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| 1 | Embryonic endothelial evolution towards first hematopoietic stem cells revealed by single-cell transcriptomic and functional analyses显示文摘Hematopoietic stem cells(HSCs)in adults are believed to be born from hemogenic endothelial cells(HECs)in mid-gestational embryos.Due to the rare and transient nature,the HSC-competent HECs have never been stringently identified and accurately captured,let alone their genuine vascular precursors.Here,we first used high-precision single-cell transcriptomics to unbiasedly examine the relevant EC populations at continuous developmental stages with intervals of 0.5 days from embryonic day(E)9.5 to E11.0.As a consequence,we transcriptomically identified two molecularly different arterial EC populations and putative HSCprimed HECs,whose number peaked at El 0.0 and sharply decreased thereafter,in the dorsal aorta of the aorta-gonadmesonephros(AGM)region.Combining computational prediction and in vivo functional validation,we precisely captured HSCcompetent HECs by the newly constructed Neurl3-EGFP reporter mouse model,and realized the enrichment further by a combination of surface markers(Procr+Kit+CD44+,PK44).Surprisingly,the endothelial-hematopoietic dual potential was rarely but reliably witnessed in the cultures of single HECs.Noteworthy,primitive vascular ECs from E8.0 experienced two-step fate choices to become HSC-primed HECs,namely an Initial arterial fate choice followed by a hemogenic fate conversion.This finding resolves several previously observed contradictions.Taken together,comprehensive understanding of endothelial evolutions and molecular programs underlying HSC-primed HEC specification in vivo will facilitate future investigations directing HSC production in vitro. | Siyuan Hou Zongcheng Li Xiaona Zheng Yun Gao Ji Dong Yanli Ni Xiaobo Wang Yunqiao Li Xiaochen Ding Zhilin Chang Shuaili Li Yuqiong Hu Xiaoying Fan Yu Hou Lu Wen Bing Liu Fuchou Tang Yu Lan | 2020 | Cell Research2020，30，5： | 8 |
| 2 | The shortest period of coal spontaneous combustion on the basis of oxidative heat release intensity显示文摘It’s necessary to forecast the shortest spontaneous combustion period for preventing and controlling the coal spontaneous combustion.During the experimental process,a calculating model of the SSCP is established on the basis of the oxidative heat release intensity and thermal capacity at different temperatures.According to the basic parameters of spontaneous combustion,heat of water evaporation and gas desorption,the SSCPs of different coals are further predicted.Finally,this study analyzed the relationships of the SSCP and the judging indexes of the self-ignite tendency.The result shows that the SSCP non-linearly increases with the decrease of dynamic oxygen adsorption and increase of activation energy.Compared with the practical fire situation of mine,this reliable method can meet the actual requirement of mine production. | Yang Yongliang Li Zenghua Hou Shisong Gu Fanjun Gao Siyuan Tang Yibo | 2014 | International Journal of Mining Science and Technology2014，24，1： | 5 |
| 3 | The grafts modified by heparinization and catalytic nitric oxide generation used for vascular implantation in rats显示文摘Small-diameter(<6mm)vascular grafts are increasingly needed in peripheral vascular surgery but have few successes because of acute thrombosis,incomplete endothelialization and intimal hyperplasia after implantation.This study used electrospun poly(ε-caprolactone)as the matrix material.Heparin and selenium-containing catalyst-organoselenium modified polyethyleneimine were introduced through layer-by-layer assembly in order to build a vascular graft with in situ nitric oxide(NO)generation.The aim of this study was to explore the application of the graft with improved histocompatibility and biological function for vascular implantation in rats.After implantation in rats,compared to poly(ε-caprolactone),the modified grafts could promote the adhesion and proliferation of endothelial cells,and inhibit the adhesion of smooth muscle cells.The modified grafts remarkably promoted endothelialization,inhibited intimal hyperplasia and increased the ratio of alternatively activated macrophages(M2)to classical activated macrophages(M1).This work constructed a vascular graft with heparinization and catalytic NO generation for improving the vascularization,and accelerating the tissue regeneration by regulating the inflammatory response.The present study indicates that it is a promising method for regulating response and tissue regeneration of small diameter vascular grafts by a novel approach of combining heparinization and catalytic NO generation. | Jingchen Gao Li Jiang Qinge Liang Jie Shi Ding Hou Di Tang Siyuan Chen Deling Kong hufangWang | 2018 | Regenerative Biomaterials2018，5，2： | 4 |
| 4 | Effect of carbonate additive on the microstructure and corrosion resistance of plasma electrolytic oxidation coating on Mg-9Li-3Al alloy显示文摘Carbonate was added to the silicate system electrolyte to improve the corrosion resistance of the plasma electrolytic oxidation coating on Mg-9Li-3Al(wt%,LA93)alloy.The influences of carbonate on the morphology,structure,and phase composition of the coating were investigated by scanning electron microscopy,energy dispersive spectrometry,X-ray diffraction,and X-ray photoelectron spectroscopy.The corrosion resistance of the coating was evaluated by electrochemical experiment,hydrogen evolution,and immersion test.The results showed that the addition of carbonate resulted in a denser coating with increased hardness,and the corrosion-resistant Li_(2)CO_(3) phase was formed.Electrochemical experiments showed that compared with the coating without carbonate,the corrosion potential of the carbonate coating positively shifted(24 mV),and the corrosion current density was reduced by approximately an order of magnitude.The coating with carbonate addition possessed a high corrosion resistance and long-term protection capability. | Siyuan Jin Xiaochun Ma Ruizhi Wu Tingqu Li Jiaxiu Wang Boris L Krit Legan Hou Jinghuai Zhang Guixiang Wang | 2022 | International Journal of Minerals,Metallurgy and Materials2022，29，7： | 3 |
| 5 | Adult-repopulating lymphoid potential of yolk sac blood vessels is not confined to arterial endothelial cells显示文摘During embryogenesis,hematopoietic stem progenitor cells(HSPCs)are believed to be derived from hemogenic endothelial cells(HECs).Moreover,arterial feature is proposed to be a prerequisite for HECs to generate HSPCs with lymphoid potential.Although the molecular basis of hematopoietic stem cell-competent HECs has been delicately elucidated within the embryo proper,the functional and molecular characteristics of HECs in the extraembryonic yolk sac(YS)remain largely unresolved.In this study,we initially identified six molecularly different endothelial populations in the midgestational YS through integrated analysis of several single-cell RNA sequencing(scRNA-seq)datasets and validated the arterial vasculature distribution of Gja5+ECs using a Gja5-EGFP reporter mouse model.Further,we explored the hemogenic potential of different EC populations based on their Gja5-EGFP and CD44 expression levels.The hemogenic potential was ubiquitously detected in spatiotemporally different vascular beds on embryonic days(E)8.5–E9.5 and gradually concentrated in CD44-positive ECs from E10.0.Unexpectedly,B-lymphoid potential was detected in the YS ECs as early as E8.5 regardless of their arterial features.Furthermore,the capacity for generating hematopoietic progenitors with in vivo lymphoid potential was found in nonarterial as well as arterial YS ECs on E10.0–E10.5.Importantly,the distinct identities of E10.0–E10.5 HECs between YS and intraembryonic caudal region were revealed by further scRNA-seq analysis.Cumulatively,these findings extend our knowledge regarding the hemogenic potential of ECs from anatomically and molecularly different vascular beds,providing a theoretical basis for better understanding the sources of HSPCs during mammalian development. | Chaojie Wang Yandong Gong Anbang Wei Tao Huang Siyuan Hou Junjie Du Zongcheng Li Junliang Wang Bing Liu Yu Lan | 2021 | Science China(Life Sciences)2021，64，12： | 3 |
| 6 | Heterogeneity in endothelial cells and widespread venous arterialization during early vascular development in mammals显示文摘Arteriogenesis rather than unspecialized capillary expansion is critical for restoring effective circulation to compromised tissues in patients.Deciphering the origin and specification of arterial endothelial cells during embryonic development will shed light on the understanding of adult arteriogenesis.However,during early embryonic angiogenesis,the process of endothelial diversification and molecular events underlying arteriovenous fate settling remain largely unresolved in mammals.Here,we constructed the single-cell transcriptomic Iandscape of vascular endothelial cells(VECs)during the time window for the occurrenee of key vasculogenic and angiogenic events in both mouse and human embryos.We uncovered two distinct arterial VEC types,the major artery VECs and arterial plexus VECs,and un expectedly diverge nt arteriove nous characteristics among VECs that are located in morphologically undistinguishable vascular plexus intra-embryonically.Using computational prediction and further lineage tracing of venous-featured VECs with a newly developed Nr2f2^(CrexER) | Siyuan Hou Zongcheng Li Ji Dong Yun Gao Zhilin Chang Xiaochen Ding Shuaili Li Yunqiao Li Yang Zeng Qian Xin Baihan Wang Yanli Ni Xiaowei Ning Yuqiong Hu Xiaoying Fan Yu Hou Xianlong Li Lu Wen Bin Zhou Bing Liu Fuchou Tang Yu Lan | 2022 | Cell Research2022，32，4： | 2 |
| 7 | Independent variations in genome-wide expression, alternative splicing, and DNA methylation in brain tissues among castes of the buff-tailed bumblebee, Bombus terrestris显示文摘Caste differentiation in social hymenopterans is an intriguing example of phenotypic plasticity. However, the co-ordination among gene regulatory factors to mediate caste differentiation remains inconclusive. In this study, we determined the role of gene regulation and related epigenetic processes in pre-imaginal caste differentiation in the primitively eusocial bumblebee Bombus terrestris. By combining RNA-Seq data from Illumina and Pac Bio and accurately quantifying methylation at whole-genomic base pair resolution, we found that queens, workers, and drones mainly differentiate in gene expression but not in alternative splicing and DNA methylation. Gynes are the most distinct with the lowest global level of whole-genomic methylation and with the largest number of caste-specific transcripts and alternative splicing events. By contrast, workers exhibit few uniquely expressed or alternatively spliced genes. Moreover, several genes involved in hormone and neurotransmitter metabolism are related to caste differentiation, whereas several neuropeptides are linked with sex differentiation. Despite little genome-wide association among differential gene expression, splicing, and differential DNA methylation, the overlapped gene ontology(GO) terms point to nutrition-related activity. Therefore, variations in gene regulation correlate with the behavioral differences among castes and highlight the specialization of toolkit genes in bumblebee gynes at the beginning of the adult stage. | Dan Zhu Jin Ge Siyuan Guo Li Hou Rangjun Shi Xian Zhou Xin Nie Xianhui Wang | 2021 | Journal of Genetics and Genomics2021，48，8： | 1 |
| 8 | Structure elucidation,immunomodulatory activity,antitumor activity and its molecular mechanism of a novel polysaccharide from Boletus reticulatus Schaeff显示文摘A new water-soluble heteropolysaccharide with a molecular weight of 15 k Da was isolated from the fruiting bodies of Boletus reticulatus Schaeff.Structural characterization results revealed that B.reticulatus Schaeff polysaccharide(BRS-X)had a backbone of 1,6-linkedα-D-galactose and 1,2,6-linkedα-D-galactose which branches were mainly composed of a terminal 4-linkedβ-D-glucose and the ratio of D-galactose and D-glucose was 5:1.Bioactivity assays indicated that BRS-X displayed a strong proliferative activity in T cells and B cells and promoted the secretion of immunoglobulin G(Ig G),Ig E,Ig D and Ig M.In addition,BRS-X could facilitate the proliferation and phagocytosis of RAW264.7 cells and could significantly inhibit the growth of tumors in S180-bearing mice.The results of transcriptome sequencing analysis illustrated that total 46 genes enriched in MAPK and total 34 genes enriched in PI3 K/Akt signaling pathways in BRS-X group.The protein VEGF and VEGFR expression were significantly reduced under the treatment with BRS-X.These findings provide a scientific basis for the edible and medicinal value of BRS-X. | Siyuan Su Xiang Ding Yiling Hou Binbin Liu Zhouhe Du Junfeng Liu | 2023 | Food Science and Human Wellness2023，12，2： | 1 |
| 9 | China's progress in radionuclide migration study over the past decade(2010–2021):Sorption,transport and radioactive colloid显示文摘The radionuclide(RN)migration study is not only helpful to understand environmental behavior of RNs,but also can establish the basis for the safety assessment of geological disposal of high-level radioactive waste(HLW).In the context of China’s HLW disposal,this review briefly summaries the progress of China’s RN migration studies over the past decade regarding three aspects,RN sorption,RN transport and radioactive colloid.Domestic studies from other disciplines(such as geology and environmental science)are also included in this review because they can provide references for the RN migration study.Overall,China has achieved clear progress in RN migration study over the past decade,although large-scaled field experiments are lacked and a gap still exists comparing with the international advanced level.Finally,several suggestions are proposed for future RN migration research in China. | Zongyuan Chen Siyuan Wang Huijuan Hou Kang Chen Pengyuan Gao Zhen Zhang Qiang Jin Duoqiang Pan Zhijun Guo Wangsuo Wu | 2022 | Chinese Chemical Letters2022，33，7： | 1 |
| 10 | A de novo missense mutation in MPP2 confers an increased risk of Vogt–Koyanagi–Harada disease as shown by trio-based whole-exome sequencing显示文摘Vogt–Koyanagi–Harada(VKH)disease is a leading cause of blindness in young and middle-aged people.However,the etiology of VKH disease remains unclear.Here,we performed the first trio-based whole-exome sequencing study,which enrolled 25 VKH patients and 50 controls,followed by a study of 2081 VKH patients from a Han Chinese population to uncover detrimental mutations.A total of 15 de novo mutations in VKH patients were identified,with one of the most important being the membrane palmitoylated protein 2(MPP2)p.K315N(MPP2-N315)mutation.The MPP2-N315 mutation was highly deleterious according to bioinformatic predictions.Additionally,this mutation appears rare,being absent from the 1000 Genome Project and Genome Aggregation Database,and it is highly conserved in 10 species,including humans and mice.Subsequent studies showed that pathological phenotypes and retinal vascular leakage were aggravated in MPP2-N315 mutation knock-in or MPP2-N315 adeno-associated virus-treated mice with experimental autoimmune uveitis(EAU).In vitro,we used clustered regularly interspaced short palindromic repeats(CRISPR‒Cas9)gene editing technology to delete intrinsic MPP2 before overexpressing wild-type MPP2 or MPP2-N315.Levels of cytokines,such as IL-1β,IL-17E,and vascular endothelial growth factor A,were increased,and barrier function was destroyed in the MPP2-N315 mutant ARPE19 cells.Mechanistically,the MPP2-N315 mutation had a stronger ability to directly bind to ANXA2 than MPP2-K315,as shown by LC‒MS/MS and Co-IP,and resulted in activation of the ERK3/IL-17E pathway.Overall,our results demonstrated that the MPP2-K315N mutation may increase susceptibility to VKH disease. | Xianyang Liu Jiayu Meng Xingyun Liao Yusen Liu Qian Zhou Zongren Xu Shuming Yin Qingfeng Cao Guannan Su Siyuan He Wanqian Li Xiaotang Wang Guoqing Wang Dali Li Peizeng Yang Shengping Hou | 2023 | Cellular & Molecular Immunology2023，20，11： | 0 |
| 11 | Microstructural,crystallographic,and mechanical characteristics in Ni-Mn-Ga alloys directionally solidified under a transverse magnetic field显示文摘In this study,the effect of transverse magnetic field-assisted directional solidification(MFADS)on the microstructures in Ni-Mn-Ga alloys has been investigated.The results show that the magnetic field is capable of inducing transversal macrosegregation perpendicular to the magnetic field,causing the emergence of martensite clusters in the austenite matrix.Moreover,the magnetic field alleviates the microseg-regation on a dendritic scale and promotes the preferred growth of austenite dendrites.On the basis of the above investigation,several special samples are designed using the MFADS to study the crystallographic evolution and mechanical behavior during thermal/stress-induced martensite transformation.The martensite cluster in the austenite matrix is used to investigate the martensite transformation and growth under cooling-heating cycles.The crystallographic relationship and phase boundary microstructure between martensite and austenite have been characterized.In addition,the microsegregation on a dendritic scale can significantly influence the martensite variant distribution,corresponding to the performance during compressive circles based on the analysis of the deformation gradient tensor.The stress-induced superelasticity is closely dependent on orientation,well explained from the perspective of different resolved shear stress factors and correspondence variant pair formation transformation strain.The crystallographic evolution has been characterized during in-situ stress-induced transformation.The findings not only deepen the understanding of martensite transformation and mechanical behavior under a thermal/stress field in Ni-Mn-Ga alloys but also propose a promising strategy to obtain microstructure-controllable functional alloys by MFADS. | Xi Li Long Hou Siyuan Yang Ting Zhou Yue Wang Xing Yu Zongbin Li Daoyong Cong Yves Fautrelle Zhongming Ren Yanyan Zhu | 2023 | Journal of Materials Science & Technology2023，，11： | 0 |
| 12 | Research on Silicon-Based Terahertz Communication Integrated Circuits显示文摘With the increasing number of users and emerging new applications, the demand for mobile data traffic is growing rapidly. The limited spectrum resources of the traditional microwave and millimeter-wave frequency bands can no longer support the future wireless communication systems with higher system capacity and data throughput. The terahertz(THz) frequency bands have abundant spectrum resources, which can provide sufficient bandwidth to expand channel capacity and increase transmission data rate. In addition, with the rapid development of silicon-based semiconductor technology,its characteristic size keeps decreasing, and the radio frequency performance of active devices is gradually approaching the performance of III-V semiconductor technology. The realization of THz communication systems based on low-cost, high-stability, and easy-to-integrate silicon-based process has become a feasible solution. This review summarizes the reported silicon-based THz communication systems, as well as the key sub-circuit chips in these systems, including the local oscillator, power amplifier, low noise amplifier, on-chip antenna and transceiver chip, etc. | ZHOU Peigen CHEN Jixin TANG Siyuan YU Jiayang WANG Chen LI Huanbo LU Haiyan YAN Pinpin HOU Debin CHEN Zhe HONG Wei | 2022 | Chinese Journal of Electronics2022，31，3： | 0 |
| 13 | Co anchored on porphyrinic triazine-based frameworks with excellent biocompatibility for conversion of CO_(2)in H_(2)-mediated microbial electrosynthesis显示文摘Microbial electrosynthesis is a promising alternative to directly convert CO_(2)into long-chain compounds by coupling inorganic electrocatalysis with biosynthetic systems.However,problems arose that the conventional electrocatalysts for hydrogen evolution may produce extensive by-products of reactive oxygen species and cause severe metal leaching,both of which induce strong toxicity toward microorganisms.Moreover,poor stability of electrocatalysts cannot be qualified for long-term operation.These problems may result in poor biocompatibility between electrocatalysts and microorganisms.To solve the bottleneck problem,Co anchored on porphyrinic triazine-based frameworks was synthesized as the electrocatalyst for hydrogen evolution and further coupled with Cupriavidus necator H16.It showed high selectivity for a four-electron pathway of oxygen reduction reaction and low production of reactive oxygen species,owing to the synergistic effect of Co–Nx modulating the charge distribution and adsorption energy of intermediates.Additionally,low metal leaching and excellent stability were observed,which may be attributed to low content of Co and the stabilizing effect of metalloporphyrins.Hence,the electrocatalyst exhibited excellent biocompatibility.Finally,the microbial electrosynthesis system equipped with the electrocatalyst successfully converted CO_(2)to poly-β-hydroxybutyrate.This work drew up a novel strategy for enhancing the biocompatibility of electrocatalysts in microbial electrosynthesis system. | Folin Liu Shaohua Feng Siyuan Xiu Bin Yang Yang Hou Lecheng Lei Zhongjian Li | 2022 | Frontiers of Chemical Science and Engineering2022，16，12： | 0 |
| 14 | FTO-mediated m6A modification alleviates autoimmune uveitis by regulating microglia phenotypes via the GPC4/TLR4/NF-κB signaling axis显示文摘Uveitis,a vision-threatening inflammatory disease worldwide,is closely related to resident microglia.Retinal microglia are the main immune effector cells with strong plasticity,but their role in uveitis remains unclear.N6-methyladenosine(m^(6)A)modification has been proven to be involved in the immune response.Therefore,we in this work aimed to identify the potentially crucial m^(6)A regulators of microglia in uveitis.Through the single-cell sequencing(scRNA-seq)analysis and experimental verification,we found a significant decrease in the expression of fat mass and obesity-associated protein(FTO)in retinal microglia of uveitis mice and human microglia clone 3(HMC3)cells with inflammation.Additionally,FTO knockdown was found to aggravate the secretion of inflammatory factors and the mobility/chemotaxis of microglia.Mechanistically,the RNA-seq data and rescue experiments showed that glypican 4(GPC4)was the target of FTO,which regulated microglial inflammation mediated by the TLR4/NF-κB pathway.Moreover,RNA stability assays indicated that GPC4 upregulation was mainly regulated by the downregulation of the m^(6)A“reader”YTH domain family protein 3(YTHDF3).Finally,the FTO inhibitor FB23-2 further exacerbated experimental autoimmune uveitis(EAU)inflammation by promoting the GPC4/TLR4/NF-κB signaling axis,and this could be attenuated by the TLR4 inhibitor TAK-242.Collectively,a decreased FTO could facilitate microglial inflammation in EAU,suggesting that the restoration or activation of FTO function may be a potential therapeutic strategy for uveitis. | Siyuan He Wanqian Li Guoqing Wang Xiaotang Wang Wei Fan Zhi Zhang Na Li Shengping Hou | 2023 | Genes & Diseases2023，10，5： | 0 |
| 15 | Divergent expression of Neurl3 from hemogenic endothelial cells to hematopoietic stem progenitor cells during development显示文摘Prior to the generation of hematopoietic stem cells(HSCs)from the hemogenic endothelial cells(HECs)mainly in the dorsal aorta in midgestational mouse embryos,multiple hematopoietic progenitors including erythro-myeloid progenitors and lymphoid progenitors are generated from yolk sac HECs.These HSCindependent hematopoietic progenitors have recently been identified as major contributors to functional blood cell production until birth.However,little is known about yolk sac HECs.Here,combining integrative analyses of multiple single-cell RNA-sequencing datasets and functional assays,we reveal that Neurl3-EGFP,in addition to marking the continuum throughout the ontogeny of HSCs from HECs,can also serve as a single enrichment marker for yolk sac HECs.Moreover,while yolk sac HECs have much weaker arterial characteristics than either arterial endothelial cells in the yolk sac or HECs within the embryo proper,the lymphoid potential of yolk sac HECs is largely confined to the arterial-biased subpopulation featured by the Unc5b expression.Interestingly,the B lymphoid potential of hematopoietic progenitors,but not for myeloid potentials,is exclusively detected in Neurl3-negative subpopulations in midgestational embryos.Taken together,these findings enhance our understanding of blood birth from yolk sac HECs and provide theoretical basis and candidate reporters for monitoring step-wise hematopoietic differentiation. | Xiaowei Ning Junjie Du Yandong Gong Yingpeng Yao Zhijie Bai Yanli Ni Yanyan Li Zongcheng Li Haixin Zhao Jie Zhou Bing Liu Yu Lan Siyuan Hou | 2023 | Journal of Genetics and Genomics2023，50，9： | 0 |
| 16 | Discussion on the Pathogenesis of Hemorrhoids显示文摘With the efficient development of social economy,as well as the acceleration of the pace of life,the incidence of hemorrhoids remains high all year round,occupying a relatively high incidence of anorectal diseases.The author will sort out the four most representative theories of pathogenesis,and summarize and analyze them.Understanding the pathogenesis of hemorrhoids can give a deeper understanding of the nature of the disease,and it will help improve the accuracy of clinical diagnosis and treatment,which in turn is beneficial to the improvement of the cure rate. | Siyuan Liu Junming Hou Wenzhe Feng Dezhen Yang Lu Luo | 2021 | Journal of Clinical and Nursing Research2021，5，4： | 0 |
| 17 | Vitamin D receptor (VDR) mediates the quiescence of activated hepatic stellate cells (aHSCs) by regulating M2 macrophage exosomal smooth muscle cell-associated protein 5 (SMAP-5)显示文摘An effective therapeutic regimen for hepatic fibrosis requires a deep understanding of the pathogenesis mechanism.Hepatic fibrosis is characterized by activated hepatic stellate cells(aHSCs)with an excessive production of extracellular matrix.Although promoted activation of HSCs by M2 macrophages has been demonstrated,the molecular mechanism involved remains ambiguous.Herein,we propose that the vitamin D receptor(VDR)involved in macrophage polarization may regulate the communication between macrophages and HSCs by changing the functions of exosomes.We confirm that activating the VDR can inhibit the effect of M2 macrophages on HSC activation.The exosomes derived from M2 macrophages can promote HSC activation,while stimulating VDR alters the protein profiles and reverses their roles in M2 macrophage exosomes.Smooth muscle cell-associated protein 5(SMAP-5)was found to be the key effector protein in promoting HSC activation by regulating autophagy flux.Building on these results,we show that a combined treatment of a VDR agonist and a macrophage-targeted exosomal secretion inhibitor achieves an excellent anti-hepatic fibrosis effect.In this study,we aim to elucidate the association between VDR and macrophages in HSC activation.The results contribute to our understanding of the pathogenesis mechanism of hepatic fibrosis,and provide potential therapeutic targets for its treatment. | Xuwentai LIU Yue WU Yanyi LI Kaiming LI Siyuan HOU Ming DING Jingmin TAN Zijing ZHU Yingqi TANG Yuming LIU Qianhui SUN Cong WANG Can ZHANG | 2023 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2023，24，3： | 0 |
| 18 | Microstructure evolution and mechanical behavior of Ni-rich Ni-Mn-Ga alloys under compressive and tensile stresses显示文摘The microstructure evolution and mechanical behavior in directionally solidified Ni-rich Ni-Mn-Ga alloys with nominal compositions of Ni_(58)Mn_(25)Ga_(17) and Ni_(60)Mn_(25)Ga_(15) under compressive and tensile stresses have been investigated.The composition distribution shows the element Ni segregates in gamma phase,while elements Mn and Ga segregate in martensite phase.Furthermore,the microstructure orientation examined by electron backscatter diffraction(EBSD)indicates that beta phase has a preferred growth orientation of(001)_(A) in Ni_(58)Mn_(25)Ga_(17) alloys,while gamma phase has a preferred growth orientation of(001)_(γ) in Ni_(60)Mn_(25)Ga_(15) alloys.The fracture morphology suggests that the existence of ductile y phase can reduce the crack propagation and promote fracture strain,particularly in the Ni_(60)Mn_(25)Ga_(15) alloys.Finally,Schmid factor and deformation gradient tensor were calculated to well explain the crystallographic evolution during the detwinning under compressive and tensile stresses.The present findings not only elucidate the mechanism ofγphase on the mechanical behavior of Ni-rich Ni-Mn-Ga alloys,but also shed light on the composition design of high temperature Ni-Mn-Ga shape memory alloys. | Yue Wang Siyuan Yang Ting Zhou Long Hou Lansong Ba Yves Fautrelle Zhongming Ren Yanyan Zhu Zongbin Li Xi Li | 2022 | Journal of Materials Science & Technology2022，，2： | 0 |
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