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| 1 | A review of the estimation of downward surface shortwave radiation based on satellite data:Methods, progress and problems显示文摘The estimation of downward surface shortwave radiation(DSSR)is important for the Earth’s energy budget and climate change studies.This review was organised from the perspectives of satellite sensors,algorithms and future trends,retrospects and summaries of the satellite-based retrieval methods of DSSR that have been developed over the past 10 years.The shortwave radiation reaching the Earth’s surface is affected by both atmospheric and land surface parameters.In recent years,studies have given detailed considerations to the factors which affect DSSR.It is important to improve the retrieval accuracy of cloud microphysical parameters and aerosols and to reduce the uncertainties caused by complex topographies and high-albedo surfaces(such as snow-covered areas)on DSSR estimation.This review classified DSSR retrieval methods into four categories:empirical,parameterisation,look-up table and machine-learning methods,and evaluated their advantages,disadvantages and accuracy.Further efforts are needed to improve the calculation accuracy of atmospheric parameters such as cloud,haze,water vapor and other land surface parameters such as albedo of complex terrain and bright surface,organically combine machine learning and other methods,use the new-generation geostationary satellite and polar orbit satellite data to produce highresolution DSSR products,and promote the application of radiation products in hydrological and climate models. | Husi LETU Jiancheng SHI Ming LI Tianxing WANG Huazhe SHANG Yonghui LEI Dabin JI Jianguang WEN Kun YANG Liangfu CHEN | 2020 | Science China Earth Sciences2020，63，6： | 8 |
| 2 | Micro/nano-structured TiO2 surface with dual-functional antibacterial effects for biomedical applications显示文摘Implant-associated infections are generally difficult to cure owing to the bacterial antibiotic resistance which is attributed to the widespread usage of antibiotics.Given the global threat and increasing influence of antibiotic resistance,there is an urgent demand to explore novel antibacterial strategies other than using antibiotics.Recently,using a certain surface topography to provide a more persistent antibacterial solution attracts more and more attention.However,the clinical application of biomimetic nano-pillar array is not satisfactory,mainly because its antibacterial ability against Gram-positive strain is not good enough.Thus,the pillar array should be equipped with other antibacterial agents to fulfill the bacteriostatic and bactericidal requirements of clinical application.Here,we designed a novel model substrate which was a combination of periodic micro/nano-pillar array and TiO2 for basically understanding the topographical bacteriostatic effects of periodic micro/nano-pillar array and the photocatalytic bactericidal activity of TiO2.Such innovation may potentially exert the synergistic effects by integrating the persistent topographical antibacterial activity and the non-invasive X-ray induced photocatalytic antibacterial property of TiO2 to combat against antibiotic-resistant implant-associated infections.First,to separately verify the topographical antibacterial activity of TiO2 periodic micro/nano-pillar array,we systematically investigated its effects on bacterial adhesion,growth,proliferation,and viability in the dark without involving the photocatalysis of TiO2.The pillar array with sub-micron motif size can significantly inhibit the adhesion,growth,and proliferation of Staphylococcus aureus(S.aureus)and Escherichia coli(E.coli).Such antibacterial ability is mainly attributed to a spatial confinement size-effect and limited contact area availability generated by the special topography of pillar array.Moreover,the pillar array is not lethal to S.aureus and E.coli in 24 h.Then,the X-ray induced photocatalytic antibacterial property of TiO2 periodic micro/nano-pillar array in vitro and in vivo will be systematically studied in a future work.This study could shed light on the direction of surface topography design for future medical implants to combat against antibiotic-resistant implant-associated infections without using antibiotics. | Xiang Ge Chengzu Ren Yonghui Ding Guang Chen Xiong Lu Kefeng Wang Fuzeng Ren Meng Yang Zhuochen Wang Junlan Li Xinxin An Bao Qian Yang Leng | 2019 | Bioactive Materials2019，4，1： | 8 |
| 3 | Magnetic yolk-shell structured anatase-based microspheres loaded with Au nanoparticles for heterogeneous catalysis显示文摘磁性的蛋黄壳组织了基于锐钛矿的 microspheres 在磁铁矿粒子上通过连续、灵巧的大音阶的第五音胶化涂层被制作,由退火列在后面处理。在与金 nanoparticles 装载之上,获得的功能的磁性的 microspheres 在向苯乙烯氧化物与非凡的高变换(89.5%) 和选择(90.8%) 催化苯乙烯的 epoxidation 作为异构的催化剂显示出优异性能。这些迷人的材料的构造过程为创造另外的功能的 nanocomposites 展示许多含意,这被相信。 | Chun Wang Junchen Chen Xinran Zhou Wei Li Yong Liu Qin Yue Zhaoteng Xue Yuhui Li Ahmed A. Elzatahry Yonghui Deng Dongyuan Zhao | 2015 | Nano Research2015，8，1： | 7 |
| 4 | Correlation between the cumulative analgesic effect of electroacupuncture intervention and synaptic plasticity of hypothalamic paraventricular nucleus neurons in rats with sciatica显示文摘In the present study, a rat model of chronic neuropathic pain was established by ligation of the sciatic nerve and a model of learning and memory impairment was established by ovariectomy to investigate the analgesic effect of repeated electroacupuncture stimulation at bilateral Zusanli (ST36) and Yanglingquan (GB34). In addition, associated synaptic changes in neurons in the paraventricular nucleus of the hypothalamus were examined. Results indicate that the thermal pain threshold (paw withdrawal latency) was significantly increased in rats subjected to 2-week electroacupuncture intervention compared with 2-day electroacupuncture, but the analgesic effect was weakened remarkably in ovariectomized rats with chronic constrictive injury. 2-week electroacupuncture intervention substantially reversed the chronic constrictive injury-induced increase in the synaptic cleft width and thinning of the postsynaptic density. These findings indicate that repeated electroacupuncture at bilateral Zusanli and Yanglingquan has a cumulative analgesic effect and can effectively relieve chronic neuropathic pain by remodeling the synaptic structure of the hypothalamic paraventricular nucleus. | Qiuling Xu Tao Liu Shuping Chen Yonghui Gao Junying Wang Lina Qiao Junling Liu | 2013 | Neural Regeneration Research2013，8，3： | 6 |
| 5 | Comparison of efficacy, safety, and quality of life between sorafenib and sunitinib as first.line therapy for Chinese patients with metastatic renal cell carcinoma显示文摘Background: Sorafenib and sunitinib are widely used as first-line targeted therapy for metastatic renal cell carcinoma(mRCC) in China.This study aimed to compare the efficacy, safety, and quality of life(QoL) in Chinese mRCC patients treated with sorafenib and sunitinib as first-line therapy.Methods: Clinical data of patients with mRCC who received sorafenib(400 mg twice daily; 4 weeks) or sunitinib(50 mg twice daily; on a schedule of 4 weeks on treatment followed by 2 weeks off) were retrieved. Primary outcomes were overall survival(OS), progression-free survival(PFS), adverse events(AEs), and QoL(SF-36 scores), and secondary outcomes were associations of clinical characteristics with QoL.Results: Medical records of 184 patients(110 in the sorafenib group and 74 in the sunitinib group) were reviewed.PFS and OS were comparable between the sorafenib and sunitinib groups(both P > 0.05).The occurrence rates of leukocytopenia, thrombocytopenia, and hypothyroidism were higher in the sunitinib group(36.5% vs. 10.9%,P< 0.001; 40.5% vs. 10.9%, P < 0.001; 17.6% vs. 3.6%, P = 0.001), and that of diarrhea was higher in the sorafenib group(62.7% vs. 35.2%, P < 0.001). There was no significant difference in SF-36 scores between the two groups. Multivariate analysis indicated that role-physical and bodily pain scores were associated with the occurrence rate of grade 3 or 4 AEs(P = 0.017 and 0.005).Conclusions: Sorafenib has comparable efficacy and lower toxicity profile than sunitinib as first-line therapy for mRCC. Both agents showed no significant impact on QoL of patients. | Wen Cai Wen Kong Baijun Dong Jin Zhang Yonghui Chen Wei Xue Yiran Huang Lixin Zhou Jiwei Huang | 2017 | Chinese Journal of Cancer2017，36，11： | 6 |
| 6 | Help, hope and hype: ethical considerations of human microbiome research and applications显示文摘 | Yonghui Ma Hua Chen Canhui Lan Jianlin Ren | 2018 | Protein & Cell2018，9，5： | 6 |
| 7 | Enhancement of Aggression Induced by Isolation Rearing is Associated with a Lack of Central Serotonin显示文摘Isolation rearing(IR) enhances aggressive behavior, and the central serotonin(5-hydroxytryptamine,5-HT) system has been linked to IR-induced aggression.However, whether the alteration of central serotonin is the cause or consequence of enhanced aggression is still unknown. In the present study, using mice deficient in central serotonin Tph2-/-and Lmx1 b-/-, we examined the association between central serotonin and aggression with or without social isolation. We demonstrated that central serotonergic neurons are critical for the enhanced aggression after IR. 5-HT depletion in wild-type mice increased aggression. On the other hand, application of 5-HT in Lmx1 b-/-mice inhibited the enhancement of aggression under social isolation conditions. Dopamine was downregulated in Lmx1 b-/-mice. Similar to 5-HT, L-DOPA decreased aggression in Lmx1 b-/-mice. Our results linkthe serotoninergic system directly to aggression and this may have clinical implications for aggression-related human conditions. | Yiqiong Liu Yunong Sun Xiaoyan Zhao Ji-Young Kim Lu Luo Qian Wang Xiaolu Meng Yonghui Li Nan Sui Zhou-Feng Chen Chuxiong Pan Liang Li Yan Zhang | 2019 | Neuroscience Bulletin2019，35，5： | 5 |
| 8 | Controllable synthesis of highly crystallized mesoporous TiO2/WO3 heterojunctions for acetone gas sensing显示文摘Mesoporous semiconducting metal oxides(SMOs)heterojunctions are appealing sensors for gas detecting.However,due to the different hydrolysis and condensation mechanism of every metal precursor and the contradiction between high crystallinity and high surface area,the synthesis of mesoporous SMOs heterojunctions with highly o rdered mesostructures,highly crystallized frameworks,and high surface area remains a huge challenge.In this work,we develop a novel'acid-base pair'adjusted solvent evaporation induced self-assembly(EISA)strategy to prepare highly crystallized ordered mesoporous TiO2/WO3(OM-TiO2/WO3)heterojunctions.The WCl6 and titanium isopropoxide(TIPO)are used as the precursors,respectively,which function as the'acid-base pair',enabling the coassembly with the structure directing agent(PEO-b-PS)into highly ordered meso structures.In addition,PEO-b-PS can be converted to rigid carbon which can protect the meso structures from collapse during the crystallization process.The resultant OM-TiO2/WO3 heterojunctions possess primitive cubic mesostructures,large pore size(~21.1 nm),highly crystalline frameworks and surface area(~98 m2/g).As a sensor for acetone,the obtained OM-TiO2/WO3 show excellent re sponse/recovery perfo rmance(3 s/5 s),good linear dependence,repeatability,selectivity,and long-term stability(35 days). | Changyao Wang Yuhui Li Pengpeng Qiu Linlin Duan Wei Bi Yan Chen Dingyi Guo Yupu Liu Wei Luo Yonghui Deng | 2020 | Chinese Chemical Letters2020，31，5： | 4 |
| 9 | Epitope peptides of influenza H3N2 virus neuraminidase gene designed by immunoinformatics显示文摘病毒表面蛋白质 neuraminidase (NA ) 是在流行性感冒的主要子类型特定的抗原类型 A 病毒。Neuraminidase 作为酶工作打破在红血球凝聚素之间的契约(哈) 并且到版本的 sialic 酸最新从感染的房间形成了病毒。在这研究,从 H3N2 子类型病毒的 NA 基因被定序, NA 蛋白质为 B 房间 epitopes 被屏蔽并且基于 immunoinformatics 估计了。把信息,三肽 ES8, RR9,和 WK7 基于这(盖住氨基酸残余 221228, 292300,和 383389,分别地) NA,蛋白质人工地被选择并且综合。这些肽被用来皮下地使新西兰兔子免疫提起 antisera。结果证明这三肽能够以一种特定、敏感的方式对 H3N2 病毒得到抗体,由连接酶的 immunosorbent 在 vitro 检测了试金。而且, hemadsorption 释放反的效果在 1:40 的冲淡发生在三 antisera 混合物。用数据库软件的排列证明在这三 epitope 肽的氨基酸残余在在这研究定序的所有 NA 在特定的地点被代替。我们建议这些 NA epitope 肽可能被使用与一起哈蛋白质同样疫苗的抗原。 | Lijun Liang Ping Huang Miaoheng Wen Hanzhong Ni Songnuan Tan Yonghui Zhang Qiuxia Chen | 2012 | Acta Biochimica et Biophysica Sinica2012，44，2： | 4 |
| 10 | In Situ Investigation of Dynamic Silver Crystallization Driven by Chemical Reaction and Diffusion显示文摘Rational synthesis of materials is a long-term challenging issue due to the poor understanding on the formation mechanism of material structure and the limited capability in controlling nanoscale crystallization.The emergent in situ electron microscope provides an insight to this issue.By employing an in situ scanning electron microscope,silver crystallization is investigated in real time,in which a reversible crystallization is observed.To disclose this reversible crystallization,the radicals generated by the irradiation of electron beam are calculated.It is found that the concentrations of radicals are spatiotemporally variable in the liquid cell due to the diffusion and reaction of radicals.The fluctuation of the reductive hydrated electrons and the oxidative hydroxyl radicals in the cell leads to the alternative dominance of the reduction and oxidation reactions.The reduction leads to the growth of silver crystals while the oxidation leads to their dissolution,which results in the reversible silver crystallization.A regulation of radical distribution by electron dose rates leads to the formation of diverse silver structures,confirming the dominant role of local chemical concentration in the structure evolution of materials. | Ting Liu Xiangyu Dou Yonghui Xu Yongjun Chen Yongsheng Han | 2020 | Research2020，，1： | 4 |
| 11 | Recyclable Fenton-like catalyst based on zeolite Y supported ultrafine,highly-dispersed Fe_2O_3 nanoparticles for removal of organics under mild conditions显示文摘A versatile wet impregnation method was employed to conveniently and controllably deposit Fe_2O_3 nanoparticles on zeolites including commercial Y, mordenite and ZSM-5 with the similar framework Si/Al ratios and crystal sizes, respectively. The ultrafine Fe_2O_3 nanoparticles in size of 5 nm can be highly dispersed on zeolite Y matrix due to its much better wettability than ZSM-5 and mordenite. By using the obtained Fe_2O_3/zeolite composite as the heterogeneous Fenton-like catalysts, the degradation of phenol as a model reaction was systematically investigated, including the zeolite supports, particle size and dispersion of Fe_2O_3, and reaction conditions of H_2O_2 concentration, temperature, and pH value. The catalyst based on zeolite Y with Fe loading of 9% exhibited the best phenol degradation efficiency (> 90%)in neutral pH within 2 h. Its high catalytic activity in Fenton reaction can be attributed to the bifunctional properties of strong surface BrФnsted acidity and high reactivity of octahedral Fe^(3+) in the highlydispersed ultrafine Fe_2O_3 nanoparticles in size of 5 nm, which were the primary active centers to quickly decompose H_2O_2 into hydroxyl radicals. Since phenol degradation can be performed under mild conditions of ambient temperature (283-323 K) and a wide pH range (4.0-7.0), the catalysts can be easily recovered for recyclable use with stable degradation activity, which own the immense potential in deep treatment of organic pollutants in industrial wastewater. | Xuanyu Yang Xiaowei Cheng Ahmed A.Elzatahry Jinyang Chen Abdulaziz Alghamdi Yonghui Deng | 2019 | Chinese Chemical Letters2019，30，2： | 4 |
| 12 | Acupuncture effects on the hippocampal cholinergic system in a rat model of neuropathic pain显示文摘The present study observed the effects of repeated electroacupuncture of Zusanli (ST36) and Yanglingquan (GB34) on expression of hippocampal acetylcholinesterase, vesicular acetylcholine transporter, and muscarinic M1 receptor mRNA in chronic constrictive injury (neuropathic pain) and/or ovariotomy rats. Results demonstrated increased expression of hippocampal acetylcholinesterase, vesicular acetylcholine transporter, and muscarinic M1 receptor mRNA, as well as decreased pain threshold, in a rat model of chronic neuropathic pain after electroacupuncture. The effects of electroacupuncture increased with prolonged time, but the above-mentioned effects decreased in memory-deficient animals. Results indicated that repeated electroacupuncture has a cumulative analgesic effect, which is closely associated with upregulation of acetylcholinesterase and vesicular acetylcholine transporter activity, as well as M1 receptor mRNA expression and memory. | Junying Wang Junling Liu Shuping Chen Yonghui Gao Fanying Meng Lina Qiao | 2012 | Neural Regeneration Research2012，7，3： | 4 |
| 13 | Increasing the hole energy by grading the alloy composition of the p-type electron blocking layer for very high-performance deep ultraviolet light-emitting diodes显示文摘It is well known that the p-type AlGaN electron blocking layer(p-EBL) can block hole injection for deep ultraviolet light-emitting diodes(DUV LEDs). The polarization induced electric field in the p-EBL for [0001] oriented DUV LEDs makes the holes less mobile and thus further decreases the hole injection capability. Fortunately,enhanced hole injection is doable by making holes lose less energy, and this is enabled by a specifically designed p-EBL structure that has a graded AlN composition. The proposed p-EBL can screen the polarization induced electric field in the p-EBL. As a result, holes will lose less energy after going through the proposed p-EBL, which correspondingly leads to the enhanced hole injection. Thus, an external quantum efficiency of 7.6% for the 275 nm DUV LED structure is obtained. | ZI-HUI ZHANG JIANQUAN KOU SUNG-WEN HUANG CHEN HUA SHAO JIAMANG CHE CHUNSHUANG CHU KANGKAI TIAN YONGHUI ZHANG WENGANG BI HAO-CHUNG KUO | 2019 | Photonics Research2019，7，4： | 4 |
| 14 | Comparison of efficacy and safety among axitinib,sunitinib,and sorafenib as neoadjuvant therapy for renal cell carcinoma:a retrospective study显示文摘Dear editor,Renal cancer accounts for approximately 2%of all can-cer deaths worldwide,and renal cell carcinoma(RCC)is the predominant subtype[1].Radiotherapy and chemo-therapy have been found to have limited roles in the treatment of RCC.However,the treatment outcomes of metastatic RCC(mRCC)have been improved drastically since the application of molecular targeted therapeutic agents such as tyrosine kinase inhibitors(TKIs).TKIs have been gradually used for the preoperative treatment of RCC. | Wen Cai Biao Cai Juan Zhou Yonghui Chen Jin Zhang Yiran Huang Wei Xue Jiwei Huang | 2019 | Cancer Communications2019，39，1： | 4 |
| 15 | The cumulative analgesic effect of repeated electroacupuncture involves synaptic remodeling in the hippocampal CA3 region显示文摘In the present study, we examined the analgesic effect of repeated electroacupuncture at bilateral Zusanli (ST36) and Yanglingquan (GB34) once a day for 14 consecutive days in a rat model of chronic sciatic nerve constriction injury-induced neuropathic pain. In addition, concomitant changes in calcium/calmodulin-dependent protein kinase II expression and synaptic ultrastructure of neurons in the hippocampal CA3 region were examined. The thermal pain threshold (paw withdrawal latency) was increased significantly in both groups at 2 weeks after electroacupuncture intervention compared with 2 days of electroacupuncture. In ovariectomized rats with chronic constriction injury, the analgesic effect was significantly reduced. Electroacupuncture for 2 weeks significantly diminished the injury-induced increase in synaptic cleft width and thinning of the postsynaptic density, and it significantly suppressed the down-regulation of intracellular calcium/ calmodulin-dependent protein kinase II expression in the hippocampal CA3 region. Repeated electroacupuncture intervention had a cumulative analgesic effect on injury-induced neuropathic pain reactions, and it led to synaptic remodeling of hippocampal neurons and upregulated calcium/calmodulin-dependent protein kinase II expression in the hippocampal CA3 region. | Qiulinq Xu Tao Liu Shuping Chen Yonghui Gao Junying Wang Lina Qiao Junling Liu | 2012 | Neural Regeneration Research2012，7，18： | 3 |
| 16 | Improvement of whole wheat dough and bread properties by emulsifiers显示文摘Whole wheat bread is widely available worldwide,but it is always associated with less desirable dough processibility,small loaf volume,firm and gritty texture,and other distinctive attributes compared to white bread.Emulsifiers are commonly used to improve dough handling and baking quality during bread production.In present study,five emulsifiers(diacetyl tartaric acid esters of mono-and diglycerides(DATEM),polysorbate 80,sodium stearoyl lactylate(SSL),soy lecithin,and sucrose esters)were added during dough preparation of the whole wheat flour at 0.2%,0.5%,and 1.0%(flour weight basis).Dough rheological behavior and bread quality attributes,such as specific loaf volume and hardness,were measured.The results showed that DATEM,sucrose esters,and SSL increased the resistance to extension of the dough,whereas soy lecithin and polysorbate 80 increased the extensibility.Soy lecithin and polysorbate 80 were the only emulsifiers that significantly increased loaf volume compared to the control.Adding higher levels(1.0%)of sucrose esters,polysorbate 80,and SSL increased the formation of amylose-lipid complex and mitigate the crumb staling during storage.The results suggested that the emulsifiers could be applied to contribute to optimum functional quality of whole wheat bread. | Lauren Tebben Gengjun Chen Michael Tilley Yonghui Li | 2022 | Grain & Oil Science and Technology2022，5，2： | 3 |
| 17 | Macro-physical field of large diameter magnesium alloy billet electromagnetic direct-chill casting:A comparative study显示文摘A comprehensive two-dimensional axisymmetric mathematical model that couples transient electromagnetic force with fluid flow,heat transfer,and solidification was established to describe the interaction of multiphysics field during DC casting.The melt flow,heat transfer,and solidification characteristics under differential phase pulse magnetic field and differential phase low-frequency electromagnetic field(DP-PMF and DP-LFEF)were numerically investigated by means of numerical simulation during electromagnetic direct-chill(DC)casting of AZ31 alloy at the same casting conditions.The effects of differential phase electromagnetic fields on Lorentz forces distributions,melt flow,heat transfer,and liquid sump shape were discussed systematically.Based on measured current waveform,the results were compared with those obtained without magnetic field(MF)and under conventional pulse magnetic field(PMF)and low-frequency electromagnetic field(LFEF)under the same conditions.The results show that the application of magnetic fields can significantly change the solidification process of DC casting.Differential phase magnetic fields(DP-LFEF and DP-PMF)can effectively reduce the temperature of the melt in the liquid sump,and the shallower liquid sump depth can be obtained under the differential phase magnetic fields.A large velocity vibration amplitude and a lower temperature are available simultaneously under DP-PMF,resulting in more uniform temperature distribution. | Yonghui Jia Xingrui Chen Qichi Le Hang Wang Lei Bao | 2020 | Journal of Magnesium and Alloys2020，8，3： | 3 |
| 18 | Association of post.treatment hypoalbuminemia and survival in Chinese patients with metastatic renal cell carcinoma显示文摘Background:Hypoalbuminemia adversely affects the clinical outcomes of various cancers.The purpose of this study was to estimate the prognostic value of hypoalbuminemia 3-5 weeks after treatment in patients with metastatic renal cell carcinoma(mRCC) who received sorafenib or sunitinib as first-line treatment.Methods:In this single-center,retrospective study,we assessed the progression-free survival(PFS) and overall survival(OS) of 184 mRCC patients who received first-line sorafenib or sunitinib treatment.PFS and OS were compared between patients with post-treatment hypoalbuminemia(post-treatment albumin level <36.4 g/L) and those with normal post-treatment albumin level(albumin level≥36.4 g/L).The Memorial Sloan Kettering Cancer Center(MSKCC)risk model stratified mRCC patients into three risk categories.Prognostic values of all patient characteristics including MSKCC risk category were determined by using univariate and multivariate Cox regression models.Prognostic value was further determined using the Harrell concordance index and receiver operating characteristic curve analysis.Results:The median PFS and OS of the 184 patients were 11 months(95%confidence interval[CI]9-12 months)and 23 months(95%CI 19-33 months),respectively.Patients with post-treatment hypoalbuminemia had significantly shorter median PFS(6 months[95%CI 5-7 months]) and OS(11 months[95%CI 9-15 months]) than patients who had normal post-treatment albumin levels(PFS:12 months[95%CI 11-16 months],P < 0.001;OS:31 months[95%CI24-42 months],P < 0.001),respectively.Multivariate analysis showed that post-treatment hypoalbuminemia was an independent predictor of PFS(hazard ratio[HR],2.113;95%CI 1.390-3.212;P < 0.001) and OS(HR,2.388;95%CI 1.591-3.585;P < 0.001).Post-treatment hypoalbuminemia could also be combined with the MSKCC risk category for better prediction about OS.The model that included post-treatment hypoalbuminemia and MSKCC risk category improved the predictive accuracy for PFS and OS(c-index:0.68 and 0.73,respectively) compared with the basic MSKCC risk model(c-index:0.67 and 0.70,respectively).The prognostic values for PFS and OS of the integrated MSKCC risk model involving post-treatment hypoalbuminemia were significantly more accurate than the basic MSKCC risk model using likelihood ratio analysis(both P < 0.001).Conclusions:Post-treatment hypoalbuminemia can be considered an independent prognostic factor for patients with mRCC who undergo first-line treatment with tyrosine kinase inhibitors.Additionally,integrating post-treatment serum albumin level into the basic MSKCC risk model can improve the accuracy of this model in predicting patient overall survival and progression-free survival. | Wen Cai Jin Zhang Yonghui Chen Wen Kong Yiran Huang Jiwei Huang Lixin Zhou | 2017 | Chinese Journal of Cancer2017，36，7： | 3 |
| 19 | Effects of the vegetation restoration years on soil microbial community composition and biomass in degraded lands in Changting County,China显示文摘We evaluated the effects of the number of years of restoration of vegetation on soil microbial community structure and biomass in degraded ecosystems.We investigated the microbial community structure by analyzing their phospholipid fatty acids then examined microbial biomass carbon and nitrogen by chloroform fumigation extraction of restoration soils over several years.The data were compared with those of highly degraded lands and native vegetation sites.The results show that the duration of vegetation on the sites substantially increased microbial biomass and shifted the microbial community structure even after only 4 years.However,microbial communities and biomass did not recover to the status of native vegetation even after 35 years of vegetation cover.A redundancy analysis and Pearson correlation analysis indicated that soil organic carbon,total nitrogen,available potassium,soil water content,silt content and soil hardness explained 98.4%of total variability in the microbial community composition.Soil organic carbon,total nitrogen,available potassium and soil water content were positively correlated with microbial community structure and biomass,whereas,soil hardness and silt content were negatively related to microbial community structure and biomass.This study provides new insights into microbial community structure and biomass that influence organic carbon,nitrogen,phosphorus and potassium accumulation,and clay content in soils at different stages of restoration. | Yonghui Bai Xuan Zha Shifa Chen | 2020 | Journal of Forestry Research2020，31，4： | 3 |
| 20 | Advances in prostate cancer research models:From transgenic mice to tumor xenografting models显示文摘The identification of the origin and molecular characteristics of prostate cancer(PCa)has crucial implications for personalized treatment.The development of effective treatments for PCa has been limited;however,the recent establishment of several transgenicmouse lines and/or xenografting models is better reflecting the disease in vivo.With appropriate models,valuable tools for elucidating the functions of specific genes have gone deep into prostate development and carcinogenesis.In the present review,we summarize a number of important PCa research models established in our laboratories(PSA-Cre-ERT2/PTEN transgenic mouse models,AP-OX model,tissue recombination-xenografting models and PDX models),which represent advances of translational models from transgenic mouse lines to human tumor xenografting.Better understanding of the developments of these models will offer new insights into tumor progression and may help explain the functional significance of genetic variations in PCa.Additionally,this understanding could lead to new modes for curing PCa based on their particular biological phenotypes. | Yuejiao Huang Chun Cheng Chong Zhang Yonghui Zhang Miaomiao Chen Douglas W.Strand Ming Jiang | 2016 | Asian Journal of Urology2016，3，2： | 3 |
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