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| 1 | Programmable time-domain digital-coding metasurface for non-linear harmonic manipulation and new wireless communication systems显示文摘Optical non-linear phenomena are typically observed in natural materials interacting with light at high intensities, and they benefit a diverse range of applications from communication to sensing. However,controlling harmonic conversion with high efficiency and flexibility remains a major issue in modern optical and radio-frequency systems. Here, we introduce a dynamic time-domain digital-coding metasurface that enables efficient manipulation of spectral harmonic distribution. By dynamically modulating the local phase of the surface reflectivity, we achieve accurate control of different harmonics in a highly programmable and dynamic fashion, enabling unusual responses, such as velocity illusion. As a relevant application, we propose and realize a novel architecture for wireless communication systems based on the time-domain digital-coding metasurface, which largely simplifies the architecture of modern communication systems, at the same time yielding excellent performance for real-time signal transmission. The presented work, from new concept to new system, opens new pathways in the application of metamaterials to practical technology. | Jie Zhao Xi Yang Jun Yan Dai Qiang Cheng Xiang Li Ning Hua Qi Jun Chen Ke Guo Dong Bai Shuo Liu Shi Jin Andrea Alù Tie Jun Cui | 2019 | National Science Review2019，6，2： | 46 |
| 2 | Anisotropic coding metamaterials and their powerful manipulation of differently polarized terahertz waves显示文摘Metamaterials based on effective media can be used to produce a number of unusual physical properties(for example,negative refraction and invisibility cloaking)because they can be tailored with effective medium parameters that do not occur in nature.Recently,the use of coding metamaterials has been suggested for the control of electromagnetic waves through the design of coding sequences using digital elements‘0’and‘1,'which possess opposite phase responses.Here we propose the concept of an anisotropic coding metamaterial in which the coding behaviors in different directions are dependent on the polarization status of the electromagnetic waves.We experimentally demonstrate an ultrathin and flexible polarization-controlled anisotropic coding metasurface that functions in the terahertz regime using specially designed coding elements.By encoding the elements with elaborately designed coding sequences(both 1-bit and 2-bit sequences),the x-and y-polarized waves can be anomalously reflected or independently diffused in three dimensions.The simulated far-field scattering patterns and near-field distributions are presented to illustrate the dual-functional performance of the encoded metasurface,and the results are consistent with the measured results.We further demonstrate the ability of the anisotropic coding metasurfaces to generate a beam splitter and realize simultaneous anomalous reflections and polarization conversions,thus providing powerful control of differently polarized electromagnetic waves.The proposed method enables versatile beam behaviors under orthogonal polarizations using a single metasurface and has the potential for use in the development of interesting terahertz devices. | Shuo Liu Tie Jun Cui Quan Xu Di Bao Liangliang Du Xiang Wan Wen Xuan Tang Chunmei Ouyang Xiao Yang Zhou Hao Yuan Hui Feng Ma Wei Xiang Jiang Jiaguang Han Weili Zhang Qiang Cheng | 2016 | Light(Science & Applications)2016，5，1： | 36 |
| 3 | Broadband diffusion of terahertz waves by multi-bit coding metasurfaces显示文摘The terahertz region is a special region of the electromagnetic spectrum that incorporates the advantages of both microwaves and infrared light waves.In the past decade,metamaterials with effective medium parameters or gradient phases have been studied to control terahertz waves and realize functional devices.Here,we present a new approach to manipulate terahertz waves by using coding metasurfaces that are composed of digital coding elements.We propose a general coding unit based on a Minkowski closed-loop particle that is capable of generating 1-bit coding(with two phase states of 0 and 180°),2-bit coding(with four phase states of 0,90°,180°,and 270°),and multi-bit coding elements in the terahertz frequencies by using different geometric scales.We show that multi-bit coding metasurfaces have strong abilities to control terahertz waves by designing-specific coding sequences.As an application,we demonstrate a new scattering strategy of terahertz waves—broadband and wide-angle diffusion—using a 2-bit coding metasurface with a special coding design and verify it by both numerical simulations and experiments.The presented method opens a new route to reducing the scattering of terahertz waves. | Li-Hua Gao Qiang Cheng Jing Yang Shao-Jie Ma Jie Zhao Shuo Liu Hai-Bing Chen Qiong He Wei-Xiang Jiang Hui-Feng Ma Qi-Ye Wen Lan-Ju Liang Biao-Bing Jin Wei-Wei Liu Lei Zhou Jian-Quan Yao Pei-Heng Wu Tie-Jun Cui | 2015 | Light(Science & Applications)2015，4，1： | 31 |
| 4 | Direct Transmission of Digital Message via Programmable Coding Metasurface显示文摘In modern wireless communications,digital information is frstly converted to analog signal by a digital-analog convertor,which is then mixed to high-frequency microwave to be transmitted through a series of devices including modulator,mixer,amplifer,flter,and antenna and is fnally received by terminals via a reversed process.Although the wireless communication systems have evolved signifcantly over the past thirty years,the basic architecture has not been challenged.Here,we propose a method to transmit digital information directly via programmable coding metasurface.Since the coding metasurface is composed of‘0’and‘1’digital units with opposite phase responses,the digital information can be directly modulated to the metasurface with certain coding sequences and sent to space under the illumination of feeding antenna.Te information,being modulated in radiation patterns of the metasurface,can be correctly received by multiple receivers distributed in diferent locations.Tis method provides a completely new architecture for wireless communications without using complicated digital-analog convertor and a series of active/passive microwave devices.We build up a prototype to validate the new architecture experimentally,which may fnd promising applications where information security is highly demanded. | Tie Jun Cui Shuo Liu Guo Dong Bai Qian Ma | 2019 | Research2019，，1： | 20 |
| 5 | Outcomes in refractory diffuse large B-cell lymphoma:results fromamulticenter real-world study in China显示文摘Background:Diffuse large B-cell lymphoma(DLBCL)patients refractory to rituximab-based immunochemotherapy have a dismal prognosis.However,the definition of refractory DLBCL remains inconsistent and no large cohort study data is available from Asian countries.To validate the definition and outcomes of refractory DLBCL in China,we conducted a multicenter,retrospective cohort study.Methods:The REtrospective AnaLysis of Treatment REspoNse of refractory DLBCL(REAL-TREND)study was performed using real-world data from 8 centers in China.DLBCL patients with curative intent were included in the REAL-TREND dataset.Overall survival(OS)was estimated using the Kaplan-Meier method and compared by the log-rank test.Due to heterogeneity in response rates among different centers,the response rates of refractory patients were pooled using random-effect models.Multivariate survival analysis was performed using the Cox regression model.Results:A total of 2778 DLBCL patients diagnosed between January,2010 and December,2015 were enrolled to this study.After validating previous definitions,the SCHOLAR-1 study was most suitable to define refractory DLBCL.The estimated 5-year cumulative incidence of refractory patients was 20%(95% confidence Interval[CI]=18%-22%).After the determination of refractory disease,overall response rate and complete remission rate were 30%(95%CI=22%-38%)and 9%(95%CI=4%-15%),respectively.Patients with either no response to immunochemotherapy or relapse within 12 months after stem-cell transplantation had inferior survival with a median OS of 5.9 months(95%CI=5.5-7.1 months)and 2-year OS rate of 16%(95%CI=12%-20%).International prognostic index score 4-5(hazard ratio[HR]=2.22;95%CI=1.47-3.35),central nervous systemrelapse(HR=1.43;95%CI=1.04-1.97),and best response status(HR=2.68;95%CI=1.42-5.03 for partial remission.HR=5.97,95%CI=3.21-11.11 for stable disease/progressive disease)were independent unfavorable prognostic factors.Conclusions:This is the first large-scale Asian cohort study focusing on outcomes of refractory DLBCL.The definition of the SCHOLAR-1 study identifies patients with homogenously inferior survival,thus is appropriate to select refractory DLBCL.Due to poor clinical outcomes in the rituximab era,patients with refractory DLBCL may be potential candidates for novel treatment modalities. | Shuo Wang Li Wang Jianda Hu Wenbin Qian Xi Zhang Yu Hu Qi Zhu Bobin Chen Depei Wu Chung-Chou H.Chang Pengpeng Xu Xiaoyun Zheng Juying Wei Yao Liu Guohui Cui Yong Tang Yan Ma Haiwen Huang Hongmei Yi Weili Zhao | 2021 | Cancer Communications2021，41，3： | 10 |
| 6 | Negative reflection and negative surface wave conversion from obliquely incident electromagnetic waves显示文摘Complete control of spatially propagating waves(PWs)and surface waves(SWs)is an ultimate goal that scientists and engineers seek for,in which negative reflection of PW and negative surface wave are two exotic phenomena.Here,we experimentally demonstrate an anisotropic digital coding metasurface capable of controlling both PWs and SWs with a single coding pattern.On the basis of the digital description of coding metasurfaces,a simple coding method is proposed to allow dual functionalities(either PW or SW manipulations)under two orthogonal polarizations at arbitrarily oblique incidences,thus improving the adaptability of digital coding metasurfaces in more practical circumstances.With elaborately designed ellipse-shaped coding particles,we experimentally demonstrate various functions under oblique incidences,including the negative reflection of PW,negative SW,anomalous reflection and their arbitrary combinations,all having good agreements with theoretical and numerical predictions.We believe that the proposed method may enable the digital coding metasurfaces to have broad applications in radar detections,wireless communications and imaging. | Shuo Liu Tie Jun Cui Ahsan Noor Zui Tao Hao Chi Zhang Guo Dong Bai Yan Yang Xiao Yang Zhou | 2018 | Light(Science & Applications)2018，7，1： | 10 |
| 7 | Development of the personalized criteria for microscopic review following four different series of hematology analyzer in a Chinese large scale hospital显示文摘 | CUI Wei WU Wei WANG Xin WANG Geng HAO Ying-ying CHEN Yu LUO Dan SHOU Wei-ling ZHANG Shuo XIANG Xue-fang SI Yong-zhen CHEN Qian CAI Hao LI Tan SHEN Han SHANG Kun ZHANG Yong-qiang | 2010 | Chinese Medical Journal2010，，22： | 10 |
| 8 | Clinical utility of automated platelet clump count in the screening for ethylene diamine tetraacetic acid-dependent pseudothrombocytopenia显示文摘 | WU Wei GUO Ye ZHANG Lin CUI Wei LI Wei ZHANG Shuo | 2011 | Chinese Medical Journal2011，，20： | 9 |
| 9 | A high-strength mineralized collagen bone scaffold for large-sized cranial bone defect repair in sheep显示文摘Large-sized cranial bone defect repair presents a great challenge in the clinic.The ideal cranioplasty materials to realize the functional and cosmetic recovery of the defect must have sufficient mechanical support,excellent biocompatibility,good osseointegration and biodegradability as well.In this study,a high-strength mineralized collagen(MC)bone scaffold was developed with biomimetic composition,microstructure and mechanical properties for the repair of sheep largesized cranial bone defects in comparison with two traditional cranioplasty materials,polymethyl methacrylate and titanium mesh.The compact MC scaffold showed no distinct pore structure and therefore possessed good mechanical properties.The strength and elastic modulus of the scaffold were much higher than those of natural cancellous bone and slightly lower than those of natural compact bone.In vitro cytocompatibility evaluation revealed that the human bone marrow mesenchymal stem cells(hBMSC)had good viability,attachment and proliferation on the compact MC scaffold indicating its excellent biocompatibility.An adult sheep cranial bone defect model was constructed to evaluate the performances of these cranioplasty materials in repairing the cranial bone defects.The results were investigated by gross observation,computed tomography scanning as well as histological assessments.The in vivo evaluations indicated that compact MC scaffold showed notable osteoconductivity and osseointegration with surrounding cranial bone tissues by promoting bone regeneration.Our results suggested that the compact MC scaffold has a promising potential for large-sized cranial bone defect repair. | Shuo Wang Zhijun Zhao Yongdong Yang Antonios G.Mikos Zhiye Qiu Tianxi Song Fuzhai Cui XiumeiWang Chunyang Zhang | 2018 | Regenerative Biomaterials2018，5，5： | 9 |
| 10 | A multi-channel collagen scaffold loaded with neural stem cells for the repair of spinal cord injury显示文摘Collagen scaffolds possess a three-dimensional porous structure that provides sufficient space for cell growth and proliferation,the passage of nutrients and oxygen,and the discharge of metabolites.In this study,a porous collagen scaffold with axially-aligned luminal conduits was prepared.In vitro biocompatibility analysis of the collagen scaffold revealed that it enhances the activity of neural stem cells and promotes cell extension,without affecting cell differentiation.The collagen scaffold loaded with neural stem cells improved the hindlimb motor function in the rat model of T8 complete transection and promoted nerve regeneration.The collagen scaffold was completely degraded in vivo within 5 weeks of implantation,exhibiting good biodegradability.Rectal temperature,C-reactive protein expression and CD68 staining demonstrated that rats with spinal cord injury that underwent implantation of the collagen scaffold had no notable inflammatory reaction.These findings suggest that this novel collagen scaffold is a good carrier for neural stem cell transplantation,thereby enhancing spinal cord repair following injury.This study was approved by the Animal Ethics Committee of Nanjing Drum Tower Hospital(the Affiliated Hospital of Nanjing University Medical School),China(approval No.2019AE02005)on June 15,2019. | Shuo Liu Yuan-Yuan Xie Liu-Di Wang Chen-Xu Tai Dong Chen Dan Mu Yan-Yan Cui Bin Wang | 2021 | Neural Regeneration Research2021，16，11： | 6 |
| 11 | Curcuminoids Target Decreasing Serum Adipocyte-fatty Acid Binding Protein Levels in Their Glucose-lowering Effect in Patients with Type 2 Diabetes显示文摘Whether supplementation of curcuminoids decreases serum adipocyte-fatty acid binding protein(A-FABP) level and whether this decrease benefits glucose control is unclear.One-hundred participants(n=50 administered curcuminoids,n=50 administered placebo) from our previous report on the effect of curcuminoids on type 2 diabetes in a 3-month intervention were assessed for levels of serum A-FABP,oxidative stress,and inflammatory biomarkers.Curcuminoids supplementation led to significant decreases in serum A-FABP,C-reactive protein(CRP),tumor necrosis factor-α,and interleukin-6 levels.Curcuminoids supplementation also significantly increased serum superoxide dismutase(SOD) activity.The change in serum A-FABP levels showed positive correlations with changes in levels of glucose,free fatty acids(FFAs),and CRP in subjects supplemented with curcuminoids.Further stepwise regression analysis showed that A-FABP was an independent predictor for levels of FFAs,SOD,and CRP.These results suggest that curcuminoids may exert anti-diabetic effects,at least in part,by reductions in serum A-FABP level.A-FABP reduction is associated with improved metabolic parameters in human type 2 diabetes. | NA Li Xin YAN Bo Lin JIANG Shuo CUI Hong Li LI Ying SUN Chang Hao | 2014 | Biomedical and Environmental Sciences2014，27，11： | 6 |
| 12 | Study on RIZ1 gene promoter methylation status in human esophageal squamous cell carcinoma显示文摘AIM:To investigate the promoter region methylation status of retinoblastoma protein-interacting zinc finger gene 1(RIZ1) in the human esophageal squamous cell carcinoma(ESCC) cell lines and tissues and verify the relationship between methylation of RIZ1 and oncogenesis,tumor progression and metastasis etc of ESCC.METHODS:Methylation-specific polymerase chain reaction(MSP) was used to investigate the promoter region methylation status of RIZ1 in 6 ESCC cell lines.One cell line where RIZ1 promoter region methylation was detected was selected for the next study,where the cell line was treated with 5-aza-CdR.Real-time polymerase chain reaction was used to investigate its influence on the transcription of RIZ1.Experiments using frozenpathological specimens from 47 ESCC patients were performed using the same MSP methodology.RESULTS:Promoter methylation of RIZ1 gene was detected in TE13,CaEs17 and EC109 cell lines and the cell line TE13 was chosen for further study.The expression of RIZ1 mRNA in TE-13 was up-regulated after treatment with 5-aza-CdR.The rate of methylation in carcinomas tissues was significantly higher than those in matched neighboring normal and distal ending normal tissue,and the deviation of data was statistically significant(χ 2 = 24.136,P < 0.01).Analysis of the gender,age familial history,tumour deviation,tumour saturation,lymph gland displacement and clinical staging of 47 samples from ESCC patients showed that the fluctuation of data was not statistically significant.CONCLUSION:Promoter methylation may play an important role in the epigenetic silencing of RIZ1 gene expression in human ESCC.RIZ1 is considered to be a potential tumor suppressor gene and may be a biological parameter for testing early stage human ESCC. | Shang-Wen Dong Peng Zhang Yi-Mei Liu Yuan-Tao Cui Shuo Wang Shao-Jie Liang Zhun He Pei Sun Yuan-Guo Wang | 2012 | World Journal of Gastroenterology2012，18，6： | 6 |
| 13 | Topologically Protected Edge State in Two-Dimensional Su–Schrieffer–Heeger Circuit显示文摘Topological circuits,an exciting feld just emerged over the last two years,have become a very accessible platform for realizing and exploring topological physics,with many of their physical phenomena and potential applications as yet to be discovered.In this work,we design and experimentally demonstrate a topologically nontrivial band structure and the associated topologically protected edge states in an RF circuit,which is composed of a collection of grounded capacitors connected by alternating inductors in the x and y directions,in analogy to the Su–Schriefer–Heeger model.We take full control of the topological invariant(i.e.,Zak phase)as well as the gap width of the band structure by simply tuning the circuit parameters.Excellent agreement is found between the experimental and simulation results,both showing obvious nontrivial edge state that is tightly bound to the circuit boundaries with extreme robustness against various types of defects.Te demonstration of topological properties in circuits provides a convenient and fexible platform for studying topological materials and the possibility for developing fexible circuits with highly robust circuit performance. | Shuo Liu Wenlong Gao Qian Zhang Shaojie Ma Lei Zhang Changxu Liu Yuan Jiang Xiang Tie Jun Cui Shuang Zhang | 2019 | Research2019，，1： | 6 |
| 14 | A comparative study of risk factors for corneal infection in diabetic and non-diabetic patients显示文摘AIM: To compare the clinical characteristics of infectious keratopathy in type 2 diabetes mellitus(T2DM) and nondiabetes mellitus(NDM) and to investigate risk factors for infectious keratopathy in T2DM patients. METHODS: Totally 230 patients with T2DM and 168 with NDM diagnosed as infectious keratopathy were hospitalized at Qingdao Eye Hospital from 2001 to 2015. Data including sex, age, occupation, season, smoking and alcohol consumption habits, duration between onset and treatments, duration of hospitalization were collected. Initially identified indicators were analyzed with a multivariate logistic regression. Glycosylated hemoglobin A1 c(Hb A1 c) in patients with T2DM was analyzed. The infectious keratopathies in the two groups were categorized and compared.RESULTS: The diabetic group consisted of 146(63.5%) males and 84(36.5%) females. The NDM group consisted of 111(66.1%) males and 57(33.9%) females. There was no signigicantly difference in sex distribution between the two groups(P>0.05). There were significant differences in age, occupation of patients, season of the onset of diseases, duration between onset and treatment, and durations of hospitalization between the two groups(P<0.05). In most of the patients in the diabetic group, the duration between onsetand treatment was ≤3 mo, and most was ≥3 mo in the NDM group. Multivariate logistic regression analysis revealed that age and season were related to the development of corneal infection in the T2DM group(OR=1.709, 1.706). In the T2DM group, Hb A1 c was 9.09%±2.12%. There were statistically significant differences in the incidences of bacterial keratitis and herpes simplex keratitis in the two groups(P<0.05), but no significant statistical difference was found between fungal keratitis and amoebic keratitis(P>0.05). CONCLUSION: Advanced age and the summer and winter seasons are identified as risk factors for infectious keratopathy in T2DM patients, and T2DM patients are more prone to bacterial keratitis. | Bin Wang Shuo Yang Hua-Lei Zhai Yang-Yang Zhang Chun-Xia Cui Jun-Yi Wang Li-Xin Xie | 2018 | International Journal of Ophthalmology(English edition)2018，11，1： | 5 |
| 15 | Information theory of metasurfaces显示文摘We propose a theory to characterize the information and information processing abilities of metasurfaces,and demonstrate the relation between the information of the metasurface and its radiation pattern in the far-field region.By incorporating a general aperturemodel with uncertainty relation in L2-space,we propose a theory to predict the upper bound of information contained in the radiation pattern of a metasurface,and reveal the theoretical upper limit of orthogonal radiation states.Theproposed theory also provides guidance for inverse design of the metasurface with respect to given functionalities.Through investigation of the information of disordered-phase modulated metasurfaces,we find the information invariance(1?γ,whereγis Euler’s constant)of chaotic radiation patterns.That is to say,the information of the disordered-phase modulated radiation patterns is always equal to 1?γ,regardless of variations in size,the number of elements and the phase pattern of metasurface.This value might be the lower bound of radiation-pattern information of the metasurface,which can provide a theoretical limit for information modulation applications,including computational imaging,stealth technologies and wireless communications. | Haotian Wu Guo Dong Bai Shuo Liu Lianlin Li Xiang Wan Qiang Cheng Tie Jun Cui | 2020 | National Science Review2020，7，3： | 5 |
| 16 | In-situ structural evolution analysis of Zr-doped Na_(3)V_(2)(PO_(4))_(2)F_(3) coated by N-doped carbon layer as high-performance cathode for sodium-ion batteries显示文摘With great superiorities in energy density,rate capability and structural stability,Na_(3)V_(2)(PO_(4))_(2) F_(3)(NVPF)has attracted much attentions as cathode of sodium ion battery(SIB),but it also faces challenges on its poor intrinsic electronic conductivity and the controversial de/sodiation mechanism.Herein,a series of Zr-doped NVPF coated by N-doped carbon layer(~5 nm in thickness,homogenously)materials are fabricated by a sol-gel method,and the optimized heteroatom-doping amounts of Zr and N doping improve intrinsic properties on enlarging lattice distance and enhancing electronic conductivity,respectively.Specifically,among all samples of Na_(3) V_(2-x)Zr_(x)(PO_(4))_(2) F_(3)/NC(NVPF-Zr-x/NC,x=0,0.01,0.02,0.05,and 0.1),the optimized electrode of NVPF-Zr-0.02/NC delivers high reversible capacities(119.2 mAh g^(-1) at0.5 C),superior rate capability(98.1 mA h g^(-1) at 20 C)and excellent cycling performance.The structural evolution of NVPF-Zr-0.02/NC electrode,in-situ monitored by X-ray diffractometer,follows a step-wise Na-extraction/intercalation mechanism with reversible multi-phase changes,not just a solid-solutionreaction one.Full cells of NVPF-Zr-0.02/NC//hard carbon demonstrate high capacity(99.8 mA h g^(-1) at 0.5 C),high out-put voltage(3.5 V)and good cycling stability.This work is favorable to accelerate the development of high-performance cathode materials and explore possible redox reaction mechanisms of SIBs. | Chuan Guo Jianwei Yang Zhiyuan Cui Shuo Qi Qianqian Peng Weiwei Sun Li-Ping Lv Yi Xu Yong Wang Shuangqiang Chen | 2022 | Journal of Energy Chemistry2022，31，2： | 5 |
| 17 | Information entropy of coding metasurface显示文摘Because of their exceptional capability to tailor the effective medium parameters,metamaterials have been widely used to control electromagnetic waves,which has led to the observation of many interesting phenomena,for example,negative refraction,invisibility cloaking,and anomalous reflections and transmissions.However,the studies of metamaterials or metasurfaces are mainly limited to their physical features;currently,there is a lack of viewpoints on metamaterials and metasurfaces from the information perspective.Here we propose to measure the information of a coding metasurface using Shannon entropy.We establish an analytical connection between the coding pattern of an arbitrary coding metasurface and its far-field pattern.We introduce geometrical entropy to describe the information of the coding pattern(or coding sequence)and physical entropy to describe the information of the far-field pattern of the metasurface.The coding metasurface is demonstrated to enhance the information in transmitting messages,and the amount of enhanced information can be manipulated by designing the coding pattern with different information entropies.The proposed concepts and entropy control method will be helpful in new information systems(for example,communication,radar and imaging)that are based on the coding metasurfaces. | Tie-Jun Cui Shuo Liu Lian-Lin Li | 2016 | Light(Science & Applications)2016，5，1： | 4 |
| 18 | Biocompatibility of nano-hydroxyapatite/Mg-Zn-Ca alloy composite scaffolds to human umbilical cord mesenchymal stem cells from Wharton's jelly in vitro显示文摘Seeding cells and scaffolds play pivotal roles in bone tissue engineering and regenerative medicine.Wharton’s jelly-derived mesenchymal stem cells(WJCs)from human umbilical cord represent attractive and promising seeding cells in tissue regeneration and engineering for treatment applications.This study was carried out to explore the biocompatibility of scaffolds to seeding cells in vitro.Rod-like nano-hydroxyapatite(RN-HA)and flake-like micro-hydroxyapatite(FM-HA)coatings were prepared on Mg-Zn-Ca alloy substrates using micro-arc oxidation and electrochemical deposition.WJCs were utilized to investigate the cellular biocompatibility of Mg-Zn-Ca alloys after different surface modifications by observing the cell adhesion,morphology,proliferation,and osteoblastic differentiation.The in vitro results indicated that the RN-HA coating group was more suitable for cell proliferation and cell osteoblastic differentiation than the FM-HA group,demonstrating better biocompatibility.Our results suggested that the RN-HA coating on Mg-Zn-Ca alloy substrates might be of great potential in bone tissue engineering. | GUAN FangXia MA ShanShan SHI XinYi MA Xun CHI LianKai LIANG Shuo CUI YuanBo WANG ZhiBin YAO Ning GUAN ShaoKang YANG Bo | 2014 | Science China(Life Sciences)2014，57，2： | 4 |
| 19 | Prevalence and Treatment of Children's Asthma in Rura Areas Compared with Urban Areas in Beijing显示文摘 | Wen-Jing Zhu Hai-Xia Ma Hui-Ying Cui Xu Lu Ming-Jun Shao Shuo Li Yan-Qing Luo Qiang Wang Chun-Yu Xu Dong-Qun Xu Chuan-He Liu Yu-Zhi Chen | 2015 | Chinese Medical Journal2015，，17： | 4 |
| 20 | Two competitive nucleation mechanisms of calcium carbonate biomineralization in response to surface functionality in low calcium ion concentration solution显示文摘Four self-assembled monolayer surfaces terminated with–COOH,–OH,–NH_(2)and–CH_(3)functional groups are used to direct the biomineralization processes of calcium carbonate(CaCO_(3))in low Ca^(2+)concentration,and the mechanism of nucleation and initial crystallization within 12 h was further explored.On-COOH surface,nucleation occurs mainly via ion aggregation mechanism while prenucleation ions clusters may be also involved.On-OH and-NH_(2)surfaces,however,nucleation forms via calcium carbonate clusters,which aggregate in solution and then are adsorbed onto surfaces following with nucleation of amorphous calcium carbonate(ACC).Furthermore,strongly negative-charged-COOH surface facilitates the direct formation of calcites,and the-OH and-NH_(2)surfaces determine the formation of vaterites with preferred crystalline orientations.Neither ACC nor crystalline CaCO_(3)is observed on-CH_(3)surface.Our findings present a valuable model to understand the CaCO_(3)biomineralization pathway in natural system where functional groups composition plays a determining role during calcium carbonate crystallization. | Hua Deng Shuo Wang Xiumei Wang Chang Du Xingcan Shen Yingjun Wang Fuzhai Cui | 2015 | Regenerative Biomaterials2015，2，3： | 3 |
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