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| 1 | Super enhancer inhibitors suppress MYC driven transcriptional amplification and tumor progression in osteosarcoma显示文摘Osteosarcoma is the most common primary bone sarcoma that mostly occurs in young adults. The causes of osteosarcoma are heterogeneous and still not fully understood. Identification of novel, important oncogenic factors in osteosarcoma and development of better, effective therapeutic approaches are in urgent need for better treatment of osteosarcoma patients. In this study, we uncovered that the oncogene MYC is significantly upregulated in metastastic osteosarcoma samples. In addition, high MYC expression is associated with poor survival of osteosarcoma patients. Analysis of MYC targets in osteosarcoma revealed that most of the osteosarcoma super enhancer genes are bound by MYC. Treatment of osteosarcoma cells with super enhancer inhibitors THZ1 and JQ1 effectively suppresses the proliferation, migration, and invasion of osteosarcoma cells. Mechanistically,THZ1 treatment suppresses a large group of super enhancer containing MYC target genes including CDK6 and TGFB2. These findings revealed that the MYC-driven super enhancer signaling is crucial for the osteosarcoma tumorigenesis and targeting the MYC/super enhancer axis represents as a promising therapeutic strategy for treatment of osteosarcoma patients. | Demeng Chen Zhiqiang Zhao Zixin Huang Du-Chu Chen Xin-Xing Zhu Yi-Ze Wang Ya-Wei Yan Shaojun Tang Subha Madhavan Weiyi Ni Zhan-peng Huang Wen Li Weidong Ji Huangxuan Shen Shuibin Lin Yi-Zhou Jiang | 2018 | Bone Research2018，6，2： | 5 |
| 2 | Natural variations in grain length 10(GL10)regulate rice grain size显示文摘Grain size is an important determinant of grain weight and yield in rice.Although several genes related to grain size have been identified,natural variations in these genes that affect grain size are poorly characterized.Here,we describe the grain length QTL GL10,encoding MADS56,which positively regulates grain length and grain weight.A natural allelic variation of NIL-gl10,containing an~1.0-kb deletion in the first exon that abolishes its transcription,results in shorter grain length,lower grain weight and delayed flowering in gl10 plants.The knockout of GL10 in the HJX74 background leads to grain phenotypes similar to that of NIL-gl10,while overexpression of GL10 results in increased grain length and weight and earlier heading date.GL10 regulates grain length by promoting greater longitudinal cell growth in the grain glume.Additionally,GL10 participates in the regulation of gibberellic acid(GA)signaling pathway genes in young panicle tissues.Analysis of GL10 haplotypes shows obvious divergence between the japonica and indica lineages.Our findings reveal an allelic variation of GL10 that may explain differences in grain length among modern cultivars and could be used to breed rice varieties with optimized grain shape. | Penglin Zhan Shuaipeng Ma Zhili Xiao Fangping Li Xin Wei Shaojun Lin Xiaoling Wang Zhe Ji Yu Fu Jiahao Pan Mi Zhou Yue Liu Zengyuan Chang Lu Li Suhong Bu Zupei Liu Haitao Zhu Guifu Liu Guiquan Zhang Shaokui Wang | 2022 | Journal of Genetics and Genomics2022，49，5： | 3 |
| 3 | Rapid and selective uranium extraction from aqueous solution under visible light in the absence of solid photocatalyst显示文摘Extraction of uranium from radioactive waste-water is of significant importance for environmental protection and the recovery of uranium resource.Different from the previous reports to use the solid absorbent/photocatalyst for U(VI)removal,herein,we proposed a new eco-friendly method for the rapid and selective extraction of uranium from aqueous solutions under visible light without solid materials.At optimal pH value and in the presence of organics like alcohols,the U(VI)could be extracted efficiently to form brown uranium solid over wide uranium concentrations under anaerobic condition and visible light,by utilizing the excitation of the given U(VI)species.With comprehensive modelling of the electronic ultraviolet-visible(UV-Vis)properties,it is proved that pH adjusting towards U(VI)could induce efficient ligand-to-metal-charge-transfer(LMCT)within the uranyl complex under visible light and the reduction of U(VI)to form U(V),which can be transformed into U(IV)via disproportionation reaction.The resulting U(IV)in solid phase makes the extraction much more convenient in operation.More importantly,the excellent selectivity for uranium extraction over interfering alkali metal ions,transition metal ions and the lanthanide metal ions shows a powerful application potential. | Shaojun Li Yezi Hu Zewen Shen Yawen Cai Zhuoyu Ji Xiaoli Tan Zhixin Liu Guixia Zhao Shuxian Hu Xiangke Wang | 2021 | Science China Chemistry2021，64，8： | 2 |
| 4 | Analysis and Design of Trial Well Mooring in Deepwater of the South China Sea显示文摘系在的系统为钻在的半能沉入水中的钻塔起一个重要作用深海。详细分析在进行了很好在 2009 在华南海在一个深海的地点钻的试用的一个半能沉入水中的钻塔的绳索上被执行。钻塔是 30 岁并且与 457 m 的设计的最大的操作的水深度有一个浅平台。后面的系在分析,一个系在的图案被给那要求钻塔原版绳索系统升级。升级包括了几革新,例如安装八个更大的锚,即代替原来的锚并且插入一另外有存在的链的钢电线的 600 m。所有这些被做为在职务要保持进行在 476 m 的水深度钻的钻塔提高钻塔的系在的能力。钻的全面持续时间是 50 天和证明在当它在华南海正在钻试用很好时,达到使钻塔静止的目标有效的升级的绳索系统。这个成功的运动证明一个更旧的半能沉入水中的钻塔能雇用在小心的设计并且到原来的绳索系统的合适的升级和修正以后在深水里钻。 | Yongfeng Guo Shaojun Ji Changquan Tang Jiansong Li Huiquan Zhong Ong Chin Yam Ian | 2012 | Journal of Marine Science and Application2012，11，2： | 1 |
| 5 | Generation of bottle beam using low-density channel in air显示文摘Cylindrical density depressions generated by femtosecond laser pulses filamenting in air for different energy depositions are investigated numerically, by using a set of hydrodynamic equations. The evolution of density profile is calculated for different temperature elevations. The results indicate that the gas density hole is getting shallower and wider with the increasing temperature elevations. A simulation of the propagation inside low-density channel implies a new way to generate a type of bottle beam. | JI Shaojun ZHOU Xiaoming WANG Haitao ZHANG Jinghui QIAO Chunhong FAN Chengyu | 2022 | Optoelectronics Letters2022，18，9： | 0 |
| 6 | Environmental heterogeneity and productivity drive the assemblage of benthic diatom:a case study of the Three Gorges Reservoir显示文摘Dam construction has a critical effect on river ecosystems in the world,resulting in a rapid decline in biodiversity and ecosystem health.However,the effect of dam construction on the assemblage pattern of benthic diatoms remains unclear.The benthic diatoms assemblages in the tributary backwater area of the Three Gorges Reservoir(TGR)were investigated under low water level(LWL)and high water level(HWL)conditions.Results show that Discostella stelligera,Nitzschia palea,and Craticula subminuscula were dominant species in LWL,while Achnanthidium minutissimum and Nitzschia dissipata were dominant in HWL.Furthermore,environmental variables,productivity parameters,diversity indices,and community similarity were found significantly different between LWL and HWL periods.The Mantel test indicated that both environmental and spatial factors had significant effects on diatom communities in backwater area,while productivity was also a key driving force in LWL.The variation partitioning analysis(VPA)further demonstrated that environment factors could explain the largest variance of diatom assemblages in HWL(9%)and LWL(11%),followed by spatial factors.The relative importance of productivity to diatom community was significantly enhanced in LWL,but only a slight effect was found in HWL.These results indicate that the diatom assemblages were shaped by both environmental filtering and spatial factors.The relative importance of spatial factors depended on the degree of productivity.Therefore,the homogenization of diatom communities due to environmental disturbance,e.g.eutrophication and dam building,is the underlying mechanism in assembling the benthic diatoms. | Songqi YANG Tian OUYANG Shaojun XU Lu ZHAO Lulu JI Junqiong SHI Zhongxing WU | 2023 | Journal of Oceanology and Limnology2023，41，3： | 0 |
| 7 | Na_(2)CO_(3)-responsive Photosynthetic and ROS Scavenging Mechanisms in Chloroplasts of Alkaligrass Revealed by Phosphoproteomics显示文摘Alkali-salinity exerts severe osmotic,ionic,and high-p H stresses to plants.To understand the alkali-salinity responsive mechanisms underlying photosynthetic modulation and reactive oxygen species(ROS)homeostasis,physiological and diverse quantitative proteomics analyses of alkaligrass(Puccinellia tenuiflora)under Na_(2)CO_(3)stress were conducted.In addition,Western blot,real-time PCR,and transgenic techniques were applied to validate the proteomic results and test the functions of the Na_(2)CO_(3)-responsive proteins.A total of 104 and 102 Na_(2)CO_(3)-responsive proteins were identified in leaves and chloroplasts,respectively.In addition,84 Na_(2)CO_(3)-responsive phosphoproteins were identified,including 56 new phosphorylation sites in 56 phosphoproteins from chloroplasts,which are crucial for the regulation of photosynthesis,ion transport,signal transduction,and energy homeostasis.A full-length Pt FBA encoding an alkaligrass chloroplastic fructosebisphosphate aldolase(FBA)was overexpressed in wild-type cells of cyanobacterium Synechocystis sp.Strain PCC 6803,leading to enhanced Na_(2)CO_(3)tolerance.All these results indicate that thermal dissipation,state transition,cyclic electron transport,photorespiration,repair of photosystem(PS)Ⅱ,PSI activity,and ROS homeostasis were altered in response to Na_(2)CO_(3)stress,which help to improve our understanding of the Na_(2)CO_(3)-responsive mechanisms in halophytes. | Jinwei Suo Heng Zhang Qi Zhao Nan Zhang Yongxue Zhang Ying Li Baohua Song Juanjuan Yu Jianguo Cao Tai Wang Ji Luo Lihai Guo Jun Ma Xumin Zhang Yimin She Lianwei Peng Weimin Ma Siyi Guo Yuchen Miao Sixue Chen Zhi Qin Shaojun Dai | 2020 | Genomics, Proteomics & Bioinformatics2020，18，3： | 0 |
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