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| 1 | Mesozoic tectono-magmatic activities in South China:Retrospect and prospect显示文摘The South China Block was formed through the collisional orogeny between the Cathaysia Block and the Yangtze Block in the Early Neoproterozoic.The northern,western and southern sides of the South China Block were affected by disappearance of the Paleo-Tethyan Ocean during the Paleozoic.The southern and northern sides of the South China Block were respectively collided with the Indo-China Block and North China Block in the latest Paleozoic to form the basic framework of the Eastern China.The Eastern China has been affected by the westward subduction of the Pacific Plate since the Mesozoic.Therefore,the South China Block was influenced by the three major tectonic systems,leading to a superposed compound tectonics.The comparative study of the Mesozoic geology between the South China Block and its surrounding areas suggests that although the Mesozoic South China Block was adjacent to the subduction zone of the western Pacific,no juvenile arc-type crust has been found in the eastern margin.The main Mesozoic geology in South China is characterized by reworking of ancient continental margins to intracontinental tectonics,lacking oceanic arc basalts and continental arc andesites.Therefore,a key to understanding of the Mesozoic geology in South China is to determine the temporal-spatial distribution and tectonic evolution of Mesozoic magmatic rocks in this region.This paper presents a review on the tectonic evolution of the South China Block through summarizing the magmatic rock records from the compressional to extensional tectonic process with the transition at the three juncture zones and using the deformation and geophysic data from the deep part of the South China continental lithosphere.Our attempt is to promote the study of South China’s geology and to make it as a typical target for development of plate tectonic theory. | MAO JianRen LI ZiLong YE HaiMin | 2014 | Science China Earth Sciences2014，57，12： | 64 |
| 2 | Failure mechanism and coupled static-dynamic loading theory in deep hard rock mining: A review显示文摘Rock failure phenomena,such as rockburst,slabbing(or spalling) and zonal disintegration,related to deep underground excavation of hard rocks are frequently reported and pose a great threat to deep mining.Currently,the explanation for these failure phenomena using existing dynamic or static rock mechanics theory is not straightforward.In this study,new theory and testing method for deep underground rock mass under coupled static-dynamic loading are introduced.Two types of coupled loading modes,i.e.'critical static stress + slight disturbance' and 'elastic static stress + impact disturbance',are proposed,and associated test devices are developed.Rockburst phenomena of hard rocks under coupled static-dynamic loading are successfully reproduced in the laboratory,and the rockburst mechanism and related criteria are demonstrated.The results of true triaxial unloading compression tests on granite and red sandstone indicate that the unloading can induce slabbing when the confining pressure exceeds a certain threshold,and the slabbing failure strength is lower than the shear failure strength according to the conventional Mohr-Column criterion.Numerical results indicate that the rock unloading failure response under different in situ stresses and unloading rates can be characterized by an equivalent strain energy density.In addition,we present a new microseismic source location method without premeasuring the sound wave velocity in rock mass,which can efficiently and accurately locate the rock failure in hard rock mines.Also,a new idea for deep hard rock mining using a non-explosive continuous mining method is briefly introduced. | Xibing Li Fengqiang Gong Ming Tao Longjun Dong Kun Du Chunde Ma Zilong Zhou Tubing Yin | 2017 | Journal of Rock Mechanics and Geotechnical Engineering2017，9，4： | 68 |
| 3 | A seven-gene-deleted African swine fever virus is safe and effective as a live attenuated vaccine in pigs显示文摘African swine fever(ASF)is a devastating infectious disease in swine that is severely threatening the global pig industry.An efficacious vaccine is urgently required.Here,we used the Chinese ASFV HLJ/18 as a backbone and generated a series of genedeleted viruses.The virulence,immunogenicity,safety,and protective efficacy evaluation in specific-pathogen-free pigs,commercial pigs,and pregnant sows indicated that one virus,namely HLJ/18-7GD,which has seven genes deleted,is fully attenuated in pigs,cannot convert to the virulent strain,and provides complete protection of pigs against lethal ASFV challenge.Our study shows that HLJ/-18-7GD is a safe and effective vaccine against ASFV,and as such is expected to play an important role in controlling the spread of ASFV. | Weiye Chen Dongming Zhao Xijun He Renqiang Liu Zilong Wang Xianfeng Zhang Fang Li Dan Shan Hefeng Chen Jiwen Zhang Lulu Wang Zhiyuan Wen Xijun Wang Yuntao Guan Jinxiong Liu Zhigao Bu | 2020 | Science China(Life Sciences)2020，63，5： | 72 |
| 4 | Emergence and prevalence of naturally occurring lower virulent African swine fever viruses in domestic pigs in China in 2020显示文摘African swine fever virus(ASFV)has been circulating in China for more than two years,and it is not clear whether the biological properties of the virus have changed.Here,we report on our surveillance of ASFVs in seven provinces of China,from June to December,2020.A total of 22 viruses were isolated and characterized as genotype II ASFVs,with mutations,deletions,insertions,or short-fragment replacement occurring in all isolates compared with Pig/HLJ/2018(HLJ/18),the earliest isolate in China.Eleven isolates had four different types of natural mutations or deletion in the EP402R gene and displayed a nonhemadsorbing(non-HAD)phenotype.Four isolates were tested for virulence in pigs;two were found to be as highly lethal as HLJ/18.However,two non-HAD isolates showed lower virulence but were highly transmissible;infection with 106 TCID50 dose was partially lethal and caused acute or sub-acute disease,whereas 103 TCID50 dose caused non-lethal,sub-acute or chronic disease,and persistent infection.The emergence of lower virulent natural mutants brings greater difficulty to the early diagnosis of ASF and creates new challenges for ASFV control. | Encheng Sun Zhenjiang Zhang Zilong Wang Xijun He Xianfeng Zhang Lulu Wang Wenqing Wang Lianyu Huang Fei Xi Haoyue Huangfu Ghebremedhin Tsegay Hong Huo Jianhong Sun Zhijun Tian Wei Xia Xuewu Yu Fang Li Renqiang Liu Yuntao Guan Dongming Zhao Zhigao Bu | 2021 | Science China(Life Sciences)2021，64，5： | 46 |
| 5 | Cancer incidence and mortality in Shandong province,2012显示文摘Objective: Population-based cancer registration data in 2012 from all available cancer registries in Shandong province were collected by Shandong Center for Disease Control and Prevention(SDCDC). SDCDC estimated the numbers of new cancer cases and cancer deaths in Shandong province with compiled cancer incidence and mortality rates.Methods: In 2015, there were 21 cancer registries submitted data of cancer incidence and deaths occurred in 2012. All the data were checked and evaluated based on the National Central Cancer Registry(NCCR) criteria of data quality. Qualified data from 15 registries were used for cancer statistics analysis as provincial estimation. The pooled data were stratified by area(urban/rural), gender, age group(0, 1-4, 5-9, 10-14, …, 85+ years) and cancer type. New cancer cases and deaths were estimated using age-specific rates and corresponding provincial population in 2012. The Chinese census data in 2000 and Segi's population were applied for age-standardized rates. All the rates were expressed per 100,000 person-year.Results: Qualified 15 cancer registries(4 urban and 11 rural registries) covered 17,189,988 populations(7,486,039 in urban and 9,703,949 in rural areas). The percentage of cases morphologically verified(MV%) and death certificate-only cases(DCO%) were 66.12% and 2.93%, respectively, and the mortality to incidence rate ratio(M/I) was 0.60. A total of 253,060 new cancer cases and 157,750 cancer deaths were estimated in Shandong province in 2012. The incidence rate was 263.86/100,000(303.29/100,000 in males, 223.23/100,000 in females), the age-standardized incidence rates by Chinese standard population(ASIRC) and by world standard population(ASIRW) were 192.42/100,000 and 189.50/100,000 with the cumulative incidence rate(0-74 years old) of 22.07%. The cancer incidence, ASIRC and ASIRW in urban areas were 267.64/100,000, 195.27/100,000 and 192.02/100,000 compared to 262.32/100,000, 191.26/100,000 and 188.48/100,000 in rural areas, respectively. The cancer mortality was 164.47/100,000(207.42/100,000 in males, 120.23/100,000 in females), the age-standardized incidence rates by Chinese standard population(ASMRC) and by world standard population(ASMRW) were 117.54/100,000 and 116.90/100,000, and the cumulative mortality rate(0-74 years old) was 13.53%. The cancer mortality, ASMRC and ASMRW were 141.59/100,000, 101.17/100,000 and 100.33/100,000 in urban areas, and 173.79/100,000, 124.20/100,000 and 123.64/100,000 in rural areas, respectively. Cancers of the lung, stomach, liver, esophagus, colorectum, female breast, brain, leukemia, bladder and pancreas were the most common cancers, accounting for about 82.12% of all cancer new cases. Lung cancer, stomach cancer, liver cancer, esophageal cancer, colorectal cancer, female breast cancer, pancreatic cancer, brain tumor, leukemia and lymphoma were the leading causes of cancer death, accounting for about 89.01% of all cancer deaths. The cancer spectrum showed difference between urban and rural, males and females both in incidence and mortality rates.Conclusions: Cancer surveillance information in Shandong province is making great progress with the increasing number of cancer registries, population coverage and the improving data quality. Cancer registration plays a fundamental role in cancer control by providing basic information on population-based cancer incidence, mortality, survival and time trend. The disease burden of cancer is serious in Shandong province, and so cancer prevention and control in Shandong province should be enhanced including health education, health promotion, cancer screening and cancer care services. | Zhentao Fu Zilong Lu Yingmei Li jiyu Zhang Gaohui Zhang Xianxian Chen Jie Chu Jie Ren Haiyan Liu Xiaolei Guo | 2016 | Chinese Journal of Cancer Research2016，28，3： | 17 |
| 6 | Excessive UBE3A dosage impairs retinoic acid signaling and synaptic plasticity in autism spectrum disorders显示文摘孤独性光谱混乱(ASD ) 是有异构的病原学的许多人的神经病学的混乱。E3 ubiquitin (Ub ) 的活动过度 ligase UBE3A,不完全地源自 15q11-q13 拷贝数字变化,为世界范围的 ASD 盒子的 1%-3% 的报道,而是内在的机制遗体描绘了。这里,我们报导 ALDH1A2 的功能, retinoic 酸(RA ) 的限制率的酶合成,被 UBE3A 否定地以一种 ubiquitylation 依赖的方式调整。过多的 UBE3A 剂量被发现损害调停 RA 的 neuronal homeostatic synaptic 粘性。象 ASD 一样症状被 overexpressing UBE3A 在前额的外皮或由一个 ALDH1A 对手的管理在老鼠概括,而 RA 补充显著地减轻了过多的 UBE3A 导致剂量的象 ASD 一样显型。由识别在 ASD 作为内在的机制发信号的减少的 RA,显型连接了到 UBE3A 活动过度,我们的调查结果介绍 ASD 病原学的新远景并且对这逐渐地流行的疾病便于治疗学的开发的一个模式。 | Xingxing Xu Chuanyin Li Xiaobo Gao Kun Xia Hui Guo Yali Li ZijianHao Lei Zhang Daming Gao Chenfan Xu Huatai Xu Zhi-Qi Xiong Zilong Qiu Ling Mei Xiaoduo Xie Kangcheng Ruan Ronggui Hu | 2018 | Cell Research2018，28，1： | 13 |
| 7 | Early Permian Tarim Large Igneous Province in northwest China显示文摘Tarim Large Igneous Province(TLIP)is the second Late Paleozoic LIPs in China after the recognition of Emeishan LIP,and is a hot research topic in geosciences.On the basis of the analysis of research history about TLIP,this paper summarizes the research result during last twenty years and suggests the key research area in the future.The residual distribution range of TLIP is up to 250000 km2,and the largest residual thickness is 780 m.The eruption of basalt happened during 290–288 Ma and belongs to LIPs magmatic event with fast eruption of magma.The lithological units of the TLIP include basalt,diabase,layered intrusive rock,breccia pipe mica-olivine pyroxenite,olivine pyroxenite,gabbro,ultramafic dyke,quartz syenite,quartz syenite porphyry and bimodal dyke.The basalt and diabase of TLIP exhibit OIB-like trace element patterns and enrichment of LILE and HFSE,and mainly belong to high TiO2series.There is an obvious difference in isotope among the basalt from Keping and the basalt and dibase from the northern Tarim Basin.The basalt from Keping with negative Nd and high REE value derives from enriched mantle,and the diabase and basalt from the northern Tarim Basin with positive Nd and low REE value are related to depleted mantle.The crust uplifting in the Early Permian and the development of picrite and large scale dyke and formation of large scale V-Ti-Magnetite deposit in Wajilitag area support the view that the TLIP is related to mantle plume.The TLIP has a temporal-spatial relationship with Permian basic to ultra-basic igneous rock,which is distributed widely in Central Asia,and they represent a tectono-magmatic event with very important geodynamic setting.This paper also suggests that the deep geological process,the relation with mantle plume,mineralization,the relation with environmental change and biological evolution,and the geodynamics of the TLIP will be the key research topics in the future. | YANG ShuFeng CHEN HanLin LI ZiLong LI YinQi YU Xing LI DongXu MENG LiFeng | 2013 | Science China Earth Sciences2013，56，12： | 12 |
| 8 | Geochemical characteristics,cooling history and mineralization significance of Zhangtiantang pluton in South Jiangxi Province,P.R. China显示文摘The zircon SHRIMP dating of the Zhangtiantang granite gave an age of 159±7 Ma.,which shows that the granite was produced at the early Late Jurassic.The Ar-Ar plateau ages of biotite and K-feldspar from the Zhangtiantang pluton are 153.2±1.1 Ma and 135.8±1.2 Ma,respectively.The Ar-Ar anti-isochrone ages of biotite and K-feldspar are 152.5±1.7Ma and 135.4±2.7Ma,respectively.The ages represent the isotopic closure ages of minerals in the pluton.The Zhangtiantang granites are regarded as peraluminous crust-derived type granites to possess the typical geochemical characteristics of calc-alkaline rocks on continental margin,with enriched Si,K,Al(average value of A/CNK as 1.18),HREE,Rb,U,and Th,heavily depleted V,Cr,Co,Ni,Ti,Nb-Ta,Zr,Sr,P,and Ba,strongly negative Eu and common corundum normative(average value of C as 1.84).The εNd(t) values of the Zhangtiantang granite are-5.84 to-7.79,and t2DM values are 1.69 to 1.83 Ga,which indicates partial melting of continental-crust metamorphic sedimentary rocks during the Middle Proterozoic.The cooling history of the Zhangtiantang granitic pluton indicates that the cooling velocity of pluton was faster(about 67℃ /Ma) from zircon(158 Ma) to biotite(152 Ma),and was slower(about12℃ /Ma) from biotite(152.5 Ma) to K-feldspar(135.8 Ma).It can be deduced that the temporal gap(about 10 Ma) between the granite formmation and W-Sn mineralization in South China may be related to ordinary magma-hydrothermal processes by the variational cooling curve of the pluton.The Zhangtiantang pluton was formed in a compressive setting,with differentiation evolution and mineralization occurring in a relative relaxation setting. | MAO Jianren LI Zilong ZHAO Xilin ZHOU Jie YE Haimin ZENG Qitao | 2010 | Chinese Journal Of Geochemistry2010，29，1： | 11 |
| 9 | Complete genome sequence of the rifamycin SV-producing Amycolatopsis mediterranei U32 revealed its genetic characteristics in phylogeny and metabolism显示文摘Amycolatopsis mediterranei 被用于 rifamycin 的工业规模生产,它在 antimycobacterial 治疗起一个重要作用。作为类 Amycolatopsis 的首先定序的染色体, 236 715 底配对的包括 10 的紧张 U32 的染色体,最大的原核生物的染色体之一到目前为止曾经被定序。不同于在 streptomycetes 发现的线性拓扑学,这个染色体是圆形的,特别地类似于 Saccharopolyspora erythraea 和奴卡氏菌属 farcinica,在发展史和分类代表他们的靠近的关系。尽管在 A 预言了 9 228 编码蛋白质的基因。mediterranei 染色体 S 与那些分享了 orthologs 的最大的数字。erythraea,它被 Streptomyces coelicolor 而非 N 出人意料地跟随。farcinica,显示不同新陈代谢的特征经由改编演变到多样的生态的壁龛。除类似于那的一个核心区域以外在 streptomycetes 普通,有典型核心特征的一个新奇“伪核心”在非核心区域以内被定义,在 21 从 26 基因为第二等的代谢物生产聚类的总数被定位的地方。位于核心的 rifamycin 生合成基因簇为 rifamycin SV 的变换编码细胞色素 P450 酶必需品到 B,由比作 rifamycin 生产 B 紧张 S699 的高度相应的簇揭示了并且进一步由基因互补证实了。A 的 genomic 信息。mediterranei 表明在看起来复杂的规章的机制的控制下面不仅为各种各样的碳来源和无机的氮混合物的广泛的利用而且为新陈代谢的中介的有效 funneling 安排进第二等的抗菌素合成进程的一个新陈代谢的网络。 | Wei Zhao Yi Zhong Hua Yuan Jin Wang Huajun Zheng Ying Wang Xufeng Cen Feng Xu Jie Bai Xiaobiao Han Gang Lu Yongqiang Zhu Zhihui Shao Han Yan Chen Li Nanqiu Peng Zilong Zhang Yunyi Zhang Wei Lin Yun Fan Zhongjun Qin Yongfei Hu Baoli Zhu Shengyue Wang Xiaoming Ding Guo-Ping Zbao | 2010 | Cell Research2010，20，10： | 10 |
| 10 | Improvement of oxytetracycline production mediated via cooperation of resistance genes in Streptomyces rimosus显示文摘Increasing the self-resistance levels of Streptomyces is an effective strategy to improve the production of antibiotics.To increase the oxytetracycline(OTC) production in Streptomyces rimosus,we investigated the cooperative effect of three co-overexpressing OTC resistance genes:one gene encodes a ribosomal protection protein(otrA) and the other two express efflux proteins(otrB and otrC).Results indicated that combinational overexpression of otrA,otrB,and otrC(MKABC) exerted a synergetic effect.OTC production increased by 179%in the recombinant strain compared with that of the wild-type strain M4018.The resistance level to OTC was increased by approximately two-fold relative to the parental strain,thereby indicating that applying the cooperative effect of self-resistance genes is useful to improve OTC production.Furthermore,the previously identified cluster-situated activator OtcR was overexpressed in MKABC in constructing the recombinant strain MKRABC;such strain can produce OTC of approximately7.49 g L^((-1)),which represents an increase of 19%in comparison with that of the OtcR-overexpressing strain alone.Our work showed that the cooperative overexpression of self-resistance genes is a promising strategy to enhance the antibiotics production in Streptomyces. | Shouliang Yin Xuefeng Wang Mingxin Shi Fang Yuan Huizhuan Wang Xiaole Jia Fang Yuan Jinliang Sun Tiejun Liu Keqian Yang Yuxiu Zhang Keqiang Fan Zilong Li | 2017 | Science China(Life Sciences)2017，60，9： | 10 |
| 11 | Characteristics of atmospheric particles and heavy metals in winter in Chang-Zhu-Tan city clusters, China显示文摘To understand the pollution characteristics of atmospheric particles and heavy metals in winter in Chang-Zhu-Tan city clusters, China, total suspended particulate(TSP) and PM10samples were collected in cities of Changsha, Zhuzhou and Xiangtan from December 2011 to January 2012, and heavy metals of Cd, Pb, Cr, and As were analyzed. It shows that the average TSP concentration in Changsha, Zhuzhou and Xiangtan were(183 ± 73),(201 ± 84) and(190 ± 66) μg/m3respectively, and the average PM10 were(171 ± 82),(178 ± 65) and(179 ± 55) μg/m3respectively. The lowest TSP and PM10concentrations occurred at the background Shaping site of Changsha. The average ratio of ρ(PM10)/ρ(TSP) was 91.9%, ranging from 81.3% to 98.9%. Concerning heavy metals, in TSP samples, the concentration of Cr, As, Cd and Pb were 28.8–56.5, 18.1–76.3, 3.9–26.1 and 148.0–460.9 ng/m3, respectively, while in PM10samples, were 16.4–42.1, 15.5–67.9, 3.3–22.2 and 127.9–389.3 ng/m3, respectively. The enrichment factor of Cd was the highest, followed by Pb and As, while that of Cr was the lowest. | Kai Zhang Fahe Chai Zilong Zheng Qing Yang Juansheng Li Jing Wang Yujie Zhang | 2014 | Journal of Environmental Sciences2014，26，1： | 9 |
| 12 | Cellular microparticles and pathophysiolog, of traumatic brain injury显示文摘 | Zilong Zhao Yuan Zhou Ye Tian Min Li Jing-fei Dong Jianning Zhang | 2017 | Protein & Cell2017，8，11： | 9 |
| 13 | Mechanical properties of rock under coupled static-dynamic loads显示文摘Rock drilling machine,INSTRON testing system,and SHPB device are updated to investigate the characteristics of rocks at great depth,with high loads from overburden,tectonic stresses and dynamic impacts due to blasting and boring.It is verified that these testing systems can be used to study the mechanical properties of rock material under coupled static and dynamic loading condition and give useful guidance for the deep mining and underground cavern excavation.Various tests to determine the rock strength,fragmentation behavior,and energy absorption were conducted using the updated testing systems.It is shown that under coupled static-dynamic loads,if the axial prestress is lower than its elastic limit,the rock strength is higher than the individual static or dynamic strength.At the same axial prestress,rock strength under coupled loads rises with the increasing strain rates.Under coupled static and dynamic loads,rock is observed to fail with tensile mode.While shear failure may exist if axial prestress is high enough.In addition,it is shown that the percentage of small particles increases with the increasing axial prestress and impact load based on the analysis of the particle-size distribution of fragments.It is also suggested that the energy absorption ratio of a specimen varies with coupled loads,and the maximum energy absorption ratio for a rock can be obtained with an appropriate combination of static and dynamic loads. | Xibing Li Zilong Zhou Fujun Zhao Yujun Zuo Chunde Ma Zhouyuan Ye Liang Hong | 2009 | Journal of Rock Mechanics and Geotechnical Engineering2009，1，1： | 8 |
| 14 | A framework for equipment systems-of-systems effectiveness evaluation using parallel experiments approach显示文摘Equipment systems-of-systems(So S) effectiveness evaluation can provide important reference for construction and optimization of the equipment So S. After discussing the basic theory and methods of parallel experiments, we depict an So S effectiveness analysis and evaluation method using parallel experiments theory in detail. A case study is carried out which takes the missile defense system as an example. An artificial system of the missile defense system is constructed with the multi-agent modeling method. Then, single factor, multiple factors and defense position deployment computational experiments are carried out and evaluated with the statistical analysis method. Experiment results show that the altitude of the secondary interception missile is not the key factor which affects So S effectiveness and putting the defense position ahead will increase defense effectiveness. The case study demonstrates the feasibility of the proposed method. | Zilong Cheng Li Fan Yulin Zhang | 2015 | Journal of Systems Engineering and Electronics2015，26，2： | 7 |
| 15 | Study on the structure characterization and moisturizing effect of Tremella polysaccharide fermented from GCMCC5.39显示文摘The structure and moisture retention of Tremella polysaccharide fermented from GCMCC5.39(FTP)were evaluated.After UV,infrared spectrum analysis,HPAEC-PAD,HPSEC and 1 D NMR analysis,the composition of the purifi ed FTP was determined.Purifi ed components of fermented Tremella polysaccharide(FTPS)was made of galactose,mannose,glucose,galactosmine,glucosamine,and contain a large amount of hydroxyl,carbonyl and amino groups.FTPS wasα-neutral pyranose without uronic acid.FTPS-1 and FTPS-2 were obtained after purifi cation by DEAE-Sepharose Fast Flow Column.The molecular weights of FTPS-1 and FTPS-2 were 25722 and 177263 Da.FTPS-2 had a better ability to prevent moisture loss,and the optimal moisture retention period was 0–4 h.FTPS-2 could signifi cantly increase the moisture content of the skin epidermis and showed a dose-concentration relationship.The effect of FTPS-2 on the expression of different moisturizing genes was evaluated in a human skin keratinocyte model.The results showed that FTPS-2 has no cytotoxicity,and could signifi cantly promote AQP3,TGM1,CASP14,HYAL2,FLG gene expression level in HaCaT cells.It has the most signifi cant infl uence at HYAL2 protein expression on 50μg/mL. | Meng Yang Zilong Zhang Yan He Chengliang Li Jinmei Wang Xia Ma | 2021 | Food Science and Human Wellness2021，10，4： | 6 |
| 16 | Precise Dating and Geological Significance of the Caledonian Shangyou Pluton in South Jiangxi Province显示文摘摘要:为 Shangyou 花岗石标明日期年龄的锆石虾是 464 吗?? | MAO Jianren ZENG Qingtao LI Zilong HU Qing ZHAO Xilin YE Haimin | 2008 | Acta Geologica Sinica(English Edition)2008，82，2： | 6 |
| 17 | Non-human Primate Models for Brain Disorders – Towards Genetic Manipulations via Innovative Technology显示文摘Modeling brain disorders has always been one of the key tasks in neurobiological studies. A wide range of organisms including worms, fruit ?ies, zebra?sh, and rodents have been used for modeling brain disorders. However,whether complicated neurological and psychiatric symptoms can be faithfully mimicked in animals is still debatable.In this review, we discuss key ?ndings using non-human primates to address the neural mechanisms underlying stress and anxiety behaviors, as well as technical advances for establishing genetically-engineered non-human primate models of autism spectrum disorders and other disorders.Considering the close evolutionary connections and similarity of brain structures between non-human primates and humans, together with the rapid progress in genome-editing technology, non-human primates will be indispensable for pathophysiological studies and exploring potential therapeutic methods for treating brain disorders. | Zilong Qiu Xiao Li | 2017 | Neuroscience Bulletin2017，33，2： | 6 |
| 18 | Hierarchical-structure anatase TiO2 with conductive network for high-rate and high-loading lithium-ion battery显示文摘Titanium dioxides have been extensively investigated as promising anodes for Lithium ion batteries(LIBs)because of the high–rate capacity and cyclability,as well as the improved safety over graphite anode(1,2)However,as a typical insertion–type anode,anatase TiO2 exhibits low conductivity(10–12S cm-1 for electron conductivity[3]and 10–17–10–10 cm2 s1 for Li+ion diffusion coefficient[4])and poor specific capacity(only accommodate<0.5 Li per bulk TiO2 unit[5]),severely limiting its practical applications. | Xinghua Liu Lijiang Zhao Shitong Wang Meng Chao Yutong Li Jin Leng Junying Zhang Zilong Tang | 2019 | Science Bulletin2019，64，16： | 6 |
| 19 | Nanowires-assembled WO3 nanomesh for fast detection of ppb-level NO2 at low temperature显示文摘Hierarchical WO3 nanomesh,assembled from single-crystalline WO3 nanowires,is prepared via a hydrothermal method using thiourea(Tu)as the morphology-controlling agent.Formation of the hierarchical architecture comprising of WO3 nanowires takes place via Ostwald ripening mechanism with the growth orientation.The sensor based on WO3 nanomesh has good electrical conductivity and is therefore suitable as NO2 sensing material.The WO3 nanomesh sensor exhibited high response,short response and recovery time,and excellent selectivity towards ppb-level NO2 at low temperature of 160℃.The superior gas performance of the sensor was attributed to the high-purity hexagonal WO3 with high specific surface area,which gives rise to enhanced surface adsorption sites for gas adsorption.The electron depletion theory was used for explaining the NO2-sensing mechanism by the gas adsorption/desorption and charge transfer happened on the surface of WO3 nanomesh. | Di LIU Xiaowei REN Yesheng LI Zilong TANG Zhongtai ZHANG | 2020 | Journal of Advanced Ceramics2020，9，1： | 5 |
| 20 | Innovative testing technique of rock subjected to coupled static and dynamic loads显示文摘 | Xibing Li Zilong Zhou Tat-Seng Lok Liang Hong Tubing Yin | 2007 | International Journal of Rock Mechanics and Mining Sciences2007，，5： | 5 |
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