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| 1 | Efficacy of an orally active small-molecule inhibitor of RANKL in bone metastasis显示文摘Bone is one of the preferred sites for the metastasis of malignant tumours,such as breast cancer,lung cancer and malignant melanoma.Tumour cells colonizing bone have the capacity to induce the expression of receptor activator of nuclear factor-κB ligand(RANKL),which promotes osteoclast differentiation and activation.Tumour-induced osteoclastic bone resorption leads to a vicious cycle between tumours and bone cells that fuels osteolytic tumour growth,causing bone pain and hypercalcaemia.Furthermore,RANKL contributes to bone metastasis by acting as a chemoattractant to bone for tumour cells that express its receptor,RANK.Thus inhibition of the RANKL–RANK pathway is a promising treatment for bone metastasis,and a human monoclonal anti-RANKL antibody,denosumab,has been used in the clinic.However,orally available drugs targeting RANKL must be developed to increase the therapeutic benefits to patients.Here we report the efficacy of the small-molecule RANKL inhibitor AS2676293 in treating bone metastasis using mouse models.Oral administration of AS2676293 markedly inhibited bone metastasis of human breast cancer cells MDA-MB-231-5a-D-Luc2 as well as tumour-induced osteolysis.AS2676293 suppressed RANKLmediated tumour migration in the transwell assay and inhibited bone metastasis of the murine cell line B16F10,which is known not to trigger osteoclast activation.Based on the results from this study,RANKL inhibition with a small-molecule compound constitutes a promising therapeutic strategy for treating bone metastasis by inhibiting both osteoclastic bone resorption and tumour migration to bone. | Yuta Nakai Kazuo Okamoto Asuka Terashima Shogo Ehata Jun Nishida Takeshi Imamura Takashi Ono Hiroshi Takayanagi | 2019 | Bone Research2019，7，1： | 8 |
| 2 | Risk of lymph node metastases from intramucosal gastric cancer in relation to histological types: how to manage the mixed histological type for endoscopic submucosal dissection显示文摘 | Kohei Takizawa Hiroyuki Ono Naomi Kakushima Masaki Tanaka Noriaki Hasuike Hiroyuki Matsubayashi Yuichiro Yamagichi Etsuro Bando Masanori Terashima Kimihide Kusafuka Takashi Nakajima | 2013 | Gastric Cancer2013，，4： | 4 |
| 3 | Regulatory T Cells and Immune Tolerance显示文摘 | Shimon Sakaguchi Tomoyuki Yamaguchi Takashi Nomura Masahiro Ono | 2008 | Cell2008，，5： | 4 |
| 4 | Prophylactic managements of hepatitis B viral infection inliver transplantation显示文摘Liver transplantation(LT)is a considerably effective treatment for patients with end-stage hepatitis B virus(HBV)-related liver disease.However,HBV infection often recurs after LT without prophylaxis.Since the1990s,the treatment for preventing HBV reinfection after LT has greatly progressed with the introduction of hepatitis B immunoglobulin(HBIG)and nucleos(t)ide analogues(NAs),resulting in improved patient survival.The combination therapy consisting of high-dose HBIG and lamivudine is highly efficacious for preventing the recurrence of HBV infection after LT and became the standard prophylaxis for HBV recurrence.However,mainly due to the high cost of HBIG treatment,an alternative protocol for reducing the dose and duration of HBIG has been evaluated.Currently,combination therapy using low-dose HBIG and NAs is considered as the most efficacious and cost-effective prophylaxis for post-LT HBV reinfection.Recently,NA monotherapy and withdrawal of HBIG from combination therapy,along with the development of new,potent high genetic barrier NAs,have provided promising efficacy,especially for low-risk recipients.This review summarizes the prophylactic protocol and their efficacy including prophylaxis of de novo HBV infection from anti-HBc antibody-positive donors.In addition,challenging approaches such as discontinuation of all prophylaxis and active immunity through hepatitis B vaccination are discussed. | Takashi Onoe Hiroyuki Tahara Yuka Tanaka Hideki Ohdan | 2016 | World Journal of Gastroenterology2016，22，1： | 3 |
| 5 | Image-based autonomous navigation of Hayabusa2 using artificial landmarks: The design and brief in-flight results of the first landing on asteroid Ryugu显示文摘Hayabusa2 is an asteroid sample return mission carried out by the Japan Aerospace Exploration Agency.The spacecraft was launched in 2014 and arrived at the target asteroid Ryugu on June 27,2018.During the 1.5-year proximity phase,several critical operations(including two landing/sampling operations)were successfully performed.They were based on autonomous image-based descent and landing techniques.This paper describes an imagebased autonomous navigation scheme of the Hayabusa2 mission using artificial landmarks named target markers(TMs).Its basic algorithm,and the in-flight results of the first touchdown and its rehearsal,are shown. | Naoko Ogawa Fuyuto Terui Yuya Mimasu Kent Yoshikawa Go Ono Seiji Yasuda Kota Matsushima Tetsuya Masuda Hiroki Hihara Junpei Sano Takashi Matsuhisa Satoshi Danno Manabu Yamada Yasuhiro Yokota Yuto Takei Takanao Saiki Yuichi Tsuda | 2020 | Astrodynamics2020，4，2： | 2 |
| 6 | Minimally invasive surgery for resection of duodenal carcinoid tumors: endoscopic full-thickness resection under laparoscopic observation显示文摘 | Hironori Tsujimoto Takashi Ichikura Shigeaki Nagao Tomoki Sato Satoshi Ono Satoshi Aiko Shuichi Hiraki Yoshihisa Yaguchi Naoko Sakamoto Takemaru Tanimizu Junji Yamamoto Kazuo Hase | 2010 | Surgical Endoscopy2010，，2： | 2 |
| 7 | Impact of lymphovascular invasion in patients with stage I gastric cancer显示文摘 | Chikara Kunisaki Hirochika Makino Jun Kimura Ryo Takagawa Takashi Kosaka Hidetaka A. Ono Hirotoshi Akiyama Tadao Fukushima Yutaka Nagahori Masazumiu Takahashi | 2010 | Surgery2010，，2： | 2 |
| 8 | Pulmonary Function After Lobectomy Versus Segmentectomy in Patients with Stage I Non-Small Cell Lung Cancer显示文摘 | Hajime Saito Taku Nakagawa Manabu Ito Kazuhiro Imai Takashi Ono Yoshihiro Minamiya | 2014 | World Journal of Surgery2014，，8： | 2 |
| 9 | Omentum-preserving gastrectomy for advanced gastric cancer: a propensity-matched retrospective cohort study显示文摘 | Shinichi Hasegawa Chikara Kunisaki Hidetaka Ono Takashi Oshima Shoichi Fujii Masataka Taguri Satoshi Morita Tsutomu Sato Roppei Yamada Norio Yukawa Yasushi Rino Munetaka Masuda | 2013 | Gastric Cancer2013，，3： | 2 |
| 10 | Stereotactic body radiation therapy combined with transcatheter arterial chemoembolization for small hepatocellular carcinoma显示文摘 | Yohji Honda Tomoki Kimura Hiroshi Aikata Tomoki Kobayashi Takayuki Fukuhara Keiichi Masaki Takashi Nakahara Noriaki Naeshiro Atsushi Ono Daisuke Miyaki Yuko Nagaoki Tomokazu Kawaoka Shintaro Takaki Akira Hiramatsu Masaki Ishikawa Hideaki Kakizawa Masahiro | 2013 | J Gastroenterol Hepatol2013，，3： | 2 |
| 11 | Simultaneous augmentation of muscle and bone by locomomimetism through calcium-PGC-1αsignaling显示文摘Impaired locomotion has been extensively studied worldwide because those afflicted with it have a potential risk of becoming bedridden.Physical exercise at times can be an effective remedy for frailty,but exercise therapy cannot be applied in all clinical cases.Medication is safer than exercise,but there are no drugs that reinforce both muscle and bone when administered alone.Multiple medications increase the risk of adverse events;thus,there is a need for individual drugs targeting both tissues.To this end,we established a novel sequential drug screening system and identified an aminoindazole derivative,locamidazole(LAMZ),which promotes both myogenesis and osteoblastogenesis while suppressing osteoclastogenesis.Administration of this drug enhanced locomotor function,with muscle and bone significantly strengthened.Mechanistically,LAMZ induced Mef2c and PGC-1αin a calcium signaling–dependent manner.As this signaling is activated upon physical exercise,LAMZ mimics physical exercise.Thus,LAMZ is a promising therapeutic drug for locomotor diseases,including sarcopenia and osteoporosis. | Takehito Ono Ryosuke Denda Yuta Tsukahara Takashi Nakamura Kazuo Okamoto Hiroshi Takayanagi Tomoki Nakashima | 2022 | Bone Research2022，10，4： | 2 |
| 12 | Dominant human papillomavirus 16 infection in cervical neoplasia in young Japanese women; study of 881 outpatients显示文摘 | Nobuo Masumoto Takuma Fujii Mitsuya Ishikawa Makio Mukai Akiko Ono Takashi Iwata Kaneyuki Kubushiro Shiro Nozawa | 2004 | Gynecologic Oncology2004，，2： | 1 |
| 13 | Synthesis and activities of oxidative metaholites of the antiarthritic drug candidate S-2474 显示文摘 | Inagaki Masanao Jyoyama Hirokuni Ono Takashi | 2003 | Bioorg Med Chem2003，11，11： | 1 |
| 14 | Effect of hyperbaric oxygenation treatment on lengthened callus 显示文摘 | Kitakoji T Takashi S Ono Y | 1999 | Undersea Hyperb Med1999，26，3： | 1 |
| 15 | Thymosin α1 accelerates restoration of T cell-mediated neutralizing antibody response in immunocompromised hosts显示文摘 | Chun-Lin Li Ting Zhang Toshiji Saibara Yoshihisa Nemoto Masafumi Ono Naoaki Akisawa Shinji Iwasaki Takashi Maeda Saburo Onishi | 2002 | International Immunopharmacology2002，，1： | 1 |
| 16 | New method of online quantification of regional wall motion with automated segmental motion analysis显示文摘 | Takashi Fujino Shiro Ono Kazuya Murata | 2001 | J Am Soc Echocardiogr2001，14，9： | 1 |
| 17 | Resection of a locally advanced hilar tumor and the hepatic artery after stepwise hepatic arterial embolization: A case report显示文摘We herein report a case of a hilar tumor with extensive invasion to the proper hepatic artery, which was successfully treated with a radical resection in a 57-year-old female patient after a stepwise hepatic arterial embolization. She underwent right colectomy and partial hepatectomy for advanced colon cancer two years ago and radiofrequency ablation therapy for a liver metastasis one year ago, respectively. A recurrent tumor was noted around the proper hepatic artery with invasion to the left hepatic duct and right hepatic artery 7 mo previously. We planned a radical resection for the patient 5 mo after the absence of tumor progression was confirmed while he was undergoing chemotherapy. To avoid surgery-related liver failure, we tried to promote the formation of collateral hepatic arteries after stepwise arterial embolizationof the posterior and anterior hepatic arteries two weeks apart. Finally, the proper hepatic artery was occluded after formation of collateral flow from the inferior phrenic and superior mesenteric arteries was confirmed. One month later, a left hepatectomy with hepatic arterial resection was successfully performed without any major complications. | Takuya Miura Kenichi Hakamada Takashi Ohata Shunji Narumi Yoshikazu Toyoki Masaki Nara Keinosuke Ishido Motonari Ohashi Harue Akasaka Hiroyuki Jin Norihito Kubo Shuichi Ono Hiroshi Kijima Mutsuo Sasaki | 2008 | World Journal of Gastroenterology2008，14，22： | 1 |
| 18 | Possible role of single-voxel 1H-MRS in differential diagnosis of suprasellar tumors显示文摘 | Mikhail F. Chernov Takakazu Kawamata Kosaku Amano Yuko Ono Takashi Suzuki Ryoichi Nakamura Yoshihiro Muragaki Hiroshi Iseki Osami Kubo Tomokatsu Hori Kintomo Takakura | 2009 | Journal of Neuro - Oncology2009，，2： | 1 |
| 19 | Outcomes for patients following hepatic resection of metastatic tumors from gastric cancer显示文摘 | Hironori Tsujimoto Takashi Ichikura Satoshi Ono Hidekazu Sugasawa Shuichi Hiraki Naoko Sakamoto Yoshihisa Yaguchi Kazuo Hatsuse Junji Yamamoto Kazuo Hase | 2010 | Hepatology International2010，，1： | 1 |
| 20 | Successful treatment of cerebral hemorrhage using computed tomography angiography in a patient with left-ventricular-assist device显示文摘 | Haruna Morito Takashi Nishimura Masahiko Ando Osamu Kinoshita Motoyuki Hisagi Hideaki Imai Akira Iijima Noboru Motomura Shunei Kyo Minoru Ono | 2012 | Journal of Artificial Organs2012，，1： | 1 |
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