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| 1 | Targeting ferroptosis suppresses osteocyte glucolipotoxicity and alleviates diabetic osteoporosis显示文摘Diabetic osteoporosis(DOP) is the leading complication continuously threatening the bone health of patients with diabetes. A key pathogenic factor in DOP is loss of osteocyte viability. However, the mechanism of osteocyte death remains unclear. Here, we identified ferroptosis, which is iron-dependent programmed cell death, as a critical mechanism of osteocyte death in murine models of DOP. The diabetic microenvironment significantly enhanced osteocyte ferroptosis in vitro, as shown by the substantial lipid peroxidation, iron overload, and aberrant activation of the ferroptosis pathway. RNA sequencing showed that heme oxygenase-1(HO-1) expression was notably upregulated in ferroptotic osteocytes. Further findings revealed that HO-1 was essential for osteocyte ferroptosis in DOP and that its promoter activity was controlled by the interaction between the upstream NRF2 and c-JUN transcription factors. Targeting ferroptosis or HO-1 efficiently rescued osteocyte death in DOP by disrupting the vicious cycle between lipid peroxidation and HO-1 activation, eventually ameliorating trabecular deterioration. Our study provides insight into DOP pathogenesis, and our results provide a mechanism-based strategy for clinical DOP treatment. | Yiqi Yang Yixuan Lin Minqi Wang Kai Yuan Qishan Wang Pei Mu Jingke Du Zhifeng Yu Shengbing Yang Kai Huang Yugang Wang Hanjun Li Tingting Tang | 2022 | Bone Research2022，10，3： | 19 |
| 2 | Cytocompatibility with osteogenic cells and enhanced in vivo anti-infection potential of quaternized chitosan-loaded titania nanotubes显示文摘Infection is one of the major causes of failure of orthopedic implants. Our previous study demonstrated that nanotube modification of the implant surface, together with nanotubes loaded with quaternized chitosan(hydroxypropyltrimethyl ammonium chloride chitosan, HACC), could effectively inhibit bacterial adherence and biofilm formation in vitro. Therefore, the aim of this study was to further investigate the in vitro cytocompatibility with osteogenic cells and the in vivo anti-infection activity of titanium implants with HACC-loaded nanotubes(NT-H). The titanium implant(Ti), nanotubes without polymer loading(NT), and nanotubes loaded with chitosan(NT-C) were fabricated and served as controls. Firstly, we evaluated the cytocompatibility of these specimens with human bone marrow-derived mesenchymal stem cells in vitro.The observation of cell attachment, proliferation, spreading, and viability in vitro showed that NT-H has improved osteogenic activity compared with Ti and NT-C. A prophylaxis rat model with implantation in the femoral medullary cavity and inoculation with methicillin-resistant Staphylococcus aureus was established and evaluated by radiographical, microbiological, and histopathological assessments. Our in vivo study demonstrated that NT-H coatings exhibited significant anti-infection capability compared with the Ti and NT-C groups. In conclusion, HACC-loaded nanotubes fabricated on a titanium substrate show good compatibility with osteogenic cells and enhanced anti-infection ability in vivo, providing a good foundation for clinical application to combat orthopedic implant-associated infections. | Ying Yang Haiyong Ao Yugang Wang Wentao Lin Shengbing Yang Shuhong Zhang Zhifeng Yu Tingting Tang | 2016 | Bone Research2016，4，3： | 9 |
| 3 | Rapid analysis of cyclamate in foods and beverages by gas chromatography-electron capture detector(GC-ECD)显示文摘 | Shengbing Yu Binghui Zhu Fen Lv | 2012 | Food chemistry2012，134，4： | 1 |
| 4 | Protective action of bacterial melanin against DNA damage in full UV spectrums by a sensitive plasmid-based noncellular system显示文摘 | GENG Jing YU Shengbing WAN Xia | 2008 | Journal of Biochemical and Biophysical Methods2008，70，6： | 1 |
| 5 | Protective action of bacterial melanin against DNA damage in full UV spectrums by a sensitive plasmid-based noncellular system显示文摘 | GENG Jing YU Shengbing WAN Xia | 2008 | Journal of Biochemical and Biophysical Methods2008，70，6： | 1 |
| 6 | Rapid analysis of cyclamate in foods and beverages by gas chromatography-electron capture detector (GC-ECD) 显示文摘 | Yu Shengbing Zhu Binghui Lv Fen | 2012 | Food Chemistry2012，134，4： | 1 |
| 7 | Gaschromatography -mass spectrometry determination of earthy -musty odorous compounds in waters by two phase hollow -fiberliquid-phase microextraction using polyvinylidene fluoride fibers显示文摘 | Shengbing Yu Qin Xiao Binghui Zhu | 2014 | Journal of Chromatography A2014，1329，： | 1 |
| 8 | Thermochemical non-equilibrium flow characteristics of high Mach number inlet in a wide operation range显示文摘The high-temperature non-equilibrium effect is a novel and significant issue in the flows over a high Mach number(above Mach 8)air-breathing vehicle.Thus,this study attempts to investigate the high-temperature non-equilibrium flows of a curved compression two-dimensional scramjet inlet at Mach 8 to 12 utilizing the two-dimensional non-equilibrium RANS calculations.Notably,the thermochemical non-equilibrium gas model can predict the actual high-temperature flows,and the numerical results of the other four thermochemical gas models are only used for comparative analysis.Firstly,the thermochemical non-equilibrium flow fields and work performance of the inlet at Mach 8 to 12 are analyzed.Then,the influences of high-temperature non-equilibrium effects on the starting characteristics of the inlet are investigated.The results reveal that a large separation bubble caused by the cowl shock/lower wall boundary layer interaction appears upstream of the shoulder,at Mach 8.The separation zone size is smaller,and its location is closer to the downstream area while the thermal process changes from frozen to non-equilibrium and then to equilibrium.With the increase of inflow Mach number,the thermochemical non-equilibrium effects in the whole inlet flow field gradually strengthen,so their influences on the overall work performance of the high Mach number inlet are more obvious.The vibrational relaxation or thermal non-equilibrium effects can yield more visible influences on the inlet performance than the chemical non-equilibrium reactions.The inlet in the thermochemical non-equilibrium flow can restart more easily than that in the thermochemical frozen flow.This work should provide a basis for the design and starting ability prediction of the high Mach number inlet in the wide operation range. | Chunliang DAI Bo SUN Lianjie YUE Shengbing ZHOU Changfei ZHUO Changsheng ZHOU Jianyi YU | 2023 | Chinese Journal of Aeronautics2023，36，12： | 0 |
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