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| 1 | Interferon-armed RBD dimer enhances the immunogenicity of RBD for sterilizing immunity against SARS-CoV-2显示文摘Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has caused a global crisis,urgently necessitating the development of safe,efficacious,convenient-to-store,and low-cost vaccine options.A major challenge is that the receptor-binding domain(RBD)-only vaccine fails to trigger long-lasting protective immunity if used alone for vaccination. | Shiyu Sun Yueqi Cai Tian-Zhang Song Yang Pu Lin Cheng Hairong Xu Jing Sun Chaoyang Meng Yifan Lin Haibin Huang Fang Zhao Silin Zhang Yu Gao Jian-Bao Han Xiao-Li Feng Dan-Dan Yu Yalan Zhu Pu Gao Haidong Tang Jincun Zhao Zheng Zhang Jiaming Yang Zhenxiang Hu Yang-Xin Fu Yong-Tang Zheng Hua Peng | 2021 | Cell Research2021，31，9： | 7 |
| 2 | Effects of Y and Ce on Microstructures and Properties of Nb-Si System Composites显示文摘The effects of yttrium and cerium on microstructures and properties of Nb-Si system composites were investigated by scanning electron microscopy( SEM), energy dispersive spectrum(EDS), X-ray diffraction(XRD) and high temperature oxidation experiments.It is found that the coarse primary silicide phase became finer and more homogeneous with Y and Ce addition.The results of high temperature oxidation experiments show that the oxidation rates of NbSi system composites with an appropriate amount of Y and Ce decrease compared with those of alloys without Y or Ce addition, and oxidation products mainly distribute along the phase boundaries between the Nb solid solution and silicide. | Qu Shiyu Han Yafang Song Jinxia Xiao Chengbo Song Liguo | 2004 | Journal of Rare Earths2004，22，z1： | 4 |
| 3 | Comparisons of carcass traits,meat quality,and serum metabolome between Shaziling and Yorkshire pigs显示文摘This study aims to compare the meat quality of Shaziling and Yorkshire pigs and to find the potential indicator in serum for superior meat quality.Six Shaziling and Yorkshire pigs at 30,60,90,150,210,and 300 d of age were selected to examine carcass traits,meat quality,and serum metabolome.The results showed that the body weight,carcass length,and loin eye area of Shaziling pigs at 150,210,and 300 d of age were significantly lower than those of Yorkshire pigs(P<0.05).Shaziling pigs at 150 and 300 d of age had significantly lower backfat thickness than Yorkshire pigs(P<0.05).Compared with Yorkshire pigs,Shaziling pigs at all 6 ages had a lower lean percentage and a higher fat percentage(P<0.05).At 60,90,and 150 d of age,the post-mortem pH-decline,b*value(yellowness),and drip loss of Shaziling pigs were significantly lower than those of Yorkshire pigs(P<0.05).Moreover,at 150 d of age,Shaziling pigs had significantly higher a^(*)value(redness)and intramuscular fat(IMF)content than Yorkshire pigs(P<0.05).Correlation analysis between the top 40 metabolites and phenotypes indicated that L-carnitine had positive correlations with fat percentage,pH24h,and IMF content,but had negative correlations with lean percentage,L^(*)value(lightness),and b^(*)value(P<0.05).Serum L-carnitine content,fat percentage,pH24h,and IMF content all decreased first and then increased as the pigs grew,which verified the positive correlations between L-carnitine and these phenotypes.In conclusion,Shaziling pigs have a slower growth rate but a better meat quality than Yorkshire pigs.The meat quality of Shaziling pigs is the best from 150 to 210 d of age.This study suggests that a higher serum L-carnitine content is a promising indicator for better meat quality. | Bo Song Changbing Zheng Jie Zheng Shiyu Zhang Yinzhao Zhong Qiuping Guo Fengna Li Cimin Long Kang Xu Yehui Duan Yulong Yin | 2022 | Animal Nutrition2022，，1： | 3 |
| 4 | Chidamide combined with cyclophosphamide,doxorubicin,vincristine and prednisone in previously untreated patients with peripheral T-cell lymphoma显示文摘Objective:Chidamide is an oral histone deacetylase subtype-selective inhibitor approved for relapsed or refractory peripheral T-cell lymphoma(PTCL).This phase 1 b study evaluated the safety,pharmacokinetics,and preliminary efficacy of chidamide in combination with cyclophosphamide,doxorubicin,vincristine and prednisone(CHOP)for treatment-na?ve PTCL patients.Methods:This study was an open-label,multicenter trial composed of dose escalation and dose expansion.Patients received CHOP for six 21-d cycles and chidamide on d 1,4,8 and 11 in each cycle.Four dose levels of chidamide(20,25,30 and 35 mg)were evaluated.The primary objective was to evaluate the safety and tolerability of the combination regimen.Results:A total of 30 patients were evaluated in this study:15 in the dose-escalation part and 15 in the doseexpansion part.In the dose-escalation study,three patients were enrolled in the 35 mg chidamide cohort.One had dose-limiting toxicity with grade 3 vascular access complications,and one had grade 2 neutropenia with a sustained temperature>38°C.Dose escalation was stopped at this chidamide dose level.The most common(≥10%)grade 3 or 4 adverse events(AEs)were leukopenia(90.0%),neutropenia(83.3%),vomiting(13.3%),thrombocytopenia(10.0%)and febrile neutropenia(10.0%).No significant changes in chidamide pharmacokinetic properties were observed before and after combination treatment.The objective response rate for the 28 patients evaluable for preliminary efficacy was 89.3%(25/28),with 16(57.1%)achieving complete response or unconfirmed complete response.The estimated median progression-free survival was 14.0 months.In summary,we chose chidamide 30 mg as the recommended dose for phase 2.Conclusions:The addition of chidamide to standard CHOP chemotherapy was tolerable with promising preliminary efficacy in previously untreated PTCL patients,which supports further clinical studies with this combination regimen for the frontline treatment of PTCL. | Lin Gui Junning Cao Dongmei Ji Huilai Zhang Qian Fan Jun Zhu Yuqin Song Shiyu Jiang Zhiqiang Ning Jia Yu Yuankai Shi | 2021 | Chinese Journal of Cancer Research2021，33，5： | 3 |
| 5 | Exome sequencing reveals genetic architecture in patients with isolated or syndromic short stature显示文摘Short stature is among the most common endocrinological disease phenotypes of childhood and may occur as an isolated finding or in conjunction with other clinical manifestations.Although the diagnostic utility of clinical genetic testing in short stature has been implicated,the genetic architecture and the utility of genomic studies such as exome sequencing(ES)in a sizable cohort of patients with short stature have not been investigated systematically.In this study,we recruited 561 individuals with short stature from two centers in China during a 4-year period.We performed ES for all patients and available parents.All patients were retrospectively divided into two groups:an isolated short stature group(group I,n=257)and an apparently syndromic short stature group(group II,n=304).Causal variants were identified in 135 of 561(24.1%)patients.In group I,29 of 257(11.3%)of the patients were solved by variants in 24 genes.In group II,106 of 304(34.9%)patients were solved by variants in 57 genes.Genes involved in fundamental cellularprocess played an important role in the genetic architecture of syndromic short stature.Distinct genetic architectures and pathophysiological processes underlie isolated and syndromic short stature. | Xin Fan Sen Zhao Chenxi Yu Di Wu Zihui Yan Lijun Fan Yanning Song Yi Wang Chuan Li Yue Ming Baoheng Gui Yuchen Niu Xiaoxin Li Xinzhuang Yang Shiyu Luo Qiang Zhang Xiuli Zhao Hui Pan Mei Li Weibo Xia Guixing Qiu Pengfei Liu Shuyang Zhang Jianguo Zhang Zhihong Wu James R.Lupski Jennifer E.Posey Shaoke Chen Chunxiu Gong Nan Wu | 2021 | Journal of Genetics and Genomics2021，48，5： | 2 |
| 6 | Humanpapillomavirustypes16 E6 and E7 contribute differently to carcinogenesis显示文摘 | Shiyu Song Amy Lien James A | 2000 | Viology2000，267，： | 1 |
| 7 | Coaxing Polysaccharide Granules into Supramolecular Biocolloidal Additives for Papermaking显示文摘In light of developments in polysaccharide-based sustainable processes involving supramolecular interactions,we herein present our findings pertaining to coaxing polysaccharide granules into functional supramolecular biocolloids.Translucent biocolloidal dispersions containing various forms of starch are facilely designable,essentially built upon complexation between disassembled native cornstarch granules and amphiphilic ligands.Oily moieties of guest molecules are dynamically attractable into cavities of helical structures,with cationic groups pointing toward the bulk phase.This noncovalent attraction can generate core-shell biocolloidal particles.The significantly higher gelatinizability of freeze-dried biocolloids in contrast to native cornstarch granules is attributable to complex formation,and a homogenous dispersion is readily formable at room temperature.Our results also show biocolloids'ligand-related antibacterial activity.The use of biocolloids as wet-end additives for biofiber assemblies(cellulosic paper)can enhance mechanical strength,fines retention,and filler bondability.Supramolecular biocolloids with positively charged,translucent,easily gelatinizable,antibacterial,and polysaccharide-bondable functionalities would find tailorable use in the paper industry. | Yongsheng Wang Wenyuan Zhu Xueren Qian Meiyun Zhang Shunxi Song Chuyan Jing Zhengren Meng Shiyu Xu Xianhui An Xiujie Huang Jing Shen | 2020 | Paper And Biomaterials2020，5，2： | 1 |
| 8 | Electronic tattoos based on large-area Mo2C grown by chemical vapor deposition for electrophysiology显示文摘Tattoo electronics has attracted intensive interest in recent years due to its comfortable wearing and imperceivable sensing,and has been broadly applied in wearable healthcare and human-machine interface.However,the tattoo electrodes are mostly composed of metal films and conductive polymers.Two-dimensional(2D)materials,which are superior in conductivity and stability,are barely studied for electronic tattoos.Herein,we reported a novel electronic tattoo based on large-area Mo_(2)C film grown by chemical vapor deposition(CVD),and applied it to accurately and imperceivably acquire on-body electrophysiological signals and interface with robotics.High-quality Mo_(2)C film was obtained via optimizing the distribution of gas flow during CVD growth.According to the finite element simulation(FES),bottom surface of Cu foil covers more stable gas flow than the top surface,thus leading to more uniform Mo_(2)C film.The resulting Mo_(2)C film was transferred onto tattoo paper,showing a total thickness of~3μm,sheet resistance of 60-150Ω/sq,and skin-electrode impedance of~5×10^(5)Ω.Such thin Mo_(2)C electronic tattoo(MCET in short)can form conformal contact with skin and accurately record electrophysiological signals,including electromyography(EMG),electrocardiogram(ECG),and electrooculogram(EOG).These body signals collected by MCET can not only reflect the health status but also be transformed to control the robotics for human-machine interface. | Shiyu Wang Xin Wang Weifeng Zhang Xiaohu Shi Dekui Song Yan Zhang Yan Zhao Zihan Zhao Nan Liu | 2023 | Nano Research2023，16，3： | 1 |
| 9 | Effects of V and Al on Microstructure and Room Temperature Fracture Toughness of Nb-Si In-situ Composites显示文摘The effect of alloying elements V and Al on microstructure and room temperature fracture toughness of an experimental Nb-Si in-situ composite was investigated. The Nb-Si alloys with different amount of V and Al were prepared by non-consumable arc-melting furnace. The experimental results showed that with the addition of V and Al, the microstructure of the Nb-Si materials transformed from Nbss+Nb3Si to Nbss+Nb5Si3 and the lattice parameters of Nbss phase decreased, and the alloying element V promoted the formation of the finer Nbss structure. It was observed that the room temperature fracture toughness was improved by the addition of V and Al, and the optimum room-temperature fracture toughness of the material appeared in the alloy with 2.6at.%V and 3.6at.%Al. The improvement of room temperature fracture toughness may be mainly attributed to the increment of the volume fraction of Nbss phase and the decrement of the silicide phase size. | Kang Yongwang Qu Shiyu Song Jinxia Han Yafang | 2009 | 稀有金属材料与工程2009，38，A03： | 1 |
| 10 | Measurement of volume-occupying rate of cervical spinal canal and its role in cervical spondylotic myelopathy显示文摘 | Fulong Dong Cailiang Shen Shu Jiang Renjie Zhang Peiwen Song Yongqiang Yu Shiyu Wang Xiaohu Li Gang Zhao Changhai Ding | 2013 | European Spine Journal2013，，5： | 1 |
| 11 | Garnet-type solid electrolyte:Advances of ionic transport performance and its application in all-solid-state batteries显示文摘All-solid-state lithium batteries(ASSLBs),which use solid electrolytes instead of liquid ones,have become a hot research topic due to their high energy and power density,ability to solve battery safety issues,and capabilities to fulfill the increasing demand for energy storage in electric vehicles and smart grid applications.Garnet-type solid electrolytes have attracted considerable interest as they meet all the properties of an ideal solid electrolyte for ASSLBs.The garnet-type Li_(7)La_(3)Zr_(2)O_(12)(LLZO)has excellent environmental stability;experiments and computational analyses showed that this solid electrolyte has a high lithium(Li)ionic conductivity(10^(-4)-10^(-3) S·cm^(-1)),an electrochemical window as wide as 6 V,stability against Li metal anode,and compatibility with most of the cathode materials.In this review,we present the fundamentals of garnet-type solid electrolytes,preparation methods,air stability,some strategies for improving the conductivity based on experimental and computational results,interfacial issues,and finally applications and challenges for future developments of LLZO solid electrolytes for ASSLBs. | P.M.GONZALEZ PUENTE Shangbin SONG Shiyu CAO Leana Ziwen RANNALTER Ziwen PAN Xing XIANG Qiang SHEN Fei CHEN | 2021 | Journal of Advanced Ceramics2021，10，5： | 1 |
| 12 | Understanding Miocene Climate Evolution in Northeastern Tibet: Stable Carbon and Oxygen Isotope Records from the Western Tianshui Basin, China显示文摘To investigate climate evolution during the Miocene, especially during the Middle Miocene climate transition on the northeastern Tibetan Plateau, stable oxygen and carbon isotopes of carbonates from a 288-m-thick lacustrine-fluvial sediment sequence covering the period from 17.1 to 6.1 Ma from Tianshui Basin, China, were analyzed. The relatively low stable oxygen isotope values indicate the prevalence of wet climate conditions during the period of 17.1–13.6 Ma, an interval corresponding to the well-known Middle Miocene Climate Optimum. The interval between 13.6 and 11.0 Ma(i.e., the late Middle Miocene) is marked by a progressive increase in the δ18O values, indicative of a decrease in precipitation, probably linked to the expansion of the East Antarctic Ice Sheet and global cooling since about 14 Ma. The climate in the study area continued to get drier as shown by the enrichment of the heavy oxygen isotope from 11 Ma. We attribute these stepwise climatic changes as revealed by our carbonate δ18O record from the northeastern Tibetan Plateau to the sustained global cooling that may have reduced moist transport to Central Asia, which in turn led to a permanent aridification. | Zhanfang Hou Jijun Li Chunhui Song Jun Zhang Zhengchuang Hui Shiyue Chen Feng Xian | 2014 | Journal of Earth Science2014，25，2： | 1 |
| 13 | Microstructure and properties of refractory niobium-silicide-based composites显示文摘 | Qu Shiyu Han Yafang Song Liguo | 2005 | Materials Science Forum Vols2005，，： | 1 |
| 14 | Preparation of Anisotropic MnO2 Nanocatalysts for Selective Oxidation of Benzyl Alcohol and 5-Hydroxymethylfurfural显示文摘Anisotropic MnO2 nanostructures,includingα-phase nanowire,α-phase nanorod,δ-phase nanosheet,α+δ-phase nanowire,and amorphous fl occule,were synthesized by a simple hydrothermal method through adjusting the pH of the precursor solution and using diff erent counterions.The catalytic properties of the as-synthesized MnO2 nanomaterials in the selective oxidation of benzyl alcohol(BA)and 5-hydroxymethylfurfural(HMF)were evaluated.The eff ects of micromorphology,phase structure,and redox state on the catalytic activity of MnO2 nanomaterials were investigated.The results showed that the intrinsic catalytic oxidation activity was mainly infl uenced by the unique anisotropic structure and surface chemical property of MnO2.With one-dimensional and 2D structures exposing highly active surfaces,unique crystal forms,and high oxidation state of Mn,the intrinsic activities for MnO2 catalysts synthesized in pH 1,5,and 10 solutions(denoted as MnO2-pH1,MnO2-pH5,and MnO2-pH10,respectively)were twice higher than those of other MnO2 catalysts in oxidation of BA and HMF.With a moderate aspect ratio,theα+δnanowire of MnO2-pH10 exhibited the highest average oxidation state,most abundant active sites,and the best catalytic oxidation activity. | Huanlin Wang Yu Song Xuan Liu Shiyu Lu Chunmei Zhou Yuguang Jin Yanhui Yang | 2020 | Transactions of Tianjin University2020，26，5： | 1 |
| 15 | Tumor-microenvironment activated duplex genome-editing nanoprodrug for sensitized near-infrared titania phototherapy显示文摘Near-infrared(NIR)-light-triggered nanomedicine, including photodynamic therapy(PDT)and photothermal therapy(PTT), is growing an attractive approach for cancer therapy due to its high spatiotemporal controllability and minimal invasion, but the tumor eradication is limited by the intrinsic anti-stress response of tumor cells. Herein, we fabricate a tumor-microenvironment responsive CRISPR nanoplatform based on oxygen-deficient titania(TiO_(2-x)) for mild NIR-phototherapy. In tumor microenvironment, the overexpressed hyaluronidase(HAase) and glutathione(GSH) can readily destroy hyaluronic acid(HA) and disulfide bond and releases the Cas9/sgRNA from TiO_(2-x) to target the stress alleviating regulators, i.e., nuclear factor E2-related factor 2(NRF2) and heat shock protein 90a(HSP90a), thereby reducing the stress tolerance of tumor cells. Under subsequent NIR light illumination, the TiO_(2-x) demonstrates a higher anticancer effect both in vitro and in vivo. This strategy not only provides a promising modality to kills cancer cells in a minimal side-effects manner by interrupting anti-stress pathways but also proposes a general approach to achieve controllable gene editing in tumor region without unwanted genetic mutation in normal environments. | Zekun Li Yongchun Pan Shiyu Du Yayao Li Chao Chen Hongxiu Song Yueyao Wu Xiaowei Luan Qin Xu Xiaoxiang Guan Yujun Song Xin Han | 2022 | Acta Pharmaceutica Sinica B2022，12，11： | 0 |
| 16 | Investigating association between gut microbiota and sarcopenia-related traits:a Mendelian randomization study显示文摘Background Observational studies have indicated a potential link between gut microbiota and sarcopenia.However,the underlying mechanisms and a causal relationship have not been established.Thus,the objective of this study is to examine the possible causal association between gut microbiota and sarcopenia-related traits,including low hand-grip strength and appendicular lean mass(ALM),to shed light on the gut–muscle axis.Methods To investigate the potential impact of gut microbiota on low hand-grip strength and ALM,we utilized a two-sample Mendelian randomization(MR)approach.Summary statistics were obtained from genome-wide association studies of gut microbiota,low hand-grip strength,and ALM.The primary MR analysis employed the random-effects inverse-variance weighted(IVW)method.To assess the robustness,we conducted sensitivity analyses using the MR pleiotropy residual sum and outlier(MR-PRESSO)test to detect and correct for horizontal pleiotropy,as well as the MR-Egger intercept test and leave-one-out analysis.Results Alcaligenaceae,Family XIII,and Paraprevotella were positively associated with the risk of low hand-grip strength(P-values<0.05).Streptococcaceae were negatively associated with low hand-grip strength(P-values<0.05).Eight bacterial taxa(Actinomycetales,Actinomycetaceae,Bacteroidaceae,Porphyromonadaceae,Prevotellaceae,Bacteroides,Marvinbryantia,and Phascolarctobacterium)were associated with a higher risk of ALM(P-values<0.05).Eubacterium fissicatena group was negatively associated with ALM(P-values<0.05).Conclusion We found several gut microbiota components causally associated with sarcopenia-related traits.Our findings provided insights into novel strategies for the prevention and treatment of sarcopenia through the regulation of the gut microbiota,contributing to a better understanding of the gut–muscle axis. | Jiaxi Zhao Rui Liang Quhong Song Shiyu Song Jirong Yue Chenkai Wu | 2023 | Precision Clinical Medicine2023，6，2： | 0 |
| 17 | Myeloid peroxisome proliferator-activated receptor α deficiency accelerates liver regeneration via IL-6/STAT3 pathway after 2/3 partial hepatectomy in mice显示文摘Background:Liver regeneration is a fundamental process for sustained body homeostasis and liver function recovery after injury.Emerging evidence demonstrates that myeloid cells play a critical role in liver regeneration by secreting cytokines and growth factors.Peroxisome proliferator-activated receptorα(PPARα),the target of clinical lipid-lowering fibrate drugs,regulates cell metabolism,proliferation,and survival.However,the role of myeloid PPARαin partial hepatectomy(PHx)-induced liver regeneration remains unknown.Methods:Myeloid-specific PPARa-deficient(Ppara^(Mye−/−))mice and the littermate controls(Ppara^(fl/fl))were subjected to sham or 2/3 PHx to induce liver regeneration.Hepatocyte proliferation and mitosis were assessed by immunohistochemical(IHC)staining for 5-bromo-2'-deoxyuridine(BrdU)and Ki67 as well as hematoxylin and eosin(H&E)staining.Macrophage and neutrophil infiltration into livers were reflected by IHC staining for galectin-3 and myeloperoxidase(MPO)as well as flow cytometry analysis.Macrophage migration ability was evaluated by transwell assay.The mRNA levels for cell cycle or inflammation-related genes were measured by quantitative real-time RT-PCR(qPCR).The protein levels of cell proliferation related protein and phosphorylated signal transducer and activator of transcription 3(STAT3)were detected by Western blotting.Results:Ppara^(Mye−/−)mice showed enhanced hepatocyte proliferation and mitosis at 32 h after PHx compared with Ppara^(fl/fl)mice,which was consistent with increased proliferating cell nuclear antigen(Pcna)mRNA and cyclinD1(CYCD1)protein levels in Ppara^(Mye−/−)mice at 32 h after PHx,indicating an accelerated liver regeneration in Ppara^(Mye−/−)mice.IHC staining showed that macrophages and neutrophils were increased in Ppara^(Mye−/−)liver at 32 h after PHx.Livers of Ppara^(Mye−/−)mice also showed an enhanced infiltration of M1 macrophages at 32 h after PHx.In vitro,Ppara-deficient bone marrow-derived macrophages(BMDMs)exhibited markedly enhanced migratory capacity and upregulated M1 genes Il6 and Tnfa but downregulated M2 gene Arg1 expressions.Furthermore,the phosphorylation of STAT3,a key transcript factor mediating IL6-promoted hepatocyte survival and proliferation,was reinforced in the liver of Ppara^(Mye−/−)mice after PHx.Conclusions:This study provides evidence that myeloid PPARαdeficiency accelerates PHx-induced liver regeneration via macrophage polarization and consequent IL-6/STAT3 activation,thus providing a potential target for manipulating liver regeneration. | Guomin Xie Yanting Song Na Li Zhenzhen Zhang Xia Wang Ye Liu Shiyu Jiao Ming Wei Baoqi Yu Yan Wang Hua Wang Aijuan Qu | 2022 | Hepatobiliary Surgery and Nutrition2022，11，2： | 0 |
| 18 | Propagation Properties of Shock Waves in Polyurethane Foam based on Atomistic Simulations显示文摘Porous materials are widely used in the field of protection because of their excellent energy absorption characteristics.In this work,a series of polyurethane microscopic models are established and the effect of porosity on the shock waves is studied with classical molecular dynamics simulations.Firstly,shock Hugoniot relations for different porosities are obtained,which compare well with the experimental data.The pores collapse and form local stress wave,which results in the complex multi-wave structure of the shock wave.The microstructure analysis shows that the local stress increases and the local velocity decreases gradually during the process of pore collapse to complete compaction.Finally,it leads to stress relaxation and velocity homogenization.The shock stress peaks can be fitted with two exponential functions,and the amplitude of attenuation coefficient decreases with the increase of density.Besides,the pore collapse under shock or non-shock are discussed by the entropy increase rate of the system.The energy is dissipated mainly through the multiple interactions of the waves under shock.The energy is dissipated mainly by the friction between atoms under non-shock. | Zhiqiang Hu Jianli Shao Shiyu Jia Weidong Song Cheng Wang | 2024 | Defence Technology(防务技术)2024，31，1： | 0 |
| 19 | Functional characterization of novel NPRL3 mutations identified in three families with focal epilepsy显示文摘Focal epilepsy accounts for 60% of all forms of epilepsy, but the pathogenic mechanism is not well understood. In this study,three novel mutations in NPRL3(nitrogen permease regulator-like 3), c.937_945del, c.1514dup C and 6,706-bp genomic DNA(g DNA) deletion, were identified in three families with focal epilepsy by linkage analysis, whole exome sequencing(WES) and Sanger sequencing. NPRL3 protein is a component of the GATOR1 complex, a major inhibitor of m TOR signaling. These mutations led to truncation of the NPRL3 protein and hampered the binding between NPRL3 and DEPDC5, which is another component of the GATOR1 complex. Consequently, the mutant proteins enhanced m TOR signaling in cultured cells, possibly due to impaired inhibition of m TORC1 by GATOR1. Knockdown of nprl3 in Drosophila resulted in epilepsy-like behavior and abnormal synaptic development. Taken together, these findings expand the genotypic spectrum of NPRL3-associated focal epilepsy and provide further insight into how NPRL3 mutations lead to epilepsy. | Shiyue Du Sheng Zeng Li Song Hongying Ma Rui Chen Junyu Luo Xu Wang Tingbin Ma Xuan Xu Hao Sun Ping Yi Jifeng Guo Yaling Huang Mugen Liu Tao Wang Wei-Ping Liao Luoying Zhang Jing Yu Liu Beisha Tang | 2023 | Science China(Life Sciences)2023，66，9： | 0 |
| 20 | Author correction to “Tumor-microenvironment activated duplex genome-editing nanoprodrug for sensitized near-infrared titania phototherapy” [Acta Pharm Sin B (2022) 4224-4234]显示文摘The authors regret that there is an error in the article Fig.5E due to the mistake of copying and pasting in the process of assembling figures and negligence in the proofreading.Although it does not affect the conclusion,it is an obvious error.The authors have now modified as below.The authors apologize for any inconvenience caused to the journal and readers. | Zekun Li Yongchun Pan Shiyu Du Yayao Li Chao Chen Hongxiu Song Yueyao Wu Xiaowei Luan Qin Xu Xiaoxiang Guan Yujun Song Xin Han | 2024 | Acta Pharmaceutica Sinica B2024，14，2： | 0 |
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