|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Numerical Simulation and Experimental Study of the Submarine's Cold Wake Temperature Character显示文摘The temperature difference of the submarine's wake on the sea surface is the base for the IR detection. In this paper, the temperature difference on the sea surface caused by the submarine's propellers and the submarine's hull is studied by solving the three dimensional N-S equations. The results show that under the condition of sea temperature surroundings of minus gradient, such as in summer the upper water's temperature is higher than the lower water, it is cold wake on the sea surface and hot wake on the submarine's plane. The temperature difference between the wake and the water around in the wake's initial part becomes more and more obvious as the wake's distance gets longer. Through the IR camera, the submarine's propeller wake is studied under the same temperature status. Obvious IR temperature difference signals can be observed and it is consistent with the numerical simulation for the submarine. | CHEN Shengtao ZHONG Jingjun SUN Peng | 2014 | Journal of Thermal Science2014，23，3： | 8 |
| 2 | Preclinical efficacy against acute myeloid leukaemia of SH1573, a novel mutant IDH2 inhibitor approved for clinical trials in China显示文摘Acute myeloid leukaemia(AML) is the most common form of acute leukaemia in adults,with increasing incidence with age and a generally poor prognosis.Almost 20% of AML patients express mutant isocitrate dehydrogenase 2(mIDH2),which leads to the accumulation of the carcinogenic metabolite 2-hydroxyglutarate(2-HG),resulting in poor prognosis.Thus,global institutions have been working to develop mIDH2 inhibitors.SH1573 is a novel mIDH2 inhibitor that we independently designed and synthesised.We have conducted a comprehensive study on its pharmacodynamics,pharmacokinetics and safety.First,SH1573 exhibited a strong selective inhibition of mIDH2 R140 Q protein,which could effectively reduce the production of 2-HG in cell lines,serum and tumors of an animal model.It could also promote the differentiation of mutant AML cell lines and granulocytes in PDX models.Then,it was confirmed that SH1573 possessed characteristics of high bioavailability,good metabolic stability and wide tissue distribution.Finally,toxicological data showed that SH1573 had no effects on the respiratory system,cardiovascular system and nervous system,and was genetically safe.This research successfully promoted the approval of SH1573 for clinical trials(CTR20200247).All experiments demonstrated that,as a potential drug against mIDH2 R140 Q acute myeloid leukaemia,SH1573 was effective and safe. | Zhiqiang Wang Zhibo Zhang Yong Li Li Sun Dezhen Peng Danyu Du Xian Zhang Luwei Han Liwen Zhao Ligong Lu Hongzhi Du Shengtao Yuan Meixiao Zhan | 2021 | Acta Pharmaceutica Sinica B2021，11，6： | 3 |
| 3 | Robust filtering for discrete-time piecewise impulsive sys-tems显示文摘 | PAN Shengtao SUN Jitao ZHAO Shouwei | 2010 | Signal Processing2010，90，1： | 1 |
| 4 | The influence of YS-I on the Dll4-Notchl signaling pathway显示文摘在这研究,我们在表明小径的 Dll4-Notch1 调查了角色和 p43 和 YS-1 (recombinant 人 p43 蛋白质) 的分子的机制。p43 蛋白质指向的活跃、小介入的 RNA 和 recombinant plasmid 被用来感染人的脐的静脉 endothelial 房间(HUVEC ) 。三维的发芽模型, endothelial 房间移植试金,并且发芽并且试管形成试金被用来在 angiogenesis 推出 p43 和 YS-1 的函数。半量的反向的抄写聚合酶链反应和西方的污点分析被执行在在 HUVEC 发信号的 Dll4-Notch1 检测 p43 的效率。它被发现 p43 的那 silencing 和 overexpression 能 upregulate Dll4 槽口并且刺激 angiogenesis。p43 在 angiogenesis 起一个复杂作用。当集中在 100 nM 下面时,它支持 angiogenesis;相反,当集中是超过 100 nM 时,它禁止 angiogenesis。在这研究,我们发现 p43 的表示水平在 60 nM 下面。然而, recombinant 人 p43 蛋白质, YS-1,发芽的禁止的 endothelial 房间,和 YS-1 的 500 g/ml 稀释了 Dll4-Notch1 发信号的激活。这些结果建议 YS-1 能直接通过 Dll4-Notch1 信号 transduction 小径禁止 angiogenesis,当 p43 在这条发信号的小径起一个 modulating 作用时。 | Li Sun Qingqing Yang Ping Wang Datao Liu Wenlu Liang Sensen Lin Shengtao Yuan | 2014 | Acta Biochimica et Biophysica Sinica2014，46，1： | 1 |
| 5 | Charge density wave phase suppression in 1T-TiSe_(2) through Sn intercalation显示文摘Taking advantage of the unique layered structure of TiSe2,the intrinsic electronic properties of two-dimensional materials can easily be tuned via heteroatomic engineering.Herein,we show that the charge density wave(CDW)phase in 1T-TiSe_(2) single-crystals can be gradually suppressed through Sn atoms intercalation.Using angle-resolved photoemission spectroscopy(ARPES)and temperature-dependent resistivity measurements,this work reveals that Sn atoms can induce charge doping and modulate the intrinsic electronic properties in the host 1T-TiSe_(2).Notably,our temperature-dependent ARPES results highlight the role exciton-phonon interaction and the Jahn-Teller mechanism through the formation of backfolded bands and exhibition of a downward Se shift of 4p valence band in the formation of CDW in this material. | Mukhtar Lawan Adam Hongen Zhu Zhanfeng Liu Shengtao Cui Pengjun Zhang Yi Liu Guobin Zhang Xiaojun Wu Zhe Sun Li Song | 2022 | Nano Research2022，15，3： | 1 |
| 6 | Enmein-type diterpenoid analogs from natural kaurene-type oridonin: Synthesis and their antitumor biological evaluation显示文摘 | Dahong Li Shengtao Xu Hao Cai Lingling Pei Hengyuan Zhang Lei Wang Hequan Yao Xiaoming Wu Jieyun Jiang Yijun Sun Jinyi Xu | 2013 | European Journal of Medicinal Chemistry2013，，： | 1 |
| 7 | Carbon dots for optical imaging in vivo显示文摘 | Yang Shengtao Cao li Sun Yaping | 2009 | J Am Chem Soc2009，131，11： | 1 |
| 8 | Carbon dots as nontoxic and high-performance fluorescence imaging agents 显示文摘 | Sun Yaping Yang Shengtao Wang Xin | 2009 | J Phys Chem C2009，113，18： | 1 |
| 9 | Improvement of surface flashover performance in vacuum by co-firing Mo/A1203 cermets and Al2O3 ceramics 显示文摘 | LI Shengtao ZHANG Tuo SUN Jian | 2010 | IEEE Trans on DEI2010，17，6： | 1 |
| 10 | The Realization and Discussion of the Credit Risk Evaluation System显示文摘 | Shengtao Sun Xinsheng Wang | 2006 | 通讯和计算机(中英文版)2006，3，5： | 1 |
| 11 | Cloning and characterization of a novel Athspr promoter specifically active in vascular tissue显示文摘 | Liang Zhang Tao Yang Xiaoying Li Hongyan Hao Shengtao Xu Wei Cheng Yingli Sun Chongying Wang | 2014 | Plant Physiology and Biochemistry2014，，： | 1 |
| 12 | Tuning the electric transport behavior of AgCrSe_(2) by intrinsic defects显示文摘The two-dimensional(2 D)structure often leads to unusual phenomena for the impact of confined mean free path of carrier scattering.As a quasi-2 D layered material,Ag CrSe_(2)has a liquid-like phonon behavior for its unstable Ag atoms at service temperature,leading to the promising candidate for thermoelectricity and fast ionic conductor.However,the inferior electronic performance constrains its application prospects as a functional semiconductor,which provides broad opportunity to tune its electric behaviors by defect chemistry.In this work,we revealed abundant electric transport behaviors of Ag CrSe_(2)with different types of intrinsic defects.For example,the Ag CrSe_(2)changes from Anderson insulator to metal when Se defects become prevailing and the magnetoresistance alters its sign depending on the relative ratio of Ag and Cr defects.Our results reported here can give salutary boosting on regulating the electric properties of ternary transition metal selenide by defect chemistry. | Yang Hua Wei Bai Sheng Wang Yunbo Wu Shengtao Cui Zhe Sun Chong Xiao | 2021 | Science China Chemistry2021，64，11： | 0 |
| 13 | Prediction of fiber Rayleigh scattering responses based on deep learning显示文摘Distributed acoustic sensing(DAS) is a fiber sensing technology based on Rayleigh scattering,which transforms optical fiber into a series of sensing units. It has become an indispensable part in the field of seismic monitoring, vehicle tracking, and pipeline monitoring. Fiber Rayleigh scattering responses lay at the core of DAS. However, there are few in-depth studies on the purpose of acquiring fiber Rayleigh scattering responses. In this paper, we establish a deep learning framework based on the bidirectional gated recurrent unit, which is the first time to predict the fiber Rayleigh scattering responses, to the best of our knowledge. The deep learning framework is trained with a numerical simulation dataset only, but it can process experimental data successfully. Moreover, since the responses could have a wider effective bandwidth than the experimental probing pulses, a finer spatial resolution could be obtained after demodulation. This work indicates that the deep learning framework can capture the characteristics of the fiber Rayleigh scattering responses effectively, which paves the way for intelligent DAS. | Yongxin LIANG Jianhui SUN Jialei ZHANG Yuyao WANG Anchi WAN Shibo ZHANG Zhenyu YE Shengtao LIN Zinan WANG | 2023 | Science China(Information Sciences)2023，66，12： | 0 |
| 14 | Persistence of charge density wave against variation of band structures in V_(x)Ti_(1−x)Se_(2)(x=0–0.1)显示文摘Charge density wave(CDW)is a phenomenon that occurs in materials,accompanied by changes in their intrinsic electronic properties.The study of CDW and its modulation in materials holds tremendous significance in materials research,as it provides a unique approach to controlling the electronic properties of materials.TiSe_(2) is a typical layered material with a CDW phase at low temperatures.Through V substitution for Ti in TiSe_(2),we tuned the carrier concentration in V_(x)Ti_(1-x)Se_(2) to study how its electronic structures evolve.Angle-resolved photoemission spectroscopy(ARPES)shows that the band-folding effect is sustained with the doping level up to 10%,indicating the persistence of the CDW phase,even though the band structure is strikingly different from that of the parent compound TiSe_(2).Though CDW can induce the band fold effect with a driving force from the perspective of electronic systems,our studies suggest that this behavior could be maintained by lattice distortion of the CDW phase,even if band structures deviate from the electron-driven CDW scenario.Our work provides a constraint for understanding the CDW mechanism in TiSe_(2),and highlights the role of lattice distortion in the band-folding effect. | Zhanfeng Liu Tongrui Li Wen Zhu Hongwei Shou Mukhtar Lawan Adam Qilong Cui Yuliang Li Sheng Wang Yunbo Wu Hongen Zhu Yi Liu Shuangming Chen Xiaojun Wu Shengtao Cui Li Song Zhe Sun | 2024 | Nano Research2024，17，3： | 0 |
| 15 | Value of Coronary Sinus During Computed Tomography Pulmonary Angiography for Predicting Pulmonary Hypertension in Patients with Acute Pulmonary Embolism显示文摘Objective:Computed tomography pulmonary angiography(CTPA)parameters are valuable for predicting pulmonary hypertension(PH)in patients with pulmonary embolism(PE).However,few studies have used the coronary sinus ostium area(CSOA),derived from CTPA,to detect PH.This study aimed to compare the prognostic values of the CSOA,coronary sinus ostium diameter(CSOD),and right ventricular(RV)/left ventricular(LV)ratio for PH.Methods:This study retrospectively analyzed 78 patients(mean age,(51.94±12.33)years;53.8%male)with acute PE confirmed by CTPA at the Sixth and Eighth Medical Centers of the People’s Liberation Army General Hospital between June 2018 and June 2020.Patients were categorized into 2 groups using a pulmonary artery systolic pressure(PASP)cut-off of 30 mmHg.CTPA parameters were compared between these groups.Results:Patients with PASP>30 mmHg(n=22)had a larger CSOA,CSOD,RV diameter,RV/LV ratio,and inferior vena cava diameter compared with patients with PASP≤30 mmHg(n=56).The CSOA had an area under the receiver-operating characteristic curve(AUC,0.84;95%confidence interval(CI),0.74–0.94;P<0.001)similar to that of the RV/LV ratio(AUC,0.85;95%CI,0.73–0.99;P<0.001),while that of the CSOD was smaller(AUC,0.66;95%CI,0.51–0.81;P<0.05).Conclusion:Both CSOA and CSOD demonstrated a good ability to predict PH,while CSOA better predicted PASP>30 mmHg. | Chuang Zhang Qian Xin Hongling Xu Xiangyu Wang Zhiqiang Yan Shengtao Sun Xiangmin Shi Mei Tian | 2023 | Cardiology Discovery2023，3，2： | 0 |
| 16 | Superior high-temperature wear resistance of an Ir-Ta-Ni-Nb bulk metallic glass显示文摘Wear resistance is a critical consideration in engineering applications.In this study,we demonstrated an Ir-Ta-Ni-Nb bulk metallic glass(BMG)with outstanding high-temperature wear resistance and revealed its promising applications in extreme environments.The wear behavior and mechanism were systemati-cally investigated from room temperature(RT)to 750℃.The results show that the wear rate increases from∼2.65×10^(-6)mm^(3)N^(-1)m^(-1)to∼10.56×10^(-6)mm^(3)N^(-1)m^(-1)in the temperature span RT to 400℃,following abrasive wear and flash temperature-induced oxidative wear during the friction.However,at the higher temperature of 600℃,further heating due to frictional heat leads to a softening of the wear surface,resulting in a maximum wear rate of∼20.99×10^(-6)mm^(3)N^(-1)m^(-1)under softness-driven abrasive wear as well as oxidative wear.Interestingly,the wear resistance at an even higher temperature of 750℃shows a paradoxical improvement of∼7.08×10^(-6)mm^(3)N^(-1)m^(-1),which is attributed to the formation of an oxide layer with a thickness of several microns,avoiding violent wear of BMG.The re-sults demonstrate the unreported outstanding high-temperature wear resistance of the Ir-Ta-Ni-Nb BMG,especially its excellent capability to resist wear at 750℃,leading to the promising applications of BMG in the fields of aerospace,metallurgy,and nuclear industries. | Fei Sun Shengtao Deng Jianan Fu Jiahua Zhu Dandan Liang Pengfei Wang Hang Zhao Feng Gong Jiang Ma Yanhui Liu Jun Shen | 2023 | Journal of Materials Science & Technology2023，，27： | 0 |
| 17 | Semantic analysis and retrieval of spatial data based on the uncertain ontology model in Digital Earth显示文摘Metadata are the information about and description of data.In Digital Earth,metadata become variant and heterogeneous with many uncertainties.This paper studies uncertain features in the generation and application of metadata,and two types of uncertainties(incomplete and imprecise)are described based on semantic quantitative measurement method semantic relationship quantitative measurement based on possibilistic logic and probability statistic(SRQ-PP).Moreover,in the case study,we apply two types of quantitative measurements based on SRQ-PP to describe incomplete(uncertain)knowledge and imprecise(vague)information separately in spatial data service retrieval,which in turn is helpful to identify additional potential data resources and provide a quantitative analysis of the results. | Shengtao Sun Lizhe Wang Rajiv Ranjan Aizhi Wu | 2015 | International Journal of Digital Earth2015，8，1： | 0 |
| 18 | Numerical Simulation of the Stokes Wave for the Flow around a Ship Hull Coupled with the VOF Model显示文摘流动在在水的免费表面附近移动的轮船壳附近产生的表面波浪在这研究数字地被模仿。三维的含蓄的有限体积方法(FVM ) 被使用解决雷纳兹平均海军司烧(RANS ) 方程。可实现的 k-e 骚乱模型被实现了在免费表面地区在轮船壳附近捕获狂暴的流动。方法结合了的液体(VOF ) 的体积 Stokes 波浪理论被用来决定水的免费表面效果。由使用是一自由的六度当模特儿,轮船壳运动数字地一起与 Stokes 波浪被解决。在行动下面司烧海,在空气之间的接口和在一样的常规模式并且那么的水波浪上的波浪做压力和垂直速度。轮船壳搬到象波浪的一样的方法。轮船壳举的振幅是不到波浪高度因为抑制的粘性。这个方法能为轮船运动,波浪和水动力学的学习提供一本重要参考书。 | Shengtao Chen Jingjun Zhong Peng Sun | 2015 | Journal of Marine Science and Application2015，14，2： | 0 |
| 19 | Recent advances in small incision lenticule extraction(SMILE)-derived refractive lenticule preservation and clinical reuse显示文摘Small incision lenticule extraction(SMILE)has become one of the mainstream refractive surgeries in recent years,with satisfactory efficacy,safety,and predictability.SMILE-derived refractive lenticule,the byproduct of the surgery,holds great potential in clinical practice given its easy access and good biocompatibility.Numerous studies have been published to describe its applications in refractive correction,corneal ectasia diseases,and corneal defects.The feasibility and safety were validated in both animal models and clinical studies.Moreover,the preservation method is also crucial for its further promotion and application.Novel techniques are also evaluated and applied in lenticule preservation.We covered the recent advances in the preservation of corneal stromal lenticules and their clinical reuse in this review. | Xiaojun Hu Ruoyan Wei Chang Liu Yunzhe Wang Danjuan Yang Ling Sun Fei Xia Shengtao Liu Meiyan Li Xingtao Zhou | 2023 | Engineered Regeneration2023，4，2： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员