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| 1 | De novo mutation in ATP6V1B2 impairs lysosome acidification and causes dominant deafness-onychodystrophy syndrome显示文摘 | Yongyi Yuan Jianguo Zhang Qing Chang Jin Zeng Feng Xin Jianjun Wang Qingyan Zhu Jing Wu Jingqiao Lu Weiwei Guo Xukun Yan Hui Jiang Binfei Zhou Qi Li Xue Gao Huijun Yuan Shiming Yang Dongyi Han Zixu Mao Ping Chen Xi Lin Pu Dai | 2014 | Cell Research2014，24，11： | 13 |
| 2 | DETECTION OF LONGITUDINAL DEFECT IN PIPES USING TORSIONAL MODES显示文摘多模式并且在管子中驱散扭力的模式的特征 reinvestigated 理论上并且试验性地。根本频率,最低扭力的模式的阶段速度和组速度(0,1 ) 7 不变、相等砍波浪速度。7 (0,1 ) 模式根本频率是最快的扭力的模式。在实验, 7 (0,1 ) 模式在用 9 厚度的管子中激动、收到砍颤动模式压电的陶器的元素。而且, 4 m 的一个人工的纵的缺点长管子用 7 被检测(0,1 ) 模式 at50 kHz。它为纵的缺点察觉在是可行的试验性的结果表演用 7 尖叫(0,1 ) 超声的指导波浪的模式。 | LIU Zenghua WU Bin HE Cunfu YANG Shiming WANG Xiuyan | 2006 | Chinese Journal of Mechanical Engineering2006，19，1： | 7 |
| 3 | Blunted nitric oxide regulation in Tibetans under high-altitude hypoxia显示文摘Nitric oxide(NO) is an important molecule for vasomotor tone, and elevated NO signaling was previously hypothesized as a unique and adaptive physiological change in highland Tibetans. However, there has been lack of NO data from Tibetans living at low altitude and lowlander immigrants living at high altitude, which is crucial to test this hypothesis. Here, through cross-altitude(1990–5018 m) and cross-population(Tibetans and Han Chinese) analyses of serum NO metabolites(NOx) of 2086 individuals, we demonstrate that although Tibetans have a higher serum NOx level compared to lowlanders, Han Chinese immigrants living at high altitude show an even higher level than Tibetans. Consequently, our data contradict the previous proposal of increased NO signaling as the unique adaptive strategy in Tibetans.Instead, Tibetans have a relatively lower circulating NOx level at high altitude. This observation is further supported by data from the hypoxic experiments using human umbilical vein endothelial cells and gene knockout mice. No difference is detected between Tibetans and Han Chinese for endothelial nitric oxide synthase(e NOS), the key enzyme for circulating NO synthesis, suggesting that e NOS itself is unlikely to be the cause. We show that other NO synthesis-related genes(e.g. GCH1) carry Tibetan-enriched mutations significantly associated with the level of circulating NOx in Tibetans. Furthermore, gene network analysis revealed that the downregulation and upregulation of NOx is possibly achieved through distinct pathways.Collectively, our findings provide novel insights into the physiological and genetic mechanisms of the evolutionary adaptation of Tibetans to high-altitude hypoxia. | Yaoxi He Xuebin Qi Ouzhuluobu Shiming Liu Jun Li Hui Zhang Baimakangzhuo Caijuan Bai Wangshan Zheng Yongbo Guo Duojizhuoma Baimayangji Dejiquzong Bianba Gonggalanzi Yongyue Pan Qula Kangmin Cirenyangji Wei Guo Yangla Yi Peng Xiaoming Zhang Kun Xiang Zhaohui Yang Liangbang Wang Gengdeng Yanfeng Zhang Tianyi Wu Bing Su Chaoying Cui | 2018 | National Science Review2018，5，4： | 7 |
| 4 | Measurements of ^(134)Cs and ^(137)Cs in urine and estimation of the internal dose of an adult exposed to the Chernobyl Accident显示文摘To estimate the internal dose of a Chinese visiting scholar internally contaminated because of the Cherno- byl Accident, the contents of 134Cs and 137Cs in urine were measured using a Ge(Li) γ-spectrometer. The internal doses were calculated based on data from the ICRP Publications. The effective doses from 134Cs and 137Cs were estimated to be 61 μSv and 98 μ Sv, respectively. The sum of 159 μSv was lower than the total effective dose (310 μSv), from the inhalation and ingestion of natural radionuclides. The dose of 131I was also reviewed referring to the UNSCEAR 2000 Report. The equivalent effective dose of 131I was estimated to be 2.9 mSv, 18 times more than the amount of 134Cs and 137Cs. Therefore, it is considered that the earlier estimation of internal doses of 131I is important in evaluating radiation injuries from a nuclear reactor accident. | ZHAO Shuquan HUANG Shibin LIU Shiming HU Heping WU Mingyu XIANG Xiqiao ZHU Guoying | 2007 | Nuclear Science and Techniques2007，18，2： | 5 |
| 5 | Electric conductivity and electric convertibility of potassium acetate in water, ethanol, 2,2,2–trifluoroethanol, 2–propanol and their binary blends显示文摘Salinity gradient energy between the concentrated and diluted electrolyte solutions can be converted to electric energy by using reverse electrodialysis(RED) technology. Electrolyte solution is a vital factor that impacts the energy conversion efficiency. Potassium acetate(KAc) was chosen as solute, and water, ethanol, 2,2,2-trifluoroethanol(TFE), 2-propanol(IPA) and several of their binary mixtures were selected as solvents. Electric conductivity of these solutions were measured under varying conditions. KAc was easily ionized in water and possessed the maximum electric conductivity, following by KAc–H_2O–TFE and KAc–H_2O–ethanol, and then KAc in pure TFE, ethanol, and IPA respectively. For electric convertibility of these solutions working in a RED power generation system, it was found that the KAc–H_2O possessed the maximum power density, and the KAc–ethanol–H_2O possessed the larger open circuit voltage than aqueous KAc solution under the same working condition. Besides, it was observed that both the electric conductivity and electric convertibility were significantly influenced by the concentration and temperature of solution. With the increasing of concentration,electric conductivity of these solutions increased firstly and then reached to the peak, but later it decreased.Solution temperature took a positive impact role to the electric conductivity. Electric conductivity of these solutions can be estimated by using a modified amplitude version of Gaussian peak function. | Xi Wu Shiming Xu Debing Wu Huan Liu | 2018 | Chinese Journal of Chemical Engineering2018，26，12： | 5 |
| 6 | De novo assembly of a Tibetan genome and identification of novel structural variants associated with high-altitude adaptation显示文摘Structural variants(SVs) may play important roles in human adaptation to extreme environments such as high altitude but have been under-investigated. Here, combining long-read sequencing with multiple scaffolding techniques, we assembled a high-quality Tibetan genome(ZF1), with a contig N50 length of 24.57 mega-base pairs(Mb) and a scaffold N50 length of 58.80 Mb. The ZF1 assembly filled 80 remaining N-gaps(0.25 Mb in total length) in the reference human genome(GRCh38). Markedly, we detected17 900 SVs, among which the ZF1-specific SVs are enriched in GTPase activity that is required for activation of the hypoxic pathway. Further population analysis uncovered a 163-bp intronic deletion in the MKL1 gene showing large divergence between highland Tibetans and lowland Han Chinese. This deletion is significantly associated with lower systolic pulmonary arterial pressure, one of the key adaptive physiological traits in Tibetans. Moreover, with the use of the high-quality de novo assembly, we observed a much higher rate of genome-wide archaic hominid(Altai Neanderthal and Denisovan) shared non-reference sequences in ZF1(1.32%–1.53%) compared to other East Asian genomes(0.70%–0.98%),reflecting a unique genomic composition of Tibetans. One such archaic hominid shared sequence-a662-bp intronic insertion in the SCUBE2 gene-is enriched and associated with better lung function(the FEV1/FVC ratio) in Tibetans. Collectively, we generated the first high-resolution Tibetan reference genome, and the identified SVs may serve as valuable resources for future evolutionary and medical studies. | Ouzhuluobu Yaoxi He Haiyi Lou Chaoying Cui Lian Deng Yang Gao Wangshan Zheng Yongbo Guo Xiaoji Wang Zhilin Ning Jun Li Bin Li Caijuan Bai Baimakangzhuo Gonggalanzi Dejiquzong Bianba Duojizhuoma Shiming Liu Tianyi Wu Shuhua Xu Xuebin Qi Bing Su | 2020 | National Science Review2020，7，2： | 4 |
| 7 | Structure variety and its effects on biological activity of tea polysaccharides显示文摘Tea polysaccharides(TPSs),one of the major bioactive ingredients in tea,have been widely studied due to their variety of biological activities,including antioxidant,cancer prevention,hypoglycemia,anti-fatigue,anti-coagulant,anti-obesity and immunomodulatory effect.The biological effectiveness of TPSs has direct relation with their structures such as monosaccharide composition,molecular weight,glycosidic linkages,conformation and others,which can be influenced by tea materials,processing methods,extraction and purification procedures among others.Comparing to the study of tea polyphenols,the exploration of TPSs in structural elucidation and biofunctionality is very preliminary.Yet several factors affecting the structural change of TPSs have been studied and identified.Consequently,the variation of some TPS biological activity brought by the change of TPS structures has been evaluated and preliminary correlation of structure activity relationship of TPSs has been performed.Therefore,this review aims to serve as a summary research report regarding the influencing factors on TPSs structures and consequential effects on the biological activities of TPSs.We hope to provide updated information and systematic references for future study and functional food development of TPSs. | Ting Hu Peng Wu Jianfeng Zhan Weixin Wang Junfeng Shen Meiyan Wang Chi-Tang Ho Shiming Li | 2022 | Food Science and Human Wellness2022，11，3： | 2 |
| 8 | Mechanism and Kinetics of Phase Transformation in Two-phase TiAl-based Alloys显示文摘The aged and quenched microstructures of both alloys, Ti-42at-%Al and Ti-45at -%Al,homogenized in the disordered single phase field. were investigated And the results show that the quinched microstructure is a supersaturated single phase of ordered 22. When the supersaturated phase is aged in the two phase range at 1273 and 1373 K, it will transform to a lamellar microstructure of γ+α2. with a discontinuous decomposition mechanism in Ti-42at-%Al alloy and a semicontinuous decomposition mechanism in T1-45at-%Al alloy. With the methods of quantitative metallograph examination and X-ray diffraction analysis. the relationship between the amount of γ, phase precipitation and the time of isothermal transformation is | Shiming HAO+ and Wen tao WU(Dept. of Mater. Sci., Northeastern University, Shenyang, 110006, China)Chuanxi HAN(Northwest Institute for Nonferrous Metal Research, Bao ji, 721014, China) | 1994 | Journal of Materials Science & Technology1994，10，3： | 2 |
| 9 | Amniotic Membrane Transplantation for Conjunctival Tumor显示文摘Purpose: To evaluate the possibility of amniotic membrane transplantation (AMT) for the treatment of conjunctival tumor.Methods: Preserved AMT was performed in 26 patients (26 eyes) with conjunctival tumor, including 9 eyes (34.62%) with malignant tumor (conjunctival malignant melanoma,corneal and conjunctival squamous cell carcinoma, conjunctival lymphoma), 17 eyes(65.38%) with benign tumor(conjunctival papilloma, conjunctival dermoid tumor, conjunctival nevus, hemangioma etc.).Result: All the patients are followed up for 1 ~53 months. No acute rejection was observed after preserved AMT. Ideal healing was found in conjunctiva wound.Conclusion: Preserved AMT is a very effective method to repair wound after giant conjunctival tumor operation. Complete removal of tumor and perfect fixation are the key of ocular surface reconstruction. | Zhicong Chen, Jianhua Yan, Huasheng Yang, Zhongyao Wu Youjian Pang, Shiming Ai, Yuxiang Mao Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou 510060, China | 2003 | Eye Science2003，19，3： | 2 |
| 10 | Anomaly detection in smart grid based on encoder-decoder framework with recurrent neural network显示文摘Anomaly detection in smart grid is critical to enhance the reliability of power systems.Excessive manpower has to be involved in analyzing the measurement data collected from intelligent motoring devices while performance of anomaly detection is still not satisfactory.This is mainly because the inherent spatio-temporality and multi-dimensionality of the measurement data cannot be easily captured.In this paper,we propose an anomaly detection model based on encoder-decoder framework with recurrent neural network(RNN).In the model,an input time series is reconstructed and an anomaly can be detected by an unexpected high reconstruction error.Both Manhattan distance and the edit distance are used to evaluate the difference between an input time series and its reconstructed one.Finally,we validate the proposed model by using power demand data from University of California,Riverside(UCR) time series classification archive and IEEE 39 bus system simulation data.Results from the analysis demonstrate that the proposed encoder-decoder framework is able to successfully capture anomalies with a precision higher than 95%. | Zheng Fengming Li Shufang Guo Zhimin Wu Bo Tian Shiming Pan Mingming | 2017 | The Journal of China Universities of Posts and Telecommunications2017，24，6： | 2 |
| 11 | Correction of a Genetic Disease in Mouse via Use of CRISPR-Cas9显示文摘 | Yuxuan Wu Dan Liang Yinghua Wang Meizhu Bai Wei Tang Shiming Bao Zhiqiang Yan Dangsheng Li Jinsong Li | 2013 | Cell Stem Cell2013，，6： | 2 |
| 12 | Solubility of Potassium Acetate in Water,2,2,2-Trifluoroethanol,Ethanol and Their Binary Mixtures at 288.15—333.15 K显示文摘The potassium acetate solutions are new potential working fluids for the closed-type reverse electrodialy-sis(RED)power generation system driven by thennal energy.In this paper,the solubilities of potassium acetate in water,2,2,2-trilluoroethaiiol,ethanol and their binary mixtures were measured by using the laser dynamic method over the temperature range of 288.15 to 333.15 K under atmospheric pressure.The results indicate that the solubility of potassium acetate solution is influenced by both the solvent components and solution temperature evidently.Besides,it is found that the measured solubility data of the potassium acetate-water-2,2,2-trifluoroethanol solutions as per the laser dynamic method are sliglitly larger than that of the data obtained as per the static method.Finally,five correlation models,including the Van?t Hoff model,Modified Apelblat model,Yaws model,A/z model and Modified Apelblat-Jouyban-Acree model,were used to correlate the measured solubility data of those potassium acetate solutions,with the relative standard deviations within 0.23%to 1.58%. | WU Xi YANG Shuaishuai XU Shiming ZHANG Xinjie | 2020 | Chemical Research in Chinese Universities2020，36，5： | 1 |
| 13 | All-optical two-channel polarization-multiplexing format conversion from QPSK to BPSK signals in a silicon waveguide显示文摘All-optical two-channel format conversion is proposed and experimentally demonstrated from a 40 Gbit/s polarization multiplexing(Pol-MUX) non-return-to-zero quadrature phase-shift keying(QPSK) signal to Pol-MUX binary phase-shift keying(BPSK) signals by using phase-doubled four-wave mixing effects with two polarization-angled pumps in a silicon waveguide. The eye diagrams and constellation diagrams of the original QPSK sequences and the converted BPSK sequences of each channel are clearly observed on the two polarization states. Moreover,the bit error rates(BERs) of the two converted idlers are measured. The power penalties of all these converted BPSK sequences on both X and Y polarization states are less than 3.4 dB at a BER of 3.8 × 10^(-3). | Xianglian Feng Zhihang Wu Xiaoyan Wang Sailing He Shiming Gao | 2016 | Photonics Research2016，4，6： | 1 |
| 14 | Incompressible or nearly incompressible soil dynamic behaviour-A new staggered algorithm to circumvent restrictions of mixed formulation显示文摘 | Maosofig Huang Shiming Wu Zienkiewicz O C | 2001 | Soft Dynamics and Earthquake Engineering2001，21，： | 1 |
| 15 | Capillary effects on dynamic modulus of sands and silts 显示文摘 | Wu Shiming Gray D H Richart F E Jr | 1984 | Journal of Geotechnical Engineering ASCE1984，110，9： | 1 |
| 16 | Spherical wave propagation in saturated soils显示文摘 | Xu Changjie Wu Shiming | 1998 | Applied mathematics and mechanics (English edition in China)1998，20，29： | 1 |
| 17 | Development of control method and dynamic model for multievaporator air conditioners (MEAC)显示文摘 | Chen Wu Zhou Xingxi Deng Shiming | 2005 | Energy Conversion and Management2005，46，33： | 1 |
| 18 | Dynamic Soil-structure interaction for high-rise building 显示文摘 | Wu Shiming Gan Gang | 1998 | Developments in Geoteehnical Engineering1998，83，： | 1 |
| 19 | Key Techniques and Important Issues for Slurry Shield Under-passing Embankments: A Case Study of Hangzhou Qiantang River Tunnel 显示文摘 | LIN Cungang ZHANG Zhongmiao WU Shiming | 2013 | Tunnelling and Underground Space Technology2013，38，： | 1 |
| 20 | MICRODISSECTION OF MINIATURE PIG EAR显示文摘Objective To investigate the suitability of miniature pigs as an animal model for otological research.Methods Microdissection of the temporal bone was performed on 10 miniature pigs and recorded on photographs. Results The morphology and measurement of the external, middle and inner ear and the lateral recess of the miniature pigs were obtained by microdissection. Conclusion Compared to traditional animal models, the miniature pig may be a better model for biomedical research because of its many similarities in physiological functions with humans. The Similarities of the temporal bone structures, including the external, middle and inner ear and the lateral recess, between the miniature pig and human make the animal a potentially useful model for otological research. | YI Haijin GUO Weiwei CHEN Lei WU Na LI Jiana REN Lili YANG Shiming | 2013 | Journal of Otology2013，8，2： | 1 |
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