|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | s-HBEGF/SIRT1 circuit-dictated crosstalk between vascular endothelial cells and keratinocytes mediates sorafenib-induced hand-foot skin reaction that can be reversed by nicotinamide显示文摘Hand-foot skin reaction(HFSR),among the most significant adverse effects of sorafenib,has been limiting the clinical benefits of this frontline drug in treating various malignant tumors.The mechanism underlying such toxicity remains poorly understood,hence the absence of effective intervention strategies.In the present study,we show that vascular endothelial cells are the primary cellular target of sorafenib-induced HFSR wherein soluble heparin-binding epidermal growth factor(s-HBEGF)mediates the crosstalk between vascular endothelial cells and keratinocytes.Mechanistically,s-HBEGF released from vascular endothelial cells activates the epidermal growth factor receptor(EGFR)on keratinocytes and promotes the phosphorylation of c-Jun N-terminal kinase 2(JNK2),which stabilizes sirtuin 1(SIRT1),an essential keratinization inducer,and ultimately gives rise to HFSR.The administration of s-HBEGF in vivo could sufficiently induce hyper-keratinization without sorafenib treatment.Furthermore,we report that HBEGF neutralization antibody,Sirtl knockdown,and a classic SIRTI inhibitor nicotinamide could all significantly reduce the sorafenib-induced HFSR in the mouse model.It is noteworthy that nicotinic acid,a prodrug of nicotinamide,could substantially reverse the sorafenib-induced HFSR in ten patients in a preliminary clinical study.Collectively,our findings reveal the mechanism of vascular endothelial cell-promoted keratinization in keratinocytes and provide a potentially promising therapeutic strategy for the treatment of sorafenib-induced HFSR. | Peihua Luo Hao Yan Xueqin Chen Ying Zhang Ziying Zhao Ji Cao Yi Zhu Jiangxia Du Zhifei Xu Xiaochen Zhang Su Zeng Bo Yang Shenglin Ma Qiaojun He | 2020 | Cell Research2020，30，9： | 5 |
| 2 | 查看详情显示文摘 | Luo Shenglin Zhang Erlong Su Yongping | | 0，，： | 1 |
| 3 | Improvement of surface wetting properties of poly(p-phenylene benzoxazole) by incorporation of ionic groups显示文摘 | Luo Kaiqing Jin Junhong Yang Shenglin | 2006 | Materials Science and Engineering B2006，132，12： | 1 |
| 4 | Polysaccharide from Loquat Leaves to Prepare Hierarchical Porous Carbon as a Matrix for Active Sulfur显示文摘Fossil fuel exhaustion and overdevelopment usually lead to a recession,which is worsened by the environmental pollution.So it is of high priority to develop high-efficiency energy storage device.Here,agreen and environment-friendly strategy is devised to fabricate carbon materials from biomass.By water extraction and alcohol precipitation,polysaccharide is extracted from loquat leaves.After calcining under high temperature,hierarchical porous carbon materials(HPCM)are obtained,possessing a variety of macropores,mesopores and micropores.Such ample and hierarchical pores enable the electrolyte infiltration and the buffering of the volume expansion of sulfur in repeated electrochemical reactions.The structure stability of the entire electrode can thus be well maintained.When evaluated as the scaffold for sulfur,the electrochemical performance of carbon/sulfur composite was tested.Even after 500 cycles,the reversible capacity is retained as high as 485.4 mA·h/g at the current density of 1.6 A/g.It also offers a notable rate capability,attaining the discharge capacity of 700.7 mA·h/g at 2 C.All the electrochemical performance results prove the feasibility of the proposed strategy. | Luo Rui Xiong Shenglin | 2018 | Transactions of Nanjing University of Aeronautics and Astronautics2018，35，4： | 0 |
| 5 | Detection of False Data Injection Attacks on Load Frequency Control System with Renewable Energy Based on Fuzzy Logic and Neural Networks显示文摘Load frequency control(LFC)system may be destroyed by false data injection attacks(FDIAs)and consequently the security of the power system will be impacted.High-efficiency FDIA detection can reduce the damage and power loss to the power system.This paper defines various typical and hybrid FDIAs,and the influence of several FDIAs with different characteristics on the multi-area LFC system is analyzed.To detect various attacks,we introduce an improved data-driven method,which consists of fuzzy logic and neural networks.Fuzzy logic has the features of high applicability,robustness,and agility,which can make full use of samples.Further,we construct the LFC system on MATLAB/Simulink platform,and systematically simulate the experiments that FDIAs affect the LFC system by tampering with measurement data.Among them,considering the large-scale penetration of renewable energy with intermittency and volatility,we generate three simulation scenarios with or without renewable energy generation.Then,the performance for detecting FDIAs of the improved method is verified by simulation data samples. | Ziyu Chen Jizhong Zhu Shenglin Li Yun Liu Tengyan Luo | 2022 | Journal of Modern Power Systems and Clean Energy2022，10，6： | 0 |
| 6 | PRELIMINARY STRUCTURE-ACTIVITY RELATIONSHIP STUDY OF HEPTA METHINE INDOCY ANINE DYES FOR TUMOR-TARGETED IMAGING显示文摘Our research has identified a couple of near-infrared(NIR)heptamethine indocyanine dyes exhibiting preferential tumor accumnulation property for in vriwo imaging.On the basis of our foregoing work,we describe here a preliminary structure-activity relationship(SAR)study of 11 related heptamethine indocyanine dyes and several essential requirements of these structures for in vivo tumor-targeted imaging. | QINYUAN GUO SHENGLIN LUO QINGRONG QI HUNMENG SHI | 2013 | Journal of Innovative Optical Health Sciences2013，6，1： | 0 |
| 7 | Identification of a mitochondria-targeting fluorescent small molecule for dual phototherapy显示文摘Phototherapy,mainly induding photodynamic therapy(PDT)and photothermal therapy(PTT),is a noninvasive and effective approach for cancer treatment.Since integration of PDT and PTT for simultaneous synergistic PDT/PTT treatment enables us to improve phototherapeutic eficacy significantly,it has been attracting a lot of investigations in current days.Here,we introduce IR-52,a new mitochondria-targeting near infrared(NIR)fAuorescent small molecule,which possesses structure inherent PTT and PDT synergistic photother apeutic effects wit hout conjugation to specific ligands.After NIR light irradiation(808 nm,2 W/cm^(2),5min),both the hyperthermia and excessive singlet oaxygen levels were determined when dis-solving IR-52 in aqueous sohutions.In vitro photoinduced cytotoxicity studies showed signifcant lower cell viabilities and higher necrotic/apoptotic rates when cancer cells were treated with IR-52 and irradiation,and its'mitochondrial localization in cancer cells would partially explain its high cytotoxicity.Further in vivo synergetic PDT and PTT effects were demonstrated by high tumor surface temperature and sigmificant inhibition of tumor growth.Our results strongly suggest that IR-52,which possesses excellent photosensitivity,may provide a promising strategy for tumor treatment with decreased side effects. | Jie Chen Xu Tan Shenglin Luo Lei Long Lang Liu Zujuan Liu Yu Wang Chunmeng Shi | 2018 | Journal of Innovative Optical Health Sciences2018，，4： | 0 |
| 8 | Regulating local electric field to optimize the energy storage performance of antiferroelectric ceramics via a composite strategy显示文摘Electrostatic energy storage technology based on dielectrics is the basis of advanced electronics and high-power electrical systems.High polarization(P)and high electric breakdown strength(Eb)are the key parameters for dielectric materials to achieve superior energy storage performance.In this work,a composite strategy based on antiferroelectric dielectrics(AFEs)has been proposed to improve the energy storage performance.Here,AlN is selected as the second phase for the(Pb_(0.915)Ba_(0.04)La_(0.03))(Zr_(0.65)Sn_(0.3)Ti_(0.05))O_(3)(PBLZST)AFEs,which is embedded in the grain boundaries to construct insulating networks and regulate the local electric field,improving the Eb.Meanwhile,it is emphasized that AFEs have the AFE–FE and FE–AFE phase transitions,and the increase of the phase transition electric fields can further improve the recoverable energy density(Wrec).As a result,the Eb increases from 180 to 290 kV·cm−1 with a simultaneous increase of the phase transition electric fields,magnifying the Wrec to~144%of the pristine PBLZST.The mechanism for enhanced Eb and the phase transition electric fields is revealed by the finite element simulation method.Moreover,the PBLZST:1.0 wt%AlN composite ceramics exhibit favorable temperature stability,frequency stability,and charge–discharge ability,making the composite ceramics a promising candidate for energy storage applications. | Ying Yang Zhanming Dou Kailun Zou Kanghua Li Wei Luo Wen Dong Guangzu Zhang Qiuyun Fu Shenglin Jiang | 2023 | Journal of Advanced Ceramics2023，12，3： | 0 |
| 9 | LsAP2 regulates leaf morphology by inhibiting CIN-like TCP transcription factors and repressing LsKAN2 in lettuce显示文摘Leaf size and flatness directly affect photosynthesis and are closely related to agricultural yield.The final leaf size and shape are coordinately determined by cell proliferation,differentiation,and expansion during leaf development.Lettuce(Lactuca sativa L.)is one of the most important leafy vegetables worldwide,and lettuce leaves vary in shape and size.However,the molecular mechanisms of leaf development in lettuce are largely unknown.In this study,we showed that the lettuce APETALA2(LsAP2)gene regulates leaf morphology.LsAP2 encodes a transcriptional repressor that contains the conserved EAR motif,which mediates interactions with the TOPLESS/TOPLESS-RELATED(JPL/TPR)corepressors.Overexpression of LsAP2 led to small and crinkly leaves,and many bulges were seen on the surface of the leaf blade.LsAP2 physically interacted with the CINCINNATA(CIN)-like TEOSINTE BRANCHED1/CYCLOIDEA/PROLIFERATING CELL FACTOR(TCP)transcription factors and inhibited their transcriptional activation activity.RNA sequencing analysis showed that LsAP2 affected the expression of auxin-and polarity-related genes.In addition,LsAP2 directly repressed the abaxial identity gene KANAD12(LsKAN2).Together,these results indicate that LsAP2 regulates leaf morphology by inhibiting CIN-like TCP transcription factors and repressing LsKAN2,and our work provides insights into the regulatory mechanisms of leaf development in lettuce. | Chen Luo Shenglin Wang Kang Ning Zijing Chen Yixin Wang Jingjing Yang Qian Wang | 2021 | Horticulture Research2021，8，1： | 0 |
| 10 | Time-course transcriptome landscape of achene development in lettuce显示文摘Lettuce(Lactuca sativa L.),which belongs to the large Asteraceae(Compositae)family,breeds by sexual reproduction and produces seeds.Actually,lettuce seeds are achenes,which are defined as fruits.However,few studies have described the morphological characteristics of the lettuce achenes,and genes essential for achene development are largely unknown in lettuce.To investigate the gene activity during achene development and determine the possible mechanisms that influence achene development in lettuce,we performed a time-course transcriptome analysis of lettuce achenes.A total of 27,390 expressed genes were detected at the five achene development stages.We investigated the gene expression patterns during achene development and identified the enriched biological processes at the corresponding stages.Kyoto Encyclopedia of Genes and Genomes and Gene Ontology analyses revealed a variety of transcriptomic similarities and differences at different achene development stages.Further,transcription factors and phytohormones were found to play important roles during achene development.Finally,we proposed a working model to illustrate the gene expression modules and possible molecular mechanisms underlying achene development.Our time-course transcriptome data also provide a foundation for future functional studies to reveal the genetic control of achene development in lettuce. | Chen Luo Shenglin Wang Kang Ning Zijing Chen Jingjing Yang Yixin Wang Meixia Qi Qian Wang | 2022 | Horticultural Plant Journal2022，8，1： | 0 |
| 11 | Integrated sensor based on acoustics-electricity-mechanics coupling effect for wireless passive gas detection显示文摘Integrated sensor combines multiple sensor functions into a single unit,which has the advantages of miniaturization and better application potential.However,limited by the sensing platforms of the sensor and the selectivity of the sensitive film,there are still challenges to realize multi-component gas detection in one unit.Herein,a principle integration method is proposed to achieve the multi-component gas detection based on the acoustics-electricity-mechanics coupling effect.The electrical and mechanical properties of the Bi_(2)S_(3)nanobelts materials in different atmospheres indicate the possibility of realizing the principle integration.At the same time,the surface acoustic wave(SAW)sensor as a multivariable physical transducer can sense both electrical and mechanical properties.Upon exposure to 10 ppm NO_(2),NH_(3),and their mixtures,the integrated SAW gas sensor shows a 4.5 kHz positive frequency shift(acoustoelectric effect),an 11 kHz negative frequency shift(mechanics effects),and a reduced 4 kHz negative frequency shift(acoustics-electricity-mechanics coupling effect),respectively.Moreover,we realize wireless passive detection of NO_(2)and NH_(3)based on the SAW sensor.Our work provides valuable insights that can serve as a guide to the design and fabrication of single sensors offering multi-component gas detection via different gas sensing mechanisms. | Licheng Zhou Bohui Zhai Zhixiang Hu Mingqi Zhang Long Li Xiangxin Wang Guangzu Zhang Jingting Luo Honglang Li Bingbing Chen Shenglin Jiang Hua-Yao Li Huan Liu | 2023 | Nano Research2023，16，2： | 0 |
| 12 | Applications of smartphone-based near-infrared(NIR)imaging,measurement,and spectroscopy technologies to point-of-care(POC)diagnostics显示文摘The role of point-of-care(POC)diagnostics is important in public health.With the support of smartphones,POC diagnostic technologies can be greatly improved.This opportunity has arisen from not only the large number and fast spread of cell-phones across the world but also their improved imaging/diagnostic functions.As a tool,the smartphone is regarded as part of a compact,portable,and low-cost system for real-time POC,even in areas with few resources.By combining near-infrared(NIR)imaging,measurement,and spectroscopy techniques,pathogens can be detected with high sensitivity.The whole process is rapid,accurate,and low-cost,and will set the future trend for POC diagnostics.In this review,the development of smartphone-based NIR fluorescent imaging technology was described,and the quality and potential of POC applications were discussed. | Wenjing HUANG Shenglin LUO Dong YANG Sheng ZHANG | 2021 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2021，22，3： | 0 |
| 13 | Point-defect-driven flattened polar phonon bands in fluorite ferroelectrics显示文摘The scale-free ferroelectric polarization of fluorite MO_(2)(M=Hf,Zr)due to flat polar phonon bands are promising for nonvolatile memories.Defects are also widely introduced to improve the emergent ferroelectricity.However,their roles are still not fully understood at the atomic-level.Here,we report a significant effect of point-defect-driven flattening of polar phonon bands with more polar modes and polarization contribution in doped MO_(2).The polar phonon bands in La-doped MO_(2)(M=Hf,Zr)can be significantly flattened,compared with pure ones.However,the lower energy barrier with larger polarization of VO-only doped MO_(2) compared with La-doped cases suggest that VO and local lattice distortion should be balanced for high-performance fluorite ferroelectricity.The work is believed to bridge the relation between point defects and the generally enhanced induced ferroelectricity in fluorite ferroelectrics at the atomic-level and inspire their further property optimization via defect-engineering. | Pu Ai Fengjun Yan Wen Dong Shi Liu Junlei Zhao Kan-Hao Xue Syed Ul Hasnain Bakhtiar Yilong Liu Qi Ma Ling Miao Mengyuan Hua Guangzu Zhang Shenglin Jiang Wei Luo Qiuyun Fu | 2023 | npj Computational Materials2023，，1： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员