|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 利用红外相机研究卧龙国家级自然保护区绿尾虹雉的活动规律显示文摘绿尾虹雉Lophophorus lhuysii是一种仅分布在中国西部山区的珍稀雉类。由于缺乏监测研究,目前关于绿尾虹雉行为与栖息地的一手资料较少。2013年11月—2016年3月,在四川卧龙国家级自然保护区高山带布设20台红外相机,总相机工作日7 056 d,拍摄记录约12万条。其中,绿尾虹雉有效探测106次,相对多度指数15.02。统计结果显示,绿尾虹雉年活动高峰是7月;日活动高峰是08∶00—10∶00和18∶00—20∶00,日活动节律存在季节和性别差异。绿尾虹雉活动最适宜的环境温度在0~10℃,有集群和季节性垂直迁移现象,目前在保护区生存状况较好。雄性绿尾虹雉的活动强度约为雌性的2倍。本研究有助于全面了解绿尾虹雉的生态习性,为进一步保护和研究绿尾虹雉提供了基础信息。 | 唐卓 杨建 刘雪华 王鹏彦 李周园 LIU Cheng Simon | 2017 | 四川动物2017，36，5： | 18 |
| 2 | Current and future molecular diagnostics in colorectal cancer and colorectal adenoma显示文摘Colorectal cancer(CRC)is one of the most prevalent cancers in developed countries.On the other hand,CRC is also one of the most curable cancers if it is detected in early stages through regular colonoscopy or sigmoidoscopy.Since CRC develops slowly from precancerous lesions,early detection can reduce both the incidence and mortality of the disease.Fecal occult blood test is a widely used non-invasive screening tool for CRC.Although fecal occult blood test is simple and cost-effective in screening CRC,there is room for improvement in terms of the accuracy of the test.Genetic dysregulations have been found to play an important role in CRC development.With better understanding of the molecular basis of CRC,there is a growing expectation on the development of diagnostic tests based on more sensitive and specific molecular markers and those tests may provide a breakthrough to the limitations of current screening tests for CRC.In this review,the molecular basis of CRC development,the characteristics and applications of different non-invasive molecular biomarkers,as well as the technologies available for the detection were discussed.This review intended to provide a summary on the current and future molecular diagnostics in CRC and its pre-malignant state,colorectal adenoma. | Andy Hin-Fung Tsang Ka-Ho Cheng Apple Siu-Ping Wong Simon Siu-Man Ng Brigette Buig-Yue Ma Charles Ming-Lok Chan Nancy Bo-Yin Tsui Lawrence Wing-Chi Chan Benjamin Yat-Ming Yung Sze-Chuen Cesar Wong | 2014 | World Journal of Gastroenterology2014，20，14： | 7 |
| 3 | 863 genomes reveal the origin and domestication of chicken显示文摘Despite the substantial role that chickens have played in human societies across the world,both the geographic and temporal origins of their domestication remain controversial.To address this issue,we analyzed 863 genomes from a worldwide sampling of chickens and representatives of all four species of wild jungle fowl and each of the five subspecies of red jungle fowl(RJF).Our study suggests that domestic chickens were initially derived from the RJF subspecies Gallus gallus spadiceus whose present-day distribution is predominantly in southwestern China,northern Thailand and Myanmar.Following their domestication,chickens were translocated across Southeast and South Asia where they interbred locally with both RJF subspecies and other jungle fowl species.In addition,our results show that the White Leghorn chicken breed possesses a mosaic of divergent ancestries inherited from other subspecies of RJF.Despite the strong episodic gene flow from geographically divergent lineages of jungle fowls,our analyses show that domestic chickens undergo genetic adaptations that underlie their unique behavioral,morphological and reproductive traits.Our study provides novel insights into the evolutionary history of domestic chickens and a valuable resource to facilitate ongoing genetic and functional investigations of the world's most numerous domestic animal. | Ming-Shan Wang Mukesh Thakur Min-Sheng Peng Yu Jiang Laurent Alain Francois Frantz Ming Li Jin-Jin Zhang Sheng Wang Joris Peters Newton Otieno Otecko Chatmongkon Suwannapoom Xing Guo Zhu-Qing Zheng Ali Esmailizadeh Nalini Yasoda Hirimuthugoda Hidayat Ashari Sri Suladari Moch Syamsul Arifin Zein Szilvia Kusza Saeed Sohrabi Hamed Kharrati-Koopaee Quan-Kuan Shen Lin Zeng Min-Min Yang Ya-Jiang Wu Xing-Yan Yang Xue-Mei Lu Xin-Zheng Jia Qing-Hua Nie Susan Joy Lamont Emiliano Lasagna Simone Ceccobelli Humpita Gamaralalage Thilini Nisanka Gunwardana Thilina Madusanka Senasige Shao-Hong Feng Jing-Fang Si Hao Zhang Jie-Qiong Jin Ming-Li Li Yan-Hu Liu Hong-Man Chen Cheng Ma Shan-Shan Dai Abul Kashem Fazlul Haque Bhuiyan Muhammad Sajjad Khan Gamamada Liyanage Lalanie Pradeepa Silva Thi-Thuy Le Okeyo Ally Mwai Mohamed Nawaz Mohamed Ibrahim Megan Supple Beth Shapiro Olivier Hanotte Guojie Zhang Greger Larson Jian-Lin Han Dong-Dong Wu Ya-Ping Zhang | 2020 | Cell Research2020，30，8： | 7 |
| 4 | Extracellular histones stimulate collagen expression in vitro and promote liver fibrogenesis in a mouse model via the TLR4-MyD88 signaling pathway显示文摘BACKGROUND Liver fibrosis progressing to liver cirrhosis and hepatic carcinoma is very common and causes more than one million deaths annually.Fibrosis develops from recurrent liver injury but the molecular mechanisms are not fully understood.Recently,the TLR4-MyD88 signaling pathway has been reported to contribute to fibrosis.Extracellular histones are ligands of TLR4 but their roles in liver fibrosis have not been investigated.AIM To investigate the roles and potential mechanisms of extracellular histones in liver fibrosis.METHODS In vitro,LX2 human hepatic stellate cells(HSCs)were treated with histones in the presence or absence of non-anticoagulant heparin(NAHP)for neutralizing histones or TLR4-blocking antibody.The resultant cellular expression of collagen I was detected using western blotting and immunofluorescent staining.In vivo,the CCl4-induced liver fibrosis model was generated in male 6-week-old ICR mice and in TLR4 or MyD88 knockout and parental mice.Circulating histones were detected and the effect of NAHP was evaluated.RESULTS Extracellular histones strongly stimulated LX2 cells to produce collagen I.Histone-enhanced collagen expression was significantly reduced by NAHP and TLR4-blocking antibody.In CCl4-treated wild type mice,circulating histones were dramatically increased and maintained high levels during the duration of fibrosisinduction.Injection of NAHP not only reduced alanine aminotransferase and liver injury scores,but also significantly reduced fibrogenesis.Since the TLR4-blocking antibody reduced histone-enhanced collagen I production in HSC,the CCl4 model with TLR4 and MyD88 knockout mice was used to demonstrate the roles of the TLR4-MyD88 signaling pathway in CCl4-induced liver fibrosis.The levels of liver fibrosis were indeed significantly reduced in knockout mice compared to wild type parental mice.CONCLUSION Extracellular histones potentially enhance fibrogenesis via the TLR4–MyD88 signaling pathway and NAHP has therapeutic potential by detoxifying extracellular histones. | Zhi Wang Zhen-Xing Cheng Simon T Abrams Zi-Qi Lin ED Yates Qian Yu Wei-Ping Yu Ping-Sheng Chen Cheng-Hock Toh Guo-Zheng Wang | 2020 | World Journal of Gastroenterology2020，26，47： | 3 |
| 5 | Relativistic-intensity near-single-cycle light waveforms at kHz repetition rate显示文摘The development of ultra-intense and ultra-short light sources is currently a subject of intense research driven by the discovery of novel phenomena in the realm of relativistic optics,such as the production of ultrafast energetic particle and radiation beams for applications.It has been a long-standing challenge to unite two hitherto distinct classes of light sources:those achieving relativistic intensity and those with pulse durations approaching a single light cycle.While the former class traditionally involves large-scale amplification chains,the latter class places high demand on the spatiotemporal control of the electromagnetic laser field.Here,we present a light source producing waveformcontrolled 1.5-cycle pulses with a 719 nm central wavelength that can be focused to relativistic intensity at a 1 kHz repetition rate based on nonlinear post-compression in a long hollow-core fiber.The unique capabilities of this source allow us to observe the first experimental indications of light waveform effects in laser wakefield acceleration of relativistic energy electrons. | Marie Ouille Aline Vernier Frederik Bohle Maimouna Bocoum Aurelie Jullien Magali Lozano Jean-Philippe Rousseau Zhao Cheng Dominykas Gustas Andreas Blumenstein Peter Simon Stefan Haessler Jerome Faure Tamas Nagy Rodrigo Lopez-Martens | 2020 | Light(Science & Applications)2020，9，1： | 3 |
| 6 | Nomenclature,categorization and usage of formulae to adjust QT interval for heart rate显示文摘Assessment of the QT interval on a standard 12 lead electrocardiogram is of value in the recognition of a number of conditions. A critical part of its use is the adjustment for the effect of heart rate on QT interval. A systematic search was conducted to identify studiesthat proposed formulae to standardize the QT interval by heart rate. A nomenclature was developed for current and subsequent equations based on whether they are corrective(QTc) or predictive(QTp). QTc formulae attempt to separate the dependence of the length of the QT interval from the length of the RR interval. QTp formulae utilize heart rate and the output QTp is compared to the uncorrected QT interval. The nomenclature consists of the first letter of the first author's name followed by the next two consonance(whenever possible) in capital letters; with subscripts in lower case alphabetical letter if the first author develops more than one equation. The single exception was the Framingham equation,because this cohort has developed its own 'name' amongst cardiovascular studies. Equations were further categorized according to whether they were linear,rational,exponential,logarithmic,or power based. Data show that a person's QT interval adjusted for heart rate can vary dramatically with the different QTc and QTp formulae depending on the person's heart rate and QT interval. The differences in the QT interval adjustment equations encompasses values that are considered normal or significant prolonged. To further compare the equations,we considered that the slope of QTc versus heart rate should be zero if there was no correlation between QT and heart rate. Reviewing a sample of 107 patient ECGs from a hospital setting,the rank order of the slope- from best(closest to zero) to worst was QTc DMT,QTc RTHa,QTc HDG,QTc GOT,QTcF RM,QTcF RD,QTcB ZT and QTcM YD. For two recent formulae based on large data sets specifically QTcD MT and QTcR THa,there was no significant deviation of the slope from zero. In summary a nomenclature permits easy reference to QT formulae that adjust for heart rate. Twenty different formulae can produce discordant calculations of an adjusted QT interval. While the formulae developed by Bazett and Fridericia(QTc BZT and QTc FRD respectively) may continue to be used clinically,recent formulae from large population studies specifically QTcD MT and QTcR THa appear to be betterto adjust QT for heart rate in clinical practice. | Simon W Rabkin Xin Bo Cheng | 2015 | World Journal of Cardiology2015，7，6： | 2 |
| 7 | Field Cancerization in the Intestinal Epithelium of Patients With Crohn’s Ileocolitis显示文摘 | Susan Galandiuk Manuel Rodriguez–Justo Rosemary Jeffery Anna M. Nicholson Yong Cheng Dahmane Oukrif George Elia Simon J. Leedham Stuart A.C. McDonald Nicholas A. Wright Trevor A. Graham | 2012 | Gastroenterology2012，，4： | 2 |
| 8 | Vedolizumab for ulcerative colitis: Real world outcomes from a multicenter observational cohort of Australia and Oxford显示文摘BACKGROUND Vedolizumab(VDZ),a humanised monoclonal antibody that selectively inhibits alpha4-beta7 integrins is approved for use in adult moderate to severe ulcerative colitis(UC)patients.AIM To assess the efficacy and safety of VDZ in the real-world management of UC in a large multicenter cohort involving two countries and to identify predictors of achieving remission.METHODS A retrospective review of Australian and Oxford,United Kingdom data for UC patients.Clinical response at 3 mo,endoscopic remission at 6 mo and clinical remission at 3,6 and 12 mo were assessed.Cox regression models and Kaplan Meier curves were performed to assess the time to remission,time to failure and the covariates influencing them.Safety outcomes were recorded.RESULTS Three hundred and three UC patients from 14 centres in Australia and United Kingdom,[60%n=182,anti-TNF naïve]were included.The clinical response was 79%at 3 mo with more Australian patients achieving clinical response compared to Oxford(83%vs 70%P=0.01).Clinical remission for all patients was 56%,62%and 60%at 3,6 and 12 mo respectively.Anti-TNF naive patients were more likely to achieve remission than exposed patients at all the time points(3 mo 66%vs 40%P<0.001,6 mo 73%vs 46%P<0.001,12 mo 66%vs 51%P=0.03).More Australian patients achieved endoscopic remission at 6 mo compared to Oxford(69%vs 43%P=0.01).On multi-variate analysis,anti-TNF naïve patients were 1.8(95%CI:1.3-2.3)times more likely to achieve remission than anti-TNF exposed(P<0.001).32 patients(11%)had colectomy by 12 mo.CONCLUSION VDZ was safe and effective with 60%of UC patients achieving clinical remission at 12 mo and prior anti-TNF exposure influenced this outcome. | Samba Siva Reddy Pulusu Ashish Srinivasan Krupa Krishnaprasad Daniel Cheng Jakob Begun CharlotteKeung Daniel Van Langenberg Lena Thin Tamara Mogilevski Peter De Cruz Graham Radford-Smith Emma Flanagan Sally Bell Soleiman Kashkooli Miles Sparrow Simon Ghaly Peter Bampton Elise Sawyer Susan Connor Quart-ul-ain Rizvi Jane M Andrews Gillian Mahy Paola Chivers Simon Travis Ian Craig Lawrance | 2020 | World Journal of Gastroenterology2020，26，30： | 2 |
| 9 | The Dependence of Benzo-15-Crown-5 Ether-Containing Oligo Paraphenylene Vinylene (CE-OPV) Emission Upon Complexation with Metal Ions in Solution显示文摘 | Gowri Ramachandran George Simon Yibing Cheng Trevor A. Smith Liming Dai | 2003 | Journal of Fluorescence2003，，5： | 1 |
| 10 | Nanocomposites of poly (methyl methacry- late) and organically modified layered silicates by melt intercalation显示文摘 | Shen Z Simon G P Cheng Y B | 2004 | J ADpl Polym Sci2004，92，： | 1 |
| 11 | Alignment between galaxies and large-scale structure显示文摘Based on the Sloan Digital Sky Survey DR6(SDSS) and the Millennium Simulation(MS),we investigate the alignment between galaxies and large-scale struc-ture.For this purpose,we develop two new statistical tools,namely the alignment cor-relation function and the cos(2θ)-statistic.The former is a two-dimensional extension of the traditional two-point correlation function and the latter is related to the ellipticity correlation function used for cosmic shear measurements.Both are based on the cross correlation between a sample of galaxies with orientations and a reference sample which represents the large-scale structure.We apply the new statistics to the SDSS galaxy cat-alog.The alignment correlation function reveals an overabundance of reference galaxies along the major axes of red,luminous(L>~L*) galaxies out to projected separations of 60 h-1Mpc.The signal increases with central galaxy luminosity.No alignment signal is detected for blue galaxies.The cos(2θ)-statistic yields very similar results.Starting from a MS semi-analytic galaxy catalog,we assign an orientation to each red,luminous and central galaxy,based on that of the central region of the host halo(with size similar to that of the stellar galaxy).As an alternative,we use the orientation of the host halo itself.We find a mean projected misalignment between a halo and its central region of ~ 25°.The misalignment decreases slightly with increasing luminosity of the central galaxy.Using the orientations and luminosities of the semi-analytic galaxies,we repeat our alignment analysis on mock surveys of the MS.Agreement with the SDSS results is good if the central orientations are used.Predictions using the halo orientations as proxies for cen-tral galaxy orientations overestimate the observed alignment by more than a factor of 2.Finally,the large volume of the MS allows us to generate a two-dimensional map of the alignment correlation function,which shows the reference galaxy distribution to be flattened parallel to the orientations of red luminous galaxies with axis ratios of~0.5 and~0.75for haloand centralorientations,respectively.These ratios are almost independent of scale out to 60 h?1Mpc. | A. Faltenbacher Cheng Li Simon D. M. White Yi-Peng Jing Shu-De Mao Jie Wang | 2009 | Chinese Journal of Astronomy and Astrophysics2009，9，1： | 1 |
| 12 | Comparison of solution intercalation and melt intercalation of polymer-clay nanocomposites 显示文摘 | SHEN Z Q SIMON G P CHENG Y B | 2002 | Polyer2002，43，： | 1 |
| 13 | Low temperature chemically sintered nano-crystalline TiO 2 electrodes for flexible dye-sensitized solar cells显示文摘 | H.C. Weerasinghe P.M. Sirimanne G.V. Franks G.P. Simon Y.B. Cheng | 2010 | Journal of Photochemistry & Photobiology A: Chemistry2010，，1： | 1 |
| 14 | Development of polymer-ceramic composites for improved fire resistance 显示文摘 | HANU L G SIMON G P BURFORD R P CHENG Y B | 2004 | Journal of Materials Processing Tech- nology2004，，： | 1 |
| 15 | Thermal Stability and Flammability of Silicone Polymer Composites 显示文摘 | Hanu L G Simon G P Cheng Y B | 2006 | Polymer Degradation and Stability2006，91，6： | 1 |
| 16 | Formation of anatase TiOz by microwave processing显示文摘 | J N Hart R Cervini Y B Cheng G P Simon L Spiccia | 2004 | So- lar Energy MaterialsSolar Cells2004，84，： | 1 |
| 17 | Low temperature chemically sintered nano-crystalline TiO 2 electrodes for flexible dye-sensitized solar cells显示文摘 | H.C. Weerasinghe P.M. Sirimanne G.V. Franks G.P. Simon Y.B. Cheng | 2010 | Journal of Photochemistry & Photobiology A: Chemistry2010，，1： | 1 |
| 18 | Effect of organo-phosphorus and nano-clay materials on the thermal and fire performance of epoxy resins显示文摘 | Hussain M Varley R J Mathys Z Cheng Y B Simon G P | 2004 | J Appl Polym Sci2004，91，： | 1 |
| 19 | Synthesis of hyperbranched poly( tert - butyl acrylate) by self- condensing atom transfer radical poly- merization of a rnacroinimer 显示文摘 | Cheng G Simon P F W Hartenstein M | 2000 | Maeromol Rapid Commun2000，21，： | 1 |
| 20 | Expansion of the red cell distribution width and evolving iron deficiency as predictors of poor outcome in chronic heart failure显示文摘 | Nay Aung Hua Zen Ling Adrian S. Cheng Suneil Aggarwal Julia Flint Michelle Mendonca Mohammed Rashid Swan Kang Susanne Weissert Caroline J. Coats Toby Richards Martin Thomas Simon Woldman Darlington O. Okonko | 2013 | International Journal of Cardiology2013，，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员