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| 1 | Study and use of the probiotic Lactobacillus reuteri in pigs:a review显示文摘Probiotics are living microorganisms that provide a wide variety of health benefits to the host when ingested in adequate amounts.The bacterial strains most frequently used as probiotic agents are lactic acid bacteria,such as Lactobacillus reuteri,which is one of the few endogenous Lactobacillus species found in the gastrointestinal tract of vertebrates,including humans,rats,pigs and chickens.L reuteri is one of the most well documented probiotic species and has been widely utilized as a probiotic in humans and animals for many years.Initially,L reuteri was used in humans to reduce the incidence and the severity of diarrhea,prevent colic and necrotic enterocolitis,and maintain a functional mucosal barrier.As interest in alternatives to in-feed antibiotics has grown in recent years,some evidence has emerged that probiotics may promote growth,improve the efficiency of feed utilization,prevent diarrhea,and regulate the immune system in pigs.In this review,the characteristics of L reuteri are described,in order to update the evidence on the efficacy of using L.reuteri in pigs. | Chengli Hou Xiangfang Zeng Fengjuan Yang Hong Liu Shiyan Qiao | 2016 | Journal of Animal Science and Biotechnology2016，7，1： | 19 |
| 2 | Dietary modulation of endogenous host defense peptide synthesis as an alternative approach to in-feed antibiotics显示文摘Traditionally, antibiotics are included in animal feed at subtherapeutic levels for growth promotion and disease prevention.However, recent links between in-feed antibiotics and a rise in antibiotic-resistant pathogens have led to a ban of all antibiotics in livestock production by the European Union in January 2006 and a removal of medically important antibiotics in animal feeds in the United States in January 2017.An urgent need arises for antibiotic alternatives capable of maintaining animal health and productivity without triggering antimicrobial resistance.Host defense peptides(HDP) are a critical component of the animal innate immune system with direct antimicrobial and immunomodulatory activities.While in-feed supplementation of recombinant or synthetic HDP appears to be effective in maintaining animal performance and alleviating clinical symptoms in the context of disease, dietary modulation of the synthesis of endogenous host defense peptides has emerged as a cost-effective,antibiotic-alternative approach to disease control and prevention.Several different classes of smallmolecule compounds have been found capable of promoting HDP synthesis.Among the most efficacious compounds are butyrate and vitamin D.Moreover, butyrate and vitamin D synergize with each other in enhancing HDP synthesis.This review will focus on the regulation of HDP synthesis by butyrate and vitamin D in humans, chickens, pigs, and cattle and argue for potential application of HDP-inducing compounds in antibiotic-free livestock production. | Kelsy Robinson Xi Ma Yulan Liu Shiyan Qiao Yongqing Hou Guolong Zhang | 2018 | Animal Nutrition2018，，2： | 9 |
| 3 | Reduning injection for fever, rash, and ulcers in children with mild hand, foot, and mouth disease: a randomized controlled clinical study显示文摘OBJECTIVE: To assess the efficacy and safety of Reduning injection for fever, rash, and ulcers in children with mild hand, foot, and mouth disease(HFMD). METHODS: A stratified-block randomized, double-blind, parallel-controlled, and multicenter clinical trial was conducted with 360 patients in five hospitals across China: Quanzhou Children's Hospital, Shijiazhuang No. 5 Hospital, Shanghai Public Health Centre, Hunan Provincial Children's Hospital, and Kaifeng Children's Hospital. Patients were randomized into three groups with 120 in each. Group A was treated with Western Medicine, group B with Reduning injection, a Chinese herbal medicine, and group C with both Reduning injection and Western Medicine. Results were compared for treatment efficacy and safety on HFMD. The clinical outcomes were observed as follows: fever and onset time of antifebrile effect(time to bring the body temperature down ≥0.5℃ after medication); cumulative time for fever recovery(body temperature recovering to normal and lasting more than 24 h without medication); cumulative time for rash disappearance(without new rashes or ulcers appearing and the original ones fading away); and cumulative time for mouth ulcer disappearance. RESULTS: For the onset time of the antifebrile effect, there was no statistical difference between groups A and B(P>0.05) and groups B and C(P> 0.05). However, there was a statistical difference between groups A and C(P<0.05), and the effect in group C was the best. For the cumulative time for rash disappearance, there was no statistical difference between groups A and B(P>0.05). There were statistical differences between groups A and C, and groups B and C(P<0.05), and the effect in group C was the best. For the cumulative time for mouth ulcers disappearance, there were no statistical differences among the three groups(P>0.05). CONCLUSION: Reduning injection with Western Medicine for symptomatic treatment is most effective for mild HFMD. No adverse reactions were observed. | Guoliang Zhang Jie Zhao Liyun He Shiyan Yan Ziqiang Zhuo Haojie Zheng Yongping Mu Shuangjie Li Xi Zhang Jihan Huang Xiuhui Li Jianping Liu Hehe Wan Chaoyu Wei Wei Xiao | 2013 | Journal of Traditional Chinese Medicine2013，33，6： | 7 |
| 4 | Clinical phenotype network: the underlying mechanism for perso- nalized diagnosis and treatment of traditional Chinese medicine显示文摘繁体中文药(TCM ) 在个性化的药的一个典型纲要调查临床的诊断和治疗整齐,它意味着有一样的疾病的个性化的病人将从不同 TCM 医生获得不同诊断和最佳的治疗。这个原则被 TCM 临床的专业人员认出并且粘住几千年了。然而,个性化的药不是的 TCM 的内在的机制到目前为止充分调查了并且仍然保持未知。这份报纸讨论 TCM 的框架在经典文学并且在真实世界的临床的背景的个性化的药,并且调查 TCM 的内在的机制从网络药的观点的个性化的药。在失眠上基于 246 个设计得好的门诊病人记录,由评估表明观察的个人偏爱和植物药方的偏爱,我们注意了每张植物药方的重要类似和每相遇的症状类似。为了调查 TCM 的内在的机制,个性化药,我们构造了一个临床的显型网络(CPN ) ,在哪个临床的显型实体喜欢症状并且诊断作为连接表现为在这些实体之间的节点和关联。这 CPN 被用来调查症候群和症状的同现的混杂的边界。小世界的拓扑的特征与高聚类结构在 CPN 被注意,它在 TCM 的合理性上提供卓见个性化的诊断和处理。这个网络上的调查将帮助我们在 TCM 的内在的机制上获得理解个性化的药并且将为 TCM 的精炼建议一个新观点个性化的临床的技巧。 | Xuezhong Zhou Yubing Li Yonghong Peng Jingqing HU Runshun Zhang Liyun He Yinghui Wang Lijie Jiang Shiyan Yan Peng Li Qi Xie Baoyan Liu | 2014 | Frontiers of Medicine2014，8，3： | 7 |
| 5 | Altered Motor-Striatal Plasticity and Cortical Functioning in Patients with Schizophrenia显示文摘Patients with schizophrenia undergo changes in brain plasticity. In the present study, we characterized motor cortical-striatal plasticity in such patients. Compared with the potentiation following high-frequency repetitive transcranial magnetic stimulation in the control group, the patients demonstrated impaired plasticity of corticostriatal motor-evoked potentials recorded from hand muscles.Notably, the loss of cortical plasticity was correlated with impaired motor learning in a rotary pursuit task. Moreover,the loss of plasticity was correlated with the symptoms of schizophrenia. The results suggest that the progression of schizophrenia is accompanied by altered cortical plasticity and functioning. | Dongsheng Zhou Feng Pang Shiyan Liu Ying Shen Lingjiang Liu Zezhong Fang Chuang Wang Zhenyu Hu Ti-Fei Yuan | 2017 | Neuroscience Bulletin2017，33，3： | 5 |
| 6 | Sensitivity of simulated short-range high-temperature weather to land surface schemes by WRF显示文摘The simulations of a heat wave occurring in southern Yangtze-Huaihe valley and southern China during late July,2003 were conducted to examine the sensitivity of simulated surface air temperature(SAT) to different land surface schemes(LSSs) using the Weather Research and Forecasting Model(WRF) Version 2.2 in the short-range mode for 24-h integrations.Initial and boundary conditions employed a National Centers for Environmental Prediction(NCEP) analysis.The results showed that,overall,simulated high-temperature weather is sensitive to different LSSs.Large differences in simulated SAT intensity,threat score,and simulated error under different schemes are identified clearly.In addition,some systematic differences are also in-duced by the LSSs.In terms of threat score from the three LSSs,SLAB is the best,and RUC is better than NOAH.SLAB gives the lowest absolute error for area-averaged SAT,and tends to depict the western Pacific subtropical high with the east-ernmost position at low levels.The LSSs modify the simulated SAT,primarily via the transfer of sensible heat from the land surface to the atmosphere.The physical mechanism of the positive feedback between atmospheric circulation and the SAT is unimportant,with'negative'feedback over most of the simulated areas.This study emphasizes the importance of improving LSSs in SAT forecasting by numerical models. | ZENG XinMin WU ZhiHuang XIONG ShiYan SONG Shuai ZHENG YiQun LIU HuaQiang | 2011 | Science China Earth Sciences2011，54，4： | 5 |
| 7 | Magnetism in Mn and Co doped ZnO bulk samples显示文摘Bulk samples with nominal composition Zn0.95Co0.05O and Zn0.92Co0.05Mn0.03O were fabricated by a solid-state reaction method at 600℃.X-ray diffraction experiment showed that the peaks of secondary phase Co3O4 with a cubic structure were visible in both samples,besides the main peaks of wurtzite structure as ZnO.Magnetization measurement indicated that doping Co alone can induce ferromag- netism in ZnO itself,while the introduction of Mn significantly enhances ferromagnetism.However, both samples showed different magnetic behavior at temperatures below 50 K.It was also noted that ferromagnetic coupling interaction was weakened due to the presence of antiferromagnetic Co3O4. | WANG YongQiang YUAN SongLiu SONG YunXing LIU Li TIAN ZhaoMing LI Pai ZHOU YuanMing LI YunLong YIN ShiYan | 2007 | Chinese Science Bulletin2007，52，8： | 4 |
| 8 | The HDAC3 enzymatic activity regulates skeletal muscle fuel metabolism显示文摘Histone deacetylase 3 (HDAC3) is a major HDAC, whose enzymatic activity is targeted by small molecule inhibitors for treating a variety of conditions. However, its enzymatic activity is largely dispensable for its function in embryonic development and hepatic lipid metabolism.HDAC3 plays a pivotal role in regulating muscle fuel metabolism and contractile function. Here, we address whether these muscular functions of HDAC3 require its enzymatic activity. By mutating the NCoR/SMRT corepressors in a knock - in mouse model named NS-DADm, we ablated the enzymatic activity of HDAC3 without affecting its protein levels. Compared to the control mice, skeletal muscles from NS-DADm mice showed lower force generation, enhanced fatigue resistance, enhanced fatty acid oxidation, reduced glucose uptake during exercise, upregulated expression of metabolic genes involved in branchedchain amino acids catabolism, and reduced muscle mass during aging, without changes in the muscle fiber-type composition or mitochondrial protein content. These muscular phenotypes are similar to those observed in the HDAC3-depleted skeletal muscles, which demonstrates that, unlike that in the liver or embryonic development, the metabolic function of HDAC3 in skeletal muscles requires its enzymatic activity. These results suggest that drugs specifically targeting HDAC3 enzyme activity could be developed and tested to modulate muscle energy metabolism and exercise performance. | Shiyan Song Yefei Wen Hui Tong Emanuele Loro Yingyun Gong Jidong Liu Sungguan Hong Lei Li Tejvir S.Khurana Maoping Chu Zheng Sun | 2019 | Journal of Molecular Cell Biology2019，11，2： | 3 |
| 9 | The Contents of Terpene Trilactone and Flavonoid in Leaves of Seedlings from Ancient Female Ginkgo Trees in China显示文摘Flavonoids and terpene trilactones, especially, ginkgo flavonglycosides, ginkgolides and bilobalides in leaves of ginkgo trees, need to be studied for effective application of these active components with high medical and health-care values. This study was aimed to provide scientific bases for genealogies selection and harvest season confirmation for Ginkgo biloba. A high-performance liquid chromatographic method(HPLC-ELSD)was developed to determine the contents of terpene trilactone and flavonoid of 36 ancient G. biloba genealogies from 19 provinces in China.The study indicated that the content gradually increased from April to August, and thereafter declined. Analysis of variance indicated that the contents of terpene trilactone, flavonoids, and their respective components had significant difference among 36 genealogies. The cluster analysis showed that No. 72(Xing'an, Guangxi), No. 58(Youyang, Chongqing), No. 82(Rugao, Jiangsu), No. 123(Huixian, Gansu), No. 99(Dujun, Guizhou),No. 10(Tai'an, Shandong) and No. 133(Mentougou, Beijing) genealogies have higher content of terpene trilactone and flavonoid. These results can help us to select superior variety containing high content of terpene trilactone and flavonoid. | ZHANG Yanhui LIU Peiying KONG Qianqian XING Shiyan LIU Xiaojing SUN Limin | 2017 | Horticultural Plant Journal2017，3，4： | 3 |
| 10 | Liver cold preservation induce lung surfactant changes and acute lung injury in rat liver transplantation显示文摘AIM:To investigate the relationship between donor liver cold preservation,lung surfactant (LS) changes and acute lung injury (ALI) after liver transplantation.METHODS:Liver transplantation models were estab-lished using male Wistar rats.Donor livers were pre-served in University of Wisconsin solution at 4 ℃ for different lengths of time.The effect of ammonium pyr-rolidinedithiocarbamate (PDTC) on ALI was also detect-ed.All samples were harvested after 3 h reperfusion.The severity of ALI was evaluated by lung weight/body weight ratio,lung histopathological score,serum nitric oxide (NO) and endothelin (ET)-1 levels,lung tumor necrosis factor (TNF)-α and interleukin (IL)-1β levels.Lung surfactants (LSs) were determined by micellar electrokinetic capillary chromatography.RESULTS:With extended donor liver cold preservation time (CPT),lung histopathological scores,serum ET-1 levels,lung weight/body weight ratio and the level of TNF-α and IL-1β in lung were increased significantly in the 180-min group compared with the sham group (3.16 ± 0.28 vs 1.12 ± 0.21,P < 0.001;343.59 ± 53.97 vs 141.53 ± 48.48,P < 0.001;0.00687 ± 0.00037 vs 0.00557 ± 0.00056,P < 0.001;17.5 ± 3.0 vs 1.3 ± 0.3,P < 0.001;10.8 ± 2.3 vs 1.8 ± 0.4,P < 0.001),but se-rum NO levels decreased remarkably (74.67 ± 10.01 vs 24.97 ± 3.18,P < 0.001).The expression of lung phos-phatidylcholine (PC),phosphatidylethanolamine (PE),phosphatidylinositol (PI) and phosphatidylserine (PS) increased when CPT was < 120 min,and decreased when CPT was > 180 min (PC:1318.89 ± 54.79 vs 1011.18 ± 59.99,P < 0.001;PE:1504.45 ± 119.96 vs 1340.80 ± 76.39,P=0.0019;PI:201.23 ± 34.82 vs 185.88 ± 17.04,P=0.2265;PS:300.43 ± 32.95 vs 286.55 ± 55.55,P=0.5054).All these ALI-associated indexes could be partially reversed by PDTC treatment.CONCLUSION:Prolonged CPT could induce or inhibit the expression of LSs at the compensation or decom-pensation stage,and some antioxidants (e.g.,PDTC) may reverse the pathological process partially. | An Jiang,Chang Liu,Liang Yu,Yi Lv,Department of Hepatobiliary Surgery,the First Affiliated Hospital,School of Medicine,Xi’an Jiaotong University,Xi’an 710061,Shannxi Province,China An Jiang,Department of VIP Clinic,The Second Affiliated Hospital,School of Medicine,Xi’an Jiaotong University,Xi’an 710004,Shannxi Province,China Feng Liu,Department of Liver Transplantation,Qianfoshan Hospital,Jinan 250014,Shandong Province,China Yu-Long Song,Department of Anesthesiology,Renmin Hospital of Shannxi Province,Xi’an 710061,Shannxi Province,China Quan-Yuan Li,Department of Transplantation,Dongfeng Hospital,Shiyan 442008,Hubei Province,China | 2012 | World Journal of Gastroenterology2012，18，4： | 2 |
| 11 | Leucine Supplementation in a Chronically Protein-Restricted Diet Enhances Muscle Weight and Postprandial Protein Synthesis of Skeletal Muscle by Promoting the mTOR Pathway in Adult Rats显示文摘 | Bo Zhang Licui Chu Hong Liu Chunyuan Xie Shiyan Qiao Xiangfang Zeng | 2017 | Engineering2017，3，5： | 2 |
| 12 | New method for synthesizing polyorganozircosilazane as a Si/Zr/CjNbased ceramic precursor显示文摘 | Liu Chunjuan Yang Shiyan Xu Caihong | 2003 | Journal of Applied Polymer Science2003，87，13： | 1 |
| 13 | A review on the forecasting of wind speed and generated power显示文摘 | Ma Lei Luan Shiyan Jiang Chuanwen Liu Hongling Zhang Yan | 2008 | Renewable and Sustainable Energy Reviews2008，，4： | 1 |
| 14 | Quan- tity transmission and traceability methods of heavy dc standard measurement device 显示文摘 | Ren Shiyan Liu Qingxin Liu Xiaojun | 2015 | IET Sei Meas Technol2015，9，1： | 1 |
| 15 | A review on the forecasting of wind speed and generated power显示文摘 | Ma Lei Luan Shiyan Jiang Chuanwen Liu Hongling Zhang Yan | 2009 | Renewable and Sustainable Energy Reviews2009，13，1： | 1 |
| 16 | Heavy DC current calibration method based on high-precision current adder显示文摘 | Ren Shiyan Liu Qingxin Liu Xiaojun | 2014 | IEEE Trans Instrum Meas2014，63，12： | 1 |
| 17 | Low on-resistance 1.2 kV 4H-SiC power MOSFET with Ron, sp of 3.4 mΩ·cm^2显示文摘A 4H-SiC power MOSFET with specific on-resistance of 3.4 mΩ·cm^2 and breakdown voltage exceeding 1.5 kV is designed and fabricated.Numerical simulations are carried out to optimize the electric field strength in gate oxide and at the surface of the semiconductor material in the edge termination region.Additional n-type implantation in JFET region is implemented to reduce the specific on-resistance.The typical leakage current is less than 1μA at VDS=1.4 kV.Drain–source current reaches 50 A at VDS=0.75 V and VGS=20 V corresponding to an on-resistance of 15 mΩ.The typical gate threshold voltage is 2.6 V. | Qiang Liu Qian Wang Hao Liu Chenxi Fei Shiyan Li Runhua Huang Song Bai | 2020 | Journal of Semiconductors2020，41，6： | 1 |
| 18 | New method for synthesizing polyorganozircosilazane as a Si/Zr/C/N-based ceramic precursor显示文摘 | Liu Chunjuan Yang Shiyan Xu Caihong | 2003 | Journal of Applied Polymer Science2003，87，20： | 1 |
| 19 | Horizontal transfer of vanA between probiotic Enterococcus faecium and Enterococcus faecalis in fermented soybean meal and in digestive tract of growing pigs显示文摘Background: The aim of this study was to investigate the intergeneric transfer of vancomycin resistance gene vanA between probiotic enterococci in the fermentation progress of soybean meal and in the digestive tract of growing pigs.One vanA genotype vancomycin resistant E.faecium strain,Efm4,and one chloramphenicol-resistant E.faecalis strain,Efs2,were isolated from twenty-nine probiotic basis feed material/additive samples.For in vitro conjugation,Efm4 and Efs2 were used as starter to ferment soybean meal.For in vivo conjugation,thirty growing pigs were randomly assigned to five groups(n = 6),treated with a basic diet,or supplemented with 10% fermented soybean meal,1% Efm4,5% Efs2 or a combination of 1% Efm4 + 5% Efs2 for 7 d,respectively.Fecal samples of pigs in each group were collected daily for the isolation and dynamic analysis of Efm4,Efs2 and transconjugants.The sequence types(STs) of Efm4,Efs2 and transconjugants were analyzed by multilocus sequence typing(MLST).The vanA harboring plasmid in Efm4 and transconjugants was analyzed by S1-pulsed field gel electrophoresis(PFGE)and further verified by multiple alignments.Results: The results showed that,in FSBM,transconjugants were detected 1 h after the fermentation,with a conjugation frequency of ~ 10^-3 transconjugants/recipient.Transconjugants proliferated with Efm4 and Efs2 in the first 8 h and maintained steadily for 10 d till the end of the experiment.Additionally,in vivo experiment showed that transcojugants were recovered in one of six pigs in both FSBM and Efm4 + Efs2 groups,with conjugation frequency of ~ 10^-5 and ~ 10^-4,respectively.MLST revealed the ST of Efm4,Efs2 and transconjugants was ST1014,ST69 and ST69,respectively.S1-PFGE confirmed the existence of the vanA-harboring,142,988-bp plasmid,which was also a multi-drug resistant plasmid containing Tn1546-like transposon.Conclusions: The findings revealed the potential safety hazard existing in the commercial probiotic enterococci in China,because the horizontal transfer from farm to fork could potentially pose a safety risk to the public. | Ning Li Haitao Yu Hongbin Liu Yuming Wang Junyan Zhou Xi Ma Zheng Wang Chengtao Sun Shiyan Qiao | 2019 | Journal of Animal Science and Biotechnology2019，10，3： | 1 |
| 20 | The genomic characteristics and pathogenicity of a mammalian orthoreovirus within a new lineage from wild pika in plateau显示文摘Emerging and re-emerging viruses from wild animals have seriously threatened the health of humans and domesticated animals in recent years.Herein,we isolated a new mammalian orthoreovirus(MRV),Pika/MRV/GCCDC7/2019(PMRV-GCCDC7),in the Qinghai-Tibet Plateau wild pika(Ochotona curzoniae).Though the PMRVGCCDC7 shows features of a typical reovirus with ten gene segments arranged in 3:3:4 in length,the virus belongs to an independent evolutionary branch compared to other MRVs based on phylogenetic tree analysis.The results of cellular susceptibility,species tropism,and replication kinetics of PMRV-GCCDC7 indicated the virus could infect four human cell lines(A549,Huh7,HCT,and LoVo)and six non-human cell lines,including Vero-E6,LLCMK2,BHK-21,N2a,MDCK,and RfKT cell,derived from diverse mammals,i.e.monkey,mice,canine and bat,which revealed the potential of PMRV-GCCDC7 to infect a variety of hosts.Infection of BALB/c mice with PMRVGCCDC7 via intranasal inoculation led to relative weight loss,lung tissue damage and inflammation with the increase of virus titer,but no serious respiratory symptoms and death occurred.The characterization of the new reovirus from a plateau-based wild animal has expanded our knowledge of the host range of MRV and provided insight into its risk of trans-species transmission and zoonotic diseases. | Kexin Zong Yuanyuan Guo Jingdong Song Maoshun Liu Junfeng Hao Jie Zhang Xin Li Shiyan Zhu Shuting Huo Ziqian Xu Peipei Liu Yingze Zhao Yuhai Bi Jiapeng Qu George F.Gao Jun Liu | 2023 | Virologica Sinica2023，38，6： | 0 |
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