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| 1 | Surgical treatment of hepatocellular carcinoma with severe intratumoral arterioportal shunt显示文摘We report a case of hepatocellular carcinoma (HCC) that caused a severe arterioportal shunt (APS). A 49-year-old man was admitted to hospital due to esophagogastric variceal hemorrhage and HCC, and underwent endoscopic variceal ligation (EVL) and endoscopic injection sclerotherapy (EIS). He was then referred to our hospital. Abdominal computed tomography revealed a lowdensity lesion in the posterior segment of the liver and an intratumoral APS, which caused portal hypertension. Although the patient underwent EVL, EIS, Hassab’s operation, and transcatheter arterial embolization for APS, he vomited blood due to rupture of esophagogastric varices. Right hepatectomy was performed for the treatment of HCC and APS, although the indocyanine green retention value at 15 min after intravenous injection was poor (30%). The patient’s postoperative course was uneventful. Eventually, APS disappeared and the esophagogastric varices improved. | Hiromichi Ishii Teruhisa Sonoyama Shingo Nakashima Hiroyuki Nagata Atsushi Shiozaki Yoshiaki Kuriu Hisashi Ikoma Masayoshi Nakanishi Daisuke Ichikawa Hitoshi Fujiwara Kazuma Okamoto Toshiya Ochiai Yukihito Kokuba Chohei Sakakura Eigo Otsuji | 2010 | World Journal of Gastroenterology2010，16，25： | 11 |
| 2 | Claudin 1 mediates tumor necrosis factor alpha-induced cell migration in human gastric cancer cells显示文摘AIM:To investigate the role of claudin 1 in the regulation of genes involved in cell migration and tumor necrosis factor alpha(TNF-α)-induced gene expression in human gastric adenocarcinoma cells.METHODS:Knockdown experiments were conducted with claudin 1 small interfering RNA(si RNA),and theeffects on the cell cycle,apoptosis,migration and invasion were analyzed in human gastric adenocarcinoma MKN28 cells.The gene expression profiles of cells were analyzed by microarray and bioinformatics.RESULTS:The knockdown of claudin 1 significantly inhibited cell proliferation,migration and invasion,and increased apoptosis.Microarray analysis identified 245genes whose expression levels were altered by the knockdown of claudin 1.Pathway analysis showed that the top-ranked molecular and cellular function was the cellular movement related pathway,which involved MMP7,TNF-SF10,TGFBR1,and CCL2.Furthermore,TNFand nuclear frctor-κB were the top-ranked upstream regulators related to claudin 1.TNF-αtreatment increased claudin 1 expression and cell migration in MKN28 cells.Microarray analysis indicated that the depletion of claudin1 inhibited 80%of the TNF-α-induced m RNA expression changes.Further,TNF-αdid not enhance cell migration in the claudin 1 si RNA transfected cells.CONCLUSION:These results suggest that claudin 1 is an important messenger that regulates TNF-α-induced gene expression and migration in gastric cancer cells.A deeper understanding of these cellular processes may be helpful in establishing new therapeutic strategies for gastric cancer. | Atsushi Shiozaki Hiroki Shimizu Daisuke Ichikawa Hirotaka Konishi Shuhei Komatsu Takeshi Kubota Hitoshi Fujiwara Kazuma Okamoto Daisuke Iitaka Shingo Nakashima Yoshito Nako Mingyao Liu Eigo Otsuji | 2014 | World Journal of Gastroenterology2014，20，47： | 6 |
| 3 | Endoscopic submucosal dissection of a rectal carcinoid tumor using grasping type scissors forceps显示文摘Endoscopic submucosal dissection (ESD) with a knife is a technically demanding procedure associated with a high complication rate. The shortcomings of this method are the inability to fix the knife to the target lesion, and compression of the lesion. These can lead to major complications such as perforation and bleeding. To reduce the risk of complications related to ESD, we developed a new grasping type scissors forceps (GSF), which can grasp and incise the targeted tissue using electrosurgical current. Colonoscopy on a 55-year-old woman revealed a 10-mm rectal submucosal nodule. The histological diagnosis of the specimen obtained by biopsy was carcinoid tumor. Endoscopic ultrasonography demonstrated a hypoechoic solid tumor limited to the submucosa without lymph node involvement. It was safely and accurately resected without unexpected incision by ESD using a GSF. No delayed hemorrhage or perforation occurred. Histological examination confirmed the carcinoid tumor was completely excised with negative resection margin. | Kazuya Akahoshi Yasuaki Motomura Masaru Kubokawa Noriaki Matsui Manami Oda Risa Okamoto Shingo Endo Naomi Higuchi Yumi Kashiwabara Masafumi Oya Hidefumi Akahane Haruo Akiba | 2009 | World Journal of Gastroenterology2009，15，17： | 4 |
| 4 | Proteolytic Cleavage of High Mobility Group Box 1 Protein by Thrombin–Thrombomodulin Complexes显示文摘 | Takashi Ito Ko-ichi Kawahara Kohji Okamoto Shingo Yamada Minetsugu Yasuda Hitoshi Imaizumi Yuko Nawa Xiaojie Meng Binita Shrestha Teruto Hashiguchi Ikuro Maruyama | 2008 | Arteriosclerosis, Thrombosis, and Vascular Biology2008，，10： | 1 |
| 5 | Dermal carbonyl modification is related to the yellowish color change of photo-aged Japanese facial skin显示文摘 | Yuki Ogura Tomohiro Kuwahara Minoru Akiyama Shingo Tajima Kazuhisa Hattori Kouhei Okamoto Shinpei Okawa Yukio Yamada Hachiro Tagami Motoji Takahashi Tetsuji Hirao | 2011 | Journal of Dermatological Science2011，，1： | 1 |
| 6 | Protective Effect of High-Mobility Group Box 1 Blockade on Acute Liver Failure in Rats显示文摘 | Kiminori Takano Masahiro Shinoda Minoru Tanabe Taku Miyasho Shingo Yamada Shigeshi Ono Yohei Masugi Koichi Suda Koichi Fukunaga Tetsu Hayashida Taizo Hibi Hideaki Obara Hiroya Takeuchi Shigeyuki Kawachi Kazufumi Kawasako Minoru Okamoto Hiroshi Yokota Ikur | 2010 | Shock2010，，6： | 1 |
| 7 | Development of Multi-Fingered Prosthetic Hand Using Shape Memory Alloy Type Artificial Muscle显示文摘 | Jae Hoon Lee Shingo Okamoto Shinji Matsubara | 2012 | Computer Technology and Application2012，3，7： | 1 |
| 8 | XB130 as an Independent Prognostic Factor in Human Esophageal Squamous Cell Carcinoma显示文摘 | Atsushi Shiozaki Toshiyuki Kosuga Daisuke Ichikawa Shuhei Komatsu Hitoshi Fujiwara Kazuma Okamoto Daisuke Iitaka Shingo Nakashima Hiroki Shimizu Takeshi Ishimoto Maki Kitagawa Yoshito Nakou Mitsuo Kishimoto Mingyao Liu Eigo Otsuji | 2013 | Annals of Surgical Oncology2013，，： | 1 |
| 9 | Molecular Dynamics Analysis on Tensile and Shearing Properties of Nitrogen-Containing Graphene显示文摘 | Shingo Okamoto Akihiko Ito | 2013 | 通讯和计算机(中英文版)2013，10，1： | 0 |
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