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| 1 | Precise orbit determination of Beidou Satellites with precise positioning显示文摘Chinese Beidou satellite navigation system constellation currently consists of eight Beidou satellites and can provide preliminary service of navigation and positioning in the Asia-Pacific Region.Based on the self-developed software Position And Navigation Data Analysis(PANDA) and Beidou Experimental Tracking Stations (BETS),which are built by Wuhan University,the study of Beidou precise orbit determination,static precise point positioning (PPP),and high precision relative positioning,and differential positioning are carried out comprehensively.Results show that the radial precision of the Beidou satellite orbit determination is better than 10 centimeters.The RMS of static PPP can reach several centimeters to even millimeters for baseline relative positioning.The precision of kinematic pseudo-range differential positioning and RTK mode positioning are 2-4 m and 5-10 cm respectively,which are close to the level of GPS precise positioning.Research in this paper verifies that,with support of ground reference station network,Beidou satellite navigation system can provide precise positioning from several decimeters to meters in the wide area and several centimeters in the regional area.These promising results would be helpful for the implementation and applications of Beidou satellite navigation system. | SHI Chuang ZHAO QiLe LI Min TANG WeiMing HU ZhiGang LOU YiDong ZHANG HongPing NIU XiaoJi LIU JingNan | 2012 | Science China Earth Sciences2012，55，7： | 61 |
| 2 | Paleomagnetic results of Late Paleozoic rocks from northern Qiangtang Block in Qinghai-Tibet Plateau, China显示文摘Tectonic evolution of the Tethys and the boundary between the Gondwanaland and the Eurasia during the Carboniferous and Permian remain hotly debated. Qiangtang region in the Qinghai-Tibet Plateau may be a key place to study these problems. A paleomagnetic study was conducted on the Late Paleozoic rocks in the northern Qiangtang region (33.7°N, 86.7°W), Tibet. Two sites (21 samples) in the Upper Carboniferous, eleven sites (101 samples) in the Permian, and two sites (16 samples) in the Lower Triassic were investigated. The rock magnetic data revealed hematite and magnetite as the main magnetic carriers. In stepwise thermal demagnetization and/or combined alternating field (AC) demagnetization, two characteristic components in the majority of the samples were identified as (1) the Low-temperature Component (LTC), characterized by northerly decli- nation and moderate to steep inclination, corresponding to a pole position overlay with the present North Pole. A minority of the samples present single component, and their directions are the same as (2) the High-temperature Component (HTC) of double components. The combined single-component and HTC data of the Permian can pass the R-test at 95% level and the F-test at 99% level, as well as the BC-test. The pole position from the Late Carboniferous is at 31.8°S, 45.7°E with dp=2.1, dm=3.9, that from the Early and Middle (Late) Permian is at 31.7°S, 46.8°E with dp=9.2, dm=16.9 (34.4°N, 54.1°E with dp=6.9, dm=12.5) respectively, and that from the Early Triassic is at 16.9°S, 22.5°E with dp=4.9, dm=9.2. These pole positions are different from the other poles for the Qiangtang Block, which suggests the single-component and HTC directions are probably a primary magnetization and the northern Qiangtang Block was paleogeographically situated at low latitudes in the Northern Hemisphere in the Late Paleozoic. | CHENG Xin WU HanNing GUO Qiang HOU BaoNing XIA LingYan WANG HaiJun DIAO ZongBao HUO FeiFei JI WenHua LI RongShe CHEN ShouJian ZHAO ZhenMing LIU XiaoJi | 2012 | Science China Earth Sciences2012，55，1： | 9 |
| 3 | Coagulation factors VII, IX and X are effective antibacterial proteins against drug-resistant Gram-negative bacteria显示文摘Infections caused by drug-resistant“superbugs”pose an urgent public health threat due to the lack of effective drugs;however, certain mammalian proteins with intrinsic antibacterial activity might be underappreciated. Here, we reveal an antibacterial property against Gram-negative bacteria for factors VII, IX and X, three proteins with well-established roles in initiation of the coagulation cascade. These factors exert antibacterial function via their light chains (LCs). Unlike many antibacterial agents that target cell metabolism or the cytoplasmic membrane, the LCs act by hydrolyzing the major components of bacterial outer membrane, lipopolysaccharides, which are crucial for the survival of Gram-negative bacteria. The LC of factor VII exhibits in vitro efficacy towards all Gram-negative bacteria tested, including extensively drug-resistant (XDR) pathogens, at nanomolar concentrations. It is also highly effective in combating XDR Pseudomonas aeruginosa and Acinetobacter baumannii infections in vivo. Through decoding a unique mechanism whereby factors VII, IX and X behave as antimicrobial proteins, this study advances our understanding of the coagulation system in host defense, and suggests that these factors may participate in the pathogenesis of coagulation disorder-related diseases such as sepsis via their dual functions in blood coagulation and resistance to infection. Furthermore, this study may offer new strategies for combating Gram-negative “superbugs”. | Jinwu Chen Xiaojie Li Ling Li Ting Zhang Qing Zhang Fangming Wu Diyue Wang Hongze Hu Changlin Tian Dongsheng Liao Liang Zhao Danxia Song Yongyun Zhao Chuanfang Wu Xu Song | 2019 | Cell Research2019，29，9： | 6 |
| 4 | Understanding the lifestyles and pathogenicity mechanisms of obligate biotrophic fungi in wheat:The emerging genomics era显示文摘Obligate biotrophic fungi cause serious and widespread diseases of crop plants, but are challenging to investigate because they cannot be cultured in vitro. The two economically important groups of biotrophic fungi parasitizing wheat are the rust and powdery mildew pathogens, but their obligate biotrophic lifestyles and pathogenicity mechanisms are not well understood at the molecular level. With the advent of next generation sequencing technology, increasing numbers of pathogen genomes are becoming available. Research in plant pathology has entered a new genomics era. This review summarizes recent progress in understanding the biology and pathogenesis of biotrophic fungal pathogens attacking wheat based on pathogen genomics. We particularly focus on the three wheat rust and the powdery mildew fungi in regard to genome sequencing, avirulence gene cloning, effector discovery, and pathogenomics. We predict that coordinated study of both wheat and its pathogens should reveal new insights in biotrophic adaptation, pathogenicity mechanisms,and population dynamics of these fungi that will assist in development of new strategies for breeding wheat varieties with durable resistance. | Chunlei Tang Qiang Xu Mengxin Zhao Xiaojie Wang Zhensheng Kang | 2018 | The Crop Journal2018，6，1： | 6 |
| 5 | Defective Kernel 39 encodes a PPR protein required for seed development in maize显示文摘RNA editing is a posttranscriptional process that is important in mitochondria and plastids of higher plants. All RNA editing-specific trans-factors reported so far belong to PLS-class of pentatricopeptide repeat(PPR)proteins. Here, we report the map-based cloning and molecular characterization of a defective kernel mutant dek39 in maize. Loss of Dek39 function leads to delayed embryogenesis and endosperm development, reduced kernel size, and seedling lethality. Dek39 encodes an E subclass PPR protein that targets to both mitochondria and chloroplasts, and is involved in RNA editing in mitochondrial NADH dehydrogenase3(nad3) at nad3-247 and nad3-275. C-to-U editing of nad3-275 is not conserved and even lost in Arabidopsis, consistent with the idea that no close DEK39 homologs are present in Arabidopsis. However, the amino acids generated by editing nad3-247 and nad3-275 are highly conserved in many other plant species, and the reductions of editing at these two sites decrease the activity of mitochondria NADH dehydrogenase complex I,indicating that the alteration of amino acid sequence is necessary for Nad3 function. Our results indicate that Dek39 encodes an E sub-class PPR protein that is involved in RNA editing of multiple sites and is necessary for seed development of maize. | Xiaojie Li Wei Gu Silong Sun Zongliang Chen Jing Chen Weibin Song Haiming Zhao Jinsheng Lai | 2018 | Journal of Integrative Plant Biology2018，60，1： | 6 |
| 6 | Tuning the selectivity of photoreduction of CO2 to syngas over Pd/layered double hydroxide nanosheets under visible light up to 600 nm显示文摘Photocatalytic reduction of CO2 with H2 O to syngas is an effective way for producing high value-added chemical feedstocks such as methanol and light olefins in industry.Nevertheless,the precise control of CO/H2 ratio from photocatalytic CO2 reduction reaction still poses a great challenge for the further application.Herein,we prepared a series of highly efficient heterostructure based on highly dispersed palladium supported on ultrathin Co Al-layered double hydroxide(LDH).In conjunction with a Ru-complex sensitizer,the molar ratios of CO/H2 can be tuned from 1:0.74 to 1:3 under visible-light irradiation(λ>400 nm).More interestingly,the syngas can be obtained under light irradiation atλ>600 nm.Structure characterization and density functional theory calculations revealed that the remarkable catalytic activity can be due to the supported palladium,which improved the charge transfer efficiency.Meanwhile,more H atoms were used to generate H2 on the supported palladium for further tunable CO/H2 ratio.This work demonstrates a new strategy for harnessing abundant solar-energy to produce syngas from a CO2 feedstock. | Xian Wang Zelin Wang Ya Bai Ling Tan Yanqi Xu Xiaojie Hao Jikang Wang Abdul Hanif Mahadi Yufei Zhao Lirong Zheng Yu-Fei Song | 2020 | Journal of Energy Chemistry2020，29，7： | 5 |
| 7 | Numerical study of resonance induced by wave action on multiple rectangular boxes with narrow gaps显示文摘By introducing a source term into the Laplace equation, a two-dimensional fully nonlinear time-domain numerical wave flume(NWF) is developed to investigate the resonance induced by the interaction between waves and multiple objects with narrow gaps. In the numerical model, the fully nonlinear kinematic and dynamic boundary conditions are satisfied on the instantaneous free surface and the constant artificial damping is employed in the gaps to approximate the viscous dissipation due to vortex motion and flow separation. The computational domain is discretized using a higher-order boundary element method(HOBEM). The proposed model is firstly validated against the published experimental data and numerical results of the wave height in the narrow gap between two boxes, the wave heights in the two gaps of three boxes, and wave loads on the boxes.Then, the extensive numerical experiments are performed to study the influences of the number of the boxes and the gap spacing on the resonant frequency, reflected and transmitted wave heights and wave loads on the boxes. | NING Dezhi SU Xiaojie ZHAO Ming TENG Bin | 2015 | Acta Oceanologica Sinica2015，34，5： | 5 |
| 8 | Multi-scale validation strategy for satellite albedo products and its uncertainty analysis显示文摘Coarse-resolution satellite albedo products are important for climate change and energy balance research because of their capability to characterize the spatiotemporal patterns of land surface parameters at both the regional and global scales. The accuracy of coarse-resolution products is usually assessed via comparison with in situ measurements. The key issue in the comparison of remote sensing observations with in situ measurements is scaling and uncertainty. This paper presents a strategy for validating 1-km-resolution remote sensing albedo products using field measurements and high-resolution remote sensing observations. Field measurements were collected to calibrate the high-resolution(30 m) albedo products derived from HJ-1a/b images. Then, the calibrated high-resolution albedo maps were resampled(i.e., upscaled) to assess the accuracy of the coarse-resolution albedo products. The samples of field measurements and high-resolution pixels are based on an uncertainty analysis. Two types of coarse-resolution albedo datasets, from global land surface satellite(GLASS) and moderate-resolution imaging spectroradiometer(MODIS), are validated over the middle reaches of the Heihe River in China. The results indicate that the upscaled HJ(Huan Jing means environment in Chinese and this refers to a satellite constellation designed for environment and disaster monitoring by China) albedo, which was calibrated using field measurements, can provide accurate reference values for validating coarse-resolution satellite albedo products. However, the uncertainties in the upscaled HJ albedo should be estimated, and pixels with large uncertainties should be excluded from the validation process. | PENG JingJing LIU Qiang WEN JianGuang LIU QinHuo TANG Yong WANG LiZhao DOU BaoCheng YOU DongQin SUN ChangKui ZHAO XiaoJie FENG YouBin SHI Jian | 2015 | Science China Earth Sciences2015，58，4： | 5 |
| 9 | Ultrathin MoS2 with expanded interlayers supported on hierarchical polypyrrole-derived amorphous N-doped carbon tubular structures for high-performance Li/Na-ion显示文摘 | Xiaojun Zhao Gang Wang Xiaojie Liu Xinliang Zheng Hui Wang | 2018 | Nano Research2018，11，7： | 4 |
| 10 | Addition Al and/or Ti Induced Modifi cations of Microstructures, Mechanical Properties, and Corrosion Properties in CoCrFeNi High-Entropy Alloy Coatings显示文摘The purpose of this work is to study the influences of Al and/or Ti addition on the microstructures, mechanical properties and corrosion properties of CoCrFeNi-(Al, Ti) high entropy alloy(HEA) coatings. Three coatings, AlCoCrFeNi(Ⅰ), CoCrFeNiTi_(0.5)(Ⅱ) and AlCoCrFeNiTi_(0.5)(Ⅲ), were fabricated by laser cladding successfully. The AlCoCrFeNi(Ⅰ) coating exhibited a simple body-centered cubic(BCC) solid-solution structure, whereas the CoCrFeNiTi_(0.5)(Ⅱ) alloy exhibited a face-centered cubic(FCC) solid-solution and a small amount of Laves phase. The BCC phases in AlCoCrFeNiTi _(0.5)(Ⅲ) coating were characterized as Fe–Cr rich disordered BCC phases(A2) and Al-Ni–Ti-rich ordered BCC phases(L2_1) separately. The AlCoCrFeNiTi_(0.5)(Ⅲ) coating with dual-phase BCC structure showed the optimal performance of both mechanical and corrosion properties, which was superior to BCC-based AlCoCrFeNi(Ⅰ) and FCC-based CoCrFeNiTi_(0.5)(Ⅱ) coatings. Nanoindentation tests and quantitative investigations on the strengthening mechanisms of AlCoCrFeNiTi_(0.5)(Ⅲ) coating were conducted, suggesting that the precipitation strengthening is the dominant strengthening mechanism. In short, the addition of moderate amount of Al and Ti in CoCrFeNi HEA shows potential for the development of a high strength and corrosion-resistant coating. | Guoliang Ma Yong Zhao Hongzhi Cui Xiaojie Song Mingliang Wang Kwangmin Lee Xiaohua Gao Qiang Song Canming Wang | 2021 | Acta Metallurgica Sinica(English Letters)2021，34，8： | 4 |
| 11 | Mitochondrial fusion/fission process involved in the improvement of catalpol on high glucose- induced hepatic mitochondrial dysfunction显示文摘Catalpol, iridoid glycoside,被显示了由 rescuing mitochondrial 功能,而是详细机制遗体施加血糖过低的效果不清楚还。在这研究,在糖尿病的条件下面的肝的线粒体上的 catalpol 的效果和机制进一步被检验。catalpol 的口头的管理显著地在高脂肪的导致食谱、导致 streptozotocin 的糖尿病的老鼠减少了血葡萄糖, triglyceride,和胆固醇层次。另外, catalpol 在源于糖尿病的肝 mitochondrial ATP 内容稀释了减少。而且,拥有一种长尺寸的线粒体的数字在对待 catalpol 的老鼠被增加。有趣地, mitochondrial 功能的导致 catalpol 的恢复与减少的分裂蛋白质 1 被联系并且 dynamin 相关的蛋白质象增加的 mitofusin 一样的 1 个表达式在肝的 1 个表达式。在 HepG2 房间, catalpol 减轻了 ATP 内容和 mitochondrial 膜潜力的减少,并且反应的氧种类形成的增加由高葡萄糖导致了。当房间与 catalpol 被对待时,线粒体的管状的特征被维持的米托特拉克·格林污点表演。Catalpol 也减少了分裂蛋白质 1 并且 dynamin 相关的蛋白质 1 表情和增加的 mitofusin 在 HepG2 房间的 1 表情。现在的结果建议 catalpol 能改善在一名糖尿病患者下面的肝的 mitochondrial 机能障碍状态,和这可能与它 mitochondrial 的规定有关熔化和分裂事件。 | Zhimeng Xu Luyong Zhang Xiaojie Li Zhenzhou Jiang Lixin Sun Guolin Zhao Guohua Zhou Heran Zhang Jing Shang Tao Wang | 2015 | Acta Biochimica et Biophysica Sinica2015，47，9： | 4 |
| 12 | Enhancement of the Photoelectric Performance of Dye-sensitized Solar Cells by Sol-gel Modified TiO_2 Films显示文摘Modified TiO2 films have been prepared by combining commercial titania powders (Degussa P25) with sol-gel made by titanium chloride (Ti-sol). The result shows that clusters are formed by nanoparticles and large pores can be seen on the surface of the TiO2 films. The short circuit photocurrent density and photoelectric conversion efficiency of the solar cells are obviously enhanced compared with those without modification. The relationship between the photoelectric conversion efficiency and the amount of Ti-sol was investigated. With the addition of 30 wt% Ti-sol, the photoelectric conversion efficiency as high as 9.75% is achieved, increasing by 28.3% compared with the solar cells without modification. | Yunfeng Zhao Xiaojie Li Qiuping Li Changsheng Deng | 2011 | Journal of Materials Science & Technology2011，27，8： | 4 |
| 13 | Nutrient Composition of Different Foxtail Millet Seeds显示文摘Ten millet cultivars from China and abroad were analyzed for their crude fat,amylose and amylopectin,crude protein and amino acid content. A wide variation was observed in amylopectin contain,ranging from 54. 47% to 69. 26%,while amylose content ranged from 11. 26% to 23. 22%. The average crude fat in all cultivates was 3. 46%,and most cultivates ranged from 3. 1% to 3. 7%. Protein contents ranged from 8. 61% to 15. 54% with a mean value of 11. 94%. For amino acid composition,the ten cultivates were particularly rich in leucine,and the mean was 34. 57 mg/g. The millet cultivars were also high in glycine,glutamic acid and cysteine. Millet was known to be limiting in the essential amino lysine,and the mean was 5. 18 mg/g. Other amino acids,tyrosine,histidine and arginine were also very low in the ten cultivars. In general,significant nutrient composition differences were observed between the different millet cultivars,and A2( a kind of mother line of the hybrid millet) and hybrid millet registered a higher level of protein and amino acid composition which would be useful in millet breeding. | Guangyu FAN Jincheng YUAN Lina ZHANG Xiaojie LIU Xiaoming WANG Feng WANG Xiaolei FENG Guoliang SONG Haiying ZHANG Qian WANG Zhihai ZHAO Yinghui LIU | 2018 | Agricultural Biotechnology2018，7，5： | 4 |
| 14 | An easily recoverable thermo-sensitive polyelectrolyte as draw agent for forward osmosis process显示文摘As a potential solution to the crises of energy and resources, forward osmosis(FO) has been limited by the development of draw agents. An ideal draw agent should be able to generate high osmotic pressure and can be easily recovered. In this study, a thermo-sensitive polyelectrolyte of poly(N-isopropylacrylamide-co-acrylic acid)(PNA)is developed as an efficient draw agent, and two easy and simple methods are proposed to effectively recover the polyelectrolytes. After adjusting the pH value of polyelectrolyte solutions to around 6.0, the polyelectrolyte can generate relatively high osmotic pressure, and induce average water fluxes of 2.09 and 2.95 L·m^(-2)·h^(-1) during12 h FO processes when the polyelectrolyte concentrations are 0.20 and 0.38 g·ml^(-1) respectively. After acidifying and heating to 70 °C, the PNA-10 polyelectrolyte can aggregate together because of hydrophobic association and separate from water, so it can be easily recovered by either simple centrifugation or gravitational sedimentation. The recovery ratios of PNA-10 polyelectrolyte in both methods are as high as 89%, and the recovered polyelectrolytes can be reused with almost the same FO performance as fresh ones. The results in this study provide valuable guidance for designing efficient and easily recoverable draw agents for FO processes. | Yanni Wang Hairong Yu Rui Xie Kuangmin Zhao Xiaojie Ju Wei Wang Zhuang Liu Liangyin Chu | 2016 | Chinese Journal of Chemical Engineering2016，24，1： | 4 |
| 15 | Functional Near-Infrared Spectroscopy Neurofeedback of Cortical Target Enhances Hippocampal Activation and Memory Performance显示文摘Dear Editor,Neuromodulation,a rapidly expanding field attracting wide attention over recent decades,facilitates human cognition,behavior,and pathology by modifying the activity of specific neural targets.Human brain functions can be modified by exogenous brain neuromodulation techniques that deliver physical energy(e.g.,electrical current or magnetic pulses)into the brain[1],such as deep brain stimulation,transcranial magnetic stimulation,and tran-scranial direct current stimulation. | Xin Hou Xiang Xiao Yilong Gong Yihan Jiang Peipei Sun Juan Li Zheng Li Xiaojie Zhao Li Yao Antao Chen Chaozhe Zhu | 2021 | Neuroscience Bulletin2021，37，8： | 3 |
| 16 | Anatomy of the perirectal fascia at the level of rectosacral fascia revisited显示文摘Background:The relative anatomical understanding of the perirectal fasciae is of paramount importance for the proper performance of total mesorectal excision(TME).This study was to demonstrate the planes of TME and validates the intraoperative findings using cadaveric observations.Methods:In this combined retrospective and prospective study,bilateral attachment of the rectosacral fascia(RSF)was observed in 28 cadaveric specimens(male,n=14;female,n=14).From January 2018 to December 2019,surgical videos of 67 patients who underwent laparoscopic TME at the Affiliated Union Hospital of Fujian Medical University(Fuzhou,China)were reviewed and interpreted with the cadaveric findings.Results:The RSF(synonym:Waldeyer’s fascia)is the end of the pre-hypogastric fascia at the level of S4 and comprises two layers(upper and lower).These two layers provide double fascial protection for the venous sacral plexus.It inserts into the fascia propria of the rectum along a broad horizontal arc that merges anterolaterally in an oblique downward direction until it meets the posterolateral merge of Denonvilliers’fascia at the lateral rectal ligament(LRL).This ligament does not look like a true ligament but is more likely to be a fascial combination that cushions the rectal innervation and middle rectal vessels.Conclusions:Understanding the lateral attachment of RSF and its contribution to LRL provides invaluable surgical guidance to dissect this critical area.Therefore,lateral dissection is proposed from the anterior to the posterior direction to find the correct plane that guarantees an intact mesorectal envelope to protect the important nearby nerve structures. | Waleed M.Ghareeb Xiaojie Wang Pan Chi Zhifang Zheng Xiaozhen Zhao | 2022 | Gastroenterology Report2022，10，1： | 3 |
| 17 | Quantitative Analysis of Relationships Between Crack Characteristics and Properties of Soda-saline Soils in Songnen Plain, China显示文摘The Songnen Plain has a typical soda-saline soil, which often shrinks and cracks under natural conditions during water evaporation. This study aims to analyze the relationships between the crack characteristics and the soil properties of soda-saline soils quantitatively, and attempts to establish prediction models for the main soil properties of soda-saline soils based on the results. In order to achieve these objectives, a desiccation cracking test was conducted using 17 soil specimens with different salinity levels under controlled laboratory conditions. Correlation analysis was then performed between the crack characteristics and the soil properties. The results indicate that the crack characteristics can well represent the surface appearances of cracked soils, they also can well distinguish the salinity levels of soda-saline soils while the clay contents and mineralogical compositions of soils are stable. Among the crack characteristics, crack length has the best relationships with the salinity levels of soda-saline soils. Specifically, the crack length has high correlation(R2 > 0.87) with the electrical conductivity(EC), Na+, CO32– and the salinity, it also has reasonable relationship(R2 > 0.68) with HCO3–, this indicates crack length can be well used for the prediction of these properties of soda-saline soils. | REN Jianhua LI Xiaojie ZHAO Kai | 2015 | Chinese Geographical Science2015，25，5： | 3 |
| 18 | The BAH domain of BAHD1 is a histone H3K27me3 reader显示文摘 | Dan Zhao (1) (2) Xiaojie Zhang (2) Haipeng Guan (2) Xiaozhe Xiong (2) Xiaomeng Shi (3) Haiteng Deng (3) Haitao Li (2) (4) | 2016 | Protein & Cell2016，7，3： | 2 |
| 19 | Numerical investigation of solitary wave action on tworectangular boxes with a narrow gap显示文摘Based on the time-domain higher-order boundary element method(HOBEM), a two-dimensional numerical wave flume is developed to investigate solitary wave interaction with two rectangular boxes with a narrow gap.In the numerical model, the fully nonlinear boundary conditions are satisfied on the free surface, the mixed Eulerian-Lagrangian method is adopted to track the transient water surface and the fourth-order Runga-Kutta method is used to predict the velocity potential and wave elevation on the free surface. The acceleration potential technique is used to compute the transient wave forces along the wetted object surface. A piston-type wavemaker is used to generate solitary waves. The proposed model is validated by comparing the simulated wave run-up and the wave loads with the published experimental and numerical results of the reflection of a solitary wave from a vertical wall. Then, numerical experiments are performed to study the effects of the narrow gap and the size of each box on the wave run-ups at the two sides of the two-box system and in the narrow gap between two boxes, and the wave loads on the two boxes. The interaction between double solitary waves with a time interval between them with a two-box system is also investigated. | NING Dezhi SU Xiaojie ZHAO Ming | 2016 | Acta Oceanologica Sinica2016，35，12： | 2 |
| 20 | Association of human leukocyte antigen-DR-DQ-DP haplotypes with the risk of hepatitis B virus-related hepatocellular carcinoma显示文摘Aim:Genetic polymorphisms of human leukocyte antigen(HLA)class II molecules are associated with chronic hepatitis B virus(HBV)infection.We aimed to investigate the impacts of HLA-II haplotypes on viral evolution and the risks of HBV-caused liver diseases.Methods:HLA-DR-DQ-DP haplotypes were estimated in 1210 healthy controls,296 HBV clearance subjects,301 asymptomatic hepatitis B surface antigen carriers,770 chronic hepatitis B patients,443 HBV-related liver cirrhosis(LC)patients,and 1037 HBV-related hepatocellular carcinoma(HCC)patients.HBV mutations were determined by sequencing.The associations of HLA-DR-DQ-DP haplotypes with viral mutations and the risks of liver diseases were assessed by multivariate logistic regression.Results:Compared to HBV-free subjects,the haplotypes CCAACG,CCGACG,TCAATA,and TCGATA were associated with decreased HCC risk,with an odds ratio(OR)[95%confidence interval(CI)]of 0.62(0.40-0.95),0.60(0.39-0.92),0.73(0.54-0.98),and 0.58(0.42-0.78),respectively.CCAACG,CCGACG,and TCAATA were significantly associated with decreased frequencies of the HCC-risk HBV mutations:preS1 deletion,APOBECsignature HBV mutations in the core promoter and preS regions,A51C/T,G104C/T,and G146C/T.TCGATA and TTAACG were associated with increased LC risk,with an OR(95%CI)of 1.54(1.03-2.30)and 2.23(1.50-3.33),respectively.However,TCGATA and TTAACG were not consistently associated with the cirrhosis-risk HBV mutations.Conclusion:CCAACG,CCGACG,and TCAATA are inversely associated with HCC risk,possibly because they are involved in creating an immune microenvironment attenuating the generation of HCC-risk HBV mutations.TCGATA and TTAACG might predispose the polarity of immunity towards Th17 isotype related to LC. | Yifan Chen Jiansheng Lin Yang Deng Wenbin Liu Zishuai Li Xinyu Zhou Shiliang Cai Rui Pu Jianhua Yin Xiaojie Tan Jun Zhao Xue Han Guangwen Cao | 2022 | Hepatoma Research2022，8，1： | 2 |
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