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| 1 | 使用OCT评估中心性浆液性脉络膜视网膜病变患者脉络膜厚度的变化显示文摘目的:使用光谱域光学相干断层成像(SD-OCT)技术研究中心性浆液性脉络膜视网膜病变(CSCR)3mo后脉络膜厚度的变化。方法:前瞻性研究。共纳入60眼,20眼(平均年龄:33.65±5.24岁)典型急性单侧中心性浆液性脉络膜视网膜病变以及对侧正常眼,20眼为健康对照组。进行荧光素血管造影和OCT检查。测量中心凹下脉络膜厚度(SFCT),黄斑中心凹视网膜厚度(CMT),到中央凹和视网膜下液1000μm处颞部和鼻部。结果:在三个不同的位置,三组间的SFCT差异有统计学意义。中心性浆液性脉络膜视网膜病变眼中心凹下脉络膜厚度(372.40±34.39μm)在基线和随访3mo后均显著大于对侧正常眼(302.10±8.9μm)和对照组眼(279.80±14.49μm)。CSCR眼平均CMT为317±141.86μm,并且SFCT与CMT呈显著正相关。结论:不同部位脉络膜厚度的增加,以及被称为“厚脉络膜”的过度扩张和高渗透血管,似乎在包括中心性浆液性脉络膜视网膜病变在内的广泛疾病中起着重要作用。 | Ragai Magdy Hatata Mohamed Abdelhamid Nassif Sherin Hassan Sadek | 2020 | 国际眼科杂志2020，20，4： | 5 |
| 2 | Hepatocellular carcinoma in Egypt: A single center study over a decade显示文摘AIM: To identify the trend, possible risk factors and any pattern change of hepatocellular carcinoma (HCC) in Egyptover a decade.METHODS: All HCC patients attending Cairo Liver Center between January 1993 and December 2002, were enrolledin the study. Diagnosis of HCC was based on histopath ological examination and/or detection of hepatic focal lesions by two imaging techniques plus α-fetoprotein level above 200 ng/mL. The duration of the study was divided into two periods of 5 years each; period Ⅰ (1993-1997) and period Ⅱ (1998-2002). Trend, demographic features of patients (age, gender, and residence), risk factors (HBsAg,HCV-Ab, schistosomiasis and others) and pattern of the focal lesions were compared between the two periods.Logistic regression model was fitted to calculate the adjusted odds ratios for the potential risk factors. The population attributable risk percentage was calculated to estimate the proportion of HCC attributed to hepatitis B and C viral infections.RESULTS: Over a decade, 1 328 HCC patients out of 22 450 chronic liver disease (CLD) patients were diagnosed with an overall proportion of 5.9%. The annual proportion of HCC showed a significant rising trend from 4.0% in 1993 to 7.2% in 2002 (P = 0.000). A significant increase in male proportion from 82.5% to 87.6% (P = 0.009); M/F from 5:1 to 7:1 and a slight increase of the predominant age group (40-59 years) from 62.6% to 66.8% (P = 0.387)in periods Ⅰ and Ⅱ respectively, reflecting a shift to younger age group. In the bivariate analysis, HCC was significantly higher in rural residents, patients with history of schistosomiasis and/or blood transfusion. Yet, after adjustment, these variables did not have a significant risk for development of HCC. There was a significant decline of HBsAg from 38.6% to 20.5% (P = 0.000), and a slight increase of HCV-Ab from 85.6% to 87.9% in periods Ⅰ and Ⅱ respectively. HBV conferred a higher risk to develop HCC more than HCV in period Ⅰ (OR 1.9 vs 1.6) and period Ⅱ (OR 2.7 vs 2.0), but the relative contribution of HBV for development of HCC declined in period Ⅱ compared to period Ⅰ (PAR% 4.2%, 21.32%). At presentation,diagnostic α-fetoprotein level (≥200 ng/mL) was demonstrated in 15.6% vs28.9% and small HCC (≤3 cm)represented 14.9% vs 22.7% (P = 0.0002) in periods Ⅰ and Ⅱ respectively.CONCLUSION: Over a decade, there was nearly a twofold increase of the proportion of HCC among CLD patients in Egypt with a significant decline of HBV and slight increase of HCV as risk factors. α-Fetoprotein played a limited role in diagnosis of HCC, compared to imaging techniques.Increased detection of small lesions at presentation reflects increased awareness of the condition. | Adbel-Rahman El-Zayadi Hanaa M Badran Eman MF Barakat Mohy El-Deen Attia Sherine Shawky Mostafa K Mohamed Osaima Selim Ahmed Saeid | 2005 | World Journal of Gastroenterology2005，11，33： | 5 |
| 3 | Assessment of lnc RNA GAS5, lnc RNA HEIH, lnc RNA BISPR and its m RNA BST2 as serum innovative non-invasive biomarkers: Recent insights into Egyptian patients with hepatitis C virus type 4显示文摘BACKGROUND Hepatitis C virus(HCV)infection and its consequent complications are undeniably a public health burden worldwide,particularly in Egypt.Emerging evidence suggests that many lncRNAs have relevant roles in viral infections and antiviral responses.AIM To investigate the expression profiles of circulating lncRNAGAS5,lncRNAHEIH,lncRNABISPR and mRNABST2 in naïve,treated and relapsed HCV Egyptian patients,to elucidate relation to HCV infection and their efficacy as innovative biomarkers for the diagnosis and prognosis of HCV GT4.METHODS One hundred and thirty HCV-infected Egyptian patients and 20 healthy controls were included in this study.Serum lncRNAs and mRNABST2 were measured using quantitative real-time polymerase chain reaction(qRT-PCR).RESULTS Our results indicated that serum lncRNAGAS5 and LncRNABISPR were upregulated,whereas mRNA BST2 and LncRNA HEIH were downregulated in naïve patients.In contrast,HCV patients treated with sofosbuvir and simeprevir;with sofosbuvir and daclatasvir;or with sofosbuvir,daclatasvir and ribavirin exhibited lower levels of lncRNAGAS5 and lncRNABISPR with higher mRNABST2 compared to naïve patients.Notably,patients relapsed from sofosbuvir and simeprevir showed higher levels of these lncRNAs with lower mRNABST2 compared to treated patients.LncRNAGAS5 and lncRNABISPR were positively correlated with viral load and ALT at P<0.001,whereas mRNABST2 was negatively correlated with viral load at P<0.001 and ALT at P<0.05.Interestingly,a significant positive correlation between lncRNA HEIH and AFP was observed at P<0.001.CONCLUSION Differential expression of these RNAs suggests their involvement in HCV pathogenesis or antiviral response and highlights their promising roles in diagnosis and prognosis of HCV. | Nourhan M El Samaloty Marwa I Shabayek Ramy S Ghait Shohda A El-Maraghy Sherine M Rizk Maha M El-Sawalhi | 2020 | World Journal of Gastroenterology2020，26，2： | 2 |
| 4 | Glucose Metabolism in the Late Preterm Infant显示文摘 | Meena Garg Sherin U. Devaskar | 2006 | Clinics in Perinatology2006，，4： | 2 |
| 5 | Making an impact on mortaLity in rheumatoid arthritis:targeting cardiovascuLar comorbidity显示文摘 | Maarten Boers Ben Dijkmans Sherine GabrieL | 2004 | Arthritis Rheum2004，50，： | 1 |
| 6 | Peltzman effect and resurgence of COVID-19 in India显示文摘With a daily rise of over 400000 cases,the deadly COVID-19 wave has gripped India with grim milestones.India’s test positivity rate(TPR)was 16%with 1356133 tests[1,2](Figure 1).The number is still steeply climbing and has burdened the already overwhelmed health system.A frightening situation of lack of availability of hospital beds and critical care units has been witnessed in several states in recent days. | Simi Thankappan Sherin Nedumpillil | 2021 | Asian Pacific Journal of Tropical Medicine2021，14，5： | 1 |
| 7 | Peroxidative breskdown of phospholipids in human spermatozoa, spermicidal property of fatty acid peroxides, and protective action of seminal plasma显示文摘 | JONES R MANN T SHERINS R | 1997 | Fertil Steril1997，31，7： | 1 |
| 8 | Coronary Neutrophil Extracellular Trap Burden and Deoxyribonuclease Activity in ST-Elevation Acute Coronary Syndrome Are Predictors of ST-Segment Resolution and Infarct Size显示文摘 | Andreas Mangold Sherin Alias Thomas Scherz Thomas Hofbauer Johannes Jakowitsch Adelheid Panzenb?ck Daniel Simon Daniela Laimer Christine Bangert Andreas Kammerlander Julia Mascherbauer Max-Paul Winter Klaus Distelmaier Christopher Adlbrecht Klaus T. Preis | 2015 | Circulation Research2015，，7： | 1 |
| 9 | Anisotropie chemical reactivity of gold spheroids and nanorods显示文摘 | Nikhil R Jana Latha Gearheart Sherine O Obare | 2002 | Langmuir2002，18，3： | 1 |
| 10 | Effects of postoperative adjuvant chemotherapy and radiotherapy on ovarian function in women undergoing treatment for soft tissue sarcoma显示文摘 | Shamberger RC Sherins RJ Ziegler JL | 1981 | J Natl Cancer Inst1981，67，6： | 1 |
| 11 | Determinants of patient′s adherence to hypertension medications in a rural population of Kancheepuram District in Tamil Nadu, South India显示文摘 | J Venkatachalam Sherin Abrahm Zile Singh P Stalin G Sathya | 2015 | Indian Journal of Community Medicine2015，，： | 1 |
| 12 | ICTECT-CBIR : Integrating Curvelettransform with enhanced dominant colors extractionand texture analysis for efficient content-based imageretrieval 显示文摘 | Sherin M Y | 2012 | Computers and Electrical Engineering2012，38，5： | 1 |
| 13 | Evidence for induction of germinal aplasia in male rats by environmental exposure to boron显示文摘 | Lee I P Sherins R J Dixon R | 1978 | Toxicology and Applied Pharmacology1978，45，2： | 1 |
| 14 | Intracytoplasmic sperm injection facilitates fertilization even in the most severe forms of male infertility: pregnancy outcome correlates with maternal age and number of eggs available显示文摘 | Thorsell L P Dorfmann A | 1995 | Fertil Steril1995，64，2： | 1 |
| 15 | Hypoglycemia induced behavioural deficit and decreased GABA receptor, CREB expres- sion in the cerebellum of streptozoticin induced diabetic rats 显示文摘 | Sherin A Peeyush KT Naijil G | 2010 | Brain Res Bull2010，83，6： | 1 |
| 16 | Percutaneous testicular sperm aspiration:a convenient and effective office procedure to reteive sperm for in vitro fertilization with intracytop lasmic sperm injection显示文摘 | BELKER A M SHERINS R J DENNISON LAGOS L | 1998 | The Journal of U rology1998，160，6： | 1 |
| 17 | Innervation of hista-minergic tuberomammillary neurons by GABAergic and galaniner-gic neurons in the ventrolateral preoptic nucleus of the rat 显示文摘 | Sherin J E Elmquist J K Torrealba F | 1998 | JNeurosci1998，18，12： | 1 |
| 18 | Immunogenicity and safety of an investigational AS02 v -adjuvanted hepatitis B vaccine in patients with renal insufficiency who failed to respond or to maintain antibody levels after prior vaccination: Results of two open, randomized, comparative trials显示文摘 | Christian L. Tielemans Jiri Vlasak Dezider Kosa Jean-Marie Billiouw Gert A. Verpooten Ilona Mezei Miroslav Ryba Patrick C. Peeters Olivier Mat Michel Y. Jadoul Vladimir Polakovic Michel Dhaene Serge Treille Sherine O. Kuriyakose Maarten Leyssen Sophie A. | 2010 | Vaccine2010，，： | 1 |
| 19 | Correlation between changes in diastolic dys- function and health-related quality of life after cardiac rehabil- itation program in dilated cardiomyopathy 显示文摘 | SHERIN H M M | 2013 | Journal of Ad- vanced Research2013，4，2： | 1 |
| 20 | Jacqueline griesdom and Louellen finn //Creating social relation- ships ; the role of technology in preservice teacher prepara- tion 显示文摘 | Louis M Gomez Miriam Gamoran Sherin | 2008 | Journal of Teacher Education2008，，： | 1 |
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