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| 1 | Long-chain acyl-CoA synthetase in fatty acid metabolism involved in liver and other diseases:An update显示文摘Long-chain acyl-Co A synthetase(ACSL) family members include five different ACSL isoforms, each encoded by a separate gene and have multiple spliced variants. ACSLs on endoplasmic reticulum and mitochondrial outer membrance catalyze fatty acids with chain lengths from 12 to 20 carbon atoms to form acyl-Co As, which are lipid metabolic intermediates and involved in fatty acid metabolism, membrane modifications and various physiological processes. Gain- or lossof-function studies have shown that the expression of individual ACSL isoforms can alter the distribution and amount of intracellular fatty acids. Changes in the types and amounts of fatty acids, in turn, can alter the expression of intracellular ACSLs. ACSL family members affect not only the proliferation of normal cells, but the proliferation of malignant tumor cells. They also regulate cell apoptosis through different signaling pathways and molecular mechanisms. ACSL members have individual functions in fatty acid metabolism in different types of cells depending on substrate preferences, subcellular location and tissue specificity, thus contributing to liver diseases and metabolic diseases, such as fatty liver disease, obesity, atherosclerosis and diabetes. They are also linked to neurological disorders and other diseases. However, the mechanisms are unclear. This review addresses new findings in the classification and properties of ACSLs and the fatty acid metabolismassociated effects of ACSLs in diseases. | Sheng Yan Xue-Feng Yang Hao-Lei Liu Nian Fu Yan Ouyang Kai Qing | 2015 | World Journal of Gastroenterology2015，21，12： | 18 |
| 2 | Ultrasonographic features of medullary thyroid carcinoma and their diagnostic values显示文摘背景髓的甲状腺癌(MTC ) 是一个稀罕恶性肿瘤并且通常困难与超声诊断。学习的目的是总结 MTC 的 sonographic 特征并且评估他们我们分析了的诊断 values.Methods 关于榴状的尺寸, echogenecity,内部内容,形状,高度 / 宽度,边阶,外部光圈,石灰化和颜色的 35 MTC 和 50 个良性的小瘤的 sonographic 特征流动模式。比率也长在在 MTC 之间的 sonographic 特征处于颈的淋巴 nodes.The 差别被估计到短轴, echogenecity,内部内容和石灰化,良性的小瘤与迟一起被分析平方测试。每个 sonographic 特征的诊断效率是主要 sonographic MTC 展示的 determined.Results 是 hypoechogenicity (包括的显著 hypoechogenicity )(n=34,97%),内部稳固的内容( n=29 ,83%),比高宽( n=34 ,97%),明确的边阶( n=24 ,69%), microcalcifications 或 macrocalcifications ( n=23 ,66%)。, echogenicity,内部内容,形状,外部光圈和石灰化在这二个组之间是显著地不同的高 / 宽,边阶,和 pednodular 和 intranodular vascularisation 不是显著地不同的。在所有单个 sonographic 特征之中,不规则的形状与 51% 的敏感和 92% 的特性有最高诊断的效率。显著 hypoechogenicity, microcalcifications,和不规则的形状的联合产出 77% 的敏感和典型 sonographic MTC 展示的 86%.Conclusions 的特性是 hypoechogenicity,主要稳固,不规则地与微石灰化的 intranodular 或宏石灰化塑造了。多重 sonographic 特征的联合有用,然而并非权威,为 MTC 的诊断。 | CAI Sheng LIU He LI Wen-bo OUYANG Yun-shu ZHANG Bo LI Peng WANG Xue-lian ZHANG Xiao-yan LI Jian-chu JIANG Yu-xin | 2010 | Chinese Medical Journal2010，，21： | 9 |
| 3 | The production of biobased diamines from renewable carbon sources: Current advances and perspectives显示文摘Bio-based diamines are considered to be a promising alternative to traditional fossil-fuel-based diamines,the important platform chemical for the synthesis of polymer materials.In this review,the current status of the art of the synthesis of aliphatic and aromatic diamines from renewable biomass are considered.In the case of aliphatic diamines,we describe strategies for biologically producing diamines with different carbon numbers including 1,3-diaminopropane,1,4-butanediamine,1,5-pentanediamine,1,6-diaminohexane,1,8-diaminooctane,1,10-diaminodecane,and 1,12-diaminododecane.In addition,aromatic diamines produced from various kinds of renewable biomass,including lignin,cashew nut shell,and terpenoids,are reviewed here.Furthermore,the application of typical diamines in synthesis of polyurethane and polyamide are also reviewed. | Xin Wang Siyuan Gao Jing Wang Sheng Xu Hui Li Kequan Chen Pingkai Ouyang | 2021 | Chinese Journal of Chemical Engineering2021，34，2： | 5 |
| 4 | Classification of four distinct osteoarthritis subtypes with a knee joint tissue transcriptome atlas显示文摘The limited molecular classifications and disease signatures of osteoarthritis(OA)impede the development of prediagnosis and targeted therapeutics for OA patients.To classify and understand the subtypes of OA,we collected three types of tissue including cartilage,subchondral bone,and synovium from multiple clinical centers and constructed an extensive transcriptome atlas of OA patients.By applying unsupervised clustering analysis to the cartilage transcriptome,OA patients were classified into four subtypes with distinct molecular signatures:a glycosaminoglycan metabolic disorder subtype(C1),a collagen metabolic disorder subtype(C2),an activated sensory neuron subtype(C3),and an inflammation subtype(C4).Through ligand-receptor crosstalk analysis of the three knee tissue types,we linked molecular functions with the clinical symptoms of different OA subtypes.For example,the Gene Ontology functional term of vasculature development was enriched in the subchondral bone-cartilage crosstalk of C2 and the cartilage-subchondral bone crosstalk of C4,which might lead to severe osteophytes in C2 patients and apparent joint space narrowing in C4 patients.Based on the marker genes of the four OA subtypes identified in this study,we modeled OA subtypes with two independent published RNA-seq datasets through random forest classification.The findings of this work contradicted traditional OA diagnosis by medical imaging and revealed distinct molecular subtypes in knee OA patients,which may allow for precise diagnosis and treatment of OA. | Chunhui Yuan Zongyou Pan Kun Zhao Jun Li Zixuan Sheng Xudong Yao Hua Liu Xiaolei Zhang Yang Yang Dongsheng Yu Yu Zhang Yuzi Xu Zhi-Yong Zhang Tianlong Huang Wanlu Liu Hongwei Ouyang | 2020 | Bone Research2020，8，4： | 4 |
| 5 | Attractor for Lattice System of Dissipative Zakharov Equation显示文摘我们认为一个无限的格子的解决方案的 asymptotic 行为是消散的 Zakharov 方程的动态系统。由介绍在空格和建立的制服的内部产品和标准在“解决方案的尾巴结束”估计的新重量,我们克服 Sobolev 协议在无限的格子系统下面嵌入的缺乏引起的一些困难,并且证明全球引起注意的人的存在;然后由在有限维的空间使用元素分解和一个多面体的盖住的性质,我们为全球引起注意的人的 Kolmogorov ɛ-entropy 获得上面的界限;最后,我们在场全球引起注意的人的上面的半连续性。 | Fu Qi YIN Sheng Fan ZHOU Zi Gen OUYANG Cui Hui XIAO | 2009 | Acta Mathematica Sinica,English Series2009，25，2： | 4 |
| 6 | Ameliorating end-product inhibition to improve cadaverine production in engineered Escherichia coli and its application in the synthesis of bio-based diisocyanates显示文摘Cadaverine is an important C5 platform chemical with a wide range of industrial applications.However,the cadaverine inhibition on the fermenting strain limited its industrial efficiency of the strain.In this study,we report an engineered Escherichia coli strain with high cadaverine productivity that was generated by developing a robust host coupled with metabolic engineering to mitigate cadaverine inhibition.First,a lysine producing E.coli was treated with a combination of radiation(ultraviolet and visible spectrum)and ARTP(atmospheric and room temperature plasma)mutagenesis to obtain a robust host with high cadaverine tolerance.Three mutant targets including HokD,PhnI and PuuR are identified for improved cadaverine tolerance.Further transcriptome analysis suggested that cadaverine suppressed the synthesis of ATP and lysine precursor.Accordingly,the related genes involved in glycolysis and lysine precursor,as well as cadaverine exporter was engineered to release the cadaverine inhibition.The final engineered strain was fed-batch cultured and a titer of 58.7 g/L cadaverine was achieved with a yield of 0.396 g/g,both of which were the highest level reported to date in E.coli.The bio-based cadaverine was purified to>99.6%purity,and successfully used for the synthesis of polyurethane precursor 1,5-pentamethylene diisocyanate(PDI)through the approach of carbamate decomposition. | Xin Wang Xing Guo Jing Wang Hui Li Feng He Sheng Xu Kequan Chen Pingkai Ouyang | 2021 | Synthetic and Systems Biotechnology2021，6，4： | 3 |
| 7 | Targeting a novel inducible GPX4 alternative isoform to alleviate ferroptosis and treat metabolic-associated fatty liver disease显示文摘Metabolic-associated fatty liver disease(MAFLD),which is previously known as non-alcoholic fatty liver disease(NAFLD),represents a major health concern worldwide with limited therapy.Here,we provide evidence that ferroptosis,a novel form of regulated cell death characterized by iron-driven lipid peroxidation,was comprehensively activated in liver tissues from MAFLD patients.The canonical-GPX4(cGPX4),which is the most important negative controller of ferroptosis,is downregulated at protein but not mRNA level.Interestingly,a non-canonical GPX4 transcript-variant is induced(inducible-GPX4,iGPX4)in MAFLD condition.The high fat-fructose/sucrose diet(HFFD)and methionine/choline-deficient diet(MCD)-induced MAFLD pathologies,including hepatocellular ballooning,steatohepatitis andfibrosis,were attenuated and aggravated,respectively,in cGPX4-and iGPX4-knockin mice.cGPX4 and iGPX4 isoforms also displayed opposing effects on oxidative stress and ferroptosis in hepatocytes.Knockdown of iGPX4 by siRNA alleviated lipid stress,ferroptosis and cell injury.Mechanistically,the triggered iGPX4 interacts with cGPX4 to facilitate the transformation of cGPX4 from enzymatic-active monomer to enzymatic-inactive oligomers upon lipid stress,and thus promotes ferroptosis.Co-immunoprecipitation and nano LC–MS/MS analyses confirmed the interaction between iGPX4 and cGPX4.Our results reveal a detrimental role of non-canonical GPX4 isoform in ferroptosis,and indicate selectively targeting iGPX4 may be a promising therapeutic strategy for MAFLD. | Jie Tong Dongjie Li Hongbo Meng Diyang Sun Xiuting Lan Min Ni Jiawei Ma Feiyan Zeng Sijia Sun Jiangtao Fu Guoqiang Li Qingxin Ji Guoyan Zhang Qirui Shen Yuanyuan Wang Jiahui Zhu Yi Zhao Xujie Wang Yi Liu Shenxi Ouyang Chunquan Sheng Fuming Shen Pei Wang | 2022 | Acta Pharmaceutica Sinica B2022，12，9： | 3 |
| 8 | Rational design of a biosensor circuit with semi-log dose-response function in Escherichia coli显示文摘 | Haoqian Zhang Ying Sheng Qianzhu Wu Ao Liu Yuheng Lu Zhenzhen Yin Yuansheng Cao Weiqian Zeng Qi Ouyang | 2013 | Frontiers of Electrical and Electronic Engineering in China2013，8，3： | 2 |
| 9 | Microstructure and tensile behavior of hybrid nano-micro SiC reinforced iron matrix composites produced by selective laser melting显示文摘 | Bo Song Shujuan Dong Pierre Coddet Genshu Zhou Sheng Ouyang Hanlin Liao Christian Coddet | 2013 | Journal of Alloys and Compounds2013，，： | 2 |
| 10 | Synthesis and antibacterial activity of new layered perovskite compounds,Ag_xNa_(2-x)La_2Ti_3O_(10)显示文摘有 Ruddlesden 扑扑儿(R-P ) 的三种新分层的 perovskite 混合物分阶段执行, AgxNa2 ? xLa2Ti3O10 (x = 0.2, 0.3 和 0.5 ) ,被 Na2La2Ti3O10 的离子交换反应与 AgNO3 综合答案。混合物的结构被 EDX 和 XRD 描绘,并且他们的抗菌活性和轻抵抗的性质被评估。结果显示 AgxNa2 的分子式 ? xLa2Ti3O10 (x = 0.2, 0.3 和 0.5 ) 被证实,并且 Na2La2Ti3O10 的晶体结构不是,这显然由银离子的交换影响了。对大肠杆菌关口 i 的 Ag0.3Na1.7La2Ti3O10 的最小的禁止的集中(MIC )(E。关口 i ) ,葡萄球菌 aureus (S。aureus ) 分别地,当它的褪色没在 24 h 光老化试验以后被观察时,是 180 μ g /mL 和 240 μ g /mL。 | Shao Zao Tan Liu Cai Ding Ying Liang Liu You Sheng Ouyang Yi Ben Chen | 2007 | Chinese Chemical Letters2007，18，1： | 2 |
| 11 | Iterative layer-peeling algorithm for designing fiber Bragg gratings with fabrication constraints显示文摘 | Ouyang Y Sheng Y L Bernier M | 2005 | J Lightwave Technol2005，23，11： | 1 |
| 12 | Preparation and Properties of Bio-Based Flame Retardant Polyvinyl Alcohol显示文摘Polyvinyl alcohol (PVA) has been widely used in the fields of medical, food and packaging due to its excellentbiocompatibility, good fiber-forming and film-forming properties. However, the high flammability of PVA hasgreatly limited its wider applications. The flame-retardant PVA was prepared by melt blending of a bio-basedflame retardant (prepared from lignin, phosphoric acid and carbamide) with thermoplastic PVA (TPVA). Thechemical structure, morphology, thermal properties, mechanical properties, fire property and fluidity of thisflame retardant PVA were investigated by Fourier transform infrared spectrometer(FTIR), field emission scanning electron microscope(SEM), thermogravimetric analyzer(TGA), impact tester, universal testing machine,horizontal-vertical burning tester, limiting oxygen indexer(LOI) and melt flow rate meter(MFR). The resultsshowed that the prepared flame retardant had good compatibility with the PVA substrate;The impact strength,melt flow rate, fire property and char residue of this PVA material increased with the content of bio-based flameretardant. When the content of flame retardant was of 20%, the five indices including impact strength, meltflow rate, UL-94 level, LOI and char residual were 11.3 KJ/m^(2), 21.2 g/10 min, V-0 UL-94 level, 33.1%, and19.2%, respectively. This research can promote the high-value utilization of lignin and the application ofPVA in the fields of fire protection. | You Shu Qionglin Luo Hongwei Lin Yuejun Ouyang Xiaomin Zhang Liping Sheng Shengpei Su | 2021 | Journal of Renewable Materials2021，9，5： | 1 |
| 13 | Carbon distribution of n-paraffins in diesel and the effects on the sensitivity of flow improvers 显示文摘 | Lu Ya OUYANG Fusheng WANG Sheng | 2006 | Petroleum Science and Technology2006，24，： | 1 |
| 14 | Carbon distribution of n-paraffins in diesel and the effects on the sensitivity of flow improvers显示文摘 | Lü Ya Ouyang Fusheng Wang Sheng | 2006 | Petroleum Science and Technology2006，24，： | 1 |
| 15 | Efficient production of D-1,2,4-butanetriol from D-xylose by engineered Escherichia coli whole-cell biocataiysts显示文摘We have developed a whole-cell bioconversion system for the production ofD-1,2,4-butanetriol (BT)from renewable biomass.A plasmid pETduet-xylB-yjhG-T7- adhP-T7-mdlC was constructed and transformed to Escherichia coli BL21(DE3)to obtain the whole cells of E.coli BL2I-XYMA capable of bioconversion D-xylose to BT.Then,the factors including carbon sources,nitrogen sources,metal ions,and culture conditions (pH,temperature,IPTG)were identified,and their effects on the wholecell activity for BT production were investigated.To obtain the highest whole-cell activity,the optimal cultivation parameters are:15g·L^-1 yeast extract,5g·L^-1 sucrose, 3g·L^-1 KH2PO4,5g·L^-1 NaCl,3g·L^-1 NH4Cl,0.25g·L^-1 MgSO4·7H2O and 1mL·L^-1 the mixture of trace elements.With the optimized whole cells of E.coli BL21-XYMA,60g·L^-1 of xylose was converted to 28g·L^-1 BT with a molar yield of 66%,which is higher than those reported in the biotechnological system. | Shewei Hu Qian Gao Xin Wang Jianming Yang Nana Xu Kequan Chen Sheng Xu Pingkai Ouyang | 2018 | Frontiers of Chemical Science and Engineering2018，12，4： | 1 |
| 16 | Microstructure and tensile behavior of hybrid nano-micro SiC reinforced iron matrix composites produced by selective laser melting显示文摘 | Bo Song Shujuan Dong Pierre Coddet Genshu Zhou Sheng Ouyang Hanlin Liao Christian Coddet | 2013 | Journal of Alloys and Compounds2013，，： | 1 |
| 17 | Determination of Fipronil and Its Metabolites in Eggs by Indirect Competitive ELISA and Lateral-flow Immunochromatographic Strip显示文摘Fipronil is a phenylpyrrole insecticide that is widely used to control a variety of pests associated with crops in both agricultural and non-agricultural areas[1]. In the natural environment, fipronil can degrade to fipronil-desulfinyl, fipronil-sulfone, or fipronil-sulfide by photolysis, oxidation, or reduction,and these metabolites are more toxic to animal tissue than the parent molecule[2]. | ZHOU Xing Hua ZHANG Cai Qin ZHANG Xun SUN Cheng LI Jie XIAO Xiang ZHAO Yan Sheng OUYANG Qin WANG Yunu | 2020 | Biomedical and Environmental Sciences2020，33，9： | 1 |
| 18 | Splenic siderotic nodules in patients with liver cirrhosis显示文摘 | Huang?Qing Ouyang Zuo?Jiong Gong Yun?Fei Zha Chang?Sheng Liu Zhao?Hui Yang | 2013 | Experimental and Therapeutic Medicine2013，，2： | 1 |
| 19 | Genome-wide high-resolution mapping of mitotic DNA synthesis sites and common fragile sites by direct sequencing显示文摘Common fragile sites(CFSs)are genomic loci prone to the formation of breaks or gaps on metaphase chromosomes.They are hotspots for chromosome rearrangements and structural variations,which have been extensively implicated in carcinogenesis,aging,and other pathological processes.Although many CFSs were identified decades ago,a consensus is still lacking for why they are particularly unstable and sensitive to replication perturbations.This is in part due to the lack of high-resolution mapping data for the vast majority of the CFSs,which has hindered mechanistic interrogations.Here,we seek to map human CFSs with high resolution on a genome-wide scale by sequencing the sites of mitotic DNA synthesis(MiDASeq)that are specific for CFSs.We generated a nucleotide-resolution atlas of MiDAS sites(MDSs)that covered most of the known CFSs,and comprehensively analyzed their sequence characteristics and genomic features.Our data on MDSs tallied well with long-standing hypotheses to explain CFS fragility while highlighting the contributions of late replication timing and large transcription units.Notably,the MDSs also encompassed most of the recurrent double-strand break clusters previously identified in mouse neural stem/progenitor cells,thus bridging evolutionarily conserved break points across species.Moreover,MiDAseq provides an important resource that can stimulate future research on CFSs to further unravel the mechanisms and biological relevance underlying these labile genomic regions. | Fang Ji Hongwei Liao Sheng Pan Liujian Ouyang Fang Jia Zaiyang Fu Fengjiao Zhang Xinwei Geng Xinming Wang Tingting Li Shuangying Liu Madiha Zahra Syeda Haixia Chen Wen Li Zhihua Chen Huahao Shen Songmin Ying | 2020 | Cell Research2020，30，11： | 1 |
| 20 | Utilization of surface differences to improve dyeing properties of poly(m-phenylene isophthalamide) membranes显示文摘 | Shenshen OUYANG Tao WANG Longgang ZHONG Shunli WANG Sheng WANG | 2018 | Frontiers of Materials Science2018，12，2： | 1 |
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