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| 1 | Brain-wide Mapping of Mono-synaptic Afferents to Different Cell Types in the Laterodorsal Tegmentum显示文摘The laterodorsal tegmentum(LDT) is a brain structure involved in distinct behaviors including arousal,reward, and innate fear. How environmental stimuli and top-down control from high-order sensory and limbic cortical areas converge and coordinate in this region to modulate diverse behavioral outputs remains unclear.Using a modified rabies virus, we applied monosynaptic retrograde tracing to the whole brain to examine the LDT cell type specific upstream nuclei. The LDT received very strong midbrain and hindbrain afferents and moderate cortical and hypothalamic innervation but weak connections to the thalamus. The main projection neurons from cortical areas were restricted to the limbic lobe, including the ventral orbital cortex(VO), prelimbic, and cingulate cortices. Although different cell populations received qualitatively similar inputs, primarily via afferents from the periaqueductal gray area, superior colliculus, and the LDT itself, parvalbumin-positive(PV?) GABAergic cells received preferential projections from local LDT neurons.With regard to the different subtypes of GABAergic cells, aconsiderable number of nuclei, including those of the ventral tegmental area, central amygdaloid nucleus, and VO, made significantly greater inputs to somatostatinpositive cells than to PV?cells. Diverse inputs to the LDT on a system-wide level were revealed. | Xiaomeng Wang Hongbin Yang Libiao Pan Sijia Hao Xiaotong Wu Li Zhan Yijun Liu Fan Meng Huifang Lou Ying Shen Shumin Duan Hao Wang | 2019 | Neuroscience Bulletin2019，35，5： | 3 |
| 2 | Accelerated plasma degradation of organic pollutants in milliseconds and examinations by mass spectrometry显示文摘The rapid degradation of organic pollutants,process monitoring and online controlling to obtain advanced products and decreased by-products are great and challenging tasks in environmental treatments.Herein,an accelerated plasma degradation in milliseconds was achieved by combining electrospray-based acceleration and plasma-based degradation.Taking the degradation of chloroaniline as an example,97%of the degradation can be achieved in milliseconds.The velocity distribution of droplets was determined to be 40-50 m/s after being degraded for 0.30 ms,which exhibited different degradation behaviors in different milliseconds.Simultaneously,by virtue of the real-time and on-line detection ability of ambient mass spectrometry,intermediates,by-products and advanced products were monitored.Therefore,degradation mechanisms for different degradation times were proposed,which would provide theoretical guidance on obtaining efficient and green degradation.The fabrication,examining and understanding of accelerated plasma degradation not only enlarged application of accelerated reactions,but also promoted green and efficient degradation for environmental treatments. | Hua Lu Yiyan Yin Jianghui Sun Weixiang Li Xiaotong Shen Xiujuan Feng Jin Ouyang Na Na | 2021 | Chinese Chemical Letters2021，32，11： | 2 |
| 3 | Ammonia-induced oxidative stress triggered proinflammatory response and apoptosis in pig lungs显示文摘Ammonia,a common toxic gas,is not only one of the main causes of haze,but also can enter respiratory tract and directly affect the health of humans and animals.Pig was used as an animal model for exploring the molecular mechanism and dose effect of ammonia toxicity to lung.In this study,the apoptosis of type II alveolar epithelial cells was observed in high ammonia exposure group using transmission electron microscopy.Gene and protein expression analysis using transcriptome sequencing and western blot showed that low ammonia exposure induced T-cell-involved proinflammatory response,but high ammonia exposure repressed the expression of DNA repair-related genes and affected ion transport.Moreover,high ammonia exposure significantly increased 8-hydroxy-2-deoxyguanosine (8-OHdG) level,meaning DNA oxidative damage occurred.In addition,both low and high ammonia exposure caused oxidative stress in pig lungs.Integrated analysis of transcriptome and metabolome revealed that the up-regulation of LDHB and ND2 took part in high ammonia exposure-affected pyruvate metabolism and oxidative phosphorylation progress,respectively.Inclusion,oxidative stress mediated ammonia-induced proinflammatory response and apoptosis of porcine lungs.These findings may provide new insights for understanding the ammonia toxicity to workers in livestock farms and chemical fertilizer plants. | Daojie Li Long Shen Di Zhang Xiaotong Wang Qiankun Wang Wenhao Qin Yun Gao Xiaoping Li | 2023 | Journal of Environmental Sciences2023，，4： | 2 |
| 4 | Proportional odds regression and sieve maximum likelihood estimation显示文摘 | Shen Xiaotong | 1998 | Biometrika1998，85，： | 1 |
| 5 | Synergies of carbon neutrality, air pollution control, and health improvement - a case study of China Energy Interconnection scenario显示文摘Climate change and air pollution are primarily caused by the combustion and utilization of fossil fuels.Both climate change and air pollution cause health problems.Based on the development of China,it is extremely important to explore the synergies of the energy transition,CO_(2) reduction,air pollution control,and health improvement under the target of carbon peaking before 2030 and carbon neutrality before 2060.This study introduces the policy evolution and research progress related to energy,climate change,and the environment in China and proposes a complete energy-climate-air-health mechanism framework.Based on the MESSAGE-GLOBIOM integrated assessment model,emission inventory and chemical transport model,and exposure-response function,a comprehensive assessment method of energy-climate-air-health synergies was established and applied to quantify the impacts of Chinese Energy Interconnection Carbon Neutrality(CEICN)scenario.The results demonstrate that,by 2060,the SO_(2),NO_(x) and PM_(2.5) emissions are estimated to be reduced by 91%,85%,and 90%respectively compared to the business-as-usual(BAU)scenario.The direct health impacts brought by achieving the goal of carbon neutrality will drive the proactive implementation of more emission reduction measures and bring greater benefits to human health. | Jianxiang Shen Wenjia Cai Xiaotong Chen Xing Chen Zijian Zhao Zhiyuan Ma Fang Yang Shaohui Zhang | 2022 | Global Energy Interconnection2022，5，5： | 1 |
| 6 | An improved fast marching method and its application in Alzheimer's disease显示文摘 | Zhao Xiaojie Wen Xiaotong Shen Jiahui | 2013 | In- ternational Journal of Imaging Systems and Technology2013，23，4： | 1 |
| 7 | Cluster analysis: Unsupervised learning via supervised learning with a non- convex penalty 显示文摘 | Pan Weip Shen Xiaotong Liu Binghui | 2013 | Journal of Machine Learning Research2013，14，4： | 1 |
| 8 | Proportional odds regression and sieve maximum likelihood estimation 显示文摘 | Shen Xiaotong | 1998 | Biometrika1998，85，： | 1 |
| 9 | Proportional odds regression and sieve maximum likelihood estimation显示文摘 | Shen Xiaotong | 1998 | Bimetrika1998，85，： | 1 |
| 10 | Multi-category support vector machines, feature selection, and solution path显示文摘 | Wang Lifeng Shen Xiaotong | 2006 | Statistica Sini- ca2006，16，： | 1 |
| 11 | Penalized Model--based Clustering with Cluster--specific Diagonal Covariance Matrices and Grouped Variables显示文摘 | Xie Benhuai Pan Wei Shen Xiaotong | 2008 | Electronic Journal of Statistics2008，，2： | 1 |
| 12 | Expression of peanut Iron Regulated Transporter 1 in tobacco and rice plants confers improved iron nutrition显示文摘 | Hongchun Xiong Xiaotong Guo Takanori Kobayashi Yusuke Kakei Hiromi Nakanishi Tomoko Nozoye Lixia Zhang Hongyun Shen Wei Qiu Naoko K. Nishizawa Yuanmei Zuo | 2014 | Plant Physiology and Biochemistry2014，，： | 1 |
| 13 | Sieve extremum estimates for weakly dependent data 显示文摘 | Xiaohong Chen Xiaotong Shen | 1998 | Econo- metrica1998，66，2： | 1 |
| 14 | The genetic program Of oocytes can be modified in vivo in the zebrafish ovary显示文摘Oocytes,the irreplaceable gametes for generating a new organism,are matured in the ovary of living female animals.It is unknown whether any genetic manipulations can be applied to immature oocytes inside the living ovaries.As a proof-of-concept, we here demonstrate genetic amendments of zebrafish immature oocytes within the ovary.Oocyte microinjection in situ (OMIS) stimulates tissue repair responses,but some of the microinjected immature oocytes are matured,ovulated and fertilizable.By OMIS-mediated Cas9 approach,ntla and gata5 loci of oocytes arrested at prophase I of meiosis are successfully edited before fertilization.Through OMIS,high efficiency of biaUeUc mutations in single or multiple loci using Cas9/gRNAs allows immediate manifestation of mutant phenotypes in Fo embryos and multiple transgenes can co-express the reporters in Fo embryos with patterns similar to germline transgenic embryos.Furthermore,maternal knockdown of dnmt1 by antisense morphoino via OMIS results in a dramatic decrease of global DNA methylation level at the dome stage and causes embryonic lethalityprior to segmentation period.Therefore,OMIS opens a door to efficiently modify the genome and provides a possibility to re repair genetically abnormal oocytes in situ. | Xiaotong Wu Weimin Shen Bingjie Zhang Anming Meng | 2018 | Journal of Molecular Cell Biology2018，10，6： | 0 |
| 15 | BGB-A445,a novel non-ligand-blocking agonistic anti-OX40 antibody,exhibits superior immune activation and antitumor effects in preclinical models显示文摘t OX40 is a costimulatory receptor that is expressed primarily on activated CD4+,CD8+,and regulatory T cells.The ligation of OX40 to its sole ligand OX40L potentiates T cell expansion,differentiation,and activation and also promotes dendritic cells to mature to enhance their cytokine production.Therefore,the use of agonistic anti-Ox40 antibodies for cancer immunotherapy has gained great interest.However,most of the agonistic anti-OX40 antibodies in the clinic are OX40L-competitive and show limited efficacy.Here,we discovered that BGB-A445,a non-ligand-competitive agonistic anti-OX40 antibody currently under clinical investigation,induced optimal T cell activation without impairing dendritic cell function.In addition,BGB-A445 dose-dependently and significantly depleted regulatory T cells in vitro and in vivo via antibody-dependent cellular cytotoxicity.In the MC38 syngeneic model established in humanized OX40 knock-in mice,BGB-A445 demonstrated robust and dose-dependent antitumor efficacy,whereas the ligand-competitive anti-Ox40 antibody showed antitumor efficacy characterized by a hook effect.Furthermore,BGB-A445 demonstrated a strong combination antitumor effect with an anti-PD-1 antibody.Taken together,our findings show that BGB-A445,which does not block OX40-OX40L interaction in contrast to clinical-stage anti-OX40 antibodies,shows superior immune-stimulating effects and antitumor efficacy and thus warrants further clinical investigation. | Beibei Jiang Tong Zhang Minjuan Deng Wei Jin Yuan Hong Xiaotong Chen Xin Chen Jing Wang Hongjia Hou Yajuan Gao Wenfeng Gong Xing Wang Haiying Li Xiaosui Zhou Yingcai Feng Bo Zhang Bin Jiang Xueping Lu Lijie Zhang Yang Li Weiwei Song Hanzi Sun Zuobai Wang Xiaomin Song Zhirong Shen Xuesong Liu Kang Li Lai Wangl Ye Liu | 2023 | Frontiers of Medicine2023，17，6： | 0 |
| 16 | Self-Assembly Protein Superstructures as a Powerful Chemodynamic Therapy Nanoagent for Glioblastoma Treatment显示文摘Glioblastoma(GBM) remains a formidable challenge in oncology.Chemodynamic therapy(CDT) that triggers tumor cell death by reactive oxygen species(ROS) could open up a new door for GBM treatment.Herein,we report a novel CDT nanoagent.Hemoglobin(Hb)and glucose oxidase(GOx) were employed as powerful CDT catalysts.Instead of encapsulating the proteins in drug delivery nanocarriers,we formulate multimeric superstructures as self-delivery entities by crosslinking techniques.Red blood cell(RBC) membranes are camouflaged on the protein superstructures to promote the delivery across blood-brain barrier.The as-prepared RBC@Hb@GOx nanoparticles(NPs) offer superior biocompatibility,simplified structure,and high accumulation at the tumor site.We successfully demonstrated that the NPs could efficiently produce toxic ROS to kill U87 MG cancer cells in vitro and inhibit the growth of GBM tumor in vivo,suggesting that the new CDT nanoagent holds great promise for treating GBM. | Tao Zheng Wentao Wang Jon Ashley Ming Zhang Xiaotong Feng Jian Shen Yi Sun | 2020 | Nano-Micro Letters2020，12，11： | 0 |
| 17 | The response and anti-stress mechanisms of nitrifying sludge under long-term exposure to Cd Se quantum dots显示文摘The wide application of CdSe quantum dots(QDs)increases its stress risk to sewage treatment systems.This study evaluated the response of nitrification performance,floc characteristics and microbial community of nitrifying sludge under long-term exposure to CdSe QDs.Results showed CdSe QDs(≥1 mg/L)would decrease the activity of ammonia monooxygenase(AMO).Under the stress of 30 mg/L CdSe QDs,the activity of AMO was reduced by 66%,while the activities of hydroxylamine oxidase and nitrite oxidoreductase were enhanced by 19.1%and 26%,respectively.Thus,the final nitrification effects were not adversely affected,and the production rates of NO_(2)^(-)-N and NO_(3)^(-)-N were accelerated.Additionally,CdSe QDs improved biomass concentration in sludge and maintained the stability of sludge settleability.High throughput sequencing analysis showed that CdSe QDs evidently reduced the abundance and diversity of microbial community in nitrifying sludge.The abundances of amino acid metabolism and lipid metabolism were enriched.Moreover,CdSe QDs decreased the fluorescence intensity of tryptophan-like protein from 2,326 to 1,179 a.u.in loosely bound extracellular polymeric substances(EPSs)and from 3,792 to 3,117 a.u.in tightly bound EPSs.To relieve CdSe QD stress,the polysaccharide content increased from0.31 to 0.61 mg/g MLSS and intracellular antioxidant defense was activated.With CdSe QD level increasing to 30 mg/L,the total antioxygenic capacity and the activities of catalase were enhanced up to 411%and 143.2%,respectively.Thereby,CdSe QDs had little adverse effects on cell membrane integrity,microbial metabolism and the abundance of Nitrospirae. | Linkai Guo Lei Yang Yongxiang Ren Shen Cui Xiaotong Li Jia Wang Jun Lan Haoqi Lu Yuchao Wang | 2024 | Journal of Environmental Sciences2024，，1： | 0 |
| 18 | Evaluation of global ocean tide models based on tidal gravity observations in China显示文摘Previous studies show that the calculated loading effects from global ocean tide models do not match actual measurements of gravity attraction and loading effects in Southeast Asia.In this paper,taking advantage of a unique network of gravity tidal stations all over the Chinese mainland,we compare the observed and modeled tidal loading effects on the basis of the most recent global ocean tide models.The results show that the average efficiencies of the ocean tidal loading correction for O_(1),K_(1),M_(2) are 77%,7 s3%and 59%,respectively.The loading correction efficiencies using recent ocean tidal models are better than the 40 years old Schwiderskis model at coastal stations,but relative worse at stations far from ocean. | Hongbo Tan Olivier Francis Guiju Wu Guangliang Yang Jiapei Wang Xiaotong Zhang Jinshui Huang Chongyang Shen | 2021 | Geodesy and Geodynamics2021，12，6： | 0 |
| 19 | A Review on Nanomaterial-based Strategies for Manipulating Tumor Microenvironment to Enhance Chemodynamic Therapy显示文摘Cancer is a leading cause of death worldwide,and a series of strategies has been reported for tumor-specific therapy.Currently,chemodynamic therapy(CDT)has become a research hotspot for antitumor treatment due to its advantages of high specificity,endogenous stimulation,and high biosafety.However,the therapeutic effects of CDT are normally limited in the complex tumor microenvironment(TME),such as insufficient acidity,tumor hypoxia,low hydrogen peroxide(H2O2),and high glutathione(GSH).Consequently,different kinds of multifunctional nanomaterials have been designed to manipulate TME conditions,which provided more opportunities to improve the efficiency of CDT.This review focuses on nanomaterial-based strategies for enhancing CDT through manipulating TME.Upon CDT enhancements,this review would provide a reference for the future development of efficient CDT nanomaterials. | CAO Mengyu XING Xiner SHEN Xiaotong OUYANG Jin NA Na | 2024 | Chemical Research in Chinese Universities2024，40，2： | 0 |
| 20 | Sieve likelihood ratio inference on general parameter space显示文摘In this paper,a theory on sieve likelihood ratio inference on general parameter spaces(including infinite dimensional) is studied.Under fairly general regularity conditions,the sieve log-likelihood ratio statistic is proved to be asymptotically x2 distributed,which can be viewed as a generalization of the well-known Wilks' theorem.As an example,a emiparametric partial linear model is investigated. | SHI Jian SHEN Xiaotong | 2005 | Science China Mathematics2005，48，1： | 0 |
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