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1Isolation and characterization of H7N9 viruses from live poultry markets--Implication of the source of current H7N9 infection in humans显示文摘On March 31, 2013, the National Health and Family Planning Commission announced that human infections with a previously undescribed influenza A (H7N9) virus had occurred in Shanghai and Anhui Province, China. To investigate the possible origins of the H7N9 viruses causing these human infections, we collected 970 samples, including drinking water, soil, and cloacal and tracheal swabs of poultry from live poultry markets and poultry farms in Shanghai and Anhui Province. Twenty samples were positive for the H7N9 influenza virus. Notably, all 20 viruses were isolated from samples collected from live poultry markets in Shanghai. Phylogenetic analyses showed that the six internal genes of these novel human H7N9 viruses were derived from avian H9N2 viruses, but the ancestor of their HA and NA genes is uncertain. When we examined the phylogenetic relationship between the H7N9 isolates from live poultry markets and the viruses that caused the human infections, we found that they shared high homology across all eight gene segments. We thus identified the direct avian origin of the H7N9 influenza viruses that caused the human infections. Importantly, we observed that the H7N9 viruses isolated from humans had acquired critical mutations that made them more 'human-like'. It is therefore imperative to take strong measures to control the spread of H7N9 viruses in birds and humans to prevent further threats to human health.SHI JianZhong DENG GuoHua LIU PeiHong ZHOU JinPing GUAN LiZheng LI WenHui LI XuYong GUO Jing WANG GuoJun FAN Jun WANG JinLiang LI YuanYuan JIANG YongPing LIU LiLing TIAN GuoBin LI ChengJun CHEN HuaLan 2013Chinese Science Bulletin2013,58,16:85
2H7N9 virulent mutants detected in chickens in China pose an increased threat to humans显示文摘Jianzhong Shi Guohua Deng Huihui Kong Chunyang Gu Shujie Ma Xin Yin Xianying Zeng Pengfei Cui Yan Chen Huanliang Yang Xiaopeng Wan Xiurong Wang Liling Liu Pucheng Chen Yongping Jiang Jinxiong Liu Yuntao Guan Yasuo Suzuki Mei Li Zhiyuan Qu Lizheng Guan Jinkai Zang Wenli Gu Shuyu Han Yangming Song Yuzhen Hu Zeng Wang Linlin Gu Wenyu Yang Libin Liang Hongmei Bao Guobin Tian Yanbing Li Chuanling Qiao Li Jiang Chengjun Li Zhigao Bu Hualan Chen 2017Cell Research2017,27,12:70
3Temporal and spatial variations of the active layer along the Qinghai-Tibet Highway in a permafrost region显示文摘Using monitored active layer thickness(ALT) and environmental variables of 10 observation fields along the Qinghai-Tibet Highway in permafrost region of the Qinghai-Tibetan Plateau(QTP),a model for ALT estimation was developed.The temporal and spatial characteristics of the ALT were also analyzed.The results showed that in the past 30 years ALT in the study region increased at a rate of 1.33 cm a-1.Temperatures at the upper limit of permafrost and at 50 cm depth,along with soil cumulative temperature at 5 cm depth also exhibited a rising trend.Soil heat flux increased at a rate of 0.1 Wm-2 a-1.All the above changes demonstrated that the degradation of permafrost happened in the study region on the QTP.The initial thawing date of active layer was advanced,while the initial freezing date was delayed.The number of thawing days increased to a rate of 1.18 da-1.The variations of active layer were closely related to the permafrost type,altitude,underlying surface type and soil composition.The variations were more evident in cold permafrost region than in warm permafrost region,in high-altitude region than in low-altitude region,in alpine meadow region than in alpine steppe region;and in fine-grained soil region than in coarse-grained soil region.LI Ren ZHAO Lin DING YongJian WU TongHua XIAO Yao DU ErJi LIU GuangYue QIAO YongPing 2012Chinese Science Bulletin2012,57,35:51
4CRISPR-Cas9-mediated multiplex gene editing in CAR-T cells显示文摘Xiaojuan Liu Yongping Zhang Chen Cheng Albert W Cheng Xingying Zhang Na Li Changqing Xia Xiaofei Wei Xiang Liu Haoyi Wang 2017Cell Research2017,27,1:40
5Development of a Haploid-Inducer Mediated Genome Editing System for Accelerating Maize Breeding显示文摘Crop breeding aims to generate pure in bred lines with multiple desired traits. Doubled haploid (DH) and genome editing using CRISPR/Cas9 are two powerful game-changing technologies in crop breeding. However, both of them still fall short for rapid generation of pure elite lines with integrated favorable traits. Here, we report the development of a Haploid-Inducer Mediated Genome Editing (IMGE) approach, which utilizes a maize haploid inducer line carrying a CRISPR/Cas9 cassette targeting for a desired agronomic trait to pollinate an elite maize in bred line and to generate genome-edited haploids in the elite maize background. Homozygous pure DH lines with the desired trait improvement could be generated within two generations, thus bypassing the lengthy procedure of repeated crossing and backcrossing used in conventional breeding for integrating a desirable trait into elite commercial backgrounds.Baobao Wang Lei Zhu Binbin Zhao Yongping Zhao Yurong Xie Zhigang Zheng Yaoyao Li Juan Sun Haiyang Wang 2019Molecular Plant2019,12,4:32
6Whole-genome sequencing of 508 patients identifies key molecular features associated with poor prognosis in esophageal squamous cell carcinoma显示文摘Esophageal squamous cell carcinoma(ESCC)is a poor-prognosis cancer type with limited understanding of its molecular etiology.Using 508 ESCC genomes,we identified five novel significantly mutated genes and uncovered mutational signature clusters associated with metastasis and patients’outcomes.Several functional assays implicated that NFE2L2 may act as a tumor suppressor in ESCC and that mutations in NFE2L2 probably impaired its tumor-suppressive function,or even conferred oncogenic activities.Additionally,we found that the NFE2L2 mutations were significantly associated with worse prognosis of ESCC.We also identified potential noncoding driver mutations including hotspot mutations in the promoter region of SLC35E2 that were correlated with worse survival.Approximately 5.9%and 15.2%of patients had high tumor mutation burden or actionable mutations,respectively,and may benefit from immunotherapy or targeted therapies.We found clinically relevant coding and noncoding genomic alterations and revealed three major subtypes that robustly predicted patients’outcomes.Collectively,we report the largest dataset of genomic profiling of ESCC useful for developing ESCC-specific biomarkers for diagnosis and treatment.Yongping Cui Hongyan Chen Ruibin Xi Heyang Cui Yahui Zhao Enwei Xu Ting Yan Xiaomei Lu Furong Huang Pengzhou Kong Yang Li Xiaolin Zhu Jiawei Wang Wenjie Zhu Jie Wang Yanchun Ma Yong Zhou Shiping Guo Ling Zhang Yiqian Liu Bin Wang Yanfeng Xi Ruifang Sun Xiao Yu Yuanfang Zhai Fang Wang Jian Yang Bin Yang Caixia Cheng Jing Liu Bin Song Hongyi Li Yi Wang Yingchun Zhang Xiaolong Cheng Qimin Zhan Yanhong Li Zhihua Liu-Show 2020Cell Research2020,30,10:19
7Activity criterion of pre-existing fabrics in non-homogeneous deformation domain显示文摘The Anderson's model can be applied only to elastic homogeneous deformation and cannot explain complicated phenomena of natural faults, which to a large degree limits the model to practical application. By combing the Coulomb-Mohr Criterion with the sandbox modeling and considering non-homogeneous deformation, mechanisms of how basement pre-existing fabrics control fault formation and evolution are analyzed and a mechanical factor, activation-coefficient (faS) of pre-existing fabrics, is proposed. It is determined by the attitude and mechanical properties of pre-existing fabric, and the stress state (the magnitudes and directions of the three principal stresses). The coefficient has taken the heterogeneity of rocks into account and may serve as a criterion for evaluating the activity of a pre-existing fabric. The Mohr-Coulomb Criterion is expanded to non-homogeneous deformation domain in terms of activation-coefficient (faS) of pre-existing fabrics, the general law of the activity of a pre-existing fabric is predicted, the fault complexity real of rift basin is revealed in theory, and the controlling law of basement pre-existing faults to fault formation and evolution is determined, and checked with sandbox modeling. A new way is provided for in-depth study of faulting.TONG HengMao CAI DongSheng WU YongPing LI XiaoGuang LI XuShen MENG LingJian 2010Science China Earth Sciences2010,53,8:17
8Research Progress in the Application of Chinese Herbal Medicines in Aquaculture: A Review显示文摘Hongyu Pu Xiaoyu Li Qingbo Du Hao Cui Yongping Xu 2017Engineering2017,3,5:17
9MiR-181b suppresses proliferation of and reduces chemoresistance to temozolomide in U87 glioma stem cells显示文摘MicroRNAs regulate self renewal and differentiation of cancer stem cells.There,we sought to identify the expression of miR-181b in glioma stem cells and investigate the biological effect of miR-181b on glioma stem cells in this study.MiR-181b expression was measured by real-time PCR in glioma stem cells isolated from U87 cells by FACS sorting.After miR-181b was overexpressed in U87 glioma stem cells by miR-181b lentiviral expression vector and/or treatment of temozolomide,secondary neurosphere assay,soft agar colony assay and MTT assay were performed.Compared with U87 cells,the expression of miR-181b was significantly decreased in U87 glioma stem cells.Overexpression of miR-181b decreased neurosphere formation by U87 glioma stem cells in vitro and suppressed colony formation in soft agar,and the cell growth inhibition rates increased in a time-dependent manner in U87 glioma stem cells infected with miR-181b lentivirus.Furthermore,miR-181b had a synergistic effect on temozolomide-induced inhibition of secondary neurosphere and soft agar colony,and on cell growth inhibition rates.MiR-181b functions as a tumor suppressor that suppresses proliferation and reduces chemoresistance to temozolomide in glioma stem cells.Ping Li Xiaoming Lu Yingyi Wang Lihua Sun Chunfa Qian Wei Yan Ning Liu Yongping You Zhen Fu 2010The Journal of Biomedical Research2010,24,6:14
10CRISPR-Cas9 mediated LAG-3 disruption in CAR-T cells显示文摘Yongping Zhang Xingying Zhang Chen Cheng Wei Mu Xiaojuan Liu Na Li Xiaofei Wei Xiang Liu Changqing Xia Haoyi Wang 2017Frontiers of Medicine2017,11,4:9
11FHY3 and FAR1 Integrate Light Signals with the miR156-SPL Module-Mediated Aging Pathway to Regulate Arabidopsis Flowering显示文摘In response to competition for light from their neighbors,shade-intolerant plants flower precociously to ensure reproductive success and survival.However,the molecular mechanisms underlying this key developmental switch are not well understood.Here,we show that a pair of Arabidopsis transcription factors essential for phytochrome A signaling,FAR-RED ELONGATED HYPOCOTYL3(FHY3)and FAR-RED IMPAIRED RESPONSE1(FAR1),regulate flowering time by integrating environmental light signals with the miR156-SPL module-mediated aging pathway.We found that FHY3 and FAR1 directly interact with three flowering-promoting SQUAMOSA-PROMOTER BINDING PROTEIN-LIKE(SPL)transcription factors,SPL3,SPL4,and SPL5,and inhibit their binding to the promoters of several key flowering regulatory genes,including FRUITFUL(FUL),LEAFY(LFY),APETALA1(AP1),and MIR172C,thus downregulating their transcript levels and delaying flowering.Under simulated shade conditions,levels of SPL3/4/5 proteins increase,whereas levels of FHY3 and FAR1 proteins decline,thus releasing SPL3/4/5 from FHY3/FAR1 inhibition to allow activation of FUL,LFY,AP1,and MIR172C and,consequently,early flowering.Taken together,these results unravel a novel mechanism whereby plants regulate flowering time by integrating environmental cues(such as light conditions)and an internal developmental program(the miR156-SPL module-mediated aging pathway).Yurong Xie Qin Zhou Yongping Zhao Quanquan Li Yang Liu Mengdi Ma Baobao Wang Rongxin Shen Zhigang Zheng Haiyang Wang 2020Molecular Plant2020,13,3:8
12Reduning injection for fever, rash, and ulcers in children with mild hand, foot, and mouth disease: a randomized controlled clinical study显示文摘OBJECTIVE: To assess the efficacy and safety of Reduning injection for fever, rash, and ulcers in children with mild hand, foot, and mouth disease(HFMD). METHODS: A stratified-block randomized, double-blind, parallel-controlled, and multicenter clinical trial was conducted with 360 patients in five hospitals across China: Quanzhou Children's Hospital, Shijiazhuang No. 5 Hospital, Shanghai Public Health Centre, Hunan Provincial Children's Hospital, and Kaifeng Children's Hospital. Patients were randomized into three groups with 120 in each. Group A was treated with Western Medicine, group B with Reduning injection, a Chinese herbal medicine, and group C with both Reduning injection and Western Medicine. Results were compared for treatment efficacy and safety on HFMD. The clinical outcomes were observed as follows: fever and onset time of antifebrile effect(time to bring the body temperature down ≥0.5℃ after medication); cumulative time for fever recovery(body temperature recovering to normal and lasting more than 24 h without medication); cumulative time for rash disappearance(without new rashes or ulcers appearing and the original ones fading away); and cumulative time for mouth ulcer disappearance. RESULTS: For the onset time of the antifebrile effect, there was no statistical difference between groups A and B(P>0.05) and groups B and C(P> 0.05). However, there was a statistical difference between groups A and C(P<0.05), and the effect in group C was the best. For the cumulative time for rash disappearance, there was no statistical difference between groups A and B(P>0.05). There were statistical differences between groups A and C, and groups B and C(P<0.05), and the effect in group C was the best. For the cumulative time for mouth ulcers disappearance, there were no statistical differences among the three groups(P>0.05). CONCLUSION: Reduning injection with Western Medicine for symptomatic treatment is most effective for mild HFMD. No adverse reactions were observed.Guoliang Zhang Jie Zhao Liyun He Shiyan Yan Ziqiang Zhuo Haojie Zheng Yongping Mu Shuangjie Li Xi Zhang Jihan Huang Xiuhui Li Jianping Liu Hehe Wan Chaoyu Wei Wei Xiao 2013Journal of Traditional Chinese Medicine2013,33,6:7
13Progress and prospects of innovative coal-fired power plants within the energy internet显示文摘The development of electrical engineering and electronic, communications, smart power grid, and ultra-high voltage transmission technologies have driven the energy system revolution to the next generation: the energy internet. Progressive penetration of intermittent renewable energy sources into the energy system has led to unprecedented challenges to the currently wide use of coal-fired power generation technologies. Here, the applications and prospects of advanced coal-fired power generation technologies are analyzed. These technologies can be summarized into three categories:(1) large-scale and higher parameters coal-fired power generation technologies, including 620/650/700 oC ultra-supercritical thermal power and double reheat ultra-supercritical coal-fired power generation technologies;(2) system innovation and specific, highefficiency thermal cycles, which consist of renewable energy-aided coal-fired power generation technologies, a supercritical CO_2 Brayton cycle for coal-fired power plants, large-scale air-cooling coal-fired power plant technologies, and innovative layouts for waste heat utilization and enhanced energy cascade utilization;(3) coal-fired power generation combined with poly-generation technologies, which are represented by integrated gasification combined cycle(IGCC) and integrated gasification fuel cell(IGFC) technologies. Concerning the existing coal-fired power units, which are responsible for peak shaving, possible strategies for enhancing flexibility and operational stability are discussed. Furthermore, future trends for coal-fired power plants coupled with cyber-physical system(CPS) technologies are introduced. The development of advanced, coal-fired power generation technologies demonstrates the progress of science and is suitable for the sustainable development of human society.Yongping Yang Chengzhou Li Ningling Wang Zhiping Yang 2019Global Energy Interconnection2019,2,2:7
14Modeling permafrost properties in the Qinghai-Xizang(Tibet) Plateau显示文摘Water and heat dynamics in the active layer at a monitoring site in the Tanggula Mountains, located in the permafrost region of the Qinghai-Xizang(Tibet) Plateau(QXP), were studied using the physical-process-based COUPMODEL model, including the interaction between soil temperature and moisture under freeze-thaw cycles. Meteorological, ground temperature and moisture data from different depths within the active layer were used to calibrate and validate the model. The results indicate that the calibrated model satisfactorily simulates the soil temperatures from the top to the bottom of the soil layers as well as the moisture content of the active layer in permafrost regions. The simulated soil heat flux at depths of 0 to 20 cm was consistent with the monitoring data, and the simulations of the radiation balance components were reasonable. Energy consumed for phase change was estimated from the simulated ice content during the freeze/thaw processes from 2007 to 2008. Using this model, the active layer thickness and the energy consumed for phase change were predicted for future climate warming scenarios. The model predicts an increase of the active layer thickness from the current 330 cm to approximately 350–390 cm as a result of a 1–2°C warming. However, the effect active layer thickness of more precipitation is limited when the precipitation is increased by 20%–50%. The COUPMODEL provides a useful tool for predicting and understanding the fate of permafrost in the QXP under a warming climate.HU GuoJie ZHAO Lin WU XiaoDong LI Ren WU TongHua XIE ChangWei PANG QiangQiang XIAO Yao LI WangPing QIAO YongPing SHI JianZong 2015Science China Earth Sciences2015,58,12:7
15Effect of quercetin on the expression of Bcl-2/Bax apoptotic proteins in endometrial cells of lipopolysaccharide-induced-abortion mice显示文摘OBJECTIVE: To explore the effect of quercetin on the expressions of Bcl-2/Bax apoptotic proteins in endometrial cells in mice with abortion induced by lipopolysaccharide.METHODS: For in vivo experiment, twenty five Kunming mice were randomly divided into five groups at day 4 of pregnancy, with 5 mice per group. The mice were treated with lipopolysaccharide(LPS)through tail vein intravenous injection at day 4 of pregnancy, followed by different concentrations of quercetin by oral gavage consecutively at days 5 to6 of pregnancy. On day 7 of gestation, the mice were sacrificed and the histopathological changes of the uterus tissues were observed. Immunohistochemical staining was applied to the detection of Bcl-2/Bax apoptotic proteins in the endometrial cells. For in vitro experiment, the primary endometrial cells werecultured using a uterus tissue mass culturing method sampled at day 4.5 of pregnancy. The cells were treated with LPS with or without different dosages of quercetin, respectively, for 12 h after 80% confluence. The expression of Bcl-2/Bax apoptotic proteins were detected by western blotting.RESULTS: Both the in vivo and in vitro experiments showed decreased expression of Bcl-2 and enhanced expression of Bax after LPS treatment, leading to a decreased Bcl-2/Bax ratio. The expression of Bcl-2 significantly increased while the expression of Bax was significantly elevated, in the LPS plus quercetin group compared to the LPS only group.CONCLUSION: These results suggest that quercetin has protective effect by partially regulating the expression of Bcl-2/Bax proteins, which in turn inhibits endometrial cell apoptosis and benefits the embryo implantation.Wang Xiaodan Yan Yongping Yang Liu Li Mu Zhong Xiuhui 2016Journal of Traditional Chinese Medicine2016,36,6:7
16A simulation-based two-stage interval-stochastic programming model for water resources management in Kaidu-Konqi watershed,China显示文摘This study presented a simulation-based two-stage interval-stochastic programming(STIP) model to support water resources management in the Kaidu-Konqi watershed in Northwest China.The modeling system coupled a distributed hydrological model with an interval two-stage stochastic programing(ITSP).The distributed hydrological model was used for establishing a rainfall-runoff forecast system,while random parameters were provided by the statistical analysis of simulation outcomes.The developed STIP model was applied to a real case of water resources management planning in Kaidu-Konqi watershed,where three scenarios with different water resources management policies were analyzed.The results indicated that water shortage mainly occurred in agriculture,ecology and forestry sectors.In comparison,the water demand from municipality,industry and stockbreeding sectors can be satisfied due to their lower consumptions and higher economic values.Different policies for ecological water allocation can result in varied system benefits,and can help to identify desired water allocation plans with a maximum economic benefit and a minimum risk of system disruption under uncertainty.Yue HUANG Xi CHEN YongPing LI AnMing BAO YongGang MA 2012Journal of Arid Land2012,4,4:6
17Bushen Yisui Capsule ameliorates axonal injury in experimental autoimmune encephalomyelitis显示文摘A preliminary clinical study by our group demonstrated Bushen Yisui Capsule(formerly called Erhuang Formula)in combination with conventional therapy is an effective prescription for the treatment of multiple sclerosis.However,its effect on axonal injury during early multiple sclerosis remains unclear.In this study,a MOG35–55-immunized C57BL/6 mouse model of experimental autoimmune encephalomyelitis was intragastrically administered Bushen Yisui Capsule.The results showed that Bushen Yisui Capsule effectively improved clinical symptoms and neurological function of experimental autoimmune encephalomyelitis.In addition,amyloid precursor protein expression was down-regulated and microtubule-associated protein 2 was up-regulated.Experimental findings indicate that the disease-preventive mechanism of Bushen Yisui Capsule in experimental autoimmune encephalomyelitis was mediated by amelioration of axonal damage and promotion of regeneration.But the effects of the high-dose Bushen Yisui Capsule group was not better than that of the medium-dose and low-dose Bushen Yisui Capsule group in preventing neurological dysfunction.Ling Fang Qi Zheng Tao Yang Hui Zhao Qiuxia Zhang Kangning Li Li Zhou Haiyang Gong Yongping Fan Lei Wang 2013Neural Regeneration Research2013,8,35:6
18INTERVENTIONAI DIAGNOSIS AND TREATMENT OF VASCULOGENEIC PULSATILE TINNITUS显示文摘Objective To retrospectively study clinical features and diagnostic imaging of vasculogeneic pulsatile tinnitus, and the feasibility and efficacy of transvascular interventional treatment for this condition. Methods Data from 82 cases of arterial or venous pulsatile tinnitus were reviewed. DSA characteristics and possible pathophysiological mechanisms of pulsatile tinnitus in these cases were studied. Diagnoses in this group included intracranial arterovenous fistula(AVF)(n=3), spontaneous skull base dural AVF(n=16), traumatic carotid-cavernous sinus fistula(n=5), subclavian artery stenosis(n=2), internal carotid artery stenosis(n=3), intracranial arterial stenosis(n=1), kinked and/or elongated vertebrobasilar artery(n=2), venous sinus diverticulum(n=2), venous sinus stenosis on the dominant drainage side(n=46) and occipital sinus stenosis(n=2).Treatments included embolization and stenting using coils, NBCA glue, Balt balloons, self-expansion stents and intracranial micro-stents via either the femoral artery or femoral vein. Results Procedures were successful in all cases with no surgery-related complications. Tinnitus disappeared within 2 days after the procedure in all cases. Follow up duration was 5-36 months. Recurrence occurred in 4 cases of arterial tinnitus within 3 months following the initial procedure, which improved after revision embolization or symptom management. There was no recurrence in venous tinnitus cases following stent plastic or stent-coiling embolization treatments. Conclusions Endovascular intervention provides a new approach to the diagnosis and treatment of intractable pulsatile tinnitus. It is also effective in differentiating and studying other types of tinnitus.LI Baomin CAO Xiangyu LIU Xinfeng LI Sheng WANG Jun LIANG Yongping GE Aili ZHANG Alan FENG Huimin 2014Journal of Otology2014,9,1:6
19Chicken egg yolk antibodies (IgY) as non-antibiotic production enhancers for use in swine production: a review显示文摘In recent years,the use of in-feed antibiotics for growth and disease prevention in livestock production has been under severe scrutiny.The use and misuse of in-feed antibiotics has led to problems with drug residues in animal products and increased bacterial resistance.Chicken egg yolk antibodies(IgY) have attracted considerable attention as an alternative to antibiotics to maintain swine health and performance.Oral administration of IgY possesses many advantages over mammalian IgG such as cost-effectiveness,convenience and high yield.This review presents an overview of the potential to use IgY immunotherapy for the prevention and treatment of swine diarrhea diseases and speculates on the future of IgY technology.Included are a review of the potential applications of IgY in the control of enteric infections of either bacterial or viral origin such as enterotoxigenic Escherichia coli,Salmonella spp.,rotavirus,porcine transmissible gastroenteritis virus,and porcine epidemic diarrhea virus.Some potential obstacles to the adoption of IgY technology are also discussed.Xiaoyu Li Lili Wang Yuhong Zhent Shuying Li Yongping Xu 2016Journal of Animal Science and Biotechnology2016,7,1:5
20Analysis and prognosis of tropical cyclone genesis over the western North Pacific on the background of global warming显示文摘As revealed by the observational study, there are more tropical cyclones generated over the western North Pacific from the early 1950s to the early 1970s in the 20th century and less tropical cyclones from the mid-1970s to the present. The decadal change of tropical cyclones activities are closely related to the decadal changes of atmospheric general circulation in the troposphere, which provide favorable or unfavorable conditions for the formation of tropical cyclone. Furthermore, based on the simulation of corresponding atmospheric general circulation from a coupled climate model under the schemes of Intergovernmental Panel on Climate Change (IPCC) special report on emission scenarios (SRES) A2 and B2 emissions scenarios an outlook on the tropical cyclone frequency generated over the western North Pacific in the coming half century is presented. It is indicated that in response to the global climate change the general circulation of atmosphere would become unfavorable for the formation of tropical cyclone as a whole and the frequency of tropical cyclones formation would likely decrease by 5% within the next half century, although more tropical cyclones would appear during a short period in it.LI Yongping WANG Xiaofeng YU Runling QIN Zenghao 2007Acta Oceanologica Sinica2007,26,1:5
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