|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Genetically engineered K cells provide sufficient insulin to correct hyperglycemia in a nude murine model显示文摘基因类型 1 糖尿病 mellitus 的基于治疗的处理要求能综合并且响应生理的联盟者分泌机能上地活跃的胰岛素的一个代理人贝它房间的发展在周围的葡萄糖层次的相关变化。在这研究,鼠科的 enteroendocrine 房间线 STC-1 被稳定的转染遗传上修改。二个克隆房间被选择(STC-1-2 和 STC-1-14 ) 那在从 0 ~ 157.2 亩 IU/ml/10 (6 ) cells/d 表示胰岛素的 22 克隆之中分泌了胰岛素的高水平。在在文化媒介的葡萄糖集中从 1 公里被增加到 10 公里以后,分泌胰岛素从 40.3 +/- 升起了 0.8 ~ 56.3 +/- 3.2 亩 IU/ml (STC-1-2 ) ,并且从 10.8 +/- 0.8 ~ 23.6 +/- 2.3 亩 IU/ml (STC-1-14 ) 。在 STC-1-14 房间被植入进糖尿病的裸体老鼠以后,他们的血葡萄糖层次被归结为正常。身体重量损失也被改善。我们的数据建议遗传上设计的 K 房间以一种调整葡萄糖的方式分泌活跃胰岛素,并且在 vivo,学习证明多糖症能被房间的培植颠倒,建议到快速的人的胰岛素力量的遗传上设计的 K 房间的使用提供一条调整葡萄糖的途径对待糖尿病的多糖症。 | Yiqun Zhang Liqing Yao Kuntang Shen Meidong Xu Pinghong Zhou Weige Yang Xinyuan Liu Xinyu Qin | 2008 | Acta Biochimica et Biophysica Sinica2008，40，2： | 4 |
| 2 | Ultra-flat broadband micro wave frequency comb generation based on optical frequency comb with a multiple-quantumwell electro-absorption modulator in critical state显示文摘In this paper,we proposed a novel ultra・flat broadband microwave frequency comb(MFC)generation based on optical frequency comb(OFC)with a multiplequantum-well electroabsorption modulator(MQW-EAM)in critical state.The scheme is simple and easy to adjust.The performance of the MFC generation scheme is investigated using software Optisystem.The results show that the comb spacing of MFC can be adjusted from 5 to 20 GHz by changing RF signafs frequency and the MFC is almost independent on the linewidth of the tunable laser diode.The performance of the MFC can be improved by reasonably increasing the voltage of the RF,the smallsignal gain of the Erbium-doped fiber amplifier(EDFA)and the responsivity of the photodetector.The MFC generated by this scheme has 300 GHz effective bandwidth with 15 comb lines,whose power variation is 0.02 dB,when the components9 parameters in the Optisystem are set as follows:the power of tunable laser diode(TLD)is 0 dBm,the wavelength is 1552.52 nm,and linewidth is 1 MHz;RF signaPs frequency is 20 GHz and the voltage is 10 V;the reverse bias voltage of MQW-EAM is 6.92 V;the small-signal gain of the EDFA is 40 dB;the responsivity of the photodetector(PD)is 1 A/W. | Cong SHEN Peili LI Xinyuan ZHU Yuanfang ZHANG Yaqiao HAN | 2019 | Frontiers of Optoelectronics2019，12，4： | 3 |
| 3 | Long-term variations of X-ray pulse profiles for the Crab pulsar:data analysis and modeling显示文摘The pulse profiles of the Crab pulsar(as well as some other pulsars)vary with time.They can lead to a major source of intrinsic timing noise,which lacks a detailed physical model.The phase separation?between the first left peak(P1)and the second right peak(P2)is a key parameter that shows the variations of pulse profiles for the Crab pulsar.It was found that the evolution of?has a tendency with increasing rates of 0.82?±0.25?,0.80?±0.54?,and 0.77?±0.28?per century for the 2-6,6-15,and15-60 ke V bands,respectively.Furthermore,the flux ratios(P2/P1)of X-ray pulse profiles in the three bands were calculated,and the derived flux ratios were consistent with the radio and X-ray measurements of the Insight-HXMT.In addition to discovering the physical origin of the pulse changes,the high-SNR X-ray pulse profiles were simulated in the annular gap model,and two model parameters(e.g.,the maximum emission heights of the two peaks)were observed to slightly affect the variations of peak separation.We fitted the long-term variations of emission heights of the two peaks and discovered that the emission heights showed increasing tendencies with time.Variations of these emission heights induced a characteristic period derivative,and a complete formula for both the magnetic dipole radiation and wind-particle-induced variations of the moment of inertia was used for the pulsar’s spin-down to obtain the variation rate˙αof the magnetic inclination angle,which was-1.60?per century.Intrinsic timing noise is observed to be mainly induced by the variations of pulse profiles,which might correlate with a characteristic spin period derivative arising from the fluctuations of the emission regions.This work will lay a foundation for understanding the origin of intrinsic timing noise and making high-precision timing models in the future. | LunHua Shang YuanJie Du XiangQun Cui ShiJun Dang JiGuang Lu JunTao Bai QiJun Zhi YouLi Tuo LinLi Yan LiangWei Huang XinYuan Zhang XiaoMin Bei QingQing Lin GuoJun Qiao Hua Shen RiHong Zhu | 2020 | Science China(Physics,Mechanics & Astronomy)2020，63，10： | 2 |
| 4 | Imperfection sensitivity of mechanical properties in soft network materials with horseshoe microstructures显示文摘Developments of soft network materials with rationally distributed wavy microstructures have enabled many promising applications in bio-integrated electronic devices,due to their abilities to reproduce precisely nonlinear mechanical properties of human tissues/organs.In practical applications,the soft network materials usually serve as the encapsulation layer and/or substrate of bio-integrated electronic devices,where deterministic holes can be utilized to accommodate hard chips,thereby increasing the filling ratio of the device system.Therefore,it is essential to understand how the hole-type imperfection affects the stretchability of soft network materialswith various geometric constructions.Thiswork presents a systematic investigation of the imperfection sensitivity of mechanical properties in soft network materials consisting of horseshoe microstructures,through combined computational and experimental studies.A factor of imperfection insensitivity of stretchability is introduced to quantify the influence of hole imperfections,as compared to the case of perfect soft network materials.Such factor is shown to have different dependences on the arc angle and normalized width of horseshoe microstructures for triangular network materials.The soft triangular and Kagome network materials,especially with the arc angle in the range of(30?,60?),are found to be much more imperfection insensitive than corresponding traditional lattice materials with straight microstructures.Differently,the soft honeycomb network materials are not as imperfection insensitive as traditional honeycomb lattice materials. | Jianxing Liu Xinyuan Zhu Zhangming Shen Yihui Zhang | 2021 | Acta Mechanica Sinica2021，37，7： | 1 |
| 5 | Submicron ion-exchange fibers of polystyrene and styrene-butadiene-styrene copolymer blends显示文摘 | FENG Shuqin SHEN Xinyuan JI Yali | 2011 | Journal of Macromolecular Science Part B:Physics2011，50，： | 1 |
| 6 | Compatibility studies with blends based on hydroxypropylcellulose and polyacrylonitrile显示文摘 | Li Hui Shen Xinyuan Gong Guoli | 2008 | Carbohydrate Polymers2008，73，2： | 1 |
| 7 | Solubility of bacteria cellulose in zinc chloride aqueous solutions显示文摘 | Lu Xinkun Shen Xinyuan | 2011 | Carbohydrate Polymers2011，86，1： | 1 |
| 8 | Compatibility studies with blends based on hydroxypropylcellulose and polyacrylonitrile显示文摘 | Li Hui Shen Xinyuan Gong Guoli | 2008 | Carbohydrate Polymers2008，73，2： | 1 |
| 9 | Solubility of bacteria cellulose in zinc chloride aqueous solutions显示文摘 | Xinkun Lu Xinyuan Shen | 2011 | Carbohydrate Polymers2011，，1： | 1 |
| 10 | Solubility of bacteria cellulose in zinc chloride aqueous solutions显示文摘 | Xinkun Lu Xinyuan Shen | 2011 | Carbohydr Polym2011，86，1： | 1 |
| 11 | The influence of ultra-high molecular weight polyacrylonitrile on its rheological behavior in dimethylsuloxide显示文摘 | Shen Xinyuan Zhu Xinyuan Liu Yongjian | 2001 | Journal of Donghua University (Eng Ed)2001，18，3： | 1 |
| 12 | Surface modification of superfine tourmaline powder with titanate coupling agent显示文摘 | Ying Wang Jen-Taut Yeh Tongjian Yue Rongxing Yao Xinyuan Shen | 2006 | Colloid and Polymer Science2006，，12： | 1 |
| 13 | Fabrication and characterization of acid dyeable polyacrylonitrile blend fiber显示文摘 | Wang Yazhen Shen Xinyuan Du Shuping | 2007 | J Macromol Sci Part B2007，46，2： | 1 |
| 14 | Synthesis of acid dyeable acrylonitrile copolymer 显示文摘 | Wang Yazhen Shen Xinyuan Gao Yue | 2006 | J Macromol Sci Part A2006，43，11： | 1 |
| 15 | Synthesis of cellulose carbamate by supercritical CO2-assisted impregnation: Structure and rheological properties显示文摘 | Yin Cuiyu Shen Xinyuan | 2007 | European Polymer Journal2007，43，： | 1 |
| 16 | 显示文摘 | Bai Jianyun Yang Qing Shen Xinyuan | 2005 | Synthetic Tech and Appl2005，20，： | 1 |
| 17 | Tumor Microenvironment-Adaptive Nanoplatform Synergistically Enhances Cascaded Chemodynamic Therapy显示文摘Chemodynamic therapy(CDT),a noninvasive strategy,has emerged as a promising alternative to conventional chemotherapy for treating tumors.However,its therapeutic effect is limited by the amount of H_(2)O_(2),pH value,the hypoxic environment of tumors,and it has suboptimal tumor-targeting ability.In this study,tumor cell membrane-camouflaged mesoporous Fe_(3)O_(4) nanoparticles loaded with perfluoropentane(PFP)and glucose oxidase(GOx)are used as a tumor microenvironment-adaptive nanoplatform(M-mFeP@O_(2)-G),which synergistically enhances the antitumor effect of CDT.Mesoporous Fe_(3)O_(4) nanoparticles are selected as inducers for photothermal and Fenton reactions and as nanocarriers.GOx depletes glucose within tumor cells for starving the cells,while producing H2O2 for subsequent⋅OH generation.Moreover,PFP,which can carry O_(2),relieves hypoxia in tumor cells and provides O_(2) for the cascade reaction.Finally,the nanoparticles are camouflaged with osteosarcoma cell membranes,endowing the nanoparticles with homologous targeting and immune escape abilities.Both in vivo and in vitro evaluations reveal high synergistic therapeutic efficacy of M-mFeP@O_(2)-G,with a desirable tumor-inhibition rate(90.50%),which indicates the great potential of this platform for clinical treating cancer. | Yuemin Wang Duan Wang Yuyue Zhang Hong Xu Luxuan Shen Jing Cheng Xinyuan Xu Hong Tan Xingyu Chen Jianshu Li | 2023 | Bioactive Materials2023，，4： | 1 |
| 18 | Surface modification of superfine tourmaline powder with titanate coupling agent显示文摘 | Ying Wang Jen Taut Yeh Tonhjian Yue Rongxing Yao Xinyuan Shen | 2006 | Colloid Polym Sei2006，，2006： | 1 |
| 19 | Design and high-strength origin of novel (CoFeNi)_(80)Ti_(5)V_(15) medium entropy alloy with “fcc + L1_(2) ”structure显示文摘1.Introduction The multi-component high entropy alloys(HEAs)or medium entropy alloys(MEAs)attract reseachers’extensive attention,in particular,the single-face center cubic(fcc)HEAs or MEAs due to their some advantages,such as excellent ductility[1,2],good corrosion resistance[3]and high radiation tolerance[4].However,their strength is commonly insufficient for engineering applica-tions.Recently,many investigations are ongoing to improve their strength by traditional strengthening mechanisms,like fine-grained strengthening[5,6],solid strengthening[6-8],strain strengthening[9],polyphase strengthening[10-12],and precipitation strength-ening[13-15].Among these strengthening mechanisms,the co-herent L1_(2)-type nanoparticles precipitation strengthening has been proven to be a very effective way to improve their strength[13-15]. | Lei Wang Xinyuan Wu Yuan Wu Gang Liu Zhenhua Han Yunpeng Zhang Yanning Su Shengfeng Kang Jun Shen Guojun Zhang | 2023 | Journal of Materials Science & Technology2023，，18： | 0 |
| 20 | Growth substrates alter aboveground plant microbial and metabolic properties thereby influencing insect herbivore performance显示文摘The gut microbiome of plant-eaters is affected by the food they eat,but it is currently unclear how the plant metabolome and microbiome are influenced by the substrate the plant grows in and how this subsequently impacts the feeding behavior and gut microbiomes of insect herbivores.Here,we use Plutella xylostella caterpillars and show that the larvae prefer leaves of cabbage plants growing in a vermiculite substrate to those from plants growing in conventional soil systems.From a plant metabolomics analysis,we identified 20 plant metabolites that were related to caterpillar feeding performance.In a bioassay,the effects of these plant metabolites on insects'feeding were tested.Nitrate and compounds enriched with leaves of soilless cultivation promoted the feeding of insects,while compounds enriched with leaves of plants growing in natural soil decreased feeding.Several microbial groups(e.g.,Sporolactobacillus,Haliangium)detected inside the plant correlated with caterpillar feeding performance and other microbial groups,such as Ramlibacter and Methylophilus,correlated with the gut microbiome.Our results highlight the role of growth substrates on the food metabolome and microbiome and on the feeding performance and the gut microbiome of plant feeders.It illustrates how belowground factors can influence the aboveground properties of plant-animal systems,which has important implications for plant growth and pest control. | Jun Yuan Tao Wen Shengdie Yang Chao Zhang Mengli Zhao Guoqing Niu Penghao Xie Xiaoyu Liu Xinyuan Zhao Qirong Shen T.Martijn Bezemer | 2023 | Science China(Life Sciences)2023，66，8： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员