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| 1 | In vitro differentiation of adipose-derived stem cells and bone marrow-derived stromal stem cells into neuronal-like cells显示文摘Adipose-derived stem cells and bone marrow-derived stromal stem cells were co-cultured with untreated or Aβ1-40-treated PC12 cells, or grown in supernatant derived from untreated or Aβ1-40-treated PC12 cells. Analysis by western blot and quantitative real-time PCR showed that protein levels of Nanog, Oct4, and Sox2, and mRNA levels of miR/125a/3p were decreased, while expression of insulin-like growth factor-2 and neuron specific enolase was increased. In comparison, the generation of neuron specific enolase-positive cells was most successful when adipose-derived stem cells were co-cultured with Aβ1-40-treated PC12 cells. Our results demonstrate that adipose-derived stem cells and bone marrow-derived stromal stem cells exhibit trends of neuronal-like cell differentiation after co-culture with Aβ1-40-treated PC12 cells. This process may relate to a downregulation of miR-125a-3p mRNA expression and increased levels of insulin-like growth factor-2 expression. | Jin Zhou Guoping Tian Jing'e Wang Xuefeng Cong Xingkai Wu Siyang Zhang Li Li Bing Xu Feng Zhu Xuedan Luo Jian Han Fengjie Hu | 2011 | Neural Regeneration Research2011，6，19： | 21 |
| 2 | Potentiating CD8^(+) T cell antitumor activity by inhibiting PCSK9 to promote LDLR-mediated TCR recycling and signaling显示文摘Metabolic regulation has been proven to play a critical role in T cell antitumor immunity.However,cholesterol metabolism as a key component of this regulation remains largely unexplored.Herein,we found that the low-density lipoprotein receptor(LDLR),which has been previously identified as a transporter for cholesterol,plays a pivotal role in regulating CD8+T cell antitumor activity.Besides the involvement of cholesterol uptake which is mediated by LDLR in T cell priming and clonal expansion,we also found a non-canonical function of LDLR in CD8+T cells:LDLR interacts with the T-cell receptor(TCR)complex and regulates TCR recycling and signaling,thus facilitating the effector function of cytotoxic T-lymphocytes(CTLs).Furthermore,we found that the tumor microenvironment(TME)downregulates CD8+T cell LDLR level and TCR signaling via tumor cell-derived proprotein convertase subtilisin/kexin type 9(PCSK9)which binds to LDLR and prevents the recycling of LDLR and TCR to the plasma membrane thus inhibits the effector function of CTLs.Moreover,genetic deletion or pharmacological inhibition of PCSK9 in tumor cells can enhance the antitumor activity of CD8+T cells by alleviating the suppressive effect on CD8+T cells and consequently inhibit tumor progression.While previously established as a hypercholesterolemia target,this study highlights PCSK9/LDLR as a potential target for cancer immunotherapy as well. | Juanjuan Yuan Ting Cai Xiaojun Zheng Yangzi Ren Jingwen Qi Xiaofei Lu Huihui Chen Huizhen Lin Zijie Chen Mengnan Liu Shangwen He Qijun Chen Siyang Feng Yingjun Wu Zhenhai Zhang Yanqing Ding Wei Yang | 2021 | Protein & Cell2021，12，4： | 12 |
| 3 | Neuronal differentiation of adipose-derived stem cells and their transplantation for cerebral ischemia显示文摘OBJECTIVE:To review published data on the biological characteristics,differentiation and applications of adipose-derived stem cells in ischemic diseases.DATA RETRIEVAL:A computer-based online search of reports published from January 2005 to June 2012 related to the development of adipose-derived stem cells and their transplantation for treatment of cerebral ischemia was performed in Web of Science using the key words 'adipose-derived stem cells','neural-like cells','transplantation','stroke',and 'cerebral ischemia'.SELECTION CRITERIA:The documents associated with the development of adipose-derived stem cells and their transplantation for treatment of cerebral ischemia were selected,and those published in the last 3-5 years or in authoritative journals were preferred in the same field.Totally 89 articles were obtained in the initial retrieval,of which 53 were chosen based on the inclusion criteria.MAIN OUTCOME MEASURES:Biological characteristics and induced differentiation of adipose-derived stem cells and cell transplantation for disease treatment as well as the underlying mechanism of clinical application.RESULTS:The advantages of adipose-derived stem cells include their ease of procurement,wide availability,rapid expansion,low tumorigenesis,low immunogenicity,and absence of ethical constraints.Preclinical experiments have demonstrated that transplanted adipose-derived stem cells can improve neurological functions,reduce small regions of cerebral infarction,promote angiogenesis,and express neuron-specific markers.The improvement of neurological functions was demonstrated in experiments using different methods and time courses of adipose-derived stem cell transplantation,but the mechanisms remain unclear.CONCLUSION:Further research into the treatment of ischemic disease by adipose-derived stem cell transplantation is needed to determine their mechanism of action. | Guoping Tian Jin Zhou Jing'e Wang Bing Xu Li Li Feng Zhu Jian Han Jianping Li Siyang Zhang Xiaoguang Luo | 2012 | Neural Regeneration Research2012，7，25： | 2 |
| 4 | SARS-CoV-2 Aerosol Transmission Through Vertical Sanitary Drains in High-Rise Buildings--Shenzhen,Guangdong Province,China,March 2022显示文摘Summary What is already known about this topic?Aerosol transmission of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)via sanitary pipelines in high-rise buildings is possible,however,there is a lack of experimental evidence. | Keyang Lyu Siyang Feng Xia Li Qin Wang Xiaoning Zhao Shuyuan Yu Ping Zheng Jiajia Ji Guomin Chen Jing Liang Tao Lan Jinshu Feng Shuai Jiang Jianhua Lu Tianlong Xia Chaoqiong Peng Tiejian Feng Dongqun Xu | 2022 | China CDC weekly2022，4，23： | 1 |
| 5 | Co‑packaged optics(CPO):status,challenges,and solutions显示文摘Due to the rise of 5G,IoT,AI,and high-performance computing applications,datacenter trafc has grown at a compound annual growth rate of nearly 30%.Furthermore,nearly three-fourths of the datacenter trafc resides within datacenters.The conventional pluggable optics increases at a much slower rate than that of datacenter trafc.The gap between application requirements and the capability of conventional pluggable optics keeps increasing,a trend that is unsustainable.Copackaged optics(CPO)is a disruptive approach to increasing the interconnecting bandwidth density and energy efciency by dramatically shortening the electrical link length through advanced packaging and co-optimization of electronics and photonics.CPO is widely regarded as a promising solution for future datacenter interconnections,and silicon platform is the most promising platform for large-scale integration.Leading international companies(e.g.,Intel,Broadcom and IBM)have heavily investigated in CPO technology,an inter-disciplinary research feld that involves photonic devices,integrated circuits design,packaging,photonic device modeling,electronic-photonic co-simulation,applications,and standardization.This review aims to provide the readers a comprehensive overview of the state-of-the-art progress of CPO in silicon platform,identify the key challenges,and point out the potential solutions,hoping to encourage collaboration between diferent research felds to accelerate the development of CPO technology. | Min Tan Jiang Xu Siyang Liu Junbo Feng Hua Zhang Chaonan Yao Shixi Chen Hangyu Guo Gengshi Han Zhanhao Wen Bao Chen Yu He Xuqiang Zheng Da Ming Yaowen Tu Qiang Fu Nan Qi Dan Li Li Geng Song Wen Fenghe Yang Huimin He Fengman Liu Haiyun Xue Yuhang Wang Ciyuan Qiu Guangcan Mi Yanbo Li Tianhai Chang Mingche Lai Luo Zhang Qinfen Hao Mengyuan Qin | 2023 | Frontiers of Optoelectronics2023，16，1： | 1 |
| 6 | Ridge Covering High-yield Cultivation Techniques of Jinhong Apple in Cold Region显示文摘After five years of study,it was found that compared with the conventional cultivation techniques,the average yield per plant of3-5-year-old Jinhong apple trees cultivated under the ridge covering mode was increased by 2. 12 times,the stem diameter was increased by20%,the branch number was increased by 73. 5%,and the underground root number was increased by 38. 3%. Under the ridge covering mode,the main distribution area of the underground roots of Jinhong apple trees was moved down to 15-55 cm,the temperature of soil 20 cm beneath the surface of the ridges increased by 1. 3-1. 5℃,the temperature of soil 40 cm beneath the surface of the ridges rose by 0. 9-1. 0℃,and the water content of soil 20-40 cm from the ground was maintained around 5%. Under the ridge covering mode,the Jinhong apple trees grew robustly,began to fruit 3 years later and yielded highly 5 years later. In addition,the ridge covering model also has illumination-enhancing,pest-controlling and tillage-free characteristics. | Chang LIU Zhangli FENG Siyang TANG Haidong BU Minggang XIAO Guangjun GU Xianmin CHENG Wenquan YU Wanjun YE | 2019 | Asian Agricultural Research2019，11，4： | 0 |
| 7 | Fine Tuning of the Electronic Properties of Novel BTPE Using Oligosilanyl Linkages and Their Application in Rapid High-Resolution Visualization of Latent Fingerprints显示文摘Structural modifications throughπ-interactions usually result in redshifts in luminescence and,as a consequence,the loss of the natural color of the chromophore.Besides,employing Si-Siσ-bridging to manipulate the electronic properties of organic materials has remained largely unexplored.Herein,we report a series of novel bis-tetraphenylethenes(BTPEs)with oligosilanyl linkages,termed BTPE-Sin molecules,used to manipulate the photophysical properties of luminogens subtly throughσ–πconjugation.These oligosilanyl-bridged molecules were thermally,highly stable,and exhibited enhanced aggregation-induced emissions,as well as luminescence efficiencies while retaining most of their original color.Our current BTPEs fabrications have easy-to-operate,fast,and high-resolution identification properties toward LFPs.Also,they are highly specific to individuals,and hence,vital in forensic investigations.We achieved these features through the introduction of oligosilanyl chains that increased the lipophilicity of the significantly.This work offers a universal and straightforward approach for the generation of highly emissive organic materials and enables fine-tuning of their electronic properties for multifunctional applications. | Xiaoshuang Xiang Zhikuan Zhou Hongjie Feng Siyang Feng Lizhi Gai Hua Lu Zijian Guo | 2020 | CCS Chemistry2020，2，3： | 0 |
| 8 | LARGE-SCALE FARMING BENEFITS SOIL ACIDIFICATION ALLEVIATION THROUGH IMPROVED FIELD MANAGEMENT IN BANANA PLANTATIONS显示文摘Large-scale farming by agricultural land transfers has been increasingly promoted in recent years,but the possible impacts on crop production,especially cash crops,and soil acidification remain unclear.This study obtained data for 110 banana plantations in Long’an County,China,and categorized them into small(<0.67 ha),medium(0.67−6.7 ha),and large(>6.7 ha)to determine banana cultivation,nutrient management,and soil acidification rates on farms of the three sizes.Banana yield per unit area significantly increased with increased farm size,and large farms had the highest average yield(48.9 t·ha^(−1))with the least variation.Despite a significant increase in organic fertilizer and base cation inputs,nitrogen(N)surplus did not differ significantly with increasing farm size.With large farms,actual soil acidification rate was significantly lower by 19.1 to 24.0 keq·ha^(−1)·yr^(−1);however,potential soil acidification rate increased with increased overuse of phosphorus.Overall,larger banana plantations used fewer mineral N fertilizers reducing the rate of soil acidification and increasing the H+buffering provided by organic fertilizers.It is concluded that larger farms deliver the dual benefits of higher,less variable banana yield and mitigation of soil acidification by substituting organic N for mineral N fertilizers,supporting sustainable soil management and food production. | Donghao XU Jiangzhou ZHANG Yajuan LI Shiyang LI Siyang REN Yuan FENG Qichao ZHU Fusuo ZHANG | 2023 | Frontiers of Agricultural Science and Engineering2023，10，1： | 0 |
| 9 | Correction to:Potentiating CD8^(+)T cell antitumor activity by inhibiting PCSK9 to promote LDLR-mediated TCR recycling and signaling显示文摘Figure 1.LDLR deficiency hinders the antitumor activity of CD8^(+)T cells.(A)Transcriptional level of genes involved in cholesterol transport in naïve CD8^(+)T cells,CTLs and CD8^(+)TILs(isolated at Day3 or Day7 post CTLs adoptive transfer),(n=4).(B)LDLR expression level on CTLs and CD8^(+)TILs(isolated at Day3 post CTLs adoptive transfer),(n=4). | Juanjuan Yuan Ting Cai Xiaojun Zheng Yangzi Ren Jingwen Qi Xiaofei Lu Huihui Chen Huizhen Lin Zijie Chen Mengnan Liu Shangwen He Qijun Chen Siyang Feng Yingjun Wu Zhenhai Zhang Yanqing Ding Wei Yang | 2022 | Protein & Cell2022，13，9： | 0 |
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