摘The manufacturing method and functions of the RE polishing powder and comparation of the current situation of its production and application home and abroad were introduced.By analyzing the development of the liquid crystal (plate) display, the wide application of the RE polishing powder in the field of the liquid crystal display and predicts the development direction of the market of the RE polishing powder was presented.In addition, the development trends of the RE polishing powder industry and forecasts the application prospect of the RE polishing powder was analyzed. | Li Xueshun Huang Shaodong Yang Guosheng | 2004 | Journal of Rare Earths2004，22，z1： | 7 |
| 4 | A Novel Parallel Scheme for Fast Similarity Search in Large Time Series显示文摘The similarity search is one of the fundamental components in time series data mining,e.g.clustering,classification,association rules mining.Many methods have been proposed to measure the similarity between time series,including Euclidean distance,Manhattan distance,and dynamic time warping(DTW).In contrast,DTW has been suggested to allow more robust similarity measure and be able to find the optimal alignment in time series.However,due to its quadratic time and space complexity,DTW is not suitable for large time series datasets.Many improving algorithms have been proposed for DTW search in large databases,such as approximate search or exact indexed search.Unlike the previous modified algorithm,this paper presents a novel parallel scheme for fast similarity search based on DTW,which is called MRDTW(MapRedcuebased DTW).The experimental results show that our approach not only retained the original accuracy as DTW,but also greatly improved the efficiency of similarity measure in large time series. | YIN Hong YANG Shuqiang MA Shaodong LIU Fei CHEN Zhikun | 2015 | China Communications2015，12，2： | 6 |
| 5 | A fast decoupled ISAR high-resolution imaging method using structural sparse information under low SNR显示文摘Inverse synthetic aperture radar (ISAR) image can be represented and reconstructed by sparse recovery (SR) approaches. However, the existing SR algorithms, which are used for ISAR imaging, have suffered from high computational cost and poor imaging quality under a low signal to noise ratio (SNR) condition. This paper proposes a fast decoupled ISAR imaging method by exploiting the inherent structural sparse information of the targets. Firstly, the ISAR imaging problem is decoupled into two sub-problems. One is range direction imaging and the other is azimuth direction focusing. Secondly, an efficient two-stage SR method is proposed to obtain higher resolution range profiles by using jointly sparse information. Finally, the residual linear Bregman iteration via fast Fourier transforms (RLBI-FFT) is proposed to perform the azimuth focusing on low SNR efficiently. Theoretical analysis and simulation results show that the proposed method has better performence to efficiently implement higher-resolution ISAR imaging under the low SNR condition. | XIANG Long LI Shaodong YANG Jun CHEN Wenfeng XIANG Hu | 2019 | Journal of Systems Engineering and Electronics2019，30，3： | 6 |
| 6 | Optimization of dosage ratio of chlorogenic acid and gardenia glycosides in the treatment of rats with fatty liver disease induced by high-fat feed显示文摘OBJECTIVE: To investigate the optimal dosage ratio of chlorogenic acid and gardenia glycosides in treating the rates with fatty liver disease induced by high-fat feed.METHODS: A rat model of non-alcoholic fatty liver disease(NAFLD) was established by using a high-fat diet. According to mathematical model 'uniform design', varying doses of chlorogenic acid and gardenia glycosides have been combined to form 6 medications for the treatment of NAFLD.Samples were then taken to observe pathological changes of the liver tissue(HE staining); changes in the fat metabolism pathway e.g. triglyceride(TG)and free fatty acid(FFA) content; alterations in liver function, i.e. serum alanine aminotransferase(ALT)and aspartate aminotransferase(AST) activity; and differences in Malondialdehyde(MDA) and superoxide dismutase(SOD) content in the liver tissue. Multiple regression analysis was conducted to test the optimal dosage ratio of chlorogenic acid and gardenia glycosides.RESULTS: Fatty degeneration and vacuole-like changes of different degrees occurred in hepatic cells of the model group. Markers for fat metabolism, serum ALT and AST activities, and expression of MDA in liver tissue significantly increased, while SOD decreased. Combination of 90 mg chlorogenic acid and 90 mg Gardenia glycosides was the optimal dosage ratio of chlorogenic acid and gardenia glycosides in the treatment of rats with fatty liver induced by high-fat diet.CONCLUSION: Chlorogenic acid of 90 mg plus gardenia glycosides of 90 mg was the best combination in the treatment of fatty liver disease in rats induced by high-fat feed. | Liang Huiqing Yang Jiaen Tang Jinmo Wu Chuncheng Li Hongshan Chen Shaodong | 2016 | Journal of Traditional Chinese Medicine2016，36，5： | 6 |
| 7 | The ACTIVE study protocol:apatinib or placebo plus gefitinib as first-line treatment for patients with EGFR-mutant advanced non-small cell lung cancer(CTONG1706)显示文摘Background:Gefitinib,as the first epidermal growth factor receptor tyrosine kinase inhibitors(EGFR-TKI)approved for the treatment of advanced non-small cell lung cancer(NSCLC),has been proved to significantly improve the progression-free survival(PFS)in the first-line setting but suffers from resistance 7-10 months after treatment initia-tion.Apatinib(YN968D1),a potent vascular endothelial growth factor receptor(VEGFR)2-TKI,specifically binds to VEGFR2 and leads to anti-angiogenetic and anti-neoplastic effect.Concurrent inhibition of VEGFR and EGFR path-ways represents a rational approach to improve treatment responses and delay the onset of treatment resistance in EGFR-mutant NSCLC.This ACTIVE study aims to assess the combination of apatinib and gefitinib as a new treatment approach for EGFR-mutant NSCLC as a first-line setting.Methods:This multicenter,randomized,double-blind,placebo-controlled phase III study(NCT02824458)has been designed to assess the efficacy and safety of apatinib or placebo combined with gefitinib as a first-line treatment for patients with EGFR-mutant advanced NSCLC.A total of 310 patients with EGFR-mutation(19del or 21L858R),pathological stage IIIB to IV non-squamous NSCLC were to be enrolled.The primary endpoint is investigator assessment of PFS,and the secondary endpoints include independent radiological central(IRC)-confirmed PFS,overall survival(OS),objective response rate(ORR),disease control rate(DCR),time to progressive disease(TTPD),duration of response(DoR),quality of life(QoL)and safety.The patients are randomized in a 1:1 ratio to receive gefitinib(250 mg,p.o.q.d.)plus apatinib(500 mg,p.o.q.d.)or gefitinib plus placebo,given until disease progression or intolerable adverse events.Exploratory biomarker analysis will be performed.This study is being conducted across China and comprises of 30 participating centers.Enrollment commenced in August 2017 and finished in December 2018,most of the patients are in the follow-up period.Anticipated outcomes and significance:The present study will be the first to evaluate the efficacy and safety profile of the combination of apatinib plus gefitinib as a first-line therapy for patients with EGFR-positive advanced non-squamous NSCLC.Importantly,this trial will provide comprehensive evidence on the treatment of EGFR-TKIs combined with antiangiogenic therapy. | Zhonghan Zhang Fan Luo Yang Zhang Yuxiang Ma Shaodong Hong Yunpeng Yang Wenfeng Fang Yan Huang Li Zhang Hongyun Zhao | 2019 | Cancer Communications2019，39，1： | 5 |
| 8 | Long-range electron synergy over Pt_(1)-Co_(1)/CN bimetallic single-atom catalyst in enhancing charge separation for photocatalytic hydrogen production显示文摘The development of novel single-atom catalysts with optimal electron configuration and economical noble-metal cocatalyst for efficient photocatalytic hydrogen production is of great importance,but still challenging.Herein,we fabricate Pt and Co single-atom sites successively on polymeric carbon nitride(CN).In this Pt_(1)-Co_(1)/CN bimetallic single-atom catalyst,the noble-metal active sites are maximized,and the single-atomic Co_(1)N_4sites are tuned to Co_(1)N_3sites by photogenerated electrons arising from the introduced single-atomic Pt_(1)N_4sites.Mechanism studies and density functional theory(DFT)calculations reveal that the 3d orbitals of Co_(1)N_3single sites are filled with unpaired d-electrons,which lead to the improved visible-light response,carrier separation and charge migration for CN photocatalysts.Thereafter,the protons adsorption and activation are promoted.Taking this advantage of long-range electron synergy in bimetallic single atomic sites,the photocatalytic hydrogen evolution activity over Pt_(1)-Co_(1)/CN achieves 915.8 mmol g^(-1)Pt h^(-1),which is 19.8 times higher than Co_(1)/CN and 3.5 times higher to Pt_(1)/CN.While this electron-synergistic effect is not so efficient for Pt nanoclusters.These results demonstrate the synergistic effect at electron-level and provide electron-level guidance for the design of efficient photocatalysts. | Man Yang Jing Mei Yujing Ren Jie Cui Shuhua Liang Shaodong Sun | 2023 | Journal of Energy Chemistry2023，，6： | 1 |
| 9 | Recognition of self and altered self by T cells in autoimmunity and allergy显示文摘T cell recognition of foreign peptide antigen and toler-ance to self peptides is key to the proper function of the immune system.Usually,in the thymus T cells that rec-ognize self MHC+self peptides are deleted and those with the potential to recognize self MHC+foreign pep-tides are selected to mature.However there are excep-tions to these rules.Autoimmunity and allergy are two of the most common immune diseases that can be related to recognition of self.Many genes work together to lead to autoimmunity.Of those,particular MHC alleles are the most strongly associated,reflecting the key importance of MHC presentation of self peptides in autoimmunity.T cells specific for combinations of self MHC and self pep-tides may escape thymus deletion,and thus be able to drive autoimmunity,for several reasons:the relevant self peptide may be presented at low abundance in the thy-mus but at high level in particular peripheral tissues;the relevant self peptide may bind to MHC in an unusual register,not present in the thymus but apparent else-where;finally the relevant self peptide may be post translationally modified in a tissue specific fashion.In some types of allergy,the peptide+MHC combination may also be fully derived from self.However the combi-nation in question may be modified by the presence of other ligands,such as small drug molecules or metal ions.Thus these types of allergies may act like the post translationally modified peptides involved some types of autoimmunity. | Lei Yin Shaodong Dai Gina Clayton Wei Gao Yang Wang John Kappler Philippa Marrack | 2013 | Protein & Cell2013，4，1： | 1 |
| 10 | The dosedffect relationship of UVR on early skin impairment显示文摘 | Liu SHaodong | 1993 | China Envl: ronmemtal Science1993，4，3： | 1 |
| 11 | Review of time temperature indicators as quality monitors in food packaging显示文摘 | Shaodong Wang Xinghai Liu Mei Yang | 2015 | Packaging Technology and Science2015，28，10： | 1 |
| 12 | Potassium tantalate niobate crystals:Efficient quadratic electro-optic materials and their laser modulation technology显示文摘Electro-optic(EO)crystals are important material for all-solid-state laser technology,which can be used to fabricate various laser modulators,such as EO switches,laser deflectors,and optical waveguide.The improvements in new high-efficiency EO crystal materials have held great significance to the development of laser technology.Potassium tantalate niobate(KTN)is a popular multifunctional crystal because of its remarkable and excellent quadratic EO effect.KTN EO modulation technology offers numerous advantages,such as high efficiency,good stability,a quick response time,and inertia-free characteristics.In this paper,we summarize the research progress of KTN series crystals systemically,including the theoretical exploration on quadratic EO effect,solid-melt crystal growth technique,comprehensive physical characterization,new physical effect and mechanisms exploration,new EO devices development and design.The EO modulation technique based on the Kerr effect of KTN series crystal offers obvious advantages in reducing the drive voltage and device size,which could better meet the developmental needs of future lasers with a wide wavelength,miniaturization,and integration.This may provide theoretical guidance and an experimental basis for the design and development of new EO crystal devices and promote the development of laser technology. | Xuping Wang Xinguo Mao Pan Chen Qian Du Yuguo Yang Panyu Qiao Shaodong Zhang Zhijian Li Rui Zhang Bing Liu Jiyang Wang | 2023 | Journal of Materiomics2023，9，5： | 1 |
| 13 | The dose effect relationship of UVR on early skin impairment显示文摘 | Taisi Ping Liu Shaodong | 1993 | China Environ Science1993，4，3： | 1 |
| 14 | Fast ISAR imaging method based on scene segmentation显示文摘Although compressed sensing inverse synthetic aperture radar(ISAR) imaging methods are widely used in radar signal processing, its reconstructing time and memory storage space requirements are very high. The main reason is that large scene reconstruction needs a higher dimension of the sensing matrix. To reduce this limitation, a fast high resolution ISAR imaging method,which is based on scene segmentation for random chirp frequencystepped signals, is proposed. The idea of scene segmentation is used to solve the problems aforementioned. In the method,firstly, the observed scene is divided into multiple sub-scenes and then the sub-scenes are reconstructed respectively. Secondly, the whole image scene can be obtained through the stitching of the sub-scenes. Due to the reduction of the dimension of the sensing matrix, the requirement of the memory storage space is reduced substantially. In addition, due to the nonlinear superposition of the reconstructed time of the segmented sub-scenes, the reconstruction time is reduced, and the purpose of fast imaging is achieved.Meanwhile, the feasibility and the related factors which affect the performance of the proposed method are also analyzed, and the selection criterion of the scene segmentation is afforded. Finally,theoretical analysis and simulation results demonstrate the feasibility and effectiveness of the proposed method. | Mingjiu Lü Shaodong Li Wenfeng Chen Jun Yang Xiaoyan Ma | 2017 | Journal of Systems Engineering and Electronics2017，28，6： | 1 |
| 15 | Characteristics of unconnected upward leaders initiated from tall structures observed in Guangzhou显示文摘 | Lu Weitao Chen Luwen Zhang Yang Ma Ying Gao Yan Yin Qiyuan Chen Shaodong Huang Zhihui Zhang Yijun | 2012 | EN2012，，19： | 1 |
| 16 | International Meridian Circle Program显示文摘The Earth is buffered from the ferocious onslaught of the solar wind by a thin layer of matter known as the atmosphere and geospace.This layer absorbs energy from irradiance and outburst from the Sun,as well as from disasters,transient phenomena and anthropogenic emissions originated from Earth.Through complicated physics,the absorbed energy changes the atmospheric and geospace state and sometimes gets re-released to power extreme events such as space weather.Taking place globally,these complicated processes cannot be understood unless they are studied globally.The Chinese scientists have proposed the International Meridian Circle Program(IMCP)to meet this demand.By operating nearly 1000 instruments encompassing all latitudes along with the 120°E–60°W longitudes,IMCP aims,for the first time,to construct comprehensive 3D data representation of the atmosphere and geospace on a global scale and empower interdisciplinary research to tackle key questions related to Earth’s environment and climate change. | LIU William WANG Chi SHEN Xuhui WU Jian BLANC Michel YAN Yihua FU Suiyan YUE Xinan LEI Jiuhou GONG Wei ZHANG Shaodong ZHANG Qinghe WANG Xin YANG Jing ZHANG Xiaoxin GAO Jing XU Jiyao YANG Guotao LI Hui REN Liwen YANG Fang | 2020 | 空间科学学报2020，40，5： | 1 |
| 17 | A Review of Atmospheric Electricity Research in China from 2019 to 2022显示文摘Atmospheric electricity is composed of a series of electric phenomena in the atmosphere.Significant advances in atmospheric electricity research conducted in China have been achieved in recent years.In this paper,the research progress on atmospheric electricity achieved in China during 2019-22 is reviewed focusing on the following aspects:(1)lightning detection and location techniques,(2)thunderstorm electricity,(3)lightning forecasting methods and techniques,(4)physical processes of lightning discharge,(5)high energy emissions and effects of thunderstorms on the upper atmosphere,and(6)the effect of aerosol on lightning. | Weitao LYU Dong ZHENG Yang ZHANG Wen YAO Rubin JIANG Shanfeng YUAN Dongxia LIU Fanchao LYU Baoyou ZHU Gaopeng LU Qilin ZHANG Yongbo TAN Xuejuan WANG Yakun LIU Shaodong CHEN Lyuwen CHEN Qingyong LI Yijun ZHANG | 2023 | Advances in Atmospheric Sciences2023，40，8： | 0 |
| 18 | Aqueous-phase formation of N-containing secondary organic compounds affected by the ionic strength显示文摘The reaction of carbonyl-to-imine/hemiaminal conversion in the atmospheric aqueous phase is a critical pathway to produce the light-absorbing N-containing secondary organic compounds(SOC).The formation mechanism of these compounds has been wildly investigated in bulk solutions with a low ionic strength.However,the ionic strength in the aqueous phase of the polluted atmosphere may be higher.It is still unclear whether and to what extent the inorganic ions can affect the SOC formation.Here we prepared the bulk solution with certain ionic strength,in which glyoxal and ammonium were mixed to mimic the aqueous-phase reaction.Molecular characterization by High-resolution Mass Spectrometry was performed to identify the N-containing products,and the light absorption of the mixtures was measured by ultraviolet-visible spectroscopy.Thirty-nine N-containing compounds were identified and divided into four categories(N-heterocyclic chromophores,high-molecular-weight compounds with N-heterocycle,aliphatic imines/hemiaminals,and the unclassified).It was observed that the longer reaction time and higher ionic strength led to the formation of more N-heterocyclic chromophores and the increasing of the lightabsorbance of the mixture.The added inorganic ions were proposed to make the aqueous phase somewhat viscous so that the molecules were prone to undergo consecutive and intramolecular reactions to form the heterocycles.In general,this study revealed that the enhanced ionic strength and prolonged reaction time had the promotion effect on the lightabsorbing SOC formation.It implies that the aldehyde-derived aqueous-phase SOC would contribute more light-absorbing particulate matter in the industrial or populated area where inorganic ions are abundant. | Yuqi Gan Xiaohui Lu Shaodong Chen Xinghua Jiang Shanye Yang Xiewen Ma Mei Li Fan Yang Yewen Shi Xiaofei Wang | 2024 | Journal of Environmental Sciences2024，，4： | 0 |
| 19 | STILBENOIDS AND PHENANTHRENES FORM ARUNDINA GRAMINIFOLIA(DAI MONORITY MEDICINE) AND ANTITUMOR BIOACTIVITY显示文摘The objective was to isolate,elucidate and analyze the bioactive chemicals from the tuber of Arundina graminifolia(Dai Monority Medicine).The compounds were extracted by 95%alcohol and isolated by column chromatography on silica gel,Sephedax LH-20 and ODS.The structures were determined by UV,IR,NMR and MS spectra. | Meifeng Liu Shaodong Yang Xuemeng Yan | 2015 | World Journal of Traditional Chinese Medicine2015，1，4： | 0 |
| 20 | Preferable background filtering for next-generation sequencing analysis in non-small cell lung cancer:pericarcinomatous tissues or peripheral blood lymphocytes?显示文摘Dear editor,Lung cancer is the leading cause of cancer-related death worldwide,with the predominant pathological type being non-small cell lung cancer(NSCLC)[1,2].Next-gener-ation sequencing(NGS)analysis is increasingly used to help clinicians select appropriate target therapies,such as epidermal growth factor receptor-tyrosine kinase inhibitors(EGFR-TKIs)for EGFR-mutant patients[3].Both pericarcinomatous tissues and peripheral blood lymphocytes are widely used as normal control for NGS analysis.However,whether pericarcinomatous tissue is suitable for background filtering in mutation analysis remains controversial.According to the whole-genome sequencing data from The Cancer Genome Atlas(TCGA)database,there were some genomic variations in peri-carcinomatous tissue from NSCLC patients,but no driver gene mutation was detected[4,5].Therefore,deep sequencing of pericarcinomatous and tumor tissues is necessary to confirm whether pericarcinomatous tissue harbors low-frequency mutations. | Yaxiong Zhang Lianpeng Chang Wenfeng Fang Yunpeng Yang Lanjun Zhang Shaodong Hong Huaqiang Zhou Yanfang Guan Xin Yi Li Zhang | 2019 | Cancer Communications2019，39，1： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员