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| 1 | Receptor activator of NF-κB Ligand (RANKL) expression is associated with epithelial to mesenchymal transition in human prostate cancer cells显示文摘 | Valerie A Odero-Marah Ruoxiang Wang Gina Chu Majd Zayzafoon Jianchun Xu Chunmeng Shi Fray F Marshall Haiyen E Zhau Leland WK Chung | 2008 | Cell Research2008，18，8： | 6 |
| 2 | Imatinib as preoperative therapy in Chinese patients with recurrent or metastatic GISTs显示文摘Objective: Imatinib has dramatically altered the options for management of patients with gastrointestinal stromal tumours. However, it has become clear that secondary resistance to the drug develops during long-term therapy. The purpose of our study was to retrospectively analyze safety and long-term outcomes in Chinese patients with recurrent or metastatic GISTs treated with imatinib preoperatively. Methods: Between June 2003 and June 2011, 22 patients underwent surgery for recurrent or metastatic GISTs after preoperative treatment with imatinib. Results: Complete resection was accomplished in 8 of the 10 responsive disease (RD) patients (80%), and in 3 of the 12 patients (25%) who had progression disease (PD). The amount of blood loss during the operation in PD patients was higher than in RD patients. There was 1 hospital death in PD group related to surgery, while the other patients recovered with conservative therapy because complications were mild. The difference in median PFS between patients with RD and those with PD was significant (24.8 vs. 2.81 months, P<0.001). The difference in 2-year OS rate between patients with RD and those with PD was not significant (100% vs. 87.5%, P>0.05). Conclusions: Our study indicates that surgical intervention can improve the PFS of Chinese patients with recurrent or metastatic GISTs responsive to imatinib, but does not prolong OS as well as in patients who develop imatinib resistance. Surgical resection following imatinib treatment is feasible and can be considered for patients with advanced GISTs responsive to imatinib. | Chunmeng Wang Biqiang Zheng Yong Chen Xi Cao Ruming Zhang Yingqiang Shi | 2013 | Chinese Journal of Cancer Research2013，25，1： | 6 |
| 3 | An analytical biomarker for treatment of patients with recurrent B-ALL after remission induced by infusion of anti-CD19 chimeric antigen receptor T(CAR-T) cells显示文摘Anti-CD19 chimeric antigen receptor-modified T(CAR-T-19) cells have emerged as a powerful targeted immunotherapy for B-cell lineage acute lymphoblastic leukemia with a remarkable clinical response in recent trials. Nonetheless, few data are available on the subsequent clinical monitoring and treatment of the patients, especially those with disease recurrence after CAR-T-19 cell infusion. Here, we analyzed three patients who survived after our phase I clinical trial and who were studied by means of biomarkers reflecting persistence of CAR-T-19 cells in vivo and predictive factors directing further treatment. One patient achieved 9-week sustained complete remission and subsequently received an allogeneic hematopoietic stem cell transplant. Another patient who showed relapse after 20 weeks without detectable leukemia in the cerebrospinal fluid after CAR-T-19 cell treatment was able to achieve a morphological remission under the influence of stand-alone low-dose chemotherapeutic agents. The third patient gradually developed extensive extramedullary involvement in tissues with scarce immune-cell infiltration during a long period of hematopoietic remission after CAR-T-19 cell therapy. Long-term and discontinuous increases in serum cytokines(mainly interleukin 6 and C-reactive protein) were identified in two patients(Nos. 1 and 6) even though only a low copy number of CAR molecules could be detected in their peripheral blood. This finding was suggestive of persistent functional activity of CAR-T-19 cells. Combined analyses of laboratory biomarkers with their clinical manifestations before and after salvage treatment showed that the persistent immunosurveillance mediated by CAR-T-19 cells would inevitably potentiate the leukemia-killing effectiveness of subsequent chemotherapy in patients who showed relapse after CAR-T-19-induced remission. | Yajing Zhang Wenying Zhang Hanren Dai Yao Wang Fengxia Shi Chunmeng Wang Yelei Guo Yang Liu Meixia Chen Kaichao Feng Yan Zhang Chuanjie Liu Qingming Yang Suxia Li Weidong Han | 2016 | Science China(Life Sciences)2016，59，4： | 6 |
| 4 | Cellular senescence is a promising target for chronic wounds:a comprehensive review显示文摘Chronic wounds include,but are not limited to,radiation ulcers,pressure ulcers,vascular ulcers and diabetic foot ulcers.These chronic wounds can persist for years without healing and severe ulcers may lead to amputation.Unfortunately,the underlying pathologies of refractory chronic wounds are not fully characterized,and new treatments are urgently needed.Recently,increasing evidence has indicated that cell senescence plays an important role in the development of chronic wounds,and preventing cell senescence or removing senescent cells holds promise as a new therapeutic strategy.In this review,we aim to probe these latest findings to promote the understanding of cellular senescence in the pathological process and potential management of chronic wounds. | Ziwen Wang Chunmeng Shi | 2020 | Burns & Trauma2020，8，1： | 2 |
| 5 | PC4 serves as a negative regulator of skin wound healing in mice显示文摘Background:Human positive cofactor 4(PC4)was initially characterized as a multifunctional transcriptional cofactor,but its role in skin wound healing is still unclear.The purpose of this study was to explore the role of PC4 in skin wound healing through PC4 knock-in mouse model.Methods:A PC4 knock-in mouse model(PC4^(+/+))with a dorsal full-thickness wound was used to investigate the biological functions of PC4 in skin wound healing.Quantitative PCR,Western blot analysis and immunohistochemistry were performed to evaluate the expression of PC4;Sirius red staining and immunofluorescence were performed to explore the change of collagen deposition and angiogenesis.Proliferation and apoptosis were detected using Ki67 staining and TUNEL assay.Primary dermal fibroblasts were isolated from mouse skin to perform cell scratch experiments,cck-8 assay and colony formation assay.Results:The PC4^(+/+)mice were fertile and did not display overt abnormalities but showed an obvious delay in cutaneous healing of dorsal skin.Histological staining showed insufficient re-epithelialization,decreased angiogenesis and collagen deposition,increased apoptosis and decreased cell proliferation in PC4^(+/+)skin.Our data also showed decreased migration rate and proliferation ability in cultured primary fibroblasts from PC4^(+/+)mice in vitro.Conclusions:This study suggests that PC4 might serve as a negative regulator of skin wound healing in mice. | Fengying Liao Long Chen Peng Luo Zhongyong Jiang Zelin Chen Ziwen Wang Chi Zhang Yu Wang JintaoHe Qing Wang Yawei Wang Lang Liu Yu Huang Huilan Wang Qingzhi Jiang Min Luo YiboGan Yunsheng Liu Yang Wang Jie Wu Wentao Xie Zhuo Cheng Yali Dai Jialun Li Zujuan Liu Fan Yang Chunmeng Shi | 2020 | Burns & Trauma2020，8，1： | 1 |
| 6 | The Fibroblast Growth Factor Receptor-4 Arg388 Allele is Associated with Gastric Cancer Progression显示文摘 | Yanwei Ye Yingqiang Shi Ye Zhou Chunyan Du Chunmeng Wang Heqin Zhan Biqiang Zheng Xi Cao Meng-hong Sun Hong Fu | 2010 | Annals of Surgical Oncology2010，，12： | 1 |
| 7 | The correlations between the expression of FGFR4 protein and clinicopathological parameters as well as prognosis of gastric cancer patients显示文摘 | Yan‐Wei Ye Xiefu Zhang Ye Zhou Jianghong Wu Chunlin Zhao Lin Yuan Guojun Wang Chunyan Du Chunmeng Wang Yingqiang Shi | 2012 | Oncol2012，，7： | 1 |
| 8 | Quantum dots: Emerging applications in urologic oncology显示文摘 | Shi Chunmeng Zhu Ying | 2008 | Urologic Oncofogy2008，26，1： | 1 |
| 9 | The Fibroblast Growth Factor Receptor-4 Arg388 Allele is Associated with Gastric Cancer Progression显示文摘 | Yanwei Ye MD Yingqiang Shi MD Ye Zhou MD Chunyan Du MD Chunmeng Wang MD Heqin Zhan PhD Biqiang Zheng PhD Xi Cao MD Meng-hong Sun MD Hong Fu MD | 2010 | Annals of Surgical Oncology2010，，12： | 1 |
| 10 | Cyanine dyes in optical imaging of tumours显示文摘 | Chunmeng Shi Chao Zhang Yongping Su Tianmin Cheng | 2010 | Lancet Oncology2010，，9： | 1 |
| 11 | Bone Marrow Derivation of Interstitial Cells of Cajal in Small Intestine Following Intestinal Injury显示文摘 | Dengqun Liu Fengchao Wang Zhongmin Zou Shiwu Dong Junping Wang Xinze Ran Chunxue Li Chunmeng Shi Yongping Su Ronnie Gallagher | 2010 | Journal of Biomedicine and Biotechnology2010，，： | 1 |
| 12 | Engraftment of bone marrow-derived cells after nonlethal radiation in syngeneic C57BL/6mice显示文摘 | Wu Liao Tan Li Wang Yu Liu Dengqun Shi Chunmeng WuLiao TanLi WangYu LiuDengqun ShiChunmeng | 2015 | 中华放射医学与防护杂志2015，35，1： | 0 |
| 13 | General principles of developing novel radioprotective agents for nuclear emergency显示文摘With the rapid application of nuclear energy and radiological technology in national economy and military field,the risk of nuclear accidents increases as well.Exposure to irradiation causes severe damages to the human body,and radioprotective agents are required for medical protection.To find the safe and effective radioprotective agents is the key for nuclear emergency.Recently,Toll like receptors(TLRs)and PHD-HIF oxygen sensing signal pathway have been extensively studied for radioprotection.Great progress has been made in this field and a number of radioprotective agents have been found.In this review,we have summarized recent findings of radioprotective roles of TLRs signaling pathway and PHD-HIF signaling pathway and discussed the general principles of developing novel radioprotective agents.These findings will provide opportunities for developing new strategies to prevent IR-induced injuries in public health events. | Jicong Du Pei Zhang Ying Cheng Ruling Liu Hu Liu Fu Gao Chunmeng Shi Cong Liu | 2020 | Radiation Medicine and Protection2020，1，3： | 0 |
| 14 | Identification of a mitochondria-targeting fluorescent small molecule for dual phototherapy显示文摘Phototherapy,mainly induding photodynamic therapy(PDT)and photothermal therapy(PTT),is a noninvasive and effective approach for cancer treatment.Since integration of PDT and PTT for simultaneous synergistic PDT/PTT treatment enables us to improve phototherapeutic eficacy significantly,it has been attracting a lot of investigations in current days.Here,we introduce IR-52,a new mitochondria-targeting near infrared(NIR)fAuorescent small molecule,which possesses structure inherent PTT and PDT synergistic photother apeutic effects wit hout conjugation to specific ligands.After NIR light irradiation(808 nm,2 W/cm^(2),5min),both the hyperthermia and excessive singlet oaxygen levels were determined when dis-solving IR-52 in aqueous sohutions.In vitro photoinduced cytotoxicity studies showed signifcant lower cell viabilities and higher necrotic/apoptotic rates when cancer cells were treated with IR-52 and irradiation,and its'mitochondrial localization in cancer cells would partially explain its high cytotoxicity.Further in vivo synergetic PDT and PTT effects were demonstrated by high tumor surface temperature and sigmificant inhibition of tumor growth.Our results strongly suggest that IR-52,which possesses excellent photosensitivity,may provide a promising strategy for tumor treatment with decreased side effects. | Jie Chen Xu Tan Shenglin Luo Lei Long Lang Liu Zujuan Liu Yu Wang Chunmeng Shi | 2018 | Journal of Innovative Optical Health Sciences2018，，4： | 0 |
| 15 | Therapeutic implications of exosomes in the treatment of radiation injury显示文摘Radiotherapy is one of the main cancer treatments,but it may damage normal tissue and cause various side effects.At present,radioprotective agents used in clinics have side effects such as nausea,vomiting,diarrhea and hypotension,which limit their clinical application.It has been found that exosomes play an indispensable role in radiation injury.Exosomes are lipid bilayer vesicles that carry various bioactive substances,such as proteins,lipids and microRNA(miRNA),that play a key role in cell-to-cell communication and affect tissue injury and repair.In addition,studies have shown that radiation can increase the uptake of exosomes in cells and affect the composition and secretion of exosomes.Here,we review the existing studies and discuss the effects of radiation on exosomes and the role of exosomes in radiation injury,aiming to provide new insights for the treatment of radiation injury. | Shijie Dai Yuzhong Wen Peng Luo Le Ma Yunsheng Liu Junhua Ai Chunmeng Shi | 2022 | Burns & Trauma2022，10，1： | 0 |
| 16 | Enhanced autophagy protects hepatic cells from radiation injury显示文摘 | Liu Lang Liu Dengqun Wang Yu Wang Ziwen Chen Zelin Chert Jie Han Xiao Liu Zujuan Zhang Aihua Shi Chunmeng | 2018 | 中华放射医学与防护杂志2018，38，5： | 0 |
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