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| 1 | Anti-wear and friction performance of ZrO_2 nanoparticles as lubricant additive显示文摘The surface of ZrO2 nanoparticles was modified with silane coupling agent KH-560 by dispersing the nanoparticles in 20#machine oil.The tribological performance of the 20#machine oil with ZrO2 nanoparticles was evaluated by a four-ball tester and a thrust-ring machine.The loss of the thrust-ring weight was measured by an electronic balance with a precision of 0.0001 g.The worn surface was examined under a metallographic microscope with 400-times magnification.The results showed that the average friction coefficient decreased by 27.34%,and that the weight loss of the thrust-ring indicated no wear or negative wear,the wear loss after six loads tests being-0.0163 g.The anti-wear(AW)and reducing friction(RF)abilities of the oil with ZrO2 nanoparticles addition were considerably improved,maximizing at an additive concentration of 0.5wt%. | Shiyu Ma Shaohua Zheng Duxia Cao Hongna Guo | 2010 | Particuology2010，8，5： | 11 |
| 2 | Plasma spray of biofunctional(Mg, Sr)-substituted hydroxyapatite coatings for titanium alloy implants显示文摘Plasma-sprayed hydroxyapatite (HA) coatings have been widely utilized in load-bearing titanium alloy implants. In this study, Mg, Sr co-substituted HA ((Mg,Sr)-HA) nano-scale powders have been synthesized, which are further used to prepare (Mg,Sr)-HA coatings on Ti-6A1-4V alloys in order to improve the biological functions. The average size of (Mg,Sr)-HA nano particles is ~75nm. The average bonding strength for (Mg,Sr)-HA coating and samples after heat treatment at 500℃ or 600℃ for 3h are 26.17±2.11 MPa, 36.07±4.48 MPa and 37.07 ±2.95 MPa, respectively. There is a significantly increase of bonding strength likely due to low residual stress after heated treatment.MC3T3-E1 cells show a high proliferation rate when cultured with (Mg,Sr)-HA coating extract compared to the normal culture medium, which also exhibit large extension and depositi on of extracellular matrices when adhered on the coating surfaces. Thus, these (Mg,Sr)-HA coatings show high bonding strength and improved biological functions, which offer promising future applications in the fields of orthopedics and dentistry. | Lei Cao Ihsan Ullah Na Li Shiyu Niu Rujie Sun Dandan Xia Rui Yang Xing Zhang | 2019 | Journal of Materials Science & Technology2019，35，5： | 5 |
| 3 | Chidamide combined with cyclophosphamide,doxorubicin,vincristine and prednisone in previously untreated patients with peripheral T-cell lymphoma显示文摘Objective:Chidamide is an oral histone deacetylase subtype-selective inhibitor approved for relapsed or refractory peripheral T-cell lymphoma(PTCL).This phase 1 b study evaluated the safety,pharmacokinetics,and preliminary efficacy of chidamide in combination with cyclophosphamide,doxorubicin,vincristine and prednisone(CHOP)for treatment-na?ve PTCL patients.Methods:This study was an open-label,multicenter trial composed of dose escalation and dose expansion.Patients received CHOP for six 21-d cycles and chidamide on d 1,4,8 and 11 in each cycle.Four dose levels of chidamide(20,25,30 and 35 mg)were evaluated.The primary objective was to evaluate the safety and tolerability of the combination regimen.Results:A total of 30 patients were evaluated in this study:15 in the dose-escalation part and 15 in the doseexpansion part.In the dose-escalation study,three patients were enrolled in the 35 mg chidamide cohort.One had dose-limiting toxicity with grade 3 vascular access complications,and one had grade 2 neutropenia with a sustained temperature>38°C.Dose escalation was stopped at this chidamide dose level.The most common(≥10%)grade 3 or 4 adverse events(AEs)were leukopenia(90.0%),neutropenia(83.3%),vomiting(13.3%),thrombocytopenia(10.0%)and febrile neutropenia(10.0%).No significant changes in chidamide pharmacokinetic properties were observed before and after combination treatment.The objective response rate for the 28 patients evaluable for preliminary efficacy was 89.3%(25/28),with 16(57.1%)achieving complete response or unconfirmed complete response.The estimated median progression-free survival was 14.0 months.In summary,we chose chidamide 30 mg as the recommended dose for phase 2.Conclusions:The addition of chidamide to standard CHOP chemotherapy was tolerable with promising preliminary efficacy in previously untreated PTCL patients,which supports further clinical studies with this combination regimen for the frontline treatment of PTCL. | Lin Gui Junning Cao Dongmei Ji Huilai Zhang Qian Fan Jun Zhu Yuqin Song Shiyu Jiang Zhiqiang Ning Jia Yu Yuankai Shi | 2021 | Chinese Journal of Cancer Research2021，33，5： | 3 |
| 4 | Performance evaluation of deep learning-based post-processing and diagnostic reporting system for coronary CT angiography: a clinical comparative study显示文摘To the Editor:Coronary computed tomography angiography(CCTA)has been increasingly,widely performed for diagnosing coronary artery,disease,lAnatomical diagnosis,that is,stenosis grading,is stillthe main diagnostic index provided'by most CCTA tests.Post-processing and interpretation of stenosis are 2 essential'steps that need to be performed bycardiovascular imaging professionals from scan completion to diagnosis conclusion,which is repetitive and time-consuming,taking an average of 30 minutes each case in China and becoming the bottleneck and gradually creating an imbalance between supply and demand.In ine with the rapid development of artificial intelligence(Al)technology in recent years,it has been expected to solve these specific problems.We developed an AI system for automating post-processing and diagnostic reporting of CCTA data using deep learning algorithms to establishanew1-clickworkflowforeverydayuse,namely,CCTA-AI(Figure 1).To further assess its capabilities,this study intends to answer 2 following questions:To what extent can it improve the efficiency of post-processing?To what extent can CCTA-AI detect and calculate coronary artery stenosis due to each atherosclerotic plaque? | Nan Luo Yi He Jitao Fan Ning Guo Guang Yang Yuanyuan Kong Jianyong Wei Tao Bi Jie Zhou Jiaxin Cao Xianjun Han Fang Li Shiyu Zhang Rujing Sun Zhaozhao Wang Tian Ma Lixue Xu Hui Chen Hongwei Li Zhenchang Wang Zhenghan Yang | 2022 | Chinese Medical Journal2022，135，19： | 2 |
| 5 | Understanding recurrent pregnancy loss:recent advances on its etiology,clinical diagnosis,and management显示文摘Recurrent pregnancy loss(RPL)has become an important reproductive health issue worldwide.RPL affects about 2%–3%of reproductive-aged women,and makes serious threats to women’s physical and mental health.However,the etiology of approximately 50%of RPL cases remains unknown(unexplained RPL),which poses a big challenge for clinical management of these patients.RPL has been widely regarded as a complex disease where its etiology has been attributed to numerous factors.Heretofore,various risk factors for RPL have been identified,such as maternal ages,genetic factors,anatomical structural abnormalities,endocrine dysfunction,prethrombotic state,immunological factors,and infection.More importantly,development and applications of next generation sequencing technology have significantly expanded opportunities to discover chromosomal aberrations and single gene variants responsible for RPL,which provides new insight into its pathogenic mechanisms.Furthermore,based upon patients’diagnostic evaluation and etiologic diagnosis,specific therapeutic recommendations have been established.This review will highlight current understanding and recent advances on RPL,with a special focus on the immunological and genetic etiologies,clinical diagnosis and therapeutic management. | Chunwei Cao Shiyu Bai Jing Zhang Xiaoyue Sun Anming Meng Hui Chen | 2022 | Medical Review2022，2，6： | 1 |
| 6 | Mechanisms of allicin exposure for the sludge fermentation enhancement:Focusing on the fermentation processes and microbial metabolic traits显示文摘As a frequently used product with antimicrobial activity,consumed allicin might be dis-charged and concentrated in waste-activated sludge(WAS).However,the influence of al-licin(as an exogenous pollutant)on WAS fermentation has not been clearly revealed.This study aimed to disclose the impacts of allicin on volatile fatty acid(VFA)generation dur-ing WAS fermentation.The results showed that the appropriate presence of allicin(10 mg/g TSS)significantly enhanced the VFA yield(1894 versus 575 mg COD/L in the control)with increased acetate proportion(24.3%).Further exploration found that allicin promoted WAS solubilization,hydrolysis and acidification simultaneously.Metagenomic analysis revealed that the key genes involved in extracellular hydrolysis metabolism(i.e.,CAZymes),mem-brane transport(i.e.,gtsA and ytfT),substrate metabolism(i.e.,yhdR and pfkC)and fatty acid synthesis(i.e.,accA and accD)were all highly expressed.Allicin also induced the bacteria to produce more signalling molecules and regulate cellular functions,thereby enhancing the microbial adaptive and regulatory capacity to the unfavourable environment.Moreover,the variations in fermentative microbes and their contributions to the upregulation of func-tional genes(i.e.,ytfR,gltL,INV,iolD and pflD)for VFA generation were disclosed.Overall,the simultaneous stimulation of functional microbial abundances and metabolic activities contributed to VFA production in allicin-conditioned reactors. | Feng Wang Jingyang Luo Shiyu Fang Wenxuan Huang Yunqi Zhang Le Zhang Xiaoshi Cheng Wei Du Fang Fang Jiashun Cao Yang Wu | 2022 | Journal of Environmental Sciences2022，34，5： | 1 |
| 7 | Continuous culture of urine-derived bladder cancer cells for precision medicine显示文摘Dear Editor,Bladder cancer is the most common type of genitourinary cancer in China,with an estimated 80,500 new cases and 32,900 related deaths in 2015 alone(Chen et al.,2016).Unlike many other cancers,there has been no significant improvement in survival rates for bladder cancer over the last three decades.Specific treatment regimens for bladder cancer and their efficacy vary depending not only on clinical stages,but also on associated risk factors and other personal clinical characteristics.Patients with non-muscle invasive bladder cancer(NMIBC)have a high 5-year recurrence rate of 60%-70%(Berdik,2017)and those with muscle invasive bladder cancer(MIBC)has a relatively poor prognosis with approximately 65%risk of death within 5-year follow-up(Kamat et al.,2016).Therefore,there is an urgent need to develop models for bladder cancer to screen for rational treatment strategies by personalized medicine to improve the clinical assessment and treatment of bladder cancer. | Shuai Jiang Jiaqi Wang Chen Yang Renke Tan Jun Hou Yuan Shi Huihui Zhang Shiyu Ma Jianan Wang Mengmeng Zhang George Philips Zengxia Li Jian Ma Wanjun Yu Guohua Wang Yuanming Wu Richard Schlegel Huina Wang Shanbo Cao Jianming Guo Xuefeng Liu Yongjun Dang | 2019 | Protein & Cell2019，10，12： | 1 |
| 8 | Optimal boundarySVM incremental learning algorithm显示文摘 | Cao Jian Sun Shiyu Duan Xiusheng | 2013 | Applied Mechanicsand Materials2013，347，： | 1 |
| 9 | Additive and interfacial control for efficient perovskite light-emitting diodes with reduced trap densities显示文摘Metal halide perovskite semiconductors show excellent optoelectronic properties including tunable bandgaps[1,2],narrow emission bandwidths[3]and high luminescence quantum efficiencies[4],making them an ideal candidate for light-emitting diode(LED)applications.Perovskite LEDs(PeLEDs)have attracted considerable attention since the initial report of room-temperature electroluminescence(EL)from halide perovskites in 2014[5]. | Shun Tian Chen Zou Runchen Lai Chungen Hsu Xuhui Cao Shiyu Xing Baodan Zhao Dawei Di | 2022 | Journal of Semiconductors2022，43，5： | 1 |
| 10 | Garnet-type solid electrolyte:Advances of ionic transport performance and its application in all-solid-state batteries显示文摘All-solid-state lithium batteries(ASSLBs),which use solid electrolytes instead of liquid ones,have become a hot research topic due to their high energy and power density,ability to solve battery safety issues,and capabilities to fulfill the increasing demand for energy storage in electric vehicles and smart grid applications.Garnet-type solid electrolytes have attracted considerable interest as they meet all the properties of an ideal solid electrolyte for ASSLBs.The garnet-type Li_(7)La_(3)Zr_(2)O_(12)(LLZO)has excellent environmental stability;experiments and computational analyses showed that this solid electrolyte has a high lithium(Li)ionic conductivity(10^(-4)-10^(-3) S·cm^(-1)),an electrochemical window as wide as 6 V,stability against Li metal anode,and compatibility with most of the cathode materials.In this review,we present the fundamentals of garnet-type solid electrolytes,preparation methods,air stability,some strategies for improving the conductivity based on experimental and computational results,interfacial issues,and finally applications and challenges for future developments of LLZO solid electrolytes for ASSLBs. | P.M.GONZALEZ PUENTE Shangbin SONG Shiyu CAO Leana Ziwen RANNALTER Ziwen PAN Xing XIANG Qiang SHEN Fei CHEN | 2021 | Journal of Advanced Ceramics2021，10，5： | 1 |
| 11 | Perivascular localized cells commit erythropoiesis in PDGF-B-expressing solid tumors显示文摘Background:Tumors possess incessant growth features,and expansion of their masses demands sufficient oxygen supply by red blood cells(RBCs).In adult mammals,the bone marrow(BM)is the main organ regulating hematopoiesis with dedicated manners.Other than BM,extramedullary hematopoiesis is discovered in various pathophysiological settings.However,whether tumors can contribute to hematopoiesis is completely unknown.Accumulating evidence shows that,in the tumor microenvironment(TME),perivascular localized cells retain progenitor cell properties and can differentiate into other cells.Here,we sought to better understand whether and how perivascular localized pericytes in tumors manipulate hematopoiesis.Methods:To test if vascular cells can differentiate into RBCs,genome-wide expression profiling was performed using mouse-derived pericytes.Genetic tracing of perivascular localized cells employing NG2-CreERT2:R26R-tdTomato mouse strain was used to validate the findings in vivo.Fluorescence-activated cell sorting(FACS),single-cell sequencing,and colony formation assays were applied for biological studies.The production of erythroid differentiationspecific cytokine,erythropoietin(EPO),in TME was checked using quantitative polymerase chain reaction(qPCR),enzyme-linked immunosorbent assay(ELISA,magnetic-activated cell sorting and immunohistochemistry.To investigate BM function in tumor erythropoiesis,BM transplantation mouse models were employed.Results:Genome-wide expression profiling showed that in response to plateletderived growth factor subunit B(PDGF-B),neural/glial antigen 2(NG2)+perivascular localized cells exhibited hematopoietic stem and progenitor-like features and underwent differentiation towards the erythroid lineage.PDGF-B simultaneously targeted cancer-associated fibroblasts to produce high levels of EPO,a crucial hormone that necessitates erythropoiesis.FACS analysis using genetic tracing of NG2+cells in tumors defined the perivascular localized cell-derived subpopulation of hematopoietic cells.Single-cell sequencing and colony formation assays validated the fact that,upon PDGF-B stimulation,NG2+cells isolated from tumors acted as erythroblast progenitor cells,which were distinctive from the canonical BM hematopoietic stem cells.Conclusions:Our data provide a new concept of hematopoiesis within tumor tissues and novel mechanistic insights into perivascular localized cell-derived erythroid cells within TME.Targeting tumor hematopoiesis is a novel therapeutic concept for treating various cancers that may have profound impacts on cancer therapy. | Kayoko Hosaka Chenchen Wang Shiyue Zhang Xue Lv Takahiro Seki Yin Zhang Xu Jing Jieyu Wu Qiqiao Du Xingkang He Yulong Fan Xuan Li Makoto Kondo Masahito Yoshihara Hong Qian Lihong Shi Ping Zhu Yuanfu Xu Yunlong Yang Tao Cheng Yihai Cao | 2023 | Cancer Communications2023，43，6： | 1 |
| 12 | Oxidative phosphorylation safeguards pluripotency via UDP-N-acetylglucosamine显示文摘Dear Editor,Embryonic stem cells(ESCs)have been assumed to possess immature mitochondria and to favor anaerobic glycolysis over oxidative phosphorylation(OXPHOS)for energy production.This proposition is largely based on the findings that ESCs possess globular mitochondria with blurred cristae,and the facts that ESCs have higher glycolysis activity and lower mitochondrial respiration capacity than somatic cells(Kondoh et al.,2007;Folmes et al.,2011,2012;Zhang et al.,2012;Xu et al.,2013;Ito and Suda,2014;Gu et al.,2016).However,recent studies have shown that mitochondrial autophagy and mitochondrial dynamics are pivotal for ESC self-renewal and pluripotency(Todd et al.,2010;Liu et al.,2016,2020;Wang et al.,2019;Zhong et al.,2019).These studies have raised a fundamental question:what is the contribution and functional mechanism of mitochondrial respiration in pluripotency regulation? | Jiani Cao Meng Li Kun Liu Xingxing Shi Ning Sui Yuchen Yao Xiaojing Wang Shiyu Li Yuchang Tian Shaojing Tan Qian Zhao Liang Wang Xiahua Chai Lin Zhang Chong Liu Xing Li Zhijie Chang Dong Li Tongbiao Zhao | 2023 | Protein & Cell2023，14，5： | 1 |
| 13 | New insights into different surfactants’impacts on sludge fermentation:Focusing on the particular metabolic processes and microbial genetic traits显示文摘Surfactants were expected to exhibit positive effects on the waste activated sludge(WAS)disposal.However,the systematic comparison of different categories of surfactants on the WAS fermentation and the functional mechanisms,especially microbial metabolic traits,have not yet been precisely explored.This study revealed the positive effects of different surfactants on the volatile fatty acid(VFA)production,which followed the order of alkyl polysaccharides(APG)>sodium dodecylbenzene sulfonate(SDBS)>hexadecyl trimethyl ammonium bromide(HTAB).Mechanistic exploration found that the presence of different surfactants improved solubilization and hydrolysis steps,and then contributed to the subsequent acidification with different efficiencies.The functional microorganisms associated with VFA generation were enriched in surfactant-conditioned reactors.Metagenomic analysis further indicated that the key genes involved in the particular process of VFA generation were over-expressed.The simultaneous bioavailable substrate improvement,functional bacterial enrichment,and metabolic activity upregulation induced by different surfactants jointly contributed to VFA promotion during WAS fermentation.This study could provide a comprehensive realization of surfactants’impacts on theWAS fermentation process,and more importantly,it reminded the public to discern the distinct interplaying effects induced by different chemicals in regulating the WAS disposal and resource recovery. | Jingyang Luo Shiyu Fang Wenxuan Huang Feng Wang Le Zhang Fang Fang Jiashun Cao Yang Wu Dongbo Wang | 2022 | Frontiers of Environmental Science & Engineering2022，16，8： | 1 |
| 14 | Flexible Large-Area Graphene Films of 50-600 nm Thickness with High Carrier Mobility显示文摘Bulk graphene nanofilms feature fast electronic and phonon transport in combination with strong light-matter interaction and thus have great potential for versatile applications,spanning from photonic,electronic,and optoelectronic devices to charge-stripping and electromagnetic shielding,etc.However,large-area flexible close-stacked graphene nanofilms with a wide thickness range have yet to be reported.Here,we report a polyacrylonitrile-assisted’substrate replacement’strategy to fabricate large-area free-standing graphene oxide/polyacrylonitrile nanofilms(lateral size~20 cm).Linear polyacrylonitrile chains-derived nanochannels promote the escape of gases and enable macro-assembled graphene nanofilms(nMAGs)of 50-600 nm thickness following heat treatment at 3,000℃.The uniform nMAGs exhibit 802-1,540 cm^(2)V-1s-1carrier mobility,4.3-4.7 ps carrier lifetime,and>1,581 W m^(-1)K^(-1)thermal conductivity(n MAG-assembled 10μm-thick films,mMAGs).nMAGs are highly flexible and show no structure damage even after 1.0×10^(5)cycles of folding-unfolding.Furthermore,n MAGs broaden the detection region of graphene/silicon heterojunction from near-infrared to mid-infrared and demonstrate higher absolute electromagnetic interference(EMI)shielding effectiveness than state-of-the-art EMI materials of the same thickness.These results are expected to lead to the broad applications of such bulk nanofilms,especially as micro/nanoelectronic and optoelectronic platforms. | Shiyu Luo Li Peng Yangsu Xie Xiaoxue Cao Xiao Wang Xiaoting Liu Tingting Chen Zhanpo Han Peidong Fan Haiyan Sun Ying Shen Fan Guo Yuxing Xia Kaiwen Li Xin Ming Chao Gao | 2023 | Nano-Micro Letters2023，15，5： | 1 |
| 15 | Linkages of volatile fatty acids and polyhexamethylene guanidine stress during sludge fermentation:Metagenomic insights of microbial metabolic traits and adaptation显示文摘The massive use of polyhexamethylene guanidine(PHMG),as a typical bactericidal agent,raised environmental concerns to the public.This work comprehensively revealed the hormesis effects of PHMG occurred in waste activated sludge(WAS)on the generation of volatile fatty acids(VFAs)during anaerobic fermentation.The low level of PHMG(100 mg/g TSS)significantly promoted the VFAs generation(1283 mg COD/L,compared with 337 mg COD/L in the control)via synchronously facilitating the solubilization,hydrolysis,and acidification steps but inhibiting methanogenesis.Metagenomic analysis showed that the functional anaerobe(i.e.,Bacteroides,Macellibacteroide and Parabacteroide)and corresponding genetic expressions responsible for extracellular hydrolysis(i.e.,clp P),membrane transport(i.e.,ffh and gsp F),intracellular substrates metabolism(i.e.,ald and paa F)and VFAs biosynthesis(i.e.,ACACA and FASN)were enhanced in the optimal presence of PHMG.Moreover,the anaerobic species could respond and adapt to low PHMG stimuli via quorum sensing(i.e.,cqs A,rpf C and rpf G),and thus maintain the high microbial metabolic activities.However,they were unable to tolerate the toxicity of excessive PHMG,resulting in the extremely low VFAs production.This work enlightened the effects of emerging pollutants on WAS fermentation at the genetic levels,and provided guidance on the WAS treatment and resource recovery. | Feng Wang Wei Du Wenxuan Huang Shiyu Fang Xiaoshi Cheng Leiyu Feng Jiashun Cao Jingyang Luo Yang Wu | 2023 | Chinese Chemical Letters2023，34，6： | 1 |
| 16 | Hollow sphere of heterojunction(NiCu)S/NC as advanced anode for sodium-ion battery显示文摘Metal sulfide is considered as a potential anode for sodium-ion batteries(SIBs),due to the high theoretical capacity,strong thermodynamic stability and low-cost.However,their cycle capacity and rate performance are limited by the excessive expansion rate and low intrinsic conductivity.Herein,heterogeneous hollow sphere NiS-Cu_(9)S_(5)/NC(labeled as(NiCu)S/NC)based on Oswald ripening mechanism was prepared through a simple and feasible methodology.From a structural perspective,the hollow structure provides an expansion buffer and raises the electrochemical active area.In terms of electron/ion during the cycles,Na^(+)storage mechanism is optimized by NiS/Cu_(9)S_(5)heterogeneous interface,which increases the storage sites and shortens the migration path of Na^(+).The formation of built-in electric field strengthens the electron/ion mobility.Based on the first principle calculations,it is further proved the formation of heterogeneous interfaces and the direction of electron flow.As the anode for SIBs,the synthesized(NiCu)S/NC delivers high reverse capacity(559.2 mA h g^(-1)at 0.5 A g^(-1)),outstanding rate performance(185.3 mA h g^(-1)at 15 A g^(-1)),long-durable stability(342.6 mA h g^(-1)at 4 A g^(-1)after 1500cycles,150.0 m A h g^(-1)at 10 A g^(-1)after 20,000 cycles with 0.0025%average attenuation rate).The matching cathode electrode Na_(3)V_(2)(PO_(4))_(3)/C is assembled with(NiCu)S/NC for the full-battery that achieves high energy density(253.7 W h kg^(-1))and reverse capacity(288.7 mA h g^(-1)).The present work provides a distinctive strategy for constructing electrodes with excellent capacity and stability for SIBs. | Hongyi Chen Pengfei Lv Pengfu Tian Shiyue Cao Shengjun Yuan Qiming Liu | 2023 | Journal of Energy Chemistry2023，，7： | 0 |
| 17 | Nanoparticles (NPs)-mediated Siglec15 silencing and macrophage repolarization for enhanced cancer immunotherapy显示文摘cell infiltration and proliferation in tumor tissues are the main factors that significantly affect the therapeutic outcomes of cancer immunotherapy.Emerging evidence has shown that interferon-gamma(IFN)could enhance CXCL9 secretion from macrophages to recruit T cells,but Siglec15 expressed on TAMs can attenuate T cell proliferation.Therefore,targeted regulation of macrophage function could be a promising strategy to enhance cancer immunotherapy via concurrently promoting the infiltration and proliferation of T cells in tumor tissues.We herein developed reductionresponsive nanoparticles(NPs)made with poly(disulfide amide)(PDSA)and lipid-poly(ethylene glycol)(lipid-PEG)for systemic delivery of Siglec15 siRNA(siSiglec15)and IFN for enhanced cancer immunotherapy.After intravenous administration,these cargo-loaded could highly accumulate in the tumor tissues and be efficiently internalized by tumor-associated macrophages(TAMs).With the highly concentrated glutathione(GSH)in the cytoplasm to destroy the nanostructure,the loaded IFN and si-Siglec15 could be rapidly released,which could respectively repolarize macrophage phenotype to enhance CXCL9 secretion for T cell infiltration and silence Siglec15 expression to promote T cell proliferation,leading to significant inhibition of hepatocellular carcinoma(HCC)growth when combining with the immune checkpoint inhibitor.The strategy developed herein could be used as an effective tool to enhance cancer immunotherapy. | Xiaodi Liu Qi Zhang Yixia Liang Shiyu Xiong Yan Cai Jincheng Cao Yanni Xu Xiaolin Xu Ye Wu Qiang Lu Xiaoding Xu Baoming Luo | 2023 | Acta Pharmaceutica Sinica B2023，13，12： | 0 |
| 18 | Deformations of Compact Complex Manifolds with Ample Canonical Bundles显示文摘In this paper,the author discusses the deformations of compact complex manifolds with ample canonical bundles.It is known that a complex manifold has unobstructed deformations when it has a trivial canonical bundle or an ample anti-canonical bundle.When the complex manifold has an ample canonical bundle,the author can prove that this manifold also has unobstructed deformations under an extra condition. | Shiyu CAO | 2023 | Chinese Annals of Mathematics,Series B2023，44，1： | 0 |
| 19 | Development and identification of two novel wheat-rye 6R derivative lines with adult-plant resistance to powdery mildew and high-yielding potential显示文摘Powdery mildew,caused by Blumeria graminis f.sp.tritici(Bgt),is a devastating disease that seriously threatens wheat yield and quality.To control this disease,host resistance is the most effective measure.Compared with the resistance genes from common wheat,alien resistance genes can better withstand infection of this highly variable pathogen.Development of elite alien germplasm resources with powdery mildew resistance and other key breeding traits is an attractive strategy in wheat breeding.In this study,three wheat-rye germplasm lines YT4-1,YT4-2,and YT4-3 were developed through hybridization between octoploid triticale and common wheat,out of which the lines YT4-1 and YT4-2 conferred adult-plant resistance(APR)to powdery mildew while the line YT4-3 was susceptible to powdery mildew during all of its growth stages.Using genomic in situ hybridization,multi-color fluorescence in situ hybridization,multi-color GISH,and molecular marker analysis,YT4-1,YT4-2,and YT4-3 were shown to be cytogenetically stable wheat-rye 6R addition and T1RS.1BL translocation line,6RL ditelosomic addition and T1RS.1BL translocation line,and T1RS.1BL translocation line,respectively.Compared with previously reported wheat-rye derivative lines carrying chromosome 6R,YT4-1 and YT4-2 showed stable APR without undesirable pleiotropic effects on agronomic traits.Therefore,these novel wheat-rye 6R derivative lines are expected to be promising bridge resources in wheat disease breeding. | Guohao Han Jing Wang Hanwen Yan Tiantian Gu Lijun Cao Shiyu Liu Xiuquan Li Yilin Zhou Jieru Fan Zhipeng Shi Hong Liu Lihui Li Diaoguo An | 2024 | The Crop Journal2024，12，1： | 0 |
| 20 | Five-fold twinned Ir-alloyed Pt nanorods with high C1 pathway selectivity for ethanol electrooxidation显示文摘Developing efficient and robust electrocatalysts toward ethanol oxidation reaction(EOR)with high C1 pathway selectivity is critical for commercialization of direct ethanol fuel cells(DEFCs).Unfortunately,current most EOR electrocatalysts suffer from rapid activity degradation and poor C1 pathway selectivity for complete oxidation of ethanol.Herein,we report a novel electrocatalyst of five-fold twinned(FFT)Ir-alloyed Pt nanorods(NRs)toward EOR.Such FFT Pt-Ir NRs bounded by five(100)facets on the sides and ten(111)facets at two ends possess high percentage of(100)facets with tensile strain.Owing to the inherent characteristics of the FFT NR and Ir alloying,the as-prepared FFT Pt-Ir NRs display excellent alkaline EOR performance with a mass activity(MA)of 4.18 A·mgPt^(-1),a specific activity(SA)of 10.22 mA·cm^(-2),and a Faraday efficiency of 61.21%for the C1 pathway,which are 6.85,5.62,and 7.70 times higher than those of a commercial Pt black,respectively.Besides,our catalyst also exhibits robust durability.The large percentage of open tensile-strained(100)facets and Ir alloying significantly promote the cleavage of C-C bonds and facilitate oxidation of the poisonous intermediates,leading to the transformation of the dominant reaction pathway for EOR from C2 to C1 pathway,and effectively suppress the deactivation of the catalyst. | Yan Fang Shiyu Guo Dongjie Cao Genlei Zhang Qi Wang Yazhong Chen Peng Cui Sheng Cheng Wansheng Zuo | 2022 | Nano Research2022，15，5： | 0 |
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