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| 1 | Recent Advances in Self-Supported Layered Double Hydroxides for Oxygen Evolution Reaction显示文摘Electrochemical water splitting driven by clean and sustainable energy sources to produce hydrogen is an efficient and environmentally friendly energy conversion technology.Water splitting involves hydrogen evolution reaction(HER)and oxygen evolution reaction(OER),in which OER is the limiting factor and has attracted extensive research interest in the past few years.Conventional noble-metal-based OER electrocatalysts like IrO_(2) and RuO_(2) suffer from the limitations of high cost and scarce availability.Developing innovative alternative nonnoble metal electrocatalysts with high catalytic activity and long-term durability to boost the OER process remains a significant challenge.Among all of the candidates for OER catalysis,selfsupported layered double hydroxides(LDHs)have emerged as one of the most promising types of electrocatalysts due to their unique layered structures and high electrocatalytic activity.In this review,we summarize the recent progress on self-supported LDHs and highlight their electrochemical catalytic performance.Specifically,synthesis methods,structural and compositional parameters,and influential factors for optimizing OER performance are discussed in detail.Finally,the remaining challenges facing the development of self-supported LDHs are discussed and perspectives on their potential for use in industrial hydrogen production through water splitting are provided to suggest future research directions. | Libo Wu Luo Yu Xin Xiao Fanghao Zhang Shaowei Song Shuo Chen Zhifeng Ren | 2020 | Research2020，，1： | 7 |
| 2 | Structural basis for the neutralization of hepatitis E virus by a cross-genotype antibody显示文摘肝炎 E 病毒(HEV ) ,一个非包的、积极感觉的、搁浅单人赛的 RNA 病毒,是伤寒肝炎的一个主要原因。分类进家庭 Hepeviridae, HEV 包括四遗传型(遗传型 1-4 ) ,它属于单个 serotype。我们描述 monoclonal 抗体(mAb ) ,有 ~ 2.53-3.45 nM 的 8G12,同等地认出 HEV 的所有四遗传型,有约束力的亲密关系。mAb 8G12 有一保护,抵销能力,它能显著地在主人房间堵住病毒感染。动物与 1, 3 和 4 证实了跨遗传型的抵销的遗传型学习 8G12 和它肝炎 E 疾病的有效预防的能力。有丰富的遗传型的 HEV E2s 领域(病毒衣壳的最耸出的区域) 的 8G12 的复杂水晶结构 1 和 4 在 4.0 和 2.3 Å 被决定;分辨率分别地。这些结构表明 8G12 在 E2s dimerization 区域通过 epitopes 认出两遗传型。有像病毒的粒子的基于结构的 mutagenesis 和房间模型试金识别了为 8G12 中立化是必要的几保存残余(Glu549, Lys554 和 Gly591 ) 。而且, 8G12 的 epitope 作为涉及病毒主人相互作用的关键 epitope 被识别。这些调查结果将帮助为 HEV 感染的最丰富的形式的预防开发普通策略。 | Ying Gu Xuhua Tang Xiao Zhang Cuiling Song Minghua Zheng Kaihang Wang Jun Zhang Mun-Hon Ng Choy-Leong Hew Shaowei Li Ningshao Xia J. Sivaraman | 2015 | Cell Research2015，25，5： | 3 |
| 3 | Vibration signal-based chatter identification for milling of thin-walled structure显示文摘In high speed milling aeronautical part,tool condition monitoring(TCM)is very important,because it is prone to get a chatter owing to the low stiffness of thin-walled structures.And the TCM is key technology for automated machining.In this paper,aiming to chatter monitoring in thin-walled structure milling,a variational mode decomposition–energy distribution(VMD-ED)method is proposed to improve the identification accuracy.And a moving average root mean square–mean value(MARMS-MV)identification method and a variational mode decomposition–energy entropy(VMD-EE)identification method are also tested.Identification accuracy and computing time of the three methods are compared.The vibration signals collected from the spindle and worktable are also contrasted.The conducted experimental study shows that,the proposed VMD-ED method offers an identification method for chatter monitoring with greater sensitivity,better stability and less computing time,and mounting the vibration sensor on worktable is better than spindle for a chatter monitoring system. | Wenping MOU Shaowei ZHU Zhenxi JIANG Ge SONG | 2022 | Chinese Journal of Aeronautics2022，35，1： | 3 |
| 4 | Synthetic aperture ptychography:coded sensor translation for joint spatial-Fourier bandwidth expansion显示文摘Conventional ptychography translates an object through a localized probe beam to widen the field of view in real space.Fourier ptychography translates the object spectrum through a pupil aperture to expand the Fourier bandwidth in reciprocal space.Here we report an imaging modality,termed synthetic aperture ptychography(SAP),to get the best of both techniques.In SAP,we illuminate a stationary object using an extended plane wave and translate a coded image sensor at the far field for data acquisition.The coded layer attached on the sensor modulates the object exit waves and serves as an effective ptychographic probe for phase retrieval.The sensor translation process in SAP synthesizes a large complex-valued wavefront at the intermediate aperture plane.By propagating this wavefront back to the object plane,we can widen the field of view in real space and expand the Fourier bandwidth in reciprocal space simultaneously.We validate the SAP approach with transmission targets and reflection silicon microchips.A 20-mm aperture was synthesized using a 5-mm sensor,achieving a fourfold gain in resolution and 16-fold gain in field of view for object recovery.In addition,the thin sample requirement in ptychography is no longer required in SAP.One can digitally propagate the recovered exit wave to any axial position for post-acquisition refocusing.The SAP scheme offers a solution for far-field sub-diffraction imaging without using lenses.It can be adopted in coherent diffraction imaging setups with radiation sources from visible light,extreme ultraviolet,and X-ray,to electron. | PENGMING SONG SHAOWEI JIANG TIANBO WANG CHENGFEI GUO RUIHAI WANG TERRANCE ZHANG GUOAN ZHENG | 2022 | Photonics Research2022，10，7： | 2 |
| 5 | Immune escape by SARS-CoV-2 Omicron variant and structural basis of its effective neutralization by a broad neutralizing human antibody VacW-209显示文摘Dear Editor,Coronavirus disease 2019(COVID-19)caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)and its variants is still a pandemic raging across the world(Supplementary information,Fig.S1a,b).A new variant,Omicron,was first detected in South Africa and got dominant in many regions.1 Omicron has been classified as a variant of concern by the World Health Organization(WHO),whose spike carried more than 30 mutations(Supplementary information,Fig.S1c).1,2 To make a comprehensive evaluation of the susceptibility of Omicron,we summarized plasma samples from 19 convalescent individuals infected with the wild-type(WT)virus,and measured their neutralizing activities against the WT,Beta,Delta,Mu,C.1.2,and Omicron(Supplementary information,Figs.S1d and S2).The Omicron showed more serious resistance to neutralizing antibodies(nAbs)than other variants including Beta and Mu(45.6-fold,9.6-fold,and 15.4-fold,respectively,compared with that against the WT)。 | Bin Ju Qingbing Zheng Huimin Guo Qing Fan Tingting Li Shuo Song Hui Sun Senlin Shen Xinrong Zhou Wenhui Xue Lingyan Cui Bing Zhou Shaowei Li Ningshao Xia Zheng Zhang | 2022 | Cell Research2022，32，5： | 1 |
| 6 | Treatment of STAT5b-RARA positive acute promyelocytic leukemia by Venetoclax combining with homoharringtonine, cytarabine: A case report and literature review显示文摘Introduction:Acute promyelocytic leukemia(APL)is mostly due to the chromosome translocation t(15;17)(q22;q12),leading to the formation of PML-RARA fusion protein.Some patients carried rare translocation involving RARA gene,who were called variant APL caused by RAR family(RARA,RARB,and RARG)and partner genes.STAT5b-RARA was a rare type of molecular genetic abnormality with unfavorable prognosis which have been reported in only 18 cases in variant APL.Knowledge of STAT5b-RARA(+)APL treatment is still limited.Case report:We presented a 38-year-old female variant APL case,who was STAT5b-RARA positive detected by reverse transcription polymerase chain reaction.The patient failed to respond after four-drug combined induction chemotherapy:idarubicin,cytarabine,all trans retinoic acid,and arsenic trioxide(As 2 O 3).Then,the patient was re-induced with azacytidine,but still failed to achieve complete remission(CR).Next,she was treated with Venetoclax combining with homoharringtonine and cytarabine as the salvage therapy and achieved CR.Later,the patient received hematopoietic stem cell transplantation after 4 cycles of consolidation therapy.Conclusion:Venetoclax combining with homoharringtonine and cytarabine has been used as the salvage therapy in the STAT5b-RARA positive APL successfully. | Guangji Zhang Yang Song Li Wan Kaiqi Liu Shaowei Qiu Jianxiang Wang Yingchang Mi | 2022 | Blood Science2022，4，2： | 1 |
| 7 | Acoustic Prediction and Risk Evaluation of Shallow Gas in Deep-Water Areas显示文摘Shallow gas is a potential risk in deep-water drilling that must not be ignored,as it may cause major safety problems,such as well kicks and blowouts.Thus,the pre-drilling prediction of shallow gas is important.For this reason,this paper conducted deep-water shallow gas acoustic simulation experiments based on the characteristics of deep-water shallow soil properties and the theory of sound wave speed propagation.The results indicate that the propagation speed of sound waves in shallow gas increases with an in-crease in pressure and decreases with increasing porosity.Pressure and sound wave speed are basically functions of the power expo-nent.Combined with the theory of sound wave propagation in a saturated medium,this paper establishes a multivariate functional relationship between sound wave speed and formation pressure and porosity.The numerical simulation method is adopted to simulate shal-low gas eruptions under different pressure conditions.Shallow gas pressure coefficients that fall within the ranges of 1.0-1.1,1.1-1.2,and exceeding 1.2 are defined as low-,medium-,and high-risk,respectively,based on actual operations.This risk assessment me-thod has been successfully applied to more than 20 deep-water wells in the South China Sea,with a prediction accuracy of over 90%. | YANG Jin WU Shiguo TONG Gang WANG Huanhuan GUO Yongbin ZHANG Weiguo ZHAO Shaowei SONG Yu YIN Qishuai XU Fei | 2022 | Journal of Ocean University of China2022，21，5： | 1 |
| 8 | Epitranscriptomics and epiproteomics in cancer drug resistance:therapeutic implications显示文摘Drug resistance is a major hurdle in cancer treatment and a key cause of poor prognosis.Epitranscriptomics and epiproteomics are crucial in cell proliferation,migration,invasion,and epithelial–mesenchymal transition.In recent years,epitranscriptomic and epiproteomic modification has been investigated on their roles in overcoming drug resistance.In this review article,we summarized the recent progress in overcoming cancer drug resistance in three novel aspects:(i)mRNA modification,which includes alternative splicing,A-to-I modification and mRNA methylation;(ii)noncoding RNAs modification,which involves miRNAs,lncRNAs,and circRNAs;and(iii)posttranslational modification on molecules encompasses drug inactivation/efflux,drug target modifications,DNA damage repair,cell death resistance,EMT,and metastasis.In addition,we discussed the therapeutic implications of targeting some classical chemotherapeutic drugs such as cisplatin,5-fluorouridine,and gefitinib via these modifications.Taken together,this review highlights the importance of epitranscriptomic and epiproteomic modification in cancer drug resistance and provides new insights on potential therapeutic targets to reverse cancer drug resistance. | Huibin Song Dongcheng Liu Shaowei Dong Leli Zeng Zhuoxun Wu Pan Zhao Litu Zhang Zhe-Sheng Chen Chang Zou | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 0 |
| 9 | Lensless polarimetric coded ptychography for high-resolution,high-throughput gigapixel birefringence imaging on a chip显示文摘Polarimetric imaging provides valuable insights into the polarization state of light interacting with a sample.It can infer crucial birefringence properties of specimens without using labels,thereby facilitating the diagnosis of diseases such as cancer and osteoarthritis.In this study,we present a novel polarimetric coded ptychography(pol-CP)approach that enables high-resolution,high-throughput gigapixel birefringence imaging on a chip.Our platform deviates from traditional lens-based systems by employing an integrated polarimetric coded sensor for lensless coherent diffraction imaging.Utilizing Jones calculus,we quantitatively determine the birefringence retardance and orientation information of biospecimens from the recovered images.Our portable pol-CP prototype can resolve the 435 nm linewidth on the resolution target,and the imaging field of view for a single acquisition is limited only by the detector size of 41 mm2.The prototype allows for the acquisition of gigapixel birefringence images with a 180 mm^(2) field of view in~3.5 min,a performance that rivals high-end whole slide scanner but at a small fraction of the cost.To demonstrate its biomedical applications,we perform high-throughput imaging of malaria-infected blood smears,locating parasites using birefringence contrast.We also generate birefringence maps of label-free thyroid smears to identify thyroid follicles.Notably,the recovered birefringence maps emphasize the same regions as autofluorescence images,underscoring the potential for rapid on-site evaluation of label-free biopsies.Our approach provides a turnkey and portable solution for lensless polarimetric analysis on a chip,with promising applications in disease diagnosis,crystal screening,and label-free chemical imaging,particularly in resource-constrained environments. | LIMING YANG RUIHAI WANG QIANHAO ZHAO PENGMING SONG SHAOWEI JIANG TIANBO WANG XIAOPENG SHAO CHENGFEI GUO RISHIKESH PANDEY GUOAN ZHENG | 2023 | Photonics Research2023，11，12： | 0 |
| 10 | Two antibodies show broad,synergistic neutralization against SARS-CoV-2 variants by inducing conformational change within the RBD显示文摘Continual evolution of the severe acute respiratory syndrome coronavirus(SARS-CoV-2)virus has allowed for its gradual evasion of neutralizing antibodies(nAbs)produced in response to natural infection or vaccination.The rapid nature of these changes has incited a need for the development of superior broad nAbs(bnAbs)and/or the rational design of an antibody cocktail that can protect against the mutated virus strain.Here,we report two angiotensin-converting enzyme 2 competing nAbs—8H12 and 3E2—with synergistic neutralization but evaded by some Omicron subvariants.Cryo-electron microscopy reveals the two nAbs synergistic neutralizing virus through a rigorous pairing permitted by rearrangement of the 472-489 loop in the receptor-binding domain to avoid steric clashing.Bispecific antibodies based on these two nAbs tremendously extend the neutralizing breadth and restore neutralization against recent variants including currently dominant XBB.1.5.Together,these findings expand our understanding of the potential strategies for the neutralization of SARS-CoV-2 variants toward the design of broad-acting antibody therapeutics and vaccines. | Hui Sun Tingting Deng Yali Zhang Yanling Lin Yanan Jiang Yichao Jiang Yang Huang Shuo Song Lingyan Cui Tingting Li Hualong Xiong Miaolin Lan Liqin Liu Yu Li Qianjiao Fang Kunyu Yu Wenling Jiang Lizhi Zhou Yuqiong Que Tianying Zhang Quan Yuan Tong Cheng Zheng Zhang Hai Yu Jun Zhang Wenxin Luo Shaowei Li Qingbing Zheng Ying Gu Ningshao Xia | 2024 | Protein & Cell2024，15，2： | 0 |
| 11 | Hierarchical Interconnected NiMoN with Large Specific Surface Area and High Mechanical Strength for Efficient and Stable Alkaline Water/Seawater Hydrogen Evolution显示文摘NiMo-based nanostructures are among the most active hydrogen evolution reaction(HER)catalysts under an alkaline environment due to their strong water dissociation ability.However,these nanostructures are vulnerable to the destructive effects of H_(2) production,especially at industry-standard current densities.Therefore,developing a strategy to improve their mechanical strength while maintaining or even further increasing the activity of these nanocatalysts is of great interest to both the research and industrial communities.Here,a hierarchical interconnected NiMoN(HW-NiMoN-2h)with a nanorod-nanowire morphology was synthesized based on a rational combination of hydrothermal and water bath processes.HW-NiMoN-2h is found to exhibit excellent HER activity due to the accomodation of abundant active sites on its hierarchical morphology,in which nanowires con-nect free-standing nanorods,concurrently strengthening its structural stability to withstand H_(2) production at 1 A cm^(−2).Seawater is an attractive feedstock for water electrolysis since H_(2) generation and water desalination can be addressed simultaneously in a single process.The HER performance of HW-NiMoN-2h in alkaline seawater suggests that the presence of Na+ions interferes with the reation kinetics,thus lowering its activity slightly.However,benefiting from its hierarchical and interconnected characteristics,HW-NiMoN-2h is found to deliver outstanding HER activity of 1 A cm^(−2) at 130 mV overpotential and to exhibit excellent stability at 1 A cm^(−2) over 70 h in 1 M KOH seawater. | Minghui Ning Yu Wang Libo Wu Lun Yang Zhaoyang Chen Shaowei Song Yan Yao Jiming Bao Shuo Chen Zhifeng Ren | 2023 | Nano-Micro Letters2023，15，9： | 0 |
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