|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | PGE2 activates EP4 in subchondral bone osteoclasts to regulate osteoarthritis显示文摘Prostaglandin E2(PGE2), a major cyclooxygenase-2(COX-2) product, is highly secreted by the osteoblast lineage in the subchondral bone tissue of osteoarthritis(OA) patients. However, NSAIDs, including COX-2 inhibitors, have severe side effects during OA treatment. Therefore, the identification of novel drug targets of PGE2 signaling in OA progression is urgently needed. Osteoclasts play a critical role in subchondral bone homeostasis and OA-related pain. However, the mechanisms by which PGE2 regulates osteoclast function and subsequently subchondral bone homeostasis are largely unknown. Here, we show that PGE2 acts via EP4 receptors on osteoclasts during the progression of OA and OA-related pain. Our data show that while PGE2 mediates migration and osteoclastogenesis via its EP2 and EP4 receptors, tissue-specific knockout of only the EP4 receptor in osteoclasts(EP4 Lys M) reduced disease progression and osteophyte formation in a murine model of OA. Furthermore, OA-related pain was alleviated in the EP4 Lys M mice, with reduced Netrin-1 secretion and CGRP-positive sensory innervation of the subchondral bone. The expression of plateletderived growth factor-BB(PDGF-BB) was also lower in the EP4 Lys Mmice, which resulted in reduced type H blood vessel formation in subchondral bone. Importantly, we identified a novel potent EP4 antagonist, HL-43, which showed in vitro and in vivo effects consistent with those observed in the EP4 Lys Mmice. Finally, we showed that the Gαs/PI3 K/AKT/MAPK signaling pathway is downstream of EP4 activation via PGE2 in osteoclasts. Together, our data demonstrate that PGE2/EP4 signaling in osteoclasts mediates angiogenesis and sensory neuron innervation in subchondral bone, promoting OA progression and pain, and that inhibition of EP4 with HL-43 has therapeutic potential in OA. | Wenhao Jiang Yunyun Jin Shiwei Zhang Yi Ding Konglin Huo Junjie Yang Lei Zhao Baoning Nian Tao PZhong Weiqiang Lu Hankun Zhang Xu Cao Karan Mehul Shah Ning Wang Mingyao Liu Jian Luo | 2022 | Bone Research2022，10，2： | 7 |
| 2 | The heterogeneity of islet autoantibodies and the progression of islet failure in type 1 diabetic patients显示文摘Type 1 diabetes mellitus is heterogeneous in many facets. The patients suffered from type 1 diabetes present several levels of islet function as well as variable number and type of islet-specific autoantibodies. This study was to investigate prevalence and heterogeneity of the islet autoantibodies and clinical phenotypes of type 1 diabetes mellitus; and also discussed the process of islet failure and its risk factors in Chinese type 1 diabetic patients. A total of 1,291 type 1 diabetic patients were enrolled in this study. Demographic information was collected. Laboratory tests including mixed-meal tolerance test, human leukocyte antigen alleles, hemoglobin A1 c, lipids, thyroid function and islet autoantibodies were conducted. The frequency of islet-specific autoantibody in newly diagnosed T1 DM patients(duration shorter than half year) was 73% in East China. According to binary logistic regressions, autoantibody positivity, longer duration and lower Body Mass Index were the risk factors of islet failure. As the disease developed, autoantibodies against glutamic acid decarboxylase declined as well as the other two autoantibodies against zinc transporter 8 and islet antigen 2. The decrease of autoantibodies was positively correlated with aggressive beta cell destruction. Autoantibodies can facilitate the identification of classic T1 DM from other subtypes and predict the progression of islet failure. As there were obvious heterogeneity in autoantibodies and clinical manifestation in different phenotypes of the disease, we should take more factors into consideration when identifying type 1 diabetes mellitus. | Jin Liu Lingling Bian Li Ji Yang Chen Heng Chen Yong Gu Bingqin Ma Wei Gu Xinyu Xu Yun Shi Jian Wang Dalong Zhu Zilin Sun Jianhua Ma Hui Jin Xing Shi Heng Miao Bing Xin Yan Zhu Zhenwen Zhang Ruifang Bu Lan Xu Guangde Shi Wei Tang Wei Li Dongmei Zhou Jun Liang Xingbo Cheng Bimin Shi Jixiang Dong Ji Hu Chen Fang Shao Zhong Weinan Yu Weiping Lu Chenguang Wu Li Qian Jiancheng Yu Jialin Gao Xiaoqiang Fei Qingqing Zhang Xueqin Wang Shiwei Cui Jinluo Cheng Ning Xu Guofeng Wang Guoqing Han Chunrong Xu Yun Xie Minmin An Wei Zhang Zhixiao Wang Yun Cai Qi Fu Yu Fu Shuai Zheng Fan Yang Qingfang Hu Hao Dai Yu Jin Zheng Zhang Kuanfeng Xu Yifan Li Jie Shen Hongwen Zhou Wei He Xuqin Zheng Xiao Han Liping Yu Jinxiong She Mei Zhang Tao Yang | 2016 | Science China(Life Sciences)2016，59，9： | 5 |
| 3 | Preparation and characterization of urea-formaldehyde resin]reactive kaolinite composites显示文摘 | Shiwei CheN Xuchen Lu Tizhuang Wang Zhimin Zhang | 2016 | Particuology2016，14，1： | 5 |
| 4 | Petroleum coke conversion behavior in catalyst-assisted chemical looping combustion显示文摘Efficiently using petroleum coke as fuel and reducing carbon emission meanwhile have become attractive in oil processing industry.The paper is focused on the application of Chemical Looping Combustion(CLC)with petroleum coke,with the purpose of investigating its combustion performance and effects of potassium.Some experiments were performed in a laboratory scale fluidized bed facility with a natural manganese-based oxygen carrier.Experimental results indicated that the coke conversion is very sensitive to reaction temperature.The pre sent natural manganese-based oxygen carrier decorated by K has little effect on the improvement of coke conversion.XRD,SEM-EDX,and H2-TPR were adopted to characterize the reacted oxygen carrier samples.After being decorated by K,the oxygen carrier's capacity of transferring oxygen was decrea sed.A calcination temperature above the melting point of K2 CO3(891℃)shows better oxygen transfer reactivity in comparison to the one calcined at a lower temperature.The natural oxygen carrier used in the work has a high content of Si,which can easily react with K to form K(FeSi2 O6).Further,irrespective of reaction temperature,the coke conversion can be significantly enhanced by decorating the coke with K,with a demonstration of remarkably shorter reaction time,faster average coke gasification rate and higher average carbon conversion rate. | Xianyu Liu Huijun Ge Shiwei Ma Shangyi Yin Ping Lu Laihong Shen Hongcun Bai Wei Wang Tao Song | 2020 | Chinese Journal of Chemical Engineering2020，28，9： | 3 |
| 5 | The Effects of Chronic Hypoxia on Thermoregulation and Metabolism in Phrynocephalus vlangalii显示文摘Phrynocephalus vlangalii are widely distributed on Tibetan plateau spanning diverse altitudes and habitats. In the present study, P.vlangalii were exposed to 8% oxygen concentration in a hypoxic chamber for 6 weeks. Then the body temperature(T_b), standard metabolic rate(SMR), heart rate and metabolic enzyme activities of the lizards were measured at 20℃ and 30℃. The results indicated that hypoxia exposure decreased T_b, SMR and heart rate. Lactate dehydrogenase(LDH) activity of 8% O_2 group became significant elevated in liver and skeletal muscle compared with control group at 20℃, but descended significantly in heart. Using electrophoresis we found that LDH contains five isozymes(LDH1, LDH2, LDH3, LDH4 and LDH5) and are expressed specifically in liver, skeletal muscle and heart. Citrate synthase(CS) activity in the liver also decreased at 20℃ and 30℃. No significant difference of CS activity was found between the two groups in skeletal muscle and heart. | Weixin LI Shiwei LIANG Huihui WANG Ying XIN Songsong LU Xiaolong TANG Qiang CHEN | 2016 | Asian Herpetological Research2016，7，2： | 3 |
| 6 | A COVID-19 Outbreak—Nangong City,Hebei Province,China,January 2021显示文摘Summary What is known about this topic?Coronavirus disease 2019(COVID-19)is widespread globally.In China,COVID-19 has been well controlled and has appeared only in importationrelated cases.Local epidemics occur sporadically in China and have been contained relatively quickly.What is added by this report?Epidemiological investigation with genome sequence traceability analysis showed that the first case of COVID-19 in Nangong City acquired infection from a confirmed case from Shijiazhuang City. | Shiwei Liu Shuhua Yuan Yinqi Sun Baoguo Zhang Huazhi Wang Jinxing Lu Wenjie Tan Xiaoqiu Liu Qi Zhang Yunting Xia Xifang Lyu Jianguo Li Yan Guo | 2021 | China CDC weekly2021，3，19： | 3 |
| 7 | Increased Expression of Colonic Mucosal Melatonin in Patients with Irritable Bowel Syndrome Correlated with Gut Dysbiosis显示文摘Dysregulation of the gut microbiota/gut hormone axis contributes to the pathogenesis of irritable bowel syndrome(IBS).Melatonin plays a beneficial role in gut motility and immunity.However,altered expression of local mucosal melatonin in IBS and its relationship with the gut microbiota remain unclear.Therefore,we aimed to detect the colonic melatonin levels and microbiota profiles in patients with diarrhea-predominant IBS(IBS-D)and explore their relationship in germ-free(GF)rats and BON-1 cells.Thirty-two IBS-D patients and twenty-eight healthy controls(HCs)were recruited.Fecal specimens from IBS-D patients and HCs were separately transplanted into GF rats by gavage.The levels of colon mucosal melatonin were assessed by immunohistochemical methods,and fecal microbiota communities were analyzed using 16S rDNA sequencing.The effect of butyrate on melatonin synthesis in BON-1 cells was evaluated by ELISA.Melatonin levels were significantly increased and negatively correlated with visceral hypersensitivity in IBS-D patients.GF rats inoculated with fecal microbiota from IBS-D patients had high colonic melatonin levels.Butyrate-producing Clostridium cluster XIVa species,such as Roseburia species and Lachnospira species,were positively related to colonic mucosal melatonin expression.Butyrate significantly increased melatonin secretion in BON-1 cells.Increased melatonin expression may be an adaptive protective mechanism in the development of IBS-D.Moreover,some Clostridium cluster XIVa species could increase melatonin expression via butyrate production.Modulation of the gut hormone/gut microbiota axis offers a promising target of interest for IBS in the future. | Ben Wang Shiwei Zhu Zuojing Liu Hui Wei Lu Zhang Meibo He Fei Pei Jindong Zhang Qinghua Sun Liping Duan | 2020 | Genomics, Proteomics & Bioinformatics2020，18，6： | 2 |
| 8 | Reaction Process Phase Transfer Catalysis for Selective Oxidative-Reductive Carbonylation to Monuron显示文摘 | MEI Jianting LU Shiwei | 2002 | 催化学报2002，23，1： | 2 |
| 9 | Stability and demulsification of emulsions stabilized by asphaltenes or resins 显示文摘 | Xia Lixin Lu Shiwei Can Guoying | 2004 | Journal of Colloid and Interface Science2004，271，2： | 1 |
| 10 | A promising new class of plasticine: Metallic plasticine显示文摘Soft, malleable, and non-dry on exposure in air are the typical features for plain plasticine, which lead plasticine to be widely used in many industrial fields and our daily life. As a kind of clay, poorly electric conductivity and thermal conductivity of plain plasticine seriously limit its applications. Therefore,synthesizing a kind of plasticine having metallic bond is of importance for extending its applications in some special cases, such as thermal-cooling medium, anti-static electricity, electromagnetic shielding,etc. Here, we report a novel GaInSnCdZn_2 alloy, which exhibits similar behavior as compared to those of plasticine at near room temperature(30–40℃), and a good electrical conductivity due to its nature of metal. This new GaInSnCdZn_2 alloy can be called as metallic plasticine that contains the near-eutectic structure with low melting point and the other relatively high melting point phases. In this metallic plasticine, the near-eutectic structure with low melting point plays the same role as the oily ingredient in plain plasticine, dominating the plastic deformation, while the other relatively high melting point phases act as the stuffing like the CaCO3 in plain plasticine. The creation of metallic plasticine offers a general strategy for designing/preparing a new class of plasticine which possesses both the nature of metal and plasticine. | Yiping Lu Zhongyi Tang Bin Wen Gang Wang Shiwei Wu Tongmin Wang Yubo Zhang Zongning Chen Zhiqiang Cao Tingju Li | 2018 | Journal of Materials Science & Technology2018，34，2： | 1 |
| 11 | Stability and demulsification of emulsions stabilized by asphaltenes or resins显示文摘 | Xia Lixin Lu Shiwei Cao Guoying | 2004 | Journal of Colloid and Interface Science2004，271，： | 1 |
| 12 | Low- resistance Ti/A1/Ti/Au multilayer ohmic contact to n-GaN 显示文摘 | Dong-Feng Wang Feng Shiwei C Lu | 2001 | Journal of Applied Physics2001，89，11： | 1 |
| 13 | Preparation of high strength chitosan fibers by using ionic liquid as spinning solution显示文摘 | Li Lu Yuan Bing Liu Shiwei | 2012 | Journal of Materials Chemistry2012，22，： | 1 |
| 14 | Synthesis of NaA zeolite from kaolin source显示文摘 | Qian Miao Zhihui Zhou Jianhua Yang Jinming Lu Shiwei Yan Jinqu Wang | 2009 | Frontiers of Chemical Engineering in China2009，，1： | 1 |
| 15 | Stability and Demulsifi- cation of Emulsions Stabilized by Asphaltenes or Resins 显示文摘 | Xia Lixin Lu Shiwei Cao Guoying | 2004 | J Colloidlnterface Sci2004，271，2： | 1 |
| 16 | Mechanical behaviors of extruded Mg alloys with high Gd and Nd content显示文摘The influence of alloying elements and heat treatment on the microstructure and mechanical behaviors of extruded Mg–Gd–Nd ternary alloys was investigated in this study.The grain sizes dramatically decreased after extrusion,and the particles which distributed in Mg matrix had great effect on the grain size.The grain sizes of extruded alloys decreased from 26 to 5μm with the alloying content increasing.The mechanical test results show that both Gd and Nd had positive effect on the hardness,yield strength and Young’s modulus.The ultimate tensile strength(UTS)was enhanced by Gd content,decreased with Nd content.The elongation of alloys was lower with higher alloying elements.Those extruded alloys were aged for 200 h in 200℃.The Young’s moduli were decreased by ageing treatment.Combined with microstructure study,the part of the reinforcement which identified as Mg5(Gd/Nd)was dissolved in Mg matrix.Nd element obviously has influence on the solubility of Gd in Mg alloys. | Yuling Xu Shiwei Wang Yuye Wang Li Chen Lixiang Yang Lu Xiao Li Yang Norbert Hort | 2021 | Progress in Natural Science:Materials International2021，31，4： | 1 |
| 17 | Extraction of Alpha transmitter signals from single-station observations using the direction-finding method显示文摘For the applications of Alpha very-low-frequency(VLF) systems consisting of multiple transmitters, determining the origin transmitter station of received signals is a crucial problem. Based on single-station observations, this study develops a directionfinding method to extract Russian Alpha transmitter signals. First, the amplitudes of Alpha signals received in Suizhou City,Hubei Province(31.57°N, 113.32°E) in the east-west(EW) and north-south(NS) directions are obtained by the power spectrum method. The amplitude ratios of signals in the two directions are subsequently adopted to estimate the propagation angles of the signals with respect to the NS direction of the VLF receiver station. Phase ambiguity in our system is eliminated by comparing Alpha signal waveform with that from the VTX transmitter in India(8.39°N, 77.75°E) as a reference station. Finally, we can determine the quadrant where the incoming wave signals are located relative to the receiver and eventually distinguish the exact Alpha transmitters. Based on the direction-finding results, the amplitudes of each Alpha signal are extracted, and their diurnal variation features are analyzed to verify the performance of our method. These results are of great significance for the further study of Alpha signals and VLF long-distance communication. | GU XuDong CHEN Huan WANG ShiWei LU ZiLong NI BinBin LI GuangJian CHENG Wen | 2022 | Science China(Technological Sciences)2022，65，8： | 1 |
| 18 | Revealing the grain size dependent hot workability and deformation mechanisms in a Mg-Zn-Y alloy显示文摘Despite the industrial significance of grain size for enhancing mechanical properties and formability,the in-depth deformation mechanisms at elevated temperature are still unclear.To investigate the functions of grain size on hot workability and deformation mechanisms,three groups of Mg-1.2Zn-0.2Y alloy specimens with different grain sizes were hot compressed and then studied by combining constitutive model,processing map and microstructural observations.The results showed that the enhanced hot workability accompanying low deformation activation energy and small instability regime was obtained with refined grain size.During hot deformation,the decreased grain size in Mg1.2Zn-0.2Y alloy mainly improved the plastic deformation homogeneity,especially for the weakened local straining around grain boundaries.As a result,the dynamic recrystallization nucleation and texture development at lower strain level were influenced by the initial grain size.At higher strain magnitude,the growth and coarsening of dynamic recrystallized grains would further release strain localization and improve hot workability,while the texture was less impacted.Further,unlike the primary basal slip and deformation twinning in the specimen with coarse grain at low temperature,non-basal slips of dislocations were initiated with less deformation twins in the specimens with refined grain size. | Ruiqing Lu Zhiming Xu Fulin Jiang Shiwei Xu Dingfa Fu Hui Zhang Jie Teng | 2023 | Journal of Magnesium and Alloys2023，11，4： | 1 |
| 19 | Cytotoxicity and apoptosis induction on RTG-2 cells of 2,2′,4,4′-tetrabromodiphenyl ether (BDE-47) and decabrominated diphenyl ether (BDE-209)显示文摘 | Shiwei Jin Fangxing Yang Yang Hui Ying Xu Yuanan Lu Jiankang Liu | 2010 | Toxicology in Vitro2010，，4： | 1 |
| 20 | Stability and demulsi-fication of emulsions stabilized by asphaltenes or resins 显示文摘 | Xia Lixin Lu Shiwei Cao Guoying | 2004 | J Colloid Iterface Sei2004，271，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员