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| 1 | Hypermethylation of Syk gene in promoter region associated with oncogenesis and metastasis of gastric carcinoma显示文摘AIM: To investigate the rrelationship between methylation of Syk (spleen tyrosine kinase) gene in promoter region and oncogenesis, metastasis of gastric carcinoma. The relation between silencing of the Syk gene and methylation of Syk promoter region was also studied. METHODS: By using methylation-specific PCR (MSP) technique, the methylation of Syk promoter region in specimens from 61 gastric cancer patients (tumor tissues and adjacent normal tissues) was detected. Meanwhile, RTPCR was used to analyse syk expression exclusively. RESULTS: The expression of the Syk gene was detected in all normal gastric tissues. Syk expression in gastric carcinoma was lower in 14 out of 61 gastric cancer samples than in adjacent normal tissues (X^2=72.3, P<0.05). No methylation of Syk promoter was found in adjacent normal tissues, hypermethylation of Syk gene in promoter was detected 21 cases in 61 gastric carcinoma patients. The rate of methylation of Syk promoter in gastric carcinoma was higher than that in adjacent normal tissues (X^2=25.1, P<0.05). In 31 patients with lymph node metastasis, 17 were found with Syk promoter methylation. A significant difference was noted between two groups (X^2=11.4,P<0.05). CONCLUSION: Hypermethylation leads to silencing of the Syk gene in human gastric carcinoma. Methylation of Syk promoter is correlated to oncogenesis and metastasis of gastric carcinoma. Syk is considered to be a potential tumor suppressor and anti-metastasis gene in human gastric cancer. | ShuiWang Yong-BinDing Guo-YuChen Jian-GuoXia Zhen-YanWu | 2004 | World Journal of Gastroenterology2004，10，12： | 32 |
| 2 | Composition and flux of nutrients transport to the Changjiang Estuary显示文摘Based on the results of water sample measurements of nutrient concentrations at th e Datong Station of the Changjiang River from 1998 to 1999, combined w ith historical data of water quality, seasonal variations of nutrient concentrations and nutrient transports are discussed.The following results have been obtained: (1) the fluxes of the nitrate nitrogen, ammonium nitrogen and nitrite nitrogen increased by time-series from 1962 to 1990 , even if runoff volume had a little variation; (2) the concentrations and fluxes of the dissolved inorganic nitrogen (DIN) and dissolved in organic phosphorus (DIP) increased notably with time, but those of the dissolved silicon (DSI) decreased pronouncedly; and (3) the concentration s and fluxes changed synchronously with time between the Datong Station a nd the Changjiang Estuary. | ZHANG Shen,JI Hongbing,YAN Weijin,DUAN Shuiwang(Inst. of Geographic Sciences and Natural Resources Research, Beijing 100101, China) | 2003 | Journal of Geographical Sciences2003，13，1： | 13 |
| 3 | Proton and He^(2+) Temperature Anisotropies in the Solar Wind Driven by Ion Cyclotron Waves显示文摘We carried out one-dimensional hybrid simulations of resonant scattering of protons and He2+ ions by ion cyclotron waves in an initially homogeneous,collisionless and magnetized plasma. The initial ion cyclotron waves have a power spectrum and propagate both outward and inward. Due to the resonant interaction with the protons and He2+ ions, the wave power will be depleted in the resonance region. Both the protons and He2+ ions can be resonantly heated in the direction perpendicular to the ambient magnetic field and leading to anisotropic velocity distributions, with the anisotropy higher for the He2+ ions than for the protons.At the same time, the anisotropies of the protons and He2+ ions are inversely correlated with the plasma β||p = 87πnpkBT||p/B20, consistent with the prediction of the quasilinear theory (QLT). | Quan-MingLu ShuiWang | 2005 | Chinese Journal of Astronomy and Astrophysics2005，5，2： | 2 |
| 4 | Multi-class Diserimiant Kernel Learning via Convex Programming显示文摘 | Ye Jieping Ji Shuiwang Chen Jianhui | 2008 | Journal of Machine Learning Research2008，9，： | 1 |
| 5 | Analysis of lignin-derived phenols in standard referencematerials and ocean dissolved organic matter by gaschromatography/tandem mass spectrometry 显示文摘 | PATRICK L RAINER M W A SHUIWANG D | 2010 | MarineChemistry2010，118，： | 1 |
| 6 | The use of PARAFAC modeling to trace terrestrial dissolved organic matter and fingerprint water masses in coastal Canadian Arctic surface waters显示文摘 | Walker Sally A. W. Amon Rainer M. Stedmon Colin Duan Shuiwang Louchouarn Patrick | 2009 | Journal of Geophysical Research Biogeosciences2009，，： | 1 |
| 7 | Mult-class discrimi nant kernel learning via convex programming显示文摘 | YE Jieping JI Shuiwang CHEN Jianhui | | 0，，04： | 1 |
| 8 | 3D convolutional neural networks for human action recognition 显示文摘 | Ji Shuiwang Xu Wei Yang Ming | 2013 | IEEE Trans on Pattern Analysis and Machine Intelligence2013，35，1： | 1 |
| 9 | Validation of the eighth edition of the AJCC staging system for patients with pancreatic adenocarcinoma initially receiving chemoradiotherapy and proposal of modifications显示文摘Objective:To validate the eighth edition of the AJCC staging system in patients with pancreatic adenocarcinoma receiving only stereotactic body radiation therapy and chemotherapy,and to propose modifications to improve prognostic accuracy.Methods:Patients with pathologically confirmed pancreatic adenocarcinoma without metastasis who were undergoing only chemoradiotherapy were included and staged according to the seventh and eighth editions of the AJCC staging system.Meanwhile,another group of stage T4 patients from the above enrollment with only portal vein involvement with or without tumor thrombi(PV±PVTT)were retrieved for survival comparisons.Modifications were proposed according to the survival comparisons.A cohort from the SEER database was used for external validation of the modified staging system.Results:A total of 683 patients were included.Patients with N2 or N1 but different T stages had significantly different survival outcomes according to the eighth edition.The survival of patients with(PV±PVTT)was comparable to that of patients with T4 tumors.The concordance index of the seventh and eighth editions,and the modified staging system was 0.744(95%CI:0.718—0.769),0.750(95%CI:0.725—0.775),and 0.788(95%CI:0.762-0.813),respectively.For external validation,the concordance index was 0.744(95%CI:0.718-0.770),0.750(95%CI:0.724-0.776),and 0.788(95%CI:0.762-0.814),respectively.Conclusions:The modified staging system is suggested to have the m ost accurate prognostic value.Hence,PV土PVTT should be added to the definition of T4 tumors regardless of tumor size.Patients with N2 or N1 in different T stages could be regrouped into different substages.Additionally,stage III should be subclassified into IIIA(T3N 2 and T4N 0)and IIIB(T4N 1-2). | Xiaofei Zhu Di Chen Yangsen Cao Xianzhi Zhao Xiaoping Ju Yuxin Shen Fei Cao Shuiwang Qing Fang Fang Zhen Jia Huojun Zhang | 2020 | Cancer Biology & Medicine2020，17，2： | 1 |
| 10 | Particulate and dissolved amino acids in the lower Mississippi and Pearl Rivers (USA)显示文摘 | Shuiwang Duan Thomas S. Bianchi | 2007 | Marine Chemistry2007，，2： | 1 |
| 11 | Drosophila gene expression pattern annotation through multi-instance muhi label learning 显示文摘 | Li Yingxin Ji Shuiwang Kumar S | 2012 | IEEE/ACM Trans on Computational Biology and Bioinformatics2012，9，1： | 1 |
| 12 | 3D convolu- tional neural networks for human action recognition 显示文摘 | Ji Shuiwang Xu Wei Yang Ming | 2013 | IEEE Transactions on Pattern Analysis and Ma- chine Intelligence2013，35，1： | 1 |
| 13 | Transport of dissolved inorganic nitrogen from the major rivers to estuaries in China显示文摘 | Zhang shen & Huang Hongyu | 2000 | Nutrient Cycling in Agroecosystems2000，57，： | 1 |
| 14 | 3Dconvolutional neural networks for human action recognition显示文摘 | Ji Shuiwang Xu Wei Yang Ming | 2013 | IEEE Transactions on Pattern Analysis and Machine Intelligence2013，35，1： | 1 |
| 15 | Trace norm regularization: Reformulations, algorithms, and multi-task learning 显示文摘 | Pong Tingkei Tseng Paul Pi Shuiwang | 2010 | SIAM Journal on Optimization2010，20，6： | 1 |
| 16 | Generalized linear discriminant analysis: a unified framework and efficient model selection显示文摘 | JI Shuiwang YE Jieping | 2008 | IEEE Transactions on Neural Networks2008，19，10： | 1 |
| 17 | Temporal variability in the composition and aboundanee of terrestrially-derived dissolved organic matter in the lower Mississippi and Pearl rivers 显示文摘 | Shuiwang Duan Thomas S B Troy P S | 2007 | Marine Chemistry2007，103，： | 1 |
| 18 | Drosophila gene expression pattern annotation through multi-instance multi- label learning显示文摘 | Li Yingxin Ji Shuiwang Kumar S | 2011 | IEEE/ACM Transactions on Computational Biology and Bioinformatics2011，9，1： | 1 |
| 19 | Kernel uncorrelated and regularizeddiscriminant analysis: A theoretical and computational study显示文摘 | JI Shuiwang YE Japing | 2008 | IEEE Transactions on Knowledge and Data Engineering2008，20，10： | 1 |
| 20 | Canonical correlation analysis for multi-label classification: a least-squares formula- tion, extensions, and analysis显示文摘 | Sun Liang Ji Shuiwang Ye Jieping | 2011 | IEEE Transactions on Pattern Analysis and Machine Intelligence2011，33，1： | 1 |
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