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| 1 | Transmutation of ancient settlements and environmental changes between 6000-2000 aBP in the Chaohu Lake Basin, East China显示文摘Based on the temporal-spatial distribution features of ancient settlement sites from the middle and late Neolithic Age to the Han dynasty in the Chaohu Lake Basin of Anhui Province,East China,using the methods of GIS combined with the reconstructed paleoenvironment by the records of lake sediment since Holocene,the transmutation of ancient settlements with response to environmental changes in this area has been discussed.Studies show that the main feature of transmutation of ancient settlements from the middle and late Neolithic Age to the Han Dynasty was that the distribution of settlements in this area changed from high altitudes to low ones and kept approaching the Chaohu Lake with the passage of time.These could be the response to the climate change from warm-moist to a relatively warm-dry condition during the middle Holocene,leading to the lake level fluctuations.The large area of exposed land provided enough space for human activities.These indicate that the above changes in geomorphologic evolution and hydrology influenced by climate conditions affected the transmutation of ancient settlements greatly.The distribution pattern of settlement sites was that the number of sites in the west was more than in the east.This pattern may be related to the geomorphologic conditions such as frequent channel shifting of the Yangtze River as well as flood disasters during the Holocene optimum.Therefore,climate change was the inducement of the transmutation of ancient settlements in the Chaohu Lake Basin,which exerted great influence on the distribution,expansion and development of the ancient settlements. | WU Li WANG Xinyuan ZHOU Kunshu MO Duowen ZHU Cheng GAO Chao ZHANG Guangsheng LI Lan LIU Li HAN Weiguang | 2010 | Journal of Geographical Sciences2010，20，5： | 16 |
| 2 | Phosphorylcholine polymer nanocapsules prolong the circulation time and reduce the immunogenicity of therapeutic proteins显示文摘蛋白质治疗,治疗学的蛋白质在那里被交付对待混乱,为治疗疾病被认为最安全、很直接的途径。然而,它的应用被有效策略的少量高度为在他们的管理以后在 vivo 交付蛋白质和治疗学的蛋白质的快速的清理限制。这里,我们表明能显著地延长治疗学的蛋白质的发行量时间以及最小化他们的 immunogenicity 的新奇策略。这被与抵抗蛋白质吸附的 crosslinked phosphorylcholine 聚合物的薄层包含单个蛋白质分子完成。通过广泛的细胞的研究,我们证明 crosslinked phosphorylcholine 聚合物壳有效地阻止包含的蛋白质是由巨噬细胞的 phagocytosed,它在 vivo 在 nanoparticles 的清理起一个必要作用。而且,聚合物壳阻止包含的蛋白质被有免疫力的房间识别。作为结果,对治疗学的蛋白质的有免疫力的回答有效地被压制。这个工作描述一个可行方法延长循环时间并且减少治疗学的蛋白质的 immunogenicity,它可以在多样的疾病的治疗支持新奇蛋白质治疗的发展和申请。 | Sheng Liang Yang Liu Xin Jin Gan Liu Jing Wen Linlin Zhang Jie Li Xubo Yuan Irvin S.Y. Chen Wei Chen Hui Wang Linqi Shi Xinyuan Zhu Yunfeng Lu | 2016 | Nano Research2016，9，4： | 11 |
| 3 | The histone methyltransferase EZH2 primes the early differentiation of follicular helper T cells during acute viral infection显示文摘Epigenetic modifications to histones dictate the differentiation of naïve CD4^(+) T cells into different subsets of effector T helper(TH)cells.The histone methyltransferase enhancer of zeste homolog 2(EZH2)has been implicated in the mechanism regulating the differentiation of TH1,TH2 and regulatory T(Treg)cells.However,whether and how EZH2 regulates follicular helper T(TFH)cell differentiation remain unknown.Using a mouse model of acute lymphocytic choriomeningitis virus(LCMV)infection,we observed abundant EZH2 expression and associated H3K27me3 modifications preferentially in the early committed virus-specific TFH cells compared to those in TH1 cells.Ablation of EZH2 in LCMV-specific CD4^(+) T cells leads to a selective impairment of early TFH cell fate commitment,but not late TFH differentiation or memory TFH maintenance.Mechanistically,EZH2 specifically stabilizes the chromatin accessibility of a cluster of genes that are important for TFH fate commitment,particularly B cell lymphoma 6(Bcl6),and thus directs TFH cell commitment.Therefore,we identified the chromatin-modifying enzyme EZH2 as a novel regulator of early TFH differentiation during acute viral infection. | Xiangyu Chen Guoshuai Cao Jialin Wu Xinxin Wang Zhiwei Pan Jianbao Gao Qin Tian Lifan Xu Zhirong Li Yaxing Hao Qizhao Huang Pengcheng Wang Minglu Xiao Luoyingzi Xie Shupei Tang Zhenyu Liu Li Hu Jianfang Tang Ran He Li Wang Xinyuan Zhou Yuzhang Wu Mengjie Chen Beicheng Sun Bo Zhu Jun Huang Lilin Ye | 2020 | Cellular & Molecular Immunology2020，17，3： | 4 |
| 4 | Prolonging the plasma circulation of proteins by nano- encapsulation with phosphorylcholine-based polymer显示文摘突然在 vivo 循环是到蛋白质治疗学的普遍采纳的一个主要阻碍者。经由显著地展出的一个二拍子的圆舞封装过程与基于 phosphorylcholine 的聚合物的薄层包含蛋白质产生的蛋白质 nanocapsules 延长了血浆半衰期。而且,由与类似的尺寸构造 nanocapsules 但是不同表面费用和化学,我们为延长治疗学的蛋白质的血浆半衰期表明了通用策略。在里面一在里面 vitro 实验,牛的浆液白朊(BSA ) 的四种类型 nanocapsules 在磷酸盐缓冲区与胎儿的牛的浆液(FBS ) 被孵化盐(PBS ) ;由 HeLa 房间的房间举起被监视系统地在循环期间评估表面化学的特征。单个正电子排放计算断层摄影术的断层摄影术(SPECT ) 被采用在静脉内的管理以后在血浆集中的 vivo,以及 quantification 允许 BSA nanoparticle 分发的即时观察。这研究为为临床的使用翻译大量蛋白质提供一个实际方法。 | Linlin Zhang Yang Liu Gan Liu Duo Xu Sheng Liang Xinyuan Zhu Yunfeng Lu Hui Wang | 2016 | Nano Research2016，9，8： | 4 |
| 5 | Extraction of palaeochannel information from remote sensing imagery in the east of Chaohu Lake, China显示文摘Palaeochannels 是 unconsolidated 沉积或在古老的、当前不活跃的河和流隧道系统里扔的巩固半的沉积岩石的存款。它从当前活跃的河隧道的 overbank 存款是不同的,包括定期不流动的短暂的水功课。我们介绍了一光谱从有特殊时间阶段的 SPOT-5 形象的基于特征的 palaeochannel 信息抽取模型,它被遥感机制的分析的优点造了并且光谱 palaeochannel 的特征,从空间分发与它的区别结合了并且光谱当前活跃的河隧道的特征,另外,随遥感判定的建立,在遥感的 palaeochannel 的特征想象。这个模型跟随监督分类的进程[箭头权利] 掩盖的农田和主要部件分析[箭头权利] 地下的 palaeochannel 信息抽取[箭头权利] 信息联合[箭头权利] palaeochannel 系统图象。在乔胡·莱克的东方的 Zhegao 河山谷作为一个学习区域被选择,并且 SPOT-5 形象被用作数据的来源。当这个方法成功地被使用了提取 palaeochannel 信息时,结果是令人满意的,它能为地区性的遥感考古学和 neotectonic 研究提供好参考。然而,这个方法的适用性需要作为空间特征在另外的区域进一步被测试并且光谱 palaeochannel 的反应可能是不同的[出版摘要] | Xinyuan WANG Zhenya GUO Li WU Cheng ZHU Hui HE | 2012 | Frontiers of Earth Science2012，6，1： | 4 |
| 6 | Using 2D NMR to determine the degree of branching of complicated hyperbranched polymers显示文摘Degree of branching (DB) is a crucial structure parameter of hyperbranched polymers, which can be determined by 1H NMR, quantitative 13C NMR, degradative method, etc. However, for complicated hy-perbranched polymers, intricate structure and severe overlap of spectral signals hinder the determina-tion of DB using traditional methods. In this work, the architecture of complicated hyperbranched polymers has been elucidated with the help of 2D NMR techniques. Using such a method, overlapped NMR signals can be well separated into a two-dimensional space, and additional structural information is also available. Correspondingly, quantitative analysis for complicated systems can be realized. De-termination of DBs for three types of complicated hyperbranched polymers synthesized from step-polymerization, self-condensation vinyl polymerization and self-condensation ring-opening po-lymerization is shown as examples. | ZHU XinYuan CHEN Liang CHEN Yan YAN DeYue | 2008 | Science China Chemistry2008，51，11： | 3 |
| 7 | Amphiphilic drug-drug conjugate for cancer therapy with combination of chemotherapeutic and antiangiogenesis drugs显示文摘The progression and metastasis of solid tumors strongly rely on the process of forming nascent blood vessels.However,using angiogenesis inhibitors alone does not meet the cancer treatment needs.Herein,we used the amphiphilic drug-drug conjugate(ADDC)strategy to fabricate a new drug conjugate with the combination of chemotherapeutic drug and antiangiogenesis drug together.With one-step esterification of hydrophilic floxuridine(FUDR)and hydrophobic pseudolaric acid B(PAB),the conjugate was synthesized.The amphiphilic property of FUDR-PAB conjugate induced the self-assembly to form nanoparticles in water.From further in vitro and in vivo experiments,this FUDR-PAB conjugate does not only have a high antitumor effect,but also shows efficient antianiogenesis property.These results offer a promising ADDC strategy for designing drugs with combination of chemotherapeutic drug and antiangiogenesis drug together. | Mo Sun Qiuhui Qian Leilei Shi Li Xu Qunfang Liu Linzhu Zhou Xinyuan Zhu Jian-Min Yue Deyue Yan | 2020 | Science China Chemistry2020，63，1： | 3 |
| 8 | Career concerns, shareholder monitoring and investment efficiency: From the perspective of compensation contract rigidity in Chinese SOEs显示文摘This paper presents theoretical analysis of how career concerns and shareholder monitoring affect chief executive officer(CEO) agency costs. We investigate investment efficiency prior to CEO retirement based on a sample of Chinese state-owned enterprises(SOEs) during the 1999–2007 period and find that there is a significant decline in investment efficiency prior to CEO retirement, relative to other periods, and that this decline becomes less significant under stronger shareholder supervision. Our research furthers understanding of the significance of SOE incentive and monitoring mechanisms. | Hualin Wan Kai Zhu Xinyuan Chen | 2015 | China Journal of Accounting Research2015，，1： | 3 |
| 9 | Ultra-flat broadband micro wave frequency comb generation based on optical frequency comb with a multiple-quantumwell electro-absorption modulator in critical state显示文摘In this paper,we proposed a novel ultra・flat broadband microwave frequency comb(MFC)generation based on optical frequency comb(OFC)with a multiplequantum-well electroabsorption modulator(MQW-EAM)in critical state.The scheme is simple and easy to adjust.The performance of the MFC generation scheme is investigated using software Optisystem.The results show that the comb spacing of MFC can be adjusted from 5 to 20 GHz by changing RF signafs frequency and the MFC is almost independent on the linewidth of the tunable laser diode.The performance of the MFC can be improved by reasonably increasing the voltage of the RF,the smallsignal gain of the Erbium-doped fiber amplifier(EDFA)and the responsivity of the photodetector.The MFC generated by this scheme has 300 GHz effective bandwidth with 15 comb lines,whose power variation is 0.02 dB,when the components9 parameters in the Optisystem are set as follows:the power of tunable laser diode(TLD)is 0 dBm,the wavelength is 1552.52 nm,and linewidth is 1 MHz;RF signaPs frequency is 20 GHz and the voltage is 10 V;the reverse bias voltage of MQW-EAM is 6.92 V;the small-signal gain of the EDFA is 40 dB;the responsivity of the photodetector(PD)is 1 A/W. | Cong SHEN Peili LI Xinyuan ZHU Yuanfang ZHANG Yaqiao HAN | 2019 | Frontiers of Optoelectronics2019，12，4： | 3 |
| 10 | Fluorescent AIE dots encapsulated organically modified silica (ORMOSIL) nanoparticles for two-photon cellular imaging显示文摘2,3-Bis(4-(phenyl(4-(1,2,2-triphenylvinyl)phenyl)amino)phenyl) fumaronitrile (TPE-TPA-FN or TTF), which possesses aggregation-induced emission (AIE) characteristic, is doped in organically modified silica (ORMOSIL) nanoparticles. By increasing the weight ratio of TTF to the precursor of silica nanoparticles (the quantities of the precursors were kept the same), the fluorescence intensity of nanoparticles increased correspondingly, due to the formation of larger AIE dots in the cores of ORMOSIL nanoparticles. The fluorescent and biocompatible nanoprobes were then utilized for in vitro imaging of HeLa cells. Two-photon fluorescence microscopy clearly illustrated that the nanoparticles have the capacity of nucleus permeability, as well as cytoplasm staining towards tumor cells. Our experimental results may offer a promising method for fast and bright fluorescence imaging, as well as bio-molecule/drug delivery to cell nucleus. | ZHU ZhenFeng ZHAO XinYuan QIN Wei CHEN GuangDi QIAN Jun XU ZhengPing | 2013 | Science China Chemistry2013，56，9： | 3 |
| 11 | Bioreducible unimolecular micelles based on amphiphilic multiarm hyperbranched copolymers for triggered drug release显示文摘A novel type of bioreducible amphiphilic multiarm hyperbranched copolymer (H40-star-PLA-SS-PEG) based on Boltorn H40 core,poly(L-lactide) (PLA) inner-shell,and poly(ethylene glycol) (PEG) outer-shell with disulfide-linkages between the hydrophobic and hydrophilic moieties was developed as unimolecular micelles for controlled drug release triggered by reduction.The obtained H40-star-PLA-SS-PEG was characterized in detail by nuclear magnetic resonance (NMR),Fourier transform infrared (FTIR),gel permeation chromatography (GPC),differential scanning calorimeter (DSC),and thermal gravimetric analysis (TGA).Transmission electron microscopy (TEM) and dynamic light scattering (DLS) analyses suggested that H40-star-PLA-SS-PEG formed stable unimolecular micelles in aqueous solution with an average diameter of 19 nm.Interestingly,these micelles aggregated into large particles rapidly in response to 10 mM dithiothreitol (DTT),most likely due to shedding of the hydrophilic PEG outer-shell through reductive cleavage of the disulfide bonds.As a hydrophobic anticancer model drug,doxorubicin (DOX) was encapsulated into these reductive unimolecular micelles.In vitro release studies revealed that under the reduction-stimulus,the detachment of PEG outer-shell in DOX-loaded micelles resulted in a rapid drug release.Flow cytometry and confocal laser scanning microscopy (CLSM) measurements indicated that these DOX-loaded micelles were easily internalized by living cells.Methyl tetrazolium (MTT) assay demonstrated a markedly enhanced drug efficacy of DOX-loaded H40-star-PLA-SS-PEG micelles as compared to free DOX.All of these results show that these bioreducible unimolecular micelles are promising carriers for the triggered intracellular delivery of hydrophobic anticancer drugs. | PANG Yan 1,LIU JinYao 1,SU Yue 1,ZHU BangShang 2,HUANG Wei 1,ZHOU YongFeng 1,ZHU XinYuan 1,2 & YAN DeYue 1 1 School of Chemistry and Chemical Engineering,State Key Laboratory of Metal Matrix Composites,Shanghai Jiao Tong University,Shanghai 200240,China 2 Instrumental Analysis Center,Shanghai Jiao Tong University,Shanghai 200240,China | 2010 | Science China Chemistry2010，53，12： | 3 |
| 12 | Long-term variations of X-ray pulse profiles for the Crab pulsar:data analysis and modeling显示文摘The pulse profiles of the Crab pulsar(as well as some other pulsars)vary with time.They can lead to a major source of intrinsic timing noise,which lacks a detailed physical model.The phase separation?between the first left peak(P1)and the second right peak(P2)is a key parameter that shows the variations of pulse profiles for the Crab pulsar.It was found that the evolution of?has a tendency with increasing rates of 0.82?±0.25?,0.80?±0.54?,and 0.77?±0.28?per century for the 2-6,6-15,and15-60 ke V bands,respectively.Furthermore,the flux ratios(P2/P1)of X-ray pulse profiles in the three bands were calculated,and the derived flux ratios were consistent with the radio and X-ray measurements of the Insight-HXMT.In addition to discovering the physical origin of the pulse changes,the high-SNR X-ray pulse profiles were simulated in the annular gap model,and two model parameters(e.g.,the maximum emission heights of the two peaks)were observed to slightly affect the variations of peak separation.We fitted the long-term variations of emission heights of the two peaks and discovered that the emission heights showed increasing tendencies with time.Variations of these emission heights induced a characteristic period derivative,and a complete formula for both the magnetic dipole radiation and wind-particle-induced variations of the moment of inertia was used for the pulsar’s spin-down to obtain the variation rate˙αof the magnetic inclination angle,which was-1.60?per century.Intrinsic timing noise is observed to be mainly induced by the variations of pulse profiles,which might correlate with a characteristic spin period derivative arising from the fluctuations of the emission regions.This work will lay a foundation for understanding the origin of intrinsic timing noise and making high-precision timing models in the future. | LunHua Shang YuanJie Du XiangQun Cui ShiJun Dang JiGuang Lu JunTao Bai QiJun Zhi YouLi Tuo LinLi Yan LiangWei Huang XinYuan Zhang XiaoMin Bei QingQing Lin GuoJun Qiao Hua Shen RiHong Zhu | 2020 | Science China(Physics,Mechanics & Astronomy)2020，63，10： | 2 |
| 13 | Magnetic properties and microstructures of terbium coated and grain boundary diffusion treated sintered Nd-Fe-B magnets by magnetron sputtering显示文摘Tb coating on the surface of commercial sintered Nd-Fe-B magnet was prepared by DC magnetron sputtering.The secondary heat treatment was used to regulate the microstructure for the enhancement of coercivity,namely diffusion treatment and annealing treatment.The coercivity increases significantly from 18.3 to 28.0 kOe,the remanence decreases slightly from 14.1 to 14.0 kGs,and the comprehensive magnetic properties are higher than 75(Hcj+(BH)_(max)=76.7).SEM results indicate that,on the one hand,950℃is the optimal diffusion temperature.Lower diffusion temperature results in insufficient diffusion of Tb element.Higher diffusion temperature can lead to the main phase grain growth,the decrease of Nd-rich phase,and forming holes in the magnet.On the other hand,500℃is the optimal annealing temperature.Lower annealing temperature can result in the reduction of Nd-rich phase.Higher annealing temperature can generate the non-defined Nd-rich thin layer between grains. | Wei Zhu Yang Luo Zilong Wang Xinyuan Bai Haijun Peng Dunbo Yu | 2021 | Journal of Rare Earths2021，39，2： | 2 |
| 14 | Imperfection sensitivity of mechanical properties in soft network materials with horseshoe microstructures显示文摘Developments of soft network materials with rationally distributed wavy microstructures have enabled many promising applications in bio-integrated electronic devices,due to their abilities to reproduce precisely nonlinear mechanical properties of human tissues/organs.In practical applications,the soft network materials usually serve as the encapsulation layer and/or substrate of bio-integrated electronic devices,where deterministic holes can be utilized to accommodate hard chips,thereby increasing the filling ratio of the device system.Therefore,it is essential to understand how the hole-type imperfection affects the stretchability of soft network materialswith various geometric constructions.Thiswork presents a systematic investigation of the imperfection sensitivity of mechanical properties in soft network materials consisting of horseshoe microstructures,through combined computational and experimental studies.A factor of imperfection insensitivity of stretchability is introduced to quantify the influence of hole imperfections,as compared to the case of perfect soft network materials.Such factor is shown to have different dependences on the arc angle and normalized width of horseshoe microstructures for triangular network materials.The soft triangular and Kagome network materials,especially with the arc angle in the range of(30?,60?),are found to be much more imperfection insensitive than corresponding traditional lattice materials with straight microstructures.Differently,the soft honeycomb network materials are not as imperfection insensitive as traditional honeycomb lattice materials. | Jianxing Liu Xinyuan Zhu Zhangming Shen Yihui Zhang | 2021 | Acta Mechanica Sinica2021，37，7： | 1 |
| 15 | The formation mechanism of titania nanotube arrays in hydrofluoric acid electrolyte显示文摘 | Jing Bai Baoxue Zhou Longhai Li Yanbiao Liu Qing Zheng Jiahui Shao Xinyuan Zhu Weimin Cai Junsheng Liao Lexi Zou | 2008 | Journal of Materials Science2008，，6： | 1 |
| 16 | Kinetics for copolymerization of methyl methacrylate with N-cyclohexylmaleimide显示文摘 | Xulin Jiang Deyue Yan Xinyuan Zhu | 1999 | J Appl Polym Sci1999，，74： | 1 |
| 17 | Treatment and utilization of wastewater in the Beijing Zoo by an aquatic macrophyte system显示文摘 | Jiang Zhu Xinyuan Zhu | 1998 | Ecological Engineering1998，11，14： | 1 |
| 18 | herative Improvement of a solution for an Ill-Conditioned System of Linear Equations Based on a Linear Dynamic System显示文摘 | WU Xinyuan SHAO Rong ZHU Yaran | 2002 | Computers and Mathematics with Applications2002，44，： | 1 |
| 19 | thermal degradation of syndiotactic polypropylene and the influence of stereoregularity on the thermal degradation hehaviour by in situ FTIR spectroscopy 显示文摘 | Peng He Yan Xiao Puming Zhang Chunhua Xing Na Zhu Xinyuan Zhu Deyue Yan | 2005 | Polymer Degradation and Stability2005，，88： | 1 |
| 20 | Component reconstitution-driven photoelectrochemical sensor for sensitive detection of Cu2+ based on advanced CuS/CdS p-n junction显示文摘The rational design of robust photoactive material and artful sensing strategy are vital for the construction of an ultrasensitive photoelectrochemical(PEC)sensor.Although great progress has been made in PEC sensing,the resultant detection performances and adoptable sensing strategies are still limited.Herein,through the design of a subtle component reconstitution strategy,an ultrasensitive PEC sensor is developed for the detection of Cu2+based on advanced CuS/CdS nanohybrids(NHs).This proposed sensor shows superior sensing performances with a low detection limit of 0.1 nM and a wide detection range from 0.2 nM to 60 pM due to the formation of p-n junction between CuS and CdS and the component transformation of CdS to CuxS(x=1,2).Moreover,such PEC sensor also displays goodish results for monitoring the Cu^2+released from apoptotic HeLa cells in vitro.This idea of component reconstitution provides a new paradigm for the design of advanced PEC sensors. | Jing Liu Ying Liu Wei Wang Jing Li Xinyuan Yu Qinshu Zhu Zhihui Dai | 2019 | Science China Chemistry2019，62，12： | 1 |
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