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| 1 | Prostate cancer tends to metastasize in the bone-mimicking microenvironment via activating NF-κB signaling显示文摘Prostate cancer preferentially metastasizes to the bone. However, the underlying molecular mechanisms are still unclear. To explore the effects of a bone-mimicking microenvironment on PC3 prostate cancer cell growth and metastasis, we used osteoblast differentiation medium(ODM; minimal essential medium alpha supplemented with L-ascorbic acid) to mimic the bone microenvironment. PC3 cells grown in ODM underwent epithelial-mesenchymal transition and showed enhanced colony formation, migration, and invasion abilities compared to the cells grown in normal medium. PC3 cells grown in ODM showed enhanced metastasis when injected in mice. A screening of signaling pathways related to invasion and metastasis revealed that the NF-κB pathway was activated, which could be reversed by Bay 11-7082, a NF-κB pathway inhibitor. These results indicate that the cells in different culture conditions manifested significantly different biological behaviors and the NF-κB pathway is a potential therapeutic target for prostate cancer bone metastasis. | Haibo Tong Chunlin Zou Siyuan Qin Jie Meng Evan T.Keller Jian Zhang Yi Lu | 2018 | The Journal of Biomedical Research2018，32，5： | 3 |
| 2 | Histones released by NETosis enhance the infectivity of SARS-CoV-2 by bridging the spike protein subunit 2 and sialic acid on host cells显示文摘Neutrophil extracellular traps(NETs)can capture and kill viruses,such as influenza viruses,human immunodeficiency virus(HIV),and respiratory syncytial virus(RSV),thus contributing to host defense.Contrary to our expectation,we show here that the histones released by NETosis enhance the infectivity of SARS-CoV-2,as found by using live SARS-CoV-2 and two pseudovirus systems as well as a mouse model.The histone H3 or H4 selectively binds to subunit 2 of the spike(S)protein,as shown by a biochemical binding assay,surface plasmon resonance and binding energy calculation as well as the construction of a mutant S protein by replacing four acidic amino acids.Sialic acid on the host cell surface is the key molecule to which histones bridge subunit 2 of the S protein.Moreover,histones enhance cell-cell fusion.Finally,treatment with an inhibitor of NETosis,histone H3 or H4,or sialic acid notably affected the levels of sgRNA copies and the number of apoptotic cells in a mouse model.These findings suggest that SARS-CoV-2 could hijack histones from neutrophil NETosis to promote its host cell attachment and entry process and may be important in exploring pathogenesis and possible strategies to develop new effective therapies for COVID-19. | Weiqi Hong Jingyun Yang Jun Zou Zhenfei Bi Cai He Hong Lei Xuemei He Xue Li Aqu Alu Wenyan Ren Zeng Wang Xiaohua Jiang Kunhong Zhong Guowen Jia Yun Yang Wenhai Yu Qing Huang Mengli Yang Yanan Zhou Yuan Zhao Dexuan Kuang Junbin Wang Haixuan Wang Siyuan Chen Min Luo Ziqi Zhang Tiangi Lu Li Chen Haiying Que Zhiyao He Qiu Sun Wei Wang Guobo Shen Guangwen Lu Zhiwei Zhao Li Yang Jinliang Yang Zhenling Wang Jiong Li Xiangrong Song Lunzhi Dai Chong Chen Jia Geng Maling Gou Lu Chen Haohao Dong Yong Peng Canhua Huang Zhiyong Qian Wei Cheng Changfa Fan Yuquan Wei Zhaoming Su Aiping Tong Shuaiyao Lu Xiaozhong Peng Xiawei Wei | 2022 | Cellular & Molecular Immunology2022，19，5： | 2 |
| 3 | Estimating the Parental Magma Composition and Temperature of the Xiaohaizi Cumulate-Bearing Ultramafic Rock: Implication for Magma Evolution of the Tarim Large Igneous Province, Northwestern China显示文摘The ultramafic dikes in the Tarim large igneous province(Tarim LIP), exposed in the Xiaohaizi area in the northwestern Tarim Basin of northwestern China, have porphyritic textures, and the olivine and clinopyroxene are as the major phenocryst phases. The groundmass therein consists of clinopyroxene, plagioclase and Fe-Ti oxides, with the cryptocrystalline texture. The olivine phenocrysts in one typical ultramafic dike have Fo(Mg/(Mg+Fe)) numbers ranging from 73 to 85, which are not in equilibrium with the olivine(Mg# of 89) from the host rock crystalized. Combined with microscope observation, both the olivine and clinopyroxene phenocrysts as well as some Fe-Ti oxides in the ultramafic rock are accounted as cumulates. The liquid(parental magma) composition of SiO_2 of 45.00 wt.%–48.82 wt.%, MgO of 9.93 wt.%– 18.56 wt.%, FeO of 5.85 wt.%–14.17 wt.%, CaO of 7.54 wt.%–11.52 wt.%, Al_2O_3 of 8.70 wt.%–11.62 wt.% and TiO_2 of 0.00 wt.%–3.43 wt.% in the Xiaohaizi ultramafic rock was estimated by mass balance, and the results show a reasonable liquid proportion in the cumulate-bearing ultramafic dike(ca. 45%–60% in the whole rock). The estimated parental magma composition corresponds to a melting temperature of 1 300–1 550 oC, which is equal or higher than those of a normal asthenosphere mantle, supporting the involvement of a mantle plume. Combined with other previous studies, an evolution model for the formation processes of the Xiaohaizi ultramafic dike of the Tarim LIP is proposed. | Haowei Sun Yinqi Li Zilong Li Siyuan Zou Charles H.Langmuir Hanlin Chen Shufeng Yang Zhongyuan Ren | 2016 | Journal of Earth Science2016，27，3： | 2 |
| 4 | Biomarkers of aging显示文摘Aging biomarkers are a combination of biological parameters to(i)assess age-related changes,(ii)track the physiological aging process,and(iii)predict the transition into a pathological status.Although a broad spectrum of aging biomarkers has been developed,their potential uses and limitations remain poorly characterized.An immediate goal of biomarkers is to help us answer the following three fundamental questions in aging research:How old are we?Why do we get old?And how can we age slower?This review aims to address this need.Here,we summarize our current knowledge of biomarkers developed for cellular,organ,and organismal levels of aging,comprising six pillars:physiological characteristics,medical imaging,histological features,cellular alterations,molecular changes,and secretory factors.To fulfill all these requisites,we propose that aging biomarkers should qualify for being specific,systemic,and clinically relevant. | Aging Biomarker Consortium Hainan Bao Jiani Cao Mengting Chen Min Chen Wei Chen Xiao Chen Yanhao Chen Yu Chen Yutian Chen Zhiyang Chen Jagadish K Chhetri Yingjie Ding Junlin Feng Jun Guo Mengmeng Guo Chuting He Yujuan Jia Haiping Jiang Ying Jing Dingfeng Li Jiaming Li Jingyi Li Qinhao Liang Rui Liang Feng Liu Xiaoqian Liu Zuojun Liu Oscar Junhong Luo Jianwei Lv Jingyi Ma Kehang Mao Jiawei Nie Xinhua Qiao Xinpei Sun Xiaoqiang Tang Jianfang Wang Qiaoran Wang Siyuan Wang Xuan Wang Yaning Wang Yuhan Wang Rimo Wu Kai Xia Fu-Hui Xiao Lingyan Xu Yingying Xu Haoteng Yan Liang Yang Ruici Yang Yuanxin Yang Yilin Ying Le Zhang Weiwei Zhang Wenwan Zhang Xing Zhang Zhuo Zhang Min Zhou Rui Zhou Qingchen Zhu Zhengmao Zhu Feng Cao Zhongwei Cao Piu Chan Chang Chen Guobing Chen Hou-Zao Chen Jun Chen Weimin Ci Bi-Sen Ding Qiurong Ding Feng Gao Jing-Dong JHan Kai Huang Zhenyu Ju Qing-Peng Kong Ji Li Jian Li Xin Li Baohua Liu Feng Liu Lin Liu Qiang Liu Qiang Liu Xingguo Liu Yong Liu Xianghang Luo Shuai Ma Xinran Ma Zhiyong Mao Jing Nie Yaojin Peng Jing Qu Jie Ren Ruibao Ren Moshi Song Zhou Songyang Yi Eve Sun Yu Sun Mei Tian Shusen Wang Si Wang Xia Wang Xiaoning Wang Yan-Jiang Wang Yunfang Wang Catherine CL Wong Andy Peng Xiang Yichuan Xiao Zhengwei Xie Daichao Xu Jing Ye Rui Yue Cuntai Zhang Hongbo Zhang Liang Zhang Weiqi Zhang Yong Zhang Yun-Wu Zhang Zhuohua Zhang Tongbiao Zhao Yuzheng Zhao Dahai Zhu Weiguo Zou Gang Pei Guang-Hui Liu | 2023 | Science China(Life Sciences)2023，66，5： | 2 |
| 5 | Iron-Catalyzed Aminomethyloxygenative Cyclization of Hydroxy-α-diazoesters with N,O-Aminals显示文摘Summary of main observation and conclusion A new and eficient cyclization reaction has bleen developed to synthesize cyclic a,a-disubstituted B-amino esters via iron-catalyzed intramolecular aminomethyloxygenative cyclization of diazo compounds with N,O-aminal under mild reaction condi-tions.A broad range of hydroxy-a diazoesters with different substituents and various N,O-aminals were compatible with this protocol,affording the corresponding a,a-disubstitutedβ-amino esters bearing a five-to eight-membered oxacycle in good yields. | Suchen Zou Tianze Zhang Siyuan Wang Hanmin Huang | 2020 | Chinese Journal of Chemistry2020，38，4： | 1 |
| 6 | Adaptive two-filter smoothing based on second-order divided difference filter for distributed position and orientation system显示文摘The distributed position and orientation system(POS) uses transfer alignment to accurately measure multi-node time-spatial reference information, which is necessary for compensating the motion error of imaging sensors used in aerial surveys. Lever-arm deformation in transfer alignment will result in time-varying covariance of measurement noise, which decreases the estimation accuracy. To address this problem, a second-order adaptive divided difference two-filter smoother(ADDTFS) is proposed for transfer alignment. The second-order adaptive divided difference filter(ADDF2) severs as the forward filter to address nonlinearity in the system. The ADDF2 can estimate the measurement noise covariance in real time based on adaptive estimation using innovation information. The weighted statistical linear regression formulation is used in the backward filter to independently estimate the states and error covariance matrices.Then the forward and backward results are combined, to obtain high-precision estimation results in postprocessing. Finally, the vehicle experiment results show that the proposed method can improve the attitude precision of transfer alignment in a distributed POS by 27.84%, which has been successfully applied to motion compensation of airborne interferometric synthetic aperture radar(InS AR). | Jianli LI Siyuan ZOU Bin GU Jiancheng FANG | 2019 | Science China(Information Sciences)2019，62，9： | 1 |
| 7 | LIANGHEKOU:Regeneration of an Ancient Tujia Village along the Salt Road显示文摘Profile:In the upcoming tourism development,Lianghekou Village will resume its commercial function during the period of Salt Road trading and become a gathering place for locals and tourists.Timber Loggia and Silankarp Workshop in Lianghe-kou village show that the self-adaptaility of traditional Tujia wooden construction techniques can be transmitted to meet modern needs in contemporary architectural design.This project was exhibited and themed'Lianghekou:A Tujia Vllage of Re-Living-Together'on the 17th International Architecture Exhibition-La Biennale di Venezia in 2021. | ZHANG Tong XU Han WANG Chuan MA Yumeng SUI Mingming CHEN Siyu YANG Chen RENG Ziqiu ZOU Yue LIN Siyuan | 2022 | Frontiers of Architectural Research2022，11，5： | 0 |
| 8 | Rationally designed Ti_(3)C_(2) MXene/CaIn_(2)S_(4) Schottky heterojunction for enhanced photocatalytic Cr(VI) reduction:Performance,influence factors and mechanism显示文摘As a highly toxic heavy metal,Cr(VI)reduction by developing high-efficiency photocatalysts is of great significance.Herein,we firstly design few-layer Ti_(3)C_(2) MXene(FTM)by the hand-operated shaking,show-ing dual advantages of structural stability and more exposed reactive sites.Then,a refluxed process is performed to fabricate FTM/CaIn_(2)S_(4)(FTC) composites,where 2D CaIn_(2)S_(4)(CIS) nanoplates are closely con-nected with 2D FTM to form Schottky junction.The optimal 1-FTC with the FTM/CIS mass ratio of 1 wt.%exhibits the highest activity toward photocatalytic Cr(VI)reduction under visible light.It is well eluci-dated that the broadened light absorption range and promoted charge carrier separation rate induced by the introduction of FTM are responsible for improving photocatalytic activity of CIS.During Cr(VI)photoreduction,1-FTC possesses excellent photo-stability and reusability.The effects of catalyst mass,co-existing ions,water sources and pH values on the Cr(VI)photoreduction efficiency are investigated.Pho-togenerated•O_(2)^(−)and e−are the main radical species accounting for Cr(VI)photoreduction over 1-FTC.The photocatalytic mechanism along with Cr(VI)removal pathway is exploited.This work may provide some insights into constructing FTM-based Schottky junctions for the efficient water purification. | Chao Liu Wen Xiao Xingyu Liu Qiang Wang Jiawei Hu Siyuan Zhang Jianguang Xu Qinfang Zhang Zhigang Zou | 2023 | Journal of Materials Science & Technology2023，，30： | 0 |
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