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| 1 | Oncogenic AURKA-enhanced N6-methyladenosine modification increases DROSHA mRNA stability to transactivate STC1 in breast cancer stem-like cells显示文摘RNase III DROSHA is upregulated in multiple cancers and contributes to tumor progression by hitherto unclear mechanisms.Here,we demonstrate that DROSHA interacts withβ-Catenin to transactivate STC1 in an RNA cleavage-independent manner,contributing to breast cancer stem-like cell(BCSC)properties.DROSHA mRNA stability is enhanced by N6-methyladenosine(m^(6)A)modification which is activated by AURKA in BCSCs.AURKA stabilizes METTL14 by inhibiting its ubiquitylation and degradation to promote DROSHA mRNA methylation.Moreover,binding of AURKA to DROSHA transcript further strengthens the binding of the m^(6)A reader IGF2BP2 to stabilize m^(6)A-modified DROSHA.In addition,wild-type DROSHA,but not an m^(6)A methylation-deficient mutant,enhances BCSC stemness maintenance,while inhibition of DROSHA m^(6)A modification attenuates BCSC traits.Our study unveils the AURKA-induced oncogenic m^(6)A modification as a key regulator of DROSHA in breast cancer and identifies a novel DROSHA transcriptional function in promoting the BCSC phenotype. | Fei Peng Jie Xu Bai Cui Qilan Liang Sai Zeng Bin He Hong Zou Manman Li Huan Zhao Yuting Meng Jin Chen Bing Liu Shasha Lv Peng Chu Fan An Zifeng Wang Junxiu Huang Yajing Zhan Yuwei Liao Jinxin Lu Lingzhi Xu Jin Zhang Zhaolin Su Zhiguang Li Fangjun Wang Eric W-FLam Quentin Liu | 2021 | Cell Research2021，31，3： | 9 |
| 2 | Progress and perspective of the cathode/electrolyte interface construction in all-solid-state lithium batteries显示文摘Security risks of flammability and explosion represent major problems with the use of conventional lithium rechargeable batteries using a liquid electrolyte.The application of solid-state electrolytes could effectively help to avoid these safety concerns.However,integrating the solid-state electrolytes into the all-solid-state lithium batteries is still a huge challenge mainly due to the high interfacial resistance present in the entire battery,especially at the interface between the cathode and the solid-state electrolyte pellet and the interfaces inside the cathode.Herein,recent progress made from investigations of cathode/solid-state electrolyte interfacial behaviors including the contact problem,the interlayer diffusion issue,the space-charge layer effect,and electrochemical compatibility is presented according to the classification of oxide-,sulfide-,and polymer-based solid-state electrolytes.We also propose strategies for the construction of ideal next-generation cathode/solid-state electrolyte interfaces with high room-temperature ionic conductivity,stable interfacial contact during long cycling,free formation of the space-charge region,and good compatibility with high-voltage cathodes. | Shiming Su Jiabin Ma Liang Zhao Kui Lin Qidong Li Shasha Lv Feiyu Kang Yan-Bing He | 2021 | Carbon Energy2021，3，6： | 3 |
| 3 | Sensitivity of SARS-CoV-2 to different temperatures显示文摘This study was designed to investigate the sensitivity of SARS-CoV-2 to different temperatures,to provide basic data and a scientific basis for the control of COVID-19 epidemic.The virus was dispersed in 1 mL basal DMEM medium at a final concentration of 103.2 TCID 50/mL and then incubated at 4,22,30,35,37,38,39 and 40°C for up to 5 days.The infectivity of residual virus was titrated using the Vero E6 cell line.The results showed that the virus remained viable for 5 days at 4°C,and for 1 day only at 22 and 30°C.We found that the infectivity of the virus was completely lost after less than 12 hours at 37,38 and 39°C,while at 40°C,the inactivation time of the virus was rapidly reduced to 6 hours.We show that SARS-CoV-2 is sensitive to heat,is more stable at lower temperatures than higher temperature,remains viable for longer at lower temperatures,and loses viability rapidly at higher temperatures. | Qi Lv Mingya Liu Feifei Qi Shuran Gong Shasha Zhou Shisheng Zhan Linlin Bao | 2020 | Animal Models and Experimental Medicine2020，3，4： | 3 |
| 4 | Sequential immunizations confer cross-protection against variants of SARS-CoV-2,including Omicron in Rhesus macaques显示文摘Variants of concern(VOCs)like Delta and Omicron,harbor a high number of mutations,which aid these viruses in escaping a majority of known SARS-CoV-2 neutralizing antibodies(NAbs).In this study,Rhesus macaques immunized with 2-dose inactivated vaccines(Coronavac)were boosted with an additional dose of homologous vaccine or an RBD-subunit vaccine,or a bivalent inactivated vaccine(Beta and Delta)to determine the effectiveness of sequential immunization.The booster vaccination significantly enhanced the duration and levels of neutralizing antibody titers against wild-type. | Wei Deng Qi Lv Fengdi Li Jiangning Liu Zhiqi Song Feifei Qi Qiang Wei Pin Yu Mingya Liu Shasha Zhou Yaqing Zhang Hong Gao Nan Wang Zijing Jia Kai Gao Jiayi Liu Chong Xiao Haiquan Shang Xiangxi Wang Linlin Bao Chuan Qin | 2022 | Signal Transduction and Targeted Therapy2022，7，5： | 2 |
| 5 | Web Information and Social Impacts of Disasters in China显示文摘 | Jiuchang Wei Dingtao Zhao Desheng Wu Shasha Lv | 2009 | Human and Ecological Risk Assessment2009，15，2： | 1 |
| 6 | Assessment of spatial distribution and cysts resources of Artemia in late autumn in Dangxiong Co salt lake显示文摘 | Shasha Liu Xifang Liu Qinxian Jia Fanjing Kong Mianping Zheng Guangjun Lv | 2013 | Acta Ecologica Sinica2013，，： | 1 |
| 7 | Sequentially immune-induced antibodies could cross-neutralize SARS-CoV-2 variants显示文摘Background:The Omicron(B.1.1.529)SARS-COV-2 variant has raised serious concerns because of its unprecedented rapid rate of spreading and the fact that there are 36 mutations in the spike protein.Since the vaccine-induced neutralizing antibody targets are the spike protein,this may lead to the possibility of vaccine-induced hu-moral immunity escape.Methods:We measured the neutralizing activity in vitro for Omicron and compared this with wild type(WH-09)and Delta variants in human and monkey sera from different types of immunity.The monkey sera samples were collected at 1 and 3 months post three-dose inactivated(PiCoVacc)and recombinant protein(ZF2001)vaccination.Human sera were collected from 1 month post three-dose inactivated vaccination.Results:In inactivated vaccine sera,at 1/3 months post three-dose,geometric mean titers(GMTs)of neutralization antibody(NAb)against the Omicron variant were 4.9/5.2-fold lower than those of the wild type.In recombinant protein vaccine sera,GMTs of NAb against Omicron were 15.7/8.9-fold lower than those of the wild type.In human sera,at 1 month post three-dose inactivated vaccination,GMTs of NAb against Omicron were 3.1-fold lower than those of the wild type.Conclusion:This study demonstrated that despite a reduction in neutralization titers,cross-neutralizing activity against Omicron and Delta variants was still observed after three doses of inactivated and recombinant protein vaccination. | Qi Lv Shasha Zhou Feifei Qi Yaqing Zhang Fengdi Li Mingya Liu Linlin Bao | 2022 | Animal Models and Experimental Medicine2022，5，1： | 1 |
| 8 | High performance sandwich structured Si thin film anodes with LiPON coating显示文摘 | Xinyi LUO Jialiang LANG Shasha LV Zhengcao LI | 2018 | Frontiers of Materials Science2018，12，2： | 1 |
| 9 | Review on incorporation of alkali elements and their effects in Cu(In,Ga)Se_(2)solar cells显示文摘Cu(In,Ga)Se_(2)(CIGS)is a promising candidate to replace crystalline silicon solar cells and dominate the photovoltaic market in the future.Alkali elements such as sodium(Na),potassium(K),rubidium(Rb),and Cesium(Cs)are commonly accepted as indispensable parts to boost cell efficiencies of CIGS thin-film solar cells.Therefore,a comprehensive understanding of alkali effects on the electronic and chemical properties of the CIGS layer as well as the underlying mechanisms is of paramount importance for achieving high-performance solar cells.This paper reviews the development process and incorporation pathways of alkalis and then overviews the roles of different alkali elements and their effects on CIGS cells in detail.Furthermore,the unsolved problems and future development prospects are also proposed.Overall,the understanding and development of widely adopted alkali-fluoride post-deposition treatments(PDTs)are still underway,and together with newly updated research,it will likely enable the CIGS technology to make the conversion efficiency closer to its theoretical limit. | Yazi Wang Shasha Lv Zhengcao Li | 2022 | Journal of Materials Science & Technology2022，，1： | 1 |
| 10 | A Wavy-Structured Highly Stretchable Thermoelectric Generator with Stable Energy Output and Self-Rescuing Capability显示文摘Thermoelectric generators(TEGs)demonstrate great potential for flexible and wearable electronics due to the direct electrical energy harvested from waste heat.Good wearability requires high mechanical flexibility and preferable stretchability,while current TEGs are primarily developed with rigid or non-stretchable components,which do not conform well to human skin or accommodate human motions,thus hindering further applications. | Zhuoxin Liu Xiaodong Wang Shasha Wei Haicai Lv Jiaqian Zhou Peng Peng Hanfu Wang Guangming Chen | 2021 | CCS Chemistry2021，3，10： | 1 |
| 11 | AB035. Lactate receptor GPR81 modulates epigenetic modification in the subretina显示文摘Background:Retinal pigment epithelium(RPE)is vital for the homeostasis of the subretina including photoreceptors and choroid.Interestingly,our previous results suggested that the recently discovered lactate receptor GPR81 is abundantly expressed in RPE.To date,only one previous study has shown that activating GPR81 could enhance DNA repair by activating HDAC1.Consequently,we investigated whether GPR81 exhibits epigenetic modification in the subretina by using GPR81−/−mice.Methods:GPR81−/−mice and wide type littermates were generated on a background of C57BL/6J mice.The thicknesses of their choroid were evaluated by immunohistochemistry.Meanwhile,Q-PCR,western blot and choroid sprout assay were performed.In vitro,primary retinal pigment epithelium(pRPE)cells were isolated from mice,and cultured for treatments.Results:The thickness of choroid was reduced in GPR81−/−mice compared to GPR81+/+mice,suggesting that GPR81 is important for the integrity of choroid.In the choroid sprout assay,lactate treated RPE/choroid complex showed a significant increase in angiogenesis compared to controls while lactate treated KO RPE/choroid complex showed no difference compared to their controls.For Q-PCR,most of the genes screened elevated their expression in GPR81−/−mice compared to WT mice,suggesting epigenetic modification may exist,which were confirmed by histone acetylation and HDACs activity assay.Conclusions:Taking together,the lactate receptor GPR81 in RPE is very important for maintaining homeostasis of the subretina.This novel discovery sheds new light on the relationship between metabolism and epigenetic modification. | Xiaojuan Yang Raphael Rouget Tang Zhu Christiane Quiniou Shasha Lv Suna Jung Francois Duhamel Houda Tahiri Samy Omri Baraa Noueihed Xin Hou JoséCarlos Rivera Mathieu Nadeau-Vallée Pierre Lachapelle Sylvain Chemtob | 2018 | Annals of Eye Science2018，，1： | 0 |
| 12 | Nitrogen ion irradiation effect on enhancing photocatalytic performance of CdTe/ZnO heterostructures显示文摘To deal with the increasingly deteriorating environment problems, more and more harsh requirements are put forward for photocatalysis application. Building semiconductor heterostructures has been proven to be an efficient way to enhance photocatalytic performance. A kind of CdTe/ZnO heterostructures were synthesized by a hydrothermal and successive ionic layer absorption and reaction (SILAR) method and achieved obviously efficient photocatalytic performance. Moreover, after the N ion irradiation treatment, the photocatalytic activity was further enhanced, which can be ascribed to the introduction of oxygen vacancy defects. The photocatalytic performance enhancement mechanism by coupling constructing heterostructures and Ion irradiation are further studied to give us an overall understanding on ZnO nanowires. | Yazi WANG Wei LI Yimeng FENG Shasha LV Mingyang LI Zhengcao LI | 2018 | Frontiers of Materials Science2018，12，4： | 0 |
| 13 | Modulation of the Anisotropic Electronic Properties in ReS_(2) via Ferroelectric Film显示文摘Anisotropic response in two-dimensional materials has emerged with attractive potential applications in angle-sensitive areas.However,the challenge with current studies on anisotropic response is due to the main use of the structural materials of pristine to examine the physical properties in different direc-tions,which cause restriction of the anisotropic ratio within a narrow range,thereby,limiting their practical applications. | Renyan Wang Fengya Zhou Liang Lv Shasha Zhou Yiwei Yu Fuwei Zhuge Huiqiao Li Lin Gan Tianyou Zhai | 2019 | CCS Chemistry2019，1，3： | 0 |
| 14 | Cancer cell employs a microenvironmental neural signal transactivating nucleus-mitochondria coordination to acquire stemness显示文摘Cancer cell receives extracellular signal inputs to obtain a stem-like status,yet how tumor microenvironmental(TME)neural signals steer cancer stemness to establish the hierarchical tumor architectures remains elusive.Here,a pan-cancer transcriptomic screening for 10852 samples of 33 TCGA cancer types reveals that cAMP-responsive element(CRE)transcription factors are convergent activators for cancer stemness.Deconvolution of transcriptomic profiles,specification of neural markers and illustration of norepinephrine dynamics uncover a bond between TME neural signals and cancer-cell CRE activity.Specifically,neural signal norepinephrine potentiates the stemness of proximal cancer cells by activating cAMP-CRE axis,where ATF1 serves as a conserved hub.Upon activation by norepinephrine,ATF1 potentiates cancer stemness by coordinated trans-activation of both nuclear pluripotency factors MYC/NANOG and mitochondrial biogenesis regulators NRF1/TFAM,thereby orchestrating nuclear reprograming and mitochondrial rejuvenating.Accordingly,single-cell transcriptomes confirm the coordinated activation of nuclear pluripotency with mitochondrial biogenesis in cancer stem-like cells.These findings elucidate that cancer cell acquires stemness via a norepinephrine-ATF1 driven nucleus-mitochondria collaborated program,suggesting a spatialized stemness acquisition by hijacking microenvironmental neural signals. | Bin He Rui Gao Shasha Lv Ailin Chen Junxiu Huang Luoxuan Wang Yunxiu Feng Jiesi Feng Bing Liu Jie Lei Bing Deng Bin He Bai Cui Fei Peng Min Yan Zifeng Wang Eric W-F Lam Bilian Jin Zhiming Shao Yulong Li Jianwei Jiao Xi Wang Quentin Liu | 2023 | Signal Transduction and Targeted Therapy2023，8，8： | 0 |
| 15 | Energy band engineering of Bi_(2)O_(2.33)–CdS direct Z-scheme heterojunction for enhanced photocatalytic reduction of CO_(2)显示文摘In this work,a Bi_(2)O_(2.33)–CdS direct Z-scheme heterojunction was fabricated based on energy band engineering.The Bi_(2)O_(2.33)core nanoflakes were first synthesized by electrodeposition which was followed by an annealing process to fabricate this heterojunction.Then the Cd S shell was deposited on Bi_(2)O_(2.33)nanoflakes utilizing the solution method,during which a suitable concentration of Cd Clsolution was used for forming a homogeneous and continuous integrated CdS shell.A space charge region and an internal electric field from CdS(+)to Bi_(2)O_(2.33)(-),which drove a direct Z-scheme charge transfer process,were formed at the interface.The Bi_(2)O_(2.33)–CdS exhibited excellent photocatalytic performance for CO_(2)reduction mainly attributed to the satisfactory photoinduced charge separation and transport efficiency in the direct Z-scheme heterojunction.The photocatalytic CO_(2)reduction ability of Bi_(2)O_(2.33)–CdS was significantly enhanced compared with single Bi_(2)O_(2.33)or Cd S,with a CO_(2)yield rate of ca.2.9μmol/(cm^(2)h)under a 300 W Xe lamp.The reduction of CO_(2)to CO_(2)demonstrated 94.0%selectivity. | Guojing Wang Zhiwei Tang Jing Wang Shasha Lv Yunjie Xiang Feng Li Chong Liu | 2022 | Journal of Materials Science & Technology2022，，16： | 0 |
| 16 | Internal magnetic-field-enhanced photogenerated charge separation in ferromagnetic TiO_(2)surface heterojunctions显示文摘The use of the internal magnetic field of ferromagnets can effectively promote charge separation and transfer(CST)in photoelectrochemical energy conversion.However,photoelectrochemical materials with a ferromagnetic field are scarce,and the internal magnetic field is negligible in nonferromagnetic mate-rials.To address this issue,we propose a rational method for preparing ferromagnetic TiO_(2)powder using controllable oxygen vacancies in anatase TiO_(2)with co-exposed{001}and{101}facets.Accordingly,an ex-cellent saturation magnetisation of 0.0014 emu/g in TiO_(2)is achieved owing to an asymmetric and uneven charge distribution.Compared with that of nonferromagnetic TiO_(2),the efficiency of photocatalytic hydro-gen generation of ferromagnetic TiO_(2)is improved by 0.64 times.The enhancement of photocatalytic hy-drogen generation is due to the different forces exerted on the electrons and holes in the magnetic field,which significantly improve the photogenerated CST efficiency of ferromagnetic TiO_(2).This result high-lights the significant role of the synergistic regulation of the crystal structure and defects in regulating the ferromagnetic characteristics of materials.The findings of this study provide guidance for leveraging point defects to promote CST for high-efficiency solar-energy conversion systems. | Guojing Wang Shirong Xiong Yonghui Chen Chunchang Wang Shasha Lv Ke Jia Yunjie Xiang Jianbo Liu Chong Liu Zhengcao Li | 2023 | Journal of Materials Science & Technology2023，，29： | 0 |
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