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| 1 | Rheumatic manifestations of inflammatory bowel disease显示文摘This article reviews the literature concerning rheu-matic manifestations of inflammatory bowel disease (IBD),including common immune-mediated pathways,frequency,clinical course and therapy. Musculoskel-etal complications are frequent and well-recognized manifestations in IBD,and affect up to 33% of pa-tients with IBD. The strong link between the bowel and the osteo-articular system is suggested by many clinical and experimental observations,notably in HLA-B27 transgenic rats. The autoimmune pathogenic mechanisms shared by IBD and spondyloarthropathies include genetic susceptibility to abnormal antigen pre-sentation,aberrant recognition of self,the presence of autoantibodies against specific antigens shared by the colon and other extra-colonic tissues,and increased intestinal permeability. The response against microor-ganisms may have an important role through molecular mimicry and other mechanisms. Rheumatic mani-festations of IBD have been divided into peripheral arthritis,and axial involvement,including sacroiliitis,with or without spondylitis,similar to idiopathic anky-losing spondylitis. Other periarticular features can oc-cur,including enthesopathy,tendonitis,clubbing,peri-ostitis,and granulomatous lesions of joints and bones.Osteoporosis and osteomalacia secondary to IBD and iatrogenic complications can also occur. The manage-ment of the rheumatic manifestations of IBD consists of physical therapy in combination with local injection of corticosteroids and nonsteroidal anti-inflammatory drugs; caution is in order however,because of their possible harmful effects on intestinal integrity,perme-ability,and even on gut inflammation. Sulfasalazine,methotrexate,azathioprine,cyclosporine and lefluno-mide should be used for selected indications. In some cases,tumor necrosis factor-α blocking agents should be considered as first-line therapy. | Tatiana Sofía Rodríguez-Reyna Cynthia Martínez-Reyes Jesús Kazúo Yamamoto-Furusho | 2009 | World Journal of Gastroenterology2009，15，44： | 11 |
| 2 | Dietary advanced glycation end-products aggravate non-alcoholic fatty liver disease显示文摘AIM To determine if manipulation of dietary advanced glycation end product(AGE), intake affects nonalcoholic fatty liver disease(NAFLD) progression and whether these effects are mediated via RAGE. METHODS Male C57Bl6 mice were fed a high fat, high fructose, high cholesterol(HFHC) diet for 33 wk and compared with animals on normal chow. A third group were given a HFHC diet that was high in AGEs. Another group was given a HFHC diet that was marinated in vinegar to prevent the formation of AGEs. In a second experiment, RAGE KO animals were fed a HFHC diet or a high AGE HFHC diet and compared with wildtype controls. Hepatic biochemistry, histology, picrosirius red morphometry and hepatic mR NA were determined. RESULTS Long-term consumption of the HFHC diet generated significant steatohepatitis and fibrosis after 33 wk. In this model, hepatic 4-hydroxynonenal content(a marker of chronic oxidative stress), hepatocyte ballooning, picrosirius red staining, α-smooth muscle actin and collagen type 1A gene expression were all significantly increased. Increasing the AGE content of the HFHC diet by baking further increased these markers of liver damage, but this was abrogated by pre-marination in acetic acid. In response to the HFHC diet, RAGE-/-animals developed NASH of similar severity to RAGE+/+ animals but were protected from the additional harmful effects of the high AGE containing diet. Studies in isolated Kupffer cells showed that AGEs increase cell proliferation and oxidative stress, providing a likely mechanism through which these compounds contribute to liver injury. CONCLUSION In the HFHC model of NAFLD, manipulation of dietary AGEs modulates liver injury, inflammation, and liver fibrosis via a RAGE dependent pathway. This suggests that pharmacological and dietary strategies targeting the AGE/RAGE pathway could slow the progression of NAFLD. | Christopher Leung Chandana B Herath Zhiyuan Jia Sof Andrikopoulos Bronwyn E Brown Michael J Davies Leni R Rivera John B Furness Josephine M Forbes Peter W Angus | 2016 | World Journal of Gastroenterology2016，22，35： | 7 |
| 3 | 德国北部挪威云杉林可持续经营中期计划的实例分析显示文摘可持续森林经营理论为中期林业计划和收获调整提供了丰富的模型选择,其不同的方法可应用于各种特定的场合和不同经营类型。本文简要回顾了传统的森林计划方法,一种称为“多林分发展”的概念可以用于任意的经营系统,这个概念把森林看作由一系列林分组成,在每一个林分中可以预先制定多种经营措施的选项,每种选项都可以通过木材或其它产品以及消耗的资源计算出一个目标值。这种简单的概念可以应用到大量的不同森林经营场合,它为森林经营者制定切实可行的森林措施和评价森林经营计划提供方法。在本研究中,以德国北部一片包括21个小班的挪威云杉林班的一个中期计划为例,说明“多林分发展”这一经营系统在实际生产中的应用。每个小班具有不同的初始状态,每个小班预设了若干经营选项,根据小班的初始状态、生长模型为各种选项计算各时期的木材产出。在林班的水平上,经营目标方程包括两个组成部分:净现值和均衡木材收获值。用模拟退火的方法来优化总体目标方程值。优化的总体解决方案在为每个小班选定合适的经营选项的同时,在全林的水平上获得最优的经济和均衡产出组合。 | 陈伯望 Klaus.von Gadow Frantiek Vilko Sofía Sánchez Orois | 2006 | 林业科学研究2006，19，5： | 4 |
| 4 | Real-Time PCR for Diagnosing Helicobacter pylori Infection in Patients with Upper Gastrointestinal Bleeding: Comparison with Other Classical Diagnostic Methods显示文摘 | Jesús Saez Sofía Belda Miguel Santibá?ez Juan Carlos Rodríguez Javier Sola-Vera Antonio Galiana Montserrat Ruiz-García Alicia Brotons Elena López-Girona Eva Girona Carlos Sillero Gloria Royo | 2012 | Journal of Clinical Microbiology2012，，10： | 2 |
| 5 | Transgenic trees and forestry biosafety显示文摘 | Sofía Valenzuela | 2006 | Electronic Journal of Biotechnology2006，9，3： | 1 |
| 6 | Polymerase chain reaction preparation of template for massively parallel pyrosequencing显示文摘 | Whetten RW Sofía VA Frampton J | | 0，，02： | 1 |
| 7 | Accounting, network complementarities and the development of inter-organisational relations 显示文摘 | Jan Mouritsen Sof Thrane | 2006 | Accounting Organizations and Society2006，31，： | 1 |
| 8 | Innovative path dependence: Making sense of product and service innovation in path dependent innovation processes显示文摘 | Sof Thrane Steen Blaabjerg Rasmus Hannemann M?ller | 2010 | Research Policy2010，，7： | 1 |
| 9 | Combinations of simple baseline variables accurately predict sustained virological response in patients with recurrent hepatitis C after liver transplantation显示文摘 | Gonzalo Crespo José A. Carrión Mairene Coto-Llerena Zoe Mari?o Sabela Lens Sofía Pérez-del-Pulgar Montserrat García-Retortillo Rosa Miquel Jaime Bosch Miquel Navasa Xavier Forns | 2013 | Journal of Gastroenterology2013，，6： | 1 |
| 10 | Real-Time PCR for Diagnosing Helicobacter pylori Infection in Patients with Upper Gastrointestinal Bleeding: Comparison with Other Classical Diagnostic Methods显示文摘 | Jesús Saez Sofía Belda Miguel Santibá?ez Juan Carlos Rodríguez Javier Sola-Vera Antonio Galiana Montserrat Ruiz-García Alicia Brotons Elena López-Girona Eva Girona Carlos Sillero Gloria Royo | 2012 | Journal of Clinical Microbiology2012，，10： | 1 |
| 11 | Results of laparoscopic radiofrequency ablation for HCC . Could the location of the tumour influence a complete response to treatment? A single European centre experience显示文摘 | Sofía Serna Ramón Vilana Santiago Sánchez‐Cabús David Calatayud Joana Ferrer Victor Molina Constantino Fondevila Jordi Bruix Josep Fuster Juan‐Carlos García‐Valdecasas | 2015 | HPB2015，，5： | 1 |
| 12 | Serum Lipid Responses to Weight Loss Differ between Overweight Adults with Familial Hypercholesterolemia and Those with Familial Combined Hyperlipidemia1-3显示文摘 | Mateo-Gallego Rocío Perez-Calahorra Sofía Cofán Montserrat Baila-Rueda Lucía Cenarro Ana Ros Emilio Puzo José Civeira Fernando | 2014 | The Journal of Nutrition2014，，8： | 1 |
| 13 | Use of phosphates in low sodium 显示文摘 | SOF()S N J | 1989 | Meal Science1989，26，17： | 1 |
| 14 | Imaging of hepatitis C virus infection in liver grafts after liver transplantation<!-- Doctopic: TAS -->显示文摘 | Laura Mensa Sofía Pérez-del-Pulgar Gonzalo Crespo George Koutsoudakis Carlos Fernández-Carrillo Mairene Coto-Llerena Rosa Miquel Helena Allende Lluís Castells Miquel Navasa Xavier Forns | 2013 | Journal of Hepatology2013，，2： | 1 |
| 15 | Evaluation of fungal endophytes for lignocellulolytic enzyme production and wood biodegradation显示文摘 | Rómulo Oses Sofía Valenzuela Juanita Freer | 2006 | International Biodeterioration & Biodegradation2006，57，： | 1 |
| 16 | Detection of extended-spectrum β-lactamases in clinical isolates of enterobacter cloacae and enterobacter aerogenes显示文摘 | Tzelepi E Giakkoupi P Sof ianou D | 2000 | J Clin Microbiol2000，38，： | 1 |
| 17 | Inno-vative Path Dependence:Making Sense of Product and Service Innovation in Path Dependent Innovation Processes显示文摘 | Sof Thrane Steen Blaabjerg Rasmus Hannemann M渍ller | | 0，，07： | 1 |
| 18 | Potential biocontrol agents for Fusarium head blight and deoxynivalenol production in wheat显示文摘 | Juan M. Palazzini Maria L. Ramirez Adriana M. Torres Sofía N. Chulze | 2007 | Crop Protection2007，，11： | 1 |
| 19 | Biological control by Trichoderma species of Fusarium solani causing peanut brown root rot under field conditions显示文摘 | Federico G. Rojo Maria M. Reynoso Marcela Ferez Sofía N. Chulze Adriana M. Torres | 2006 | Crop Protection2006，，4： | 1 |
| 20 | Our initial experience with ALPPS technique: encouraging results显示文摘 | Sofía Sala Victoria Ardiles Marina Ulla Fernando Alvarez Juan Pekolj Eduardo Santiba?es | 2012 | Updates in Surgery2012，，3： | 1 |
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