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| 1 | Cold-chain food contamination as the possible origin of COVID-19 resurgence in Beijing显示文摘COVID-19,caused by SARS-CoV-2[1,2],has been contained in China through stringent non-pharmaceutical interventions.Border control and quarantine have effectively prevented the virus from being spread by infected travellers,but the risk of resurgence caused by other routes of introduction and transmission remains unclear,and current strategies to prevent resurgence could be flawed.Since July,SARS-CoV-2 RNA contaminations in frozen food imported from countries with ongoing epidemics have been reported in nine provinces in China[3,4].However,there is no robust evidence of COVID-19 outbreaks initiated by environmentto-human transmission.Here we add to evidence of such transmission by investigating the recent COVID-19 resurgence in Beijing. | Xinghuo Pang Lili Ren Shuangsheng Wu Wentai Ma Jian Yang Lin Di Jie Li Yan Xiao Lu Kang Shichang Du Jing Du Jing Wang Gang Li Shuguang Zhai Lijuan Chen Wenxiong Zhou Shengjie Lai Lei Gao Yang Pan Quanyi Wang Mingkun Li Jianbin Wang Yanyi Huang Jianwei Wang COVID-19 Field Response Group COVID-19 Laboratory Testing Group | 2020 | National Science Review2020，7，12： | 51 |
| 2 | Single-cell triple omics sequencing reveals genetic, epigenetic, and transcriptomic heterogeneity in hepatocellular carcinomas显示文摘 | Yu Hou Huahu Guo then Cao Xianlong Li Boqiang Hu Ping Zhu Xinglong Wu Lu Wen FuchouTang Yanyi Huang Jirun Peng | 2016 | Cell Research2016，26，3： | 48 |
| 3 | Genome-scale detection of hypermethylated CpG islands in circulating cell-free DNA of hepatocellular carcinoma patients显示文摘 | Lu Wen Jingyi Li Huahu Guo Xiaomeng Liu Shengmin Zheng Dafang Zhang Weihua Zhu Jianhui Qu Limin Guo Dexiao Du Xiao Jin Yuhao Zhang Yun Gao Jie Shen Hao Ge Fuchou Tang Yanyi Huang Jirun Peng | 2015 | Cell Research2015，25，11： | 19 |
| 4 | Chemical compound cinobufotalin potently induces FOXO1-stimulated cisplatin sensitivity by antagonizing its binding partner MYH9显示文摘In this study,we present novel molecular mechanisms by which FOXO1 functions as a tumor suppressor to prevent the pathogenesis of nasopharyngeal carcinoma(NPC).First,we observed that FOXO1 not only controlled tumor stemness and metastasis,but also sensitized NPC cells to cisplatin(DDP)in vitro and in vivo.Mechanistic studies demonstrated that FOXO1-induced miR-200b expression through the GSK3β/β-catenin/TCF4 network-mediated stimulation of ZEB1,which reduced tumor stemness and the epithelial–mesenchymal transition(EMT)signal.Furthermore,we observed FOXO1 interaction with MYH9 and suppression of MYH9 expression by modulating the PI3K/AKT/c-Myc/P53/miR-133a-3p pathway.Decreased MYH9 expression not only reduced its interactions with GSK3β,but also attenuated TRAF6 expression,which then decreased the ubiquitin-mediated degradation of GSK3βprotein.Increased GSK3βexpression stimulated theβ-catenin/TCF4/ZEB1/miR-200b network,which increased the downstream tumor stemness and EMT signals.Subsequently,we observed that chemically synthesized cinobufotalin(CB)strongly increased FOXO1-induced DDP chemosensitivity by reducing MYH9 expression,and the reduction in MYH9 modulated GSK3β/β-catenin and its downstream tumor stemness and EMT signal in NPC.In clinical samples,the combination of low FOXO1 expression and high MYH9 expression indicated the worst overall survival rates.Our studies demonstrated that CB potently induced FOXO1-mediated DDP sensitivity by antagonizing its binding partner MYH9 to modulate tumor stemness in NPC. | YongHao Li Xiong Liu Xian Lin Menyang Zhao Yanyi Xiao Chen Liu Zixi Liang Zelong Lin Renhui Yi Zibo Tang Jiahao Liu Xin Li Qingping Jiang Libo Li Yinyin Xie Zhen Liu Weiyi Fang | 2019 | Signal Transduction and Targeted Therapy2019，4，1： | 6 |
| 5 | Immobilization of insulin-like growth factor-1 onto thermosensitive hydrogels to enhance cardiac progenitor cell survival and differentiation under ischemic conditions显示文摘Stem cell therapy is a promising approach to treat myocardial infarction. However, direct delivery of stem cells into hearts experiences poor cell engraftment and differentiation, due to ischemic conditions(low nutrient and oxygen) in the infarct hearts. Development of suitable cell carriers capable of supporting cell survival and differentiation under these harsh conditions is critical for improving the efficacy of current stem cell therapy. In this work, we created a family of novel cell carriers based on thermosensitive hydrogels and insulin-like growth factor 1(IGF-1), and investigated if these cell carriers can improve cell survival and differentiation under ischemic conditions. The thermosensitive hydrogels were synthesized from N-isopropylacryla- mide, acrylic acid, acrylic acid N-hydroxysuccinicimide ester, and 2-hydroxyethyl methacrylate-oligo(hydroxybutyrate). The hydrogel solutions can be readily injected through 26G needles, and can quickly solidify at 37 oC to form highly flexible hydrogels. IGF-1 was immobilized into the hydrogels in order to support long-term cell survival and differentiation. Different amount of IGF-1 was immobilized by using hydrogels with different content of N-hydroxysuccinicimide ester groups. Cardiosphere derived cells were encapsulated in the hydrogels and cultured under ischemic conditions. The results demonstrated that a significant improvement of cell survival and differentiation was achieved after IGF-1 immobilization. These IGF-1 immobilized hydrogels have the potential to improve cell survival and differentiation in infarct hearts. | LI ZhenQing XU YanYi LI HaiChang GUAN JianJun | 2014 | Science China Chemistry2014，57，4： | 3 |
| 6 | Copy number alteration profiling facilitates differential diagnosis between ossifying fibroma and fibrous dysplasia of the jaws显示文摘Ossifying fibroma(OF)and fibrous dysplasia(FD)are two fibro-osseous lesions with overlapping clinicopathological features,making diagnosis challenging.In this study,we applied a whole-genome shallow sequencing approach to facilitate differential diagnosis via precise profiling of copy number alterations(CNAs)using minute amounts of DNA extracted from morphologically correlated microdissected tissue samples.Freshly frozen tissue specimens from OF(n=29)and FD(n=28)patients were obtained for analysis.Lesion fibrous tissues and surrounding normal tissues were obtained by laser capture microdissection(LCM),with~30–50 cells(5000–10000µm2)per sample.We found that the rate of recurrent CNAs in OF cases was much higher(44.8%,13 of 29)than that in FD cases(3.6%,1 of 28).Sixty-nine percent(9 of 13)of the CNA-containing OF cases involved segmental amplifications and deletions on Chrs 7 and 12.We also identified eight CNA-associated genes(HILPDA,CALD1,C1GALT1,MICALL2,PHF14,AIMP2,MDM2,and CDK4)with amplified expression,which was consistent with the copy number changes.We further confirmed a jaw lesion with a previous uncertain diagnosis due to its ambiguous morphological features and the absence of GNAS mutation as OF based on the typical Chr 12 amplification pattern in its CNA profile.Moreover,analysis of a set of longitudinal samples collected from an individual with a cellular lesion in suspicion of OF at the first surgery,recurrence and the latest malignant transformation revealed identical CNA patterns at the three time points,suggesting that copy number profiling can be used as an important tool to identify borderline lesions or lesions with malignant potential.Overall,CNA profiling of fibro-osseous lesions can greatly improve differential diagnosis between OF and FD and help predict disease progression. | Ming Ma Lu Liu Ruirui Shi Jianyun Zhang Xiaotian Li Xuefen Li Jiaying Bai Jianbin Wang Yanyi Huang Tiejun Li | 2021 | International Journal of Oral Science2021，13，2： | 3 |
| 7 | Improvement in the risk assessment of oral leukoplakia through morphology-related copy number analysis显示文摘Oral leukoplakia is the most common type of oral potentially malignant disorders and considered a precursor lesion to oral squamous cell carcinoma.However,a predictor of oral leukoplakia prognosis has not yet been identified.We investigated whether copy number alteration patterns may effectively predict the prognostic outcomes of oral leukoplakia using routinely processed paraffin sections.Comparison of copy number alteration patterns between oral leukoplakia with hyperplasia(HOL,n=22)and dysplasia(DOL,n=21)showed that oral leukoplakia with dysplasia had a higher copy number alteration rate(86%)than oral leukoplakia with hyperplasia(46%).Oral leukoplakia with dysplasia exhibited a wider range of genomic variations across all chromosomes compared with oral leukoplakia with hyperplasia.We also examined a retrospective cohort of 477 patients with oral leukoplakia with hyperplasia with detailed follow-up information.The malignant transformation(MT,n=19)and leukoplakia recurrence(LR,n=253)groups had higher frequencies of aneuploidy events and copy number loss rate than the free of disease(FD,n=205)group.Together,our results revealed the association between the degree of copy number alterations and the histological grade of oral leukoplakia and demonstrated that copy number alteration may be effective for prognosis prediction in oral leukoplakia patients with hyperplasia. | Xiaotian Li Lu Liu Jianyun Zhang Ming Ma Lisha Sun Xuefen Li Heyu Zhang Jianbin Wang Yanyi Huang Tiejun Li | 2021 | Science China(Life Sciences)2021，64，9： | 2 |
| 8 | Experimental Study on Hydrogen Leakage and Emission of Fuel Cell Vehicles in Confined Spaces显示文摘Hydrogen safety is one of the most important safety indicators in fuel cell vehicles(FCVs)(unlike in other types of alternative energy vehicles).This indicator in FCVs is directly related to the user’s personal safety in daily vehicle usage.This paper analyzes the safety standards of FCVs in confined spaces.A sealed test chamber and an appropriate test method are devel-oped to evaluate vehicle safety based on specific test requirements.Two FCVs are subjected to static hydrogen leakage and hydrogen emission testing performed in a confined space.The results reveal that the hydrogen concentration in the vicinity of the vehicles approximates 0.0004%which is much lower than 1%while parked for 8 h during the hydrogen leakage test.In the hydrogen emission test under operating conditions,the concentration of the hydrogen gas emitted from the vehicles exceeds 2300 ppm in the vicinity,which requires careful consideration.Based on experiment and analysis,recommendations for the hydrogen safety standards of FCVs in confined spaces are proposed. | Dong Hao Xiaobing Wang Yanyi Zhang Renguang Wang Guang Chen Jun Li | 2020 | Automotive Innovation2020，3，2： | 2 |
| 9 | Fabrication of Sulfated Silk Fibroin‑Based Blend Nanofbrous Membranes for Lysozyme Adsorption显示文摘In this work,the silk fbroin/cellulose blend nanofbrous membranes modifed with sodium-3-sulfobenzoate(S-SCBNM)were fabricated by electrospinning technique for lysozyme adsorption.The morphology and structure of membranes was observed.The efect of sulfate contents,pH values and concentration of lysozyme on adsorption performance were studied,respectively.The reuse capacity was evaluated.The results showed that the resultant S-SCBNM exhibited integrated properties of ultrathin fber diameter(148 nm),fast adsorption equilibrium,excellent adsorption performance(636 mg g−1)and good reversibility.We envision that this new class of green and natural blend membranes is particularly promising for the development of proteins separation. | Ying Zhou Jiaxue Wu Yanyi Li Wei Zhang Yushan Zou Lian Duan Xiao Yang Bo Xiao Shixiong Yi | 2022 | Advanced Fiber Materials2022，4，1： | 1 |
| 10 | Clinical analysis of 102 cases of Paget disease of the breast显示文摘 | ZHANG Yanyi ZHANG Lina GU Li | 2013 | ChinJ Gen Surg2013，28，8： | 1 |
| 11 | Thermosensitive and Highly Flexible Hydrogels Capable of Stimulating Cardiac Differentiation of Cardiosphere-Derived Cells under Static and Dynamic Mechanical Training Conditions显示文摘 | Li Zhenqing Fan Zhaobo Xu Yanyi | 2016 | Acs Applied Materials&Interfaces2016，85，15： | 1 |
| 12 | Optical frequency synthesizer referenced to an ytterbium optical clock显示文摘Optical clocks with an unprecedented accuracy of 10-18 promise innovations in precision spectroscopy and measurement. To harness the full power of optical clocks, we need optical frequency synthesizers(OFSs) to accurately convert the stabilities and accuracies of optical clocks to other desired frequencies. This work demonstrates such an OFS referenced to an ytterbium optical clock. The OFS is based on an optical frequency comb phase-locked to a commercial rubidium microwave clock;in this way most combs can operate robustly. Despite comb frequency instability at 10^(-11), the synthesis noise and uncertainty reach 6 × 10^(-18)(1 s) and 5 × 10^(-21), respectively, facilitating frequency synthesis of the best optical clocks. In the OFS, the coherence of the OFS internal oscillator at 1064 nm is accurately transferred to a 578 nm laser for resolving the hertz-level-linewidth ytterbium clock transition(unaffected by megahertz-linewidth comb lines) and faithfully referencing the OFS to an ytterbium optical clock. | YUAN YAO BO LI GUANG YANG XIAOTONG CHEN YAQIN HAO HONGFU YU YANYI JIANG LONGSHENG MA | 2021 | Photonics Research2021，9，2： | 1 |
| 13 | 显示文摘 | Xin Hao Li Fuyou Huang Yanyi | 2002 | Journal of Rare Earths2002，20，5： | 1 |
| 14 | Nucleic acids analysis显示文摘Nucleic acids are natural biopolymers of nucleotides that store, encode, transmit and express genetic information, which play central roles in diverse cellular events and diseases in living things. The analysis of nucleic acids and nucleic acids-based analysis have been widely applied in biological studies, clinical diagnosis, environmental analysis, food safety and forensic analysis.During the past decades, the field of nucleic acids analysis has been rapidly advancing with many technological breakthroughs.In this review, we focus on the methods developed for analyzing nucleic acids, nucleic acids-based analysis, device for nucleic acids analysis, and applications of nucleic acids analysis. The representative strategies for the development of new nucleic acids analysis in this field are summarized, and key advantages and possible limitations are discussed. Finally, a brief perspective on existing challenges and further research development is provided. | Yongxi Zhao Xiaolei Zuo Qian Li Feng Chen Yan-Ru Chen Jinqi Deng Da Han Changlong Hao Fujian Huang Yanyi Huang Guoliang Ke Hua Kuang Fan Li Jiang Li Min Li Na Li Zhenyu Lin Dingbin Liu Juewen Liu Libing Liu Xiaoguo Liu Chunhua Lu Fang Luo Xiuhai Mao Jiashu Sun Bo Tang Fei Wang Jianbin Wang Lihua Wang Shu Wang Lingling Wu Zai-Sheng Wu Fan Xia Chuanlai Xu Yang Yang Bi-Feng Yuan Quan Yuan Chao Zhang Zhi Zhu Chaoyong Yang Xiao-Bing Zhang Huanghao Yang Weihong Tan Chunhai Fan | 2021 | Science China Chemistry2021，64，2： | 1 |
| 15 | Auxiliary diagnostic system for ADHD in children based on AI technology显示文摘Traditional diagnosis of attention deficit hyperactivity disorder(ADHD)in children is primarily through a questionnaire filled out by parents/teachers and clinical observations by doctors.It is inefficient and heavily depends on the doctor’s level of experience.In this paper,we integrate artificial intelligence(AI)technology into a software-hardware coordinated system to make ADHD diagnosis more efficient.Together with the intelligent analysis module,the camera group will collect the eye focus,facial expression,3D body posture,and other children’s information during the completion of the functional test.Then,a multi-modal deep learning model is proposed to classify abnormal behavior fragments of children from the captured videos.In combination with other system modules,standardized diagnostic reports can be automatically generated,including test results,abnormal behavior analysis,diagnostic aid conclusions,and treatment recommendations.This system has participated in clinical diagnosis in Department of Psychology,The Children’s Hospital,Zhejiang University School of Medicine,and has been accepted and praised by doctors and patients. | Yanyi ZHANG Ming KONG Tianqi ZHAO Wenchen HONG Di XIE Chunmao WANG Rongwang YANG Rong LI Qiang ZHU | 2021 | Frontiers of Information Technology & Electronic Engineering2021，22，3： | 1 |
| 16 | Photonics-based high-speed long-distance fiber-wireless-integration communication at the W-band显示文摘With the early approach of 5G period, beyond 5G communication has become an urgent need in the industry. Because of its rich bandwidth, the W-band (75–110-GHz) millimeterwave (mm-wave) is capable of carrying ultra-high-speed signal [1–6]. Therefore, it is extremely competitive in the field of future beyond 5G communication. The feature of photonics-based W-band mm-wave generation technology is that it can effectively solve the problem of bandwidth limitation and electromagnetic interference in electronic devices. | Weiping LI Jianjun YU Yanyi WANG Feng WANG Bowen ZHU Wen ZHOU Feng ZHAO Jianguo YU | 2023 | Science China(Information Sciences)2023，66，2： | 1 |
| 17 | Photonics-aided THz-wireless transmission over 400 m at 335 GHz显示文摘The terahertz(THz)band(0.3–10 THz),with abundant bandwidth,can satisfy the need for large-capacity transmission of fiber-wireless integration communication systems,which has attracted more and more attention[1–3]. | LI WeiPing YU JianJun ZHU BoWen WANG Feng TAN YuXuan WANG YanYi ZHU Min ZHANG Jiao ZHOU Wen ZHAO Feng YU JianGuo | 2022 | Science China(Technological Sciences)2022，65，12： | 0 |
| 18 | The proposal and realization on more exact modeling of COIL performance显示文摘The chemical oxygen–iodine laser(COIL)is the shortest-wavelength high-power chemical laser that has been demonstrated.The characteristics,such as good atmospheric propagation,short wavelength and excellent transmission through optical fibers,make the COIL a good candidate for high-power laser application.To model the complete COIL lasing interaction,a three-dimensional formulation of the fluid dynamics,species continuity and radiation transport equations is necessary.The computational effort to calculate the flow field over the entire nozzle bank with a grid fine enough to resolve the injection holes is so large as to preclude doing the calculation.The approach to modeling chemical lasers then has been to reduce the complexity of the model to correspond to the available computational capability,adding details as computing power increased.The modeling of lasing in the COIL medium is proposed,which is coupling with the effects induced by transverse injection of secondary gases,non-equilibrium chemical reactions,nozzle tail flow and boundary layer.The coupled steady solutions of the fluid dynamics and optics in a COIL complex three-dimensional cavity flow field are obtained following the proposal.The modeling results show that these effects have some influence on the lasing properties.A feasible methodology and a theoretical tool are offered to predict the beam quality for large-scale COIL devices. | Shouxian Li Xiaojian Shu Yanyi Du Hua Su Yan Li Zhen Yu | 2013 | High Power Laser Science and Engineering2013，1，1： | 0 |
| 19 | Chemical approaches for mimicking logic functions within fluorescent MPT dyes显示文摘The progress of the design, synthesis, fluorescence properties and application of a new family of fluorescent molecular switches towards information processing at the molecular level was reviewed. On the basis of the high fluorescence quantum yields and surroundings-sensitive fluorescent properties of the 5-methoxy-2-(2-pyridyl)-thiazole (2-MPT, 1) and a series of its derivatives as prepared, multiple binary logic and arithmetic functionalities were realized through encoding the controllable fluorescence switching properties with binary digit. Combined with the microfluidic platform, the fabrication of the molecular logic devices was attempted. | XU ChunHu SUN Wei ZHANG Chao BAI YanChun FANG ChenJie LI WenTao HUANG YanYi YAN ChunHua | 2009 | Science China Chemistry2009，52，6： | 0 |
| 20 | A virtual sequencer reveals the dephasing patterns in error-correction code DNA sequencing显示文摘An error-correction code(ECC)sequencing approach has recently been reported to effectively reduce sequencing errors by interrogating a DNA fragment with three orthogonal degenerate sequencing-by-synthesis(SBS)reactions.However,similar to other non-single-molecule SBS methods,the reaction will gradually lose its synchronization within a molecular colony in ECC sequencing.This phenomenon,called dephasing,causes sequencing error,and in ECC sequencing,induces distinctive dephasing patterns.To understand the characteristic dephasing patterns of the dual-base flowgram in ECC sequencing and to generate a correction algorithm,we built a virtual sequencer in silico.Starting from first principles and based on sequencing chemical reactions,we simulated ECC sequencing results,identified the key factors of dephasing in ECC sequencing chemistry and designed an effective dephasing algorithm.The results show that our dephasing algorithm is applicable to sequencing signals with at least 500 cycles,or1000-bp average read length,with acceptably low error rate for further parity checks and ECC deduction.Our virtual sequencer with our dephasing algorithm can further be extended to a dichromatic form of ECC sequencing,allowing for a potentially much more accurate sequencing approach. | Wenxiong Zhou Li Kang Haifeng Duan Shuo Qiao Louis Tao Zitian Chen Yanyi Huang | 2021 | National Science Review2021，8，5： | 0 |
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