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| 1 | Recent advances and prospects toward blue perovskite materials and light-emitting diodes显示文摘Perovskite based light-emitting diodes(PeLEDs)have become a powerful candidate for next-generation solid-state lightings and high-definition displays due to their high photoluminescence quantum yield(PLQY),tunable emission wavelength over the visible spectrum,and narrow emission linewidths.Over the past few years,the development of red-and green-emissive PeLEDs has rapidly increased,and the corresponding external quantum efficiencies(EQE)have exceeded 20%.However,the research progress of blue-emitting PeLEDs is limited by its poor material quality and inappropriate device structure.Currently,the maximum EQE of blue PeLED is only 6.2%,which is far from the industrialization requirements.In order to promote the development of blue PeLEDs,we summarize the recent research progress of blue perovskite materials and LEDs and discuss several fatal challenges,mainly embodied in low efficiency and poor stability.In order to overcome these challenges,detailed analysis and strategies are put forward in terms of the materials and devices.For the former,we summarize the feasible strategy for the preparation of efficient and stable blue-emissive perovskites using component engineering.For the latter,we analyze the advantages and limitations of the different strategies for blue-emissive perovskite in LEDs.At the end of the review,a comprehensive outlook is detailed,including future development directions and several technical problems to be solved.Thus,we aim to highlight the significance and promote the industrialization of PeLEDs. | Tao Fang Fengjuan Zhang Shichen Yuan Haibo Zeng Jizhong Song | 2019 | InfoMat2019，1，2： | 9 |
| 2 | Parallel selection of distinct Tof5 alleles drove the adaptation of cultivated and wild soybean to high latitudes显示文摘Photoperiod responsiveness is a key factor limiting the geographic distribution of cultivated soybean and its wild ancestor.In particular,the genetic basis of the adaptation in wild soybean remains poorly understood.In this study,by combining whole-genome resequencing and genome-wide association studies we identified a novel locus,Time of Flowering 5(Tof5),which promotes flowering and enhances adaptation to high latitudes in both wild and cultivated soybean.By genomic,genetic and transgenic analyses we showed that Tof5 en-codes a homolog of Arabidopsis thaliana FRUITFULL(FUL).Importantly,further analyses suggested that different alleles of Tof5 have undergone parallel selection.The Tof5H1 allele was strongly selected by humans after the early domestication of cultivated soybean,while Tof5H2 allele was naturally selected in wild soybean,and in each case facilitating adaptation to high latitudes.Moreover,we found that the key flowering repressor E1 suppresses the transcription of Tof5 by binding to its promoter.In turn,Tof5 physically associates with the promoters of two important FLOWERING LOCUS T(FT),FT2a and FT5a,to upregulate their transcription and promote flowering under long photoperiods.Collectively,ourfindings provide insights into how wild soybean adapted to high latitudes through natural selection and indicate that cultivated soybean underwent changes in the same gene but evolved a distinct allele that was artificially selected after domestication. | Lidong Dong Qun Cheng Chao Fang Lingping Kong Hui Yang Zhihong Hou Yongli Li Haiyang Nan Yuhang Zhang Qingshan Chen Chunbao Zhang Kun Kou Tong Su Lingshuang Wang Shichen Li Haiyang Li Xiaoya Lin Yang Tang Xiaohui Zhao Sijia Lu Baohui Liu Fanjiang Kong | 2022 | Molecular Plant2022，15，2： | 5 |
| 3 | Effect of electro-scalp acupuncture on acute ischemic stroke: a randomized, single blind, trial显示文摘OBJECTIVE: To determine the clinical efficacy and safety of electro-scalp acupuncture in the treatment of patients with acute ischemic stroke.METHODS: Totally 74 patients with acute ischemic stroke were enrolled and divided into either body acupuncture(Control) or electro-scalp acupuncture(ESA) groups according to randomized controlled principle. The patients in the control group weregiven body acupuncture treatment once daily for28 d, whereas except for the body acupuncture,electro-scalp acupuncture was additional treatment given to the ESA group. Neurological deficits,everyday motor function and muscle strength were evaluated at baseline and the 28 th d by NIH Stroke Scale(NIHSS), Fugl-Meyer Assessment(FMA) and Modified Barthel Index Score(MBI), respectively.RESULTS: There were not obvious between-group differences in the baseline efficacy parameters(NIHSS, FMA and MBI)(all P > 0.05), whereas significant between-group differences were found in post-treatment NIHSS, FMA-UE and MBI scores(all P < 0.05). After acupuncture treatment, systematic within-group improvements were found in the two groups for any of the efficacy parameters assessed(all P < 0.01), and the ESA group showed higher significant improvements in NIHSS, FMA-UE and MBI scores(all P < 0.05).CONCLUSION: Electro-scalp acupuncture was efficacious in the treatment of acute ischemic stroke,which resulted in meaningful improvements in neurologic function, motor function and activities of daily living of patients. | Liu Xiaoxi Zhang Xuezhu Nie Kun Jia Yujie Li Jing Ling Zhenzhen Wang Yao Chang Shichen | 2018 | Journal of Traditional Chinese Medicine2018，38，1： | 5 |
| 4 | Fluid Property Discrimination in Dolostone Reservoirs Using Well Logs显示文摘The Ordovician Majiagou Formation is one of the main gas-producing strata in the Ordos Basin,China.The identification of hydrocarbon-bearing intervals via conventional well logs is a challenging task.This study describes the litholog of Ma 5(Member 5 of Majiagou Formation)dolostones,and then analyzes the responses of various conventional well logs to the presences of natural gas.The lithology of the gas bearing layers is dominantly of the dolomicrite to fine to medium crystalline dolomite.Natural gas can be produced from the low resistivity layers,and the dry layers are characterized by high resistivities.Neutron-density crossovers are not sensitive to the presences of natural gas.In addition,there are no significant increases in sonic transit times in natural gas bearing layers.NMR(nuclear magnetic resonance)logs,DSI(Dipole Sonic Imager)logs and borehole image logs(XRMI)are introduced to discriminate the fluid property in Majiagou dolostone reservoirs.The gas bearing intervals have broad NMR T2(transverse relaxation time)spectrum with tail distributions as well as large T2gm(T2 logarithmic mean values)values,and the T2 spectrum commonly display polymodal behaviors.In contrast,the dry layers and water layers have low T2gm values and very narrow T2 spectrum without tails.The gas bearing layers are characterized by low Vp/Vs ratios,low Poisson’s ratios and low P-wave impedances,therefore the fluid property can be discriminated using DSI logs,and the interpretation results show good matches with the gas test data.The apparent formation water resistivity(AFWR)spectrum can be derived from XRMI image logs by using the Archie’s formula in the flushed zone.The gas bearing layers have broad apparent formation water resistivity spectrum and tail distributions compared with the dry and water layers,and also the interpretation results from the image logs exhibit good agreement with the gas test data.The fluid property in Majiagou dolostone reservoirs can be discriminated through NMR logs,DSI logs and borehole image logs.This study helps establish a predictable model for fluid property in dolostones,and have implications in dolostone reservoirs with similar geological backgrounds worldwide. | WANG Guiwen LAI Jin LIU Bingchang FAN Zhuoying LIU Shichen SHI Yujiang ZHANG Haitao CHEN Jing | 2020 | Acta Geologica Sinica(English Edition)2020，94，3： | 4 |
| 5 | Cryo-EM structures of human m^(6)A writer complexes显示文摘N6-methyladenosine(m^(6)A)is the most abundant ribonucleotide modification among eukaryotic messenger RNAs.The m^(6)A“writer”consists of the catalytic subunit m^(6)A-METTL complex(MAC)and the regulatory subunit m^(6)A-METTL-associated complex(MACOM),the latter being essential for enzymatic activity.Here,we report the cryo-electron microscopy(cryo-EM)structures of MACOM at a 3.0-Åresolution,uncovering that WTAP and VIRMA form the core structure of MACOM and that ZC3H13 stretches the conformation by binding VIRMA.Furthermore,the 4.4-Åresolution cryo-EM map of the MACOM–MAC complex,combined with crosslinking mass spectrometry and GST pull-down analysis,elucidates a plausible model of the m^(6)A writer complex,in which MACOM binds to MAC mainly through WTAP and METTL3 interactions.In combination with in vitro RNA substrate binding and m^(6)A methyltransferase activity assays,our results illustrate the molecular basis of how MACOM assembles and interacts with MAC to form an active m^(6)A writer complex. | Shichen Su Shanshan Li Ting Deng Minsong Gao Yue Yin Baixing Wu Chao Peng Jianzhao Liu Jinbiao Ma Kaiming Zhang | 2022 | Cell Research2022，32，11： | 3 |
| 6 | Drug-loaded balloon with built-in NIR controlled tip-separable microneedles for long-effective arteriosclerosis treatment显示文摘Drug-eluting balloon(DEB)angioplasty has emerged as an effective treatment for cardiovascular and cerebrovascular diseases.However,distal embolism and late lumen restenosis could be caused by drug loss during DEB handling and rapid drug metabolization.Here,a drug-loaded balloon equipped with tip-separable microneedles on the balloon surface(MNDLB)was developed.Inbuilt near-infrared(NIR)ring laser inside the catheter inner shaft was introduced to activate the biodegradable microneedle tips for the first time.The drug-loaded tips thus could be embedded in the vasculature and then released antiproliferative drug-paclitaxel slowly via polymer degradation for more than half a year.A significant increase in drug delivery efficiency and superior therapeutic effectiveness compared with the standard DEB were demonstrated using an atherosclerosis rabbit model. | Li Huang Huaqiang Fang Teng Zhang Binbin Hu Shichen Liu Fanzhen Lv Zhaoxia Zeng Huijie Liu Weimin Zhou Xiaolei Wang | 2023 | Bioactive Materials2023，，5： | 2 |
| 7 | Variations in OsSPL10 confer drought tolerance by directly regulating OsNAC2 expression and ROS production in rice显示文摘Drought is a major factor restricting the production of rice(Oryza sativa L.).The identification of natural variants for drought stress-related genes is an important step toward developing genetically improved rice varieties.Here,we characterized a member of the SQUAMOSA PROMOTER BINDING PROTEIN-LIKE(SPL)family,OsSPL10,as a transcription factor involved in the regulation of drought tolerance in rice.OsSPL10 appears to play a vital role in drought tolerance by controlling reactive oxygen species(ROS)production and stomatal movements.Haplotype and allele frequency analyses of OsSPL10 indicated that most upland rice and improved lowland rice varieties harbor the OsSPL10Hap1allele,whereas the OsSPL10Hap2allele was mainly present in lowland and landrace rice varieties.Importantly,we demonstrated that the varieties with the OsSPL10Hap1allele showed low expression levels of OsSPL10 and its downstream gene,OsNAC2,which decreases the expression of OsAP37 and increases the expression of OsCOX11,thus preventing ROS accumulation and programmed cell death(PCD).Furthermore,the knockdown or knockout of OsSPL10 induced fast stomatal closure and prevented water loss,thereby improving drought tolerance in rice.Based on these observations,we propose that OsSPL10 confers drought tolerance by regulating OsNAC2 expression and that OsSPL10Hap1could be a valuable haplotype for the genetic improvement of drought tolerance in rice. | Yingxiu Li Shichen Han Xingming Sun Najeeb Ullah Khan Qun Zhong Zhanying Zhang Hongliang Zhang Feng Ming Zichao Li Jinjie Li | 2023 | Journal of Integrative Plant Biology2023，65，4： | 2 |
| 8 | Rice SPL10 positively regulates trichome development through expression of HL6 and auxin-related genes显示文摘Trichomes function in plant defenses against biotic and abiotic stresses;examination of glabrous lines,which lack trichomes,has revealed key aspects of trichome development and function.Tests of allelism in 51 glabrous rice(Oryza sativa)accessions collected worldwide identified OsSPL10 and OsWOX3B as regulators of trichome development in rice.Here,we report that OsSPL10 acts as a transcriptional regulator controlling trichome development.Haplotype and transient expression analyses revealed that variation in the approximately 700-bp OsSPL10 promoter region is the primary cause of the glabrous phenotype in the indica cultivar WD-17993.Disruption of OsSPL10 by genome editing decreased leaf trichome density and length in the NIL-HL6 background.Plants with genotype OsSPL10^(WD-17993)/HL6 generated by crossing WD-17993 with NIL-HL6 also had fewer trichomes in the glumes.HAIRY LEAF6(HL6)encodes another transcription factor that regulates trichome initiation and elongation,and OsSPL10 directly binds to the HL6 promoter to regulate its expression.Moreover,the transcript levels of auxin-related genes,such as OsYUCCA5 and OsPIN-FORMED1b,were altered in OsSPL10 overexpression and RNAi transgenic lines.Feeding tests using locusts(Locusta migratoria)demonstrated that non-glandular trichomes affect feeding by this herbivore.Our findings provide a molecular framework for trichome development and an ecological perspective on trichome functions. | Jinjie Li Bo Tang Yingxiu Li Chenguang Li Minjie Guo Haiyang Chen Shichen Han Jin Li Qijin Lou Wenqiang Sun Peng Wang Haifeng Guo Wei Ye Zhanying Zhang Hongliang Zhang Sibin Yu Long Zhang Zichao Li | 2021 | Journal of Integrative Plant Biology2021，63，8： | 2 |
| 9 | Bufalin loaded biotinylated chitosan nanoparticles: An efficient drug delivery system for targeted chemotherapy against breast carcinoma 显示文摘 | Xin Tian Hongzhuan Yin Shichen Zhang | 2014 | European Journal of Pharmaceutics and Biopharmaceutics2014，87，3： | 1 |
| 10 | Propagation properties of foreshock cavitons: Cluster observations显示文摘Foreshock cavitons are transient phenomena observed in the terrestrial foreshock region.They are characterized by a simultaneous depression of magnetic field magnitude and plasma density,which are bounded with enhancements of these two parameters and surrounded by ultralow frequency(ULF)waves.Previous studies focused on the interplanetary magnetic field(IMF)conditions,solar wind(SW)conditions,and the growth of the foreshock waves related to the generation of foreshock cavitons.Previously,a multipoint spacecraft analysis method using Cluster data was applied to analyze only two foreshock cavitons,and this method did not consider uncertainties.In this study,multipoint spacecraft analysis methods,including the timing method,the minimum directional derivative(MDD)method,and the spatiotemporal difference(STD)method are applied to determine the velocity in both spacecraft and solar wind frames.The propagation properties show good agreement with previous results from simulations and observations that most cavitons move sunward in the solar wind frame,with the velocities larger than the Alfvén speed.The propagation properties of foreshock cavitons support the formation mechanism of cavitons in previous simulations,which suggested that cavitons are formed due to the nonlinear evolution of compressive ULF waves.We find that there is clear decreasing trend between the size of cavitons and their velocity in the solar wind frame.In addition,the timing method considering errors has been applied to study the evolution properties by comparing the velocities with errors of the leading and trailing edges,and we identify three stable cavitons and one contracting caviton,which has not been studied before.Most cavitons should remain stable when they travel toward the Earth’s bow shock.The relationship between the size of foreshock cavitons and their distance from the bow shock is also discussed. | WANG MengMeng YAO ShuTao SHI QuanQi ZHANG Hui TIAN AnMin DEGELING Alexander William ZHANG Shuai GUO RuiLong SUN WeiJie LIU Ji BAI ShiChen SHEN XiaoChen ZHU XiaoQiong FU SuiYan PU ZuYin | 2020 | Science China(Technological Sciences)2020，63，1： | 1 |
| 11 | Formation and Urban Transformation of Lhasa City显示文摘 | ZHANG Yingzi ZHAO Shichen LIU Jiaping | 2011 | Journal of Architectural and Urban Design2011，，6： | 1 |
| 12 | Spatial Composition and Behavior Characteristics of Pilgrimage Routes in Lhasa City, Tibet显示文摘 | ZHANG Yingzi ZHAO Shichen ATUSHI D | 2011 | Journal of Architectural and Planning (Transactions of AIJ)2011，674，4： | 1 |
| 13 | Upconversion nanoparticles regulated drug&gas dual-effective nanoplatform for the targeting cooperated therapy of thrombus and anticoagulation显示文摘Thromboembolism is the leading cause of cardiovascular mortality.Currently,for the lack of targeting,short half-life,low bioavailability and high bleeding risk of the classical thrombolytic drugs,pharmacological thrombolysis is usually a slow process based on micro-pumping.In addition,frequently monitoring and regulating coagulation functions are also required during(and after)the process of thrombolysis.To address these issues,a targeted thrombolytic and anticoagulation nanoplatform(UCATS-UK)is developed based on upconversion nanoparticles(UCNPs)that can convert 808 or 980 nm near-infrared(NIR)light into UV/blue light.This nanoplatform can target and enrich in the thrombus site.Synergistic thrombolysis and anticoagulation therapy thus could be realized through the controlled release of urokinase(UK)and nitric oxide(NO).Both in vitro and in vivo experiments have confirmed the excellent thrombolytic and anticoagulative capabilities of this multifunctional nanoplatform.Combined with the unique fluorescent imaging capability of UCNPs,this work is expected to contribute to the development of clinical thrombolysis therapy towards an integrated system of imaging,diagnosis and treatment. | Shichen Liu Yao Sun Teng Zhang Longtao Cao Zhiwei Zhong Haoxin Cheng Qingqing Wang Zhuang Qiu Weimin Zhou Xiaolei Wang | 2022 | Bioactive Materials2022，7，12： | 1 |
| 14 | Numerical simulation and heat transfer in sand therapy in Uyghur medicine显示文摘 | Zhang Yina Dilina Mahemuty Jiang Shichen | 2009 | Journal of Central South University (Medical Science)2009，34，12： | 1 |
| 15 | The influence of TiO2 · H2O gel on hydrothermal synthesis of SrTiO3 powders显示文摘 | Shichen g Zhang Yuexin Han Bingchen Chen | 2001 | Materials Letters2001，51，11： | 1 |
| 16 | Analytical model test of methods to find the geometry and velocity of magnetic structures显示文摘It is important to determine the dimensionality and velocity information in the study of spatial magnetic structures. Many data analysis theories/techniques are based on the assumption of one or two dimensions. For example, the Grad-Shafranov(GS)reconstruction method assumes a dimensionality of two or less. The Minimum Direction Derivative(MDD) method provides an indication of the dimensionality. For the structure velocity, the components in each dimensionality can be calculated by SpatioTemporal Difference analysis(STD). In order to improve the convenience of use of MDD method, a new parameter Dm quantifying the dimensionality based on MDD eigenvalues is introduced in this paper. The influences of noise/turbulence,separation distance and tetrahedron configuration on MDD and the evaluation of Dmare systematically tested using two analytical models for magnetic structures, representing a magnetic mirror and magnetic flux rope. We tested and gave the threshold values of three quality indicators for MDD results using the flux rope model. We also show that the error induced by turbulence is comparable to that of random noise when the turbulence scales are less than the spacecraft separation. Besides, the accuracy of STD velocity estimation will also be influenced by turbulence for cases with excessively high data time resolution.By using Dm, we show that an ideal model of a mirror-like structure can be divided into one dimension(1-D) and three dimension(3-D) regions. This restricts the applicability of the GS method in mirror-like structures. For example, in a given reconstruction range, the GS error increased from less than 7% to more than 15% by using the data along trajectories in 1-D and 3-D regions as predicated by Dm. Thus, it is important to estimate the structure dimensionality, which can be further used to estimate the reliability of the GS reconstruction map. | TIAN AnMin SHI QuanQi DEGELING Alexander William BAI ShiChen YAO ShuTao ZHANG Shuai | 2019 | Science China(Technological Sciences)2019，62，6： | 1 |
| 17 | Optical - thermal interaction of biological tissue subjected to the surface applied laser irradiation 显示文摘 | JIANG Shichen ZHANG Xuexue | 2005 | Jourary of Optoelectronics Laser2005，16，6： | 1 |
| 18 | Development and validation of InDel markers for identification of QTL underlying flowering time in soybean显示文摘Soybean [Glycine max(L.) Merrill] is a major plant source of protein and oil. An accurate and well-saturated molecular linkage map is a prerequisite for forward genetic studies of gene function and for modern breeding for many useful agronomic traits. Next-generation sequence data available in public databases provides valuable information and offers new insights for rapid and efficient development of molecular markers. In this study, we attempted to show the feasibility and facility of using genomic resequencing data as raw material for identifying putative In Del markers. First, we identified 17,613 In Del sites among 56 soybean accessions and obtained 12,619 primer pairs. Second, we constructed a genetic map with a random subset of 2841 primer pairs and aligned 300 polymorphic markers with the 20 consensus linkage groups(LG). The total genetic distance was 2347.3 c M and the number of mapped markers per LG ranged from 10 to 23 with an average of 15 markers. The largest and smallest genetic distances between adjacent markers were 52.3 c M and 0.1 cM, respectively. Finally, we validated the genetic map constructed by newly developed In Del markers by QTL analysis of days to flowering(DTF) under different environments. One major QTL(qDTF4) and four minor QTL(qDTF20, qDTF13, qDTF12,and q DTF11) on 5 LGs were detected. These results demonstrate the utility of the In Del markers developed in this work for map-based cloning and molecular breeding in soybean. | Jialin Wang Lingping Kong Kanchao Yu Fengge Zhang Xinyi Shi Yanping Wang Haiyang Nan Xiaohui Zhao Sijia Lu Dong Cao Xiaoming Li Chao Fang Feifei Wang Tong Su Shichen Li Xiaohui Yuan Baohui Liu Fanjiang Kong | 2018 | The Crop Journal2018，6，2： | 1 |
| 19 | El Ni?o/Southern Oscillation during the 4.2 ka event recorded by growth rates of corals from the North South China Sea显示文摘The 4.2 ka event that occurred during the period from 4 500–3 900 a BP was characterized by cold and dry climates and resulted in the collapse of civilizations around the world. The cause of this climatic event, however, has been under debate. We collected four corals(Porites lutea) from Yongxing Island, Xisha Islands, South China Sea, dated them with the U-series method, and measured the annual coral growth rates using X-ray technology. The dating results showed that the coral growth ages were from 4 500–3 900 a BP, which coincide well with the period of the4.2 ka event. We then reconstructed annual sea surface temperature anomaly(SSTA) variations based on the coral growth rates. The growth rate-based SSTA results showed that the interdecadal SSTA from 4 500–3 900 a BP was lower than that during modern times(1961–2008 AD). A spectral analysis showed that the SSTA variations from4 500–3 900 a BP were under the influence of El Nino-Southern Oscillation(ENSO) activities. From 4 500–4 100 a BP, the climate exhibited La Nina-like conditions with weak ENSO intensity and relatively stable and lower SSTA amplitudes. From 4 100–3 900 a BP, the climate underwent a complicated period of ENSO variability and showed alternating El Nino-or La Nina-like conditions at interdecadal time scales and large SSTA amplitudes. We speculate that during the early and middle stages of the 4.2 ka event, the cold climate caused by weak ENSO activities largely weakened social productivity. Then, during the end stages of the 4.2 ka event, the repeated fluctuations in the ENSO intensity caused frequent extreme weather events, resulting in the collapse of civilizations worldwide. Thus, the new evidence obtained from our coral records suggests that the 4.2 ka event as well as the related collapse of civilizations were very likely driven by ENSO variability. | Shaohua Dang Kefu Yu Shichen Tao Tao Han Huiling Zhang Wei Jiang | 2020 | Acta Oceanologica Sinica2020，39，1： | 1 |
| 20 | Principal component analysis method applying to earthquake -damaged reservoir* s comprehensive Evaluation 显示文摘 | Zheng Haoyao Sheng Jinbao Zhang Shichen Sun Weiwei | 2012 | ProcediaEngineering2012，，107： | 1 |
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