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| 1 | Marginal sealing around integral bilayer scaffolds for repairing osteochondral defects based on photocurable silk hydrogels显示文摘Osteochondral repair remains a major challenge in current clinical practice despite significant advances in tissue engineering.In particular,the lateral integration of neocartilage into surrounding native cartilage is a difficult and inadequately addressed problem that determines the success of tissue repair.Here,a novel design of an integral bilayer scaffold combined with a photocurable silk sealant for osteochondral repair is reported.First,we fabricated a bilayer silk scaffold with a cartilage layer resembling native cartilage in surface morphology and mechanical strength and a BMP-2-loaded porous subchondral bone layer that facilitated the osteogenic differentiation of BMSCs.Second,a TGF-β3-loaded methacrylated silk fibroin sealant(Sil-MA)exhibiting biocompatibility and good adhesive properties was developed and confirmed to promote chondrocyte migration and differentiation.Importantly,this TGF-β3-loaded Sil-MA hydrogel provided a bridge between the cartilage layer of the scaffold and the surrounding cartilage and then guided new cartilage to grow towards and replace the degraded cartilage layer from the surrounding native cartilage in the early stage of knee repair.Thus,osteochondral regeneration and superior lateral integration were achieved in vivo by using this composite.These results demonstrate that the new approach of marginal sealing around the cartilage layer of bilayer scaffolds with Sil-MA hydrogel has tremendous potential for clinical use in osteochondral regeneration. | Xiaolin Wu Mingliang Zhou Fei Jiang Shi Yin Sihan Lin Guangzheng Yang Yuezhi Lu Wenjie Zhang Xinquan Jiang | 2021 | Bioactive Materials2021，6，11： | 7 |
| 2 | Global transcriptome analysis for identification of interactions between coding and noncoding RNAs during human erythroid differentiation显示文摘在 erythroid 开发期间编码基因, miRNAs,和 lncRNAs 上的研究在最近的年里被执行了。然而,集中于三种 RNA 类型的集成的分析还得被做。在现在的学习,我们比较了编码基因, miRNA,和 lncRNA 表示侧面的动力学。为了在在 transcriptome 控制这些变化的红血球生成和潜在的机制探索动态变化,铺平,我们利用了定序技术从绳索血获得 transcriptome 数据的高产量造血的干细胞和下列四个 erythroid 区别阶段,以及从成熟的红血房间。结果显示 lncRNAs 为 erythroid 区别正在答应房间标记候选人。聚类分析分类差别表示基因进在 stemness 维护期间对应于动态变化的四种子类型,中间区别,并且成熟。综合分析揭示了 RNA 潜在地参予了控制血细胞成熟的那 noncoding,并且特别与到氧种类和 DNA 损坏的 heme 新陈代谢和回答联系了。这些规章的相互作用在一个全面网络,在 RNA 之间的从而推断的关联和他们的联系功能被显示。这些数据为正常红血球生成的学习提供了一个大量的资源,它将允许 erythroid 开发的进一步的调查和理解并且获得 erythroid 混乱。 | Nan Ding Jiafei Xi Yanming Li Xiaoyan Xie Jian Shi Zhaojun Zhang Yanhua Li Fang Fang Sihan Wang Wen Yue Xuetao Pei Xiangdong Fang | 2016 | Frontiers of Medicine2016，10，3： | 6 |
| 3 | Orchestration of energy metabolism and osteogenesis by Mg^(2+)facilitates low-dose BMP-2-driven regeneration显示文摘The clinical application of bone morphogenetic protein-2(BMP-2)is limited by several factors,including ineffectiveness at low doses and severe adverse effects at high doses.To address these efficacy and safety limitations,we explored whether orchestration of energy metabolism and osteogenesis by magnesium ion(Mg^(2+))could reduce the dose and thereby improve the safety of BMP-2.Our results demonstrated that rapid metabolic activation triggered by BMP-2 was indispensable for subsequent osteogenesis.Moreover,inadequate metabolic stimulation was shown to be responsible for the ineffectiveness of low-dose BMP-2.Next,we identified that Mg^(2+),as an'energy propellant',substantially increased cellular bioenergetic levels to support the osteogenesis via the Akt-glycolysis-Mrs2-mitochondrial axis,and consequently enhanced the osteoinductivity of BMP-2.Based on the mechanistic discovery,microgel composite hydrogels were fabricated as low-dose BMP-2/Mg^(2+)codelivery system through microfluidic and 3D printing technologies.An in vivo study further confirmed that rapid and robust bone regeneration was induced by the codelivery system.Collectively,these results suggest that this bioenergetic-driven,cost-effective,low-dose BMP-2-based strategy has substantial potential for bone repair. | Sihan Lin Shi Yin Junfeng Shi Guangzheng Yang Xutao Wen Wenjie Zhang Mingliang Zhou Xinquan Jiang | 2022 | Bioactive Materials2022，7，12： | 2 |
| 4 | One-dimensional iron oxides nanostructures显示文摘Iron oxides,including α-Fe2O3,γ-Fe2O3,Fe3O4,etc.are one of the most widely investigated materials for their fundamental properties and potential applications.One-dimensional(1-D) iron oxides nanostructures are the focus of recent research activities because of their wide applications in magnetic refrigeration,information storage,electronics,catalysts,Li-ion battery,pigment,gas sensors,etc.This review covers the recent progress in the synthesis,properties and applications of 1-D iron oxides nanostructures.The paper begins with the introduction to 1-D iron oxides nanostructures,followed by the typical synthetic methods developed for the synthesis of 1-D iron oxides nanostructures.Then,the typical 1-D iron oxides nanostructures,including nanowires/nanorods,nanotubes,nanobelts,nanochains,and special 3-D structures built on 1-D building blocks,are introduced in detail.The properties of 1-D iron oxides nanostructures are then discussed,focusing on the magnetic,gas sensing,and electrochemical and photocatalytic properties.Finally,we draw conclusions and look at the prospects of 1-D iron oxides nanostructures. | CHEN Di XIONG Shi RAN SiHan LIU Bin WANG LiMing SHEN GuoZhen | 2011 | Science China(Physics,Mechanics & Astronomy)2011，54，7： | 2 |
| 5 | Preservation of alveolar ridge height through mechanical memory: A novel dental implant design显示文摘Irreversible marginal bone loss can hinder recovery around dental implants.Insufficient alveolar osteogenesis and stress concentration during chewing contribute to marginal bone resorption and can result in implant failure.A biomaterial with a micropore-channel structure was developed using 3D printing technology.This design facilitated bony ingrowth and provided similar mechanical stimulation at the implant neck during mastication to a natural tooth.The micropore channels provided a guiding structure for bone mesenchymal stem cell proliferation and differentiation without the need for growth factors.Specifically,this was achieved through mechanical transduction by F-actin remodeling and the activation of Yes-associated protein(YAP).The implants were verified in a canine dental implant surgery model,which demonstrated the promising use of biomaterialbased dental implants in future clinical applications. | Shi Yin Wenjie Zhang Yanmei Tang Guangzheng Yang Xiaolin Wu Sihan Lin Xuanyong Liu Huiliang Cao Xinquan Jiang | 2021 | Bioactive Materials2021，6，1： | 1 |
| 6 | Honeycomb-Like Hydrogel Microspheres for 3D Bulk Construction of Tumor Models显示文摘A two-dimensional(2D)cell culture-based model is widely applied to study tumorigenic mechanisms and drug screening.However,it cannot authentically simulate the threedimensional(3D)microenvironment of solid tumors and provide reliable and predictable data in response to in vivo,thus leading to the research ilusionis and failure of drug screening.In this study,honeycomb-like gelatin methacryloyl(GelMA)hydrogel microspheres are developed by synchronous photocrosslinking microluidic technique to construct a 3D model of osteosarcoma.The in vitro study shows that ostcosarcoma cells(K7M2)culured in 3D GelMA microspheres have stronger tumorous stemness。proliferation and migration abilitics,more osteoclastogenetic ability,and reistance to chemotherapeutic drugs(DOX)than that of cells in 2D cultures.More imporantly,the 3D-cultured K7M2 cells show more tumorigenicity in immunologically sound mice,characterized by shorter tumorigenesis time,larger tumor volumc,severe bone destruction,and higher mortality.In conclusion,honeycomb like porous microsphere scaffolds are constructed with uniform structure by micofluidic technology to massively produce tumor cells with original phenotypes.Those microspheres could recapitulate the physiology microenvironment of tumors.maintain ell-cell and cell-extracellular matrix interactions,and thus provide an efective and convenient strategy for tumor pathogenesis and drug screening research. | Jiachen He Chichi Chen Liang Chen Ruoyu Cheng Jie Sun Xingzhi Liu Lin Wang Can Zhu Sihan Hu Yuan Xue Jian Lu Huiling Yang Wenguo Cui Qin Shi | 2022 | Research2022，，2： | 1 |
| 7 | Multimaterial additive manufacturing manipulator for fabricating magnetoelectric pressure sensors显示文摘The simultaneous placement of different types of materials including polymers,ceramics,and metals,in their desired positions could be adopted to manufacture end-use devices/apparatuses with diverse functionalities and significantly reduce the fabrication cost and time.However,existing additive manufacturing(AM)approaches can only treat one material species at a time due to their intrinsic working mechanisms.Here we develop an AM manipulator for manufacturing a wide variety of material species,including polymers,ceramics,and metals,through a multifilament transport strategy assisted by laser power.The six-jaw manipulator contains three pairs of filament delivering/cutting systems for transporting diverse materials and a beam of tunable laser as the thermal source.The whole apparatus is integrated into a robotic manipulator to create a multifreedom manufacturing platform.With this innovation,products with multiple material species and desired complex geometries can be fabricated on demand.Furthermore,we synthesize a multimaterial(polymer/ceramic/metal)printed magnetoelectric pressure sensor that can convert applied mechanical forces to electricity and maintain efficiency even after undergoing 10000 cycles of pressure/recovery.With this multimaterial filament transport and laser manufacturing strategy,our AM manipulator exhibits promising application in the advanced manufacturing of embedded electronics,sensors,soft robotics,and customizable medical devices. | LIU ZhuFeng LI ZhaoQing WANG Qi WANG Yan YANG Lei NIE Xiang GENG Peng WU ZhenHua TANG SiHan YANG Lei WU HongZhi SHI YunSong CHEN Peng SU Bin ZHANG LiChao YAN ChunZe SHI YuSheng | 2022 | Science China(Technological Sciences)2022，65，11： | 1 |
| 8 | Regulating macrophage-MSC interaction to optimize BMP-2-induced osteogenesis in the local microenvironment显示文摘Bone morphogenetic protein(BMP-2)has been approved by the FDA to promote bone regeneration,but uncertain osteogenic effect and dose-dependent side effects may occur.Osteoimmunomodulation plays an important role in growth factor-based osteogenesis.Here,we explored how proinflammatory signals affect the dose-dependent osteogenic potential of BMP-2.We observed that the expression level of local IL-1βdid not increase with the dose of BMP-2 in the mouse osteogenesis model.A low dose of BMP-2 could not promote new bone formation,but trigger the release of IL-1βfrom M1 macrophages.As the dose of BMP-2 increased,the IL-1βexpression and M1 infiltration in local microenvironment were inhibited by IL-1Ra from MSCs under osteogenic differentiation induced by BMP-2,and new bone tissues formed,even excessively.Anti-inflammatory drugs(Dexamethasone,Dex)promoted osteogenesis via inhibiting M1 polarization and enhancing BMP-2-induced MSC osteo-differentiation.Thus,we suggest that the osteogenic effect of BMP-2 involves macrophage-MSC interaction that is dependent on BMP-2 dose and based on IL-1R1 ligands,including IL-1βand IL-1Ra.The dose of BMP-2 could be reduced by introducing immunoregulatory strategies. | Fei Jiang Xuanyu Qi Xiaolin Wu Sihan Lin Junfeng Shi Wenjie Zhang Xinquan Jiang | 2023 | Bioactive Materials2023，，7： | 0 |
| 9 | APOD mission status and preliminary results显示文摘On September 20 th, 2015, twenty satellites were successfully deployed into a near-polar circular orbit at 520 km altitude by the Chinese CZ-6 test rocket, which was launched from the Tai Yuan Satellite Launch Center. Among these satellites, a set of 4 Cube Sats conform the atmospheric density detection and precise orbit determination(APOD) mission, which is projected for atmospheric density estimation from in-situ detection and precise orbit products. The APOD satellites are manufactured by China Spacesat Co. Ltd. and the payload instruments include an atmospheric density detector(ADD), a dual-frequency dualmode global navigation satellite system(GNSS) receiver(GPS and Beidou), a satellite laser ranging(SLR) reflector, and an S/Xband very long baseline interferometry(VLBI) beacon. In this paper, we compare the GNSS precise orbit products with colocated SLR observations, and the 3 D orbit accuracy shows better than 10 cm RMS. These results reveal the great potential of the onboard micro-electro-mechanical system(MEMS) GNSS receiver. After calibrating ADD density estimates with precise orbit products, the accuracy of our density products can reach about 10% with respect to the background density. Density estimates from APOD are of a great importance for scientific studies on upper atmosphere variations and useful for model data assimilation. | Geshi TANG Xie LI Jianfeng CAO Shushi LIU Guangming CHEN Haijun MAN Xiaomin ZHANG Sihan SHI Ji SUN Yongping LI Andres CALABIA | 2020 | Science China Earth Sciences2020，63，2： | 0 |
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