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| 1 | 体内腺相关病毒-常间回文重复序列丛集及其相关蛋白9介导的基因编辑可改善家族性高胆固醇血症的动脉粥样硬化显示文摘低密度脂蛋白受体(low-density lipoprotein receptor,Ldlr)基因突变是家族性高胆固醇血症的主要原因之一,可导致动脉粥样硬化,并具有很高的终生心血管病风险。常间回文重复序列丛集(clustered regularly interspaced short palindromic repeats,CRISPR)/CRISPR相关蛋白9(CRISPR-related protein 9,Cas9)系统是基因编辑纠正基因突变从而改善疾病的有效工具。该研究的目的是通过腺相关病毒(adeno-associated virus,AAV)携带的CRISPR/Cas9系统进行体内体细胞基因编辑,以确定其能否在小鼠模型中治疗由Ldlr突变体引起的家族性高胆固醇血症。 | 刘青(译) 叶鹏(审校) Zhao H Li Y He L Pu W Yu W Li Y Wu YT Xu C Wei Y Ding Q Song BL Huang H Zhou B | 2020 | 中华高血压杂志2020，28，3： | 22 |
| 2 | Analysis of the composition of the bacterial community in puffer fish Takifugu obscurus显示文摘 | Yang GM Bao BL Peatman E Li HR Huang LB Ren DM | 2007 | 中国生物学文摘2007，21，8： | 19 |
| 3 | Exploring an Integrative Therapy for Treating COVID-19:A Randomized Controlled Trial显示文摘Objectives:To develop a new Chinese medicine(CM)-based drug and to evaluate its safety and effect for suppressing acute respiratory distress syndrome(ARDS)in COVID-19 patients.Methods:A putative ARDS-suppressing drug Keguan-1 was first developed and then evaluated by a randomized,controlled two-arm trial.The two arms of the trial consist of a control therapy(alpha interferon inhalation,50(x g twice daily;and lopinavir/ritonavir,400 and 100 mg twice daily,respectively)and a testing therapy(control therapy plus Keguan-119.4 g twice daily)by random number table at 1:1 ratio with 24 cases each group.After 2-week treatment,adverse events,time to fever resolution,ARDS development,and lung injury on newly diagnosed COVID-19 patients were assessed.Results:An analysis of the data from the first 30 participants showed that the control arm and the testing arm did not exhibit any significant differences in terms of adverse events.Based on this result,the study was expanded to include a total of 48 participants(24 cases each arm).The results show that compared with the control arm,the testing arm exhibited a significant improvement in time to fever resolution(P=0.035),and a significant reduction in the development of ARDS(P=0.048).Conclusions:Keguan-1-based integrative therapy was safe and superior to the standard therapy in suppressing the development of ARDS in COVID-19 patients.(Trial registration No.NCT 04251871 at www.clinicaltrials.gov). | WANG Jia-bo WANG Zhong-xia JING Jing ZHAO Peng DONG Jing-hui ZHOU Yong-feng YANG Guang NIU Ming ZHAO Xu JIANG Tian-jun Bl Jing-feng XU Zhe ZHANG Ping WU Dan BAI Zhao-fang GUO Yu-ming YU Si-miao SUN Yong-qiang ZHANG Zi-teng ZHAN Xiao-yan LI Peng-yan DING Jin-biao ZHAO Peng-fei SONG Xue-ai TANG Jian-yuan HE Dong-chu CHEN Zhu QIN En-qiang WANG Rui-lin XIAO Xiao-he | 2020 | Chinese Journal of Integrative Medicine2020，26，9： | 18 |
| 4 | Nicotine attenuates beta-amyloid-induced neurotoxicity by regulating metal homeostasis.显示文摘 | Zhang J Liu Q Chen Q Liu NQ Li FL Lu ZB Qin C Zhu H Huang YY He W Zhao BL | 2006 | 中国生物学文摘2006，20，9： | 17 |
| 5 | Jiaotai Pill (交泰丸) Alleviates Insomnia through Regulating Monoamine and Organic Cation Transporters in Rats显示文摘Objective To reveal the effect and mechanism of Jiaotai Pill(交泰丸,JTP)on insomniac rats.Methods The insomniac model was established by intraperitoneal injection of p-chlorophenylalanine(PCPA).In behavioral experiments,rats were divided into control,insomniac model,JTP[3.3 g/(kg•d)],and diazepam[4 mg/(kg•d)]groups.The treatment effect of JTP was evaluated by weight measurement(increasement of body weight),open field test(number of crossings)and forced swimming test(immobility time).A high performance liquid chromatography-electrochemical detection(HPLC-ECD)method was built to determine the concentration of monoamine transmitters in hypothalamus and peripheral organs from normal,model,JTP,citalopram[30 mg/(kg•d)],maprotiline[40 mg/(kg•d)]and bupropion[40 mg/(kg•d)]groups.Expressions of serotonin transporter(SERT),dopamine transporter(DAT),and norepinephrine transporter(NET)were analyzed by quantitative polymerase chain reaction(qPCR)and Western blot in normal,model and JTP groups.A high performance liquid chromatography-electrospray ionization mass spectrometry(HPLC-ESI-MS/MS)method was established to determine the pharmacokinetics,urine cumulative excretion of metformin in vivo,and tissue slice uptake in vitro,which were applied to assess the activity of organic cation transporters(OCTs)in hypothalamus and peripheral organs.Results Compared with the insomniac model group,the body weight and spontaneous locomotor were increased,and the immobility time was decreased after treatment with JTP(P<0.01).Both serotonin and dopamine contents in hypothalamus and peripheral organs were increased(P<0.01).The norepinephrine content was increased in peripheral organs and decreased in hypothalamus(P<0.05 or P<0.01).At the same time,SERT,DAT,OCT1,OCT2,and OCT3 were down-regulated in hypothalamus and peripheral organs(P<0.05).NET was down-regulated in peripheral organs and up-regulated in hypothalamus(P<0.05 or P<0.01).Moreover,the activity of OCTs in hypothalamus and peripheral organs was inhibited(P<0.05).Conclusion JTP alleviates insomnia through regulation of monoaminergic system and OCTs in hypothalamus and peripheral organs. | LI Zhi-hui MA Peng-kai HUANG Yun-fang ZHANG Zhe ZHENG Wei CHEN Jian-hua GUO Chang-e CHEN Ning Bl Xin-ning ZHANG Yu-jie | 2021 | Chinese Journal of Integrative Medicine2021，27，3： | 3 |
| 6 | A Model for Liquid-Diffusion Catalytically Grown Fibrous Carbon Material显示文摘A mechanism for the catalytically growth of vapor grown fibrous carbon (VGFC) preparing from the floating catalyst method has been proposed, in which liquid diffusion-determined diffusionof carbon atoms through catalyst particles is described mathematically, and the physical andchemical properties of the catalyst particIes during the growth process are taken into account.From the model the growth rate and grown length of VGFC are calculated theoretically whichcoincides with the experimental datal and the necessity of reducing gas such as hydrogen inpreparing VGFC is explained as to reduce Fe3C, which acts as intermediate catalyst shown bythe model. Fe3C formed on the surface of γ-Fe will stop the growth of carbon fiber if they cannot be reduced at once. Additionally, the growth temperature and diameter of VGFC are alsodiscussed in the paper. | Zhang, WG Cheng, HM Su, G Fan, YY Li, F Shen, ZH Zhou, BL | 1999 | Journal of Materials Science & Technology1999，15，1： | 2 |
| 7 | Angiographic follow-up of cerebral aneurysms treated with Guglielmi detachable eoils:an analysis of 162 eases with 173 aneurysms显示文摘 | Li MH Gao BL Fang C | 2006 | AJNR2006，27，： | 1 |
| 8 | Prevention and management of intraprocedural rupture of intracranial aneurysm with detachable coils during embolization显示文摘 | Li MH Gao BL Fang C | 2006 | Neuroradiology2006，48，： | 1 |
| 9 | Delayed coil migration from a small wide-necked aneurysm after stent-assisted embolization: case report and literature review显示文摘 | Gao BL Li MH Wang YL | 2006 | Neuroradiology2006，48，5： | 1 |
| 10 | Regulation of MMP- 9 production by human corneal epithelial cells显示文摘 | Li DQ kokeshwar BL Solomon A | 2001 | Exp Eye Res2001，73，4： | 1 |
| 11 | Cultured human aortic smooth muscle cells (HASMC) exhibit a phosphoroamidon-sensitive endothelin converting enzyme activity显示文摘 | Batley BL Li XY Rapundalo ST | 1993 | FASEB J1993，7，： | 1 |
| 12 | Macrophage migration inhibitory factorcontributes angiogenesis by up-regulating IL-8 and correlates withpoor prognosis of patients with primary nasopharyngeal carcinoma显示文摘 | Liao B Zhong BL Li Z | 2010 | J Surg Oncol2010，102，7： | 1 |
| 13 | Epstein-Barr virus myo- carditis as a cause of sudden death: two autopsy cases显示文摘 | Ishikawa T Zhu BL Li DR | 2005 | Int J Legal Med2005，119，4： | 1 |
| 14 | A randomized controlled study compa-ring omeprazole and cimetidine for the prophylaxis of stress-relatedupper gastrointestinal bleeding in patients with intracerebral hemor-rhage显示文摘 | Liu BL Li B Zhang X | 2013 | Journal of Neurosurgery2013，118，1： | 1 |
| 15 | Intranasal dexmedetomidine following failed chloral hydrate sedation in children 显示文摘 | Li BL Yuan VM Song XR | 2014 | An- aesthesia2014，69，： | 1 |
| 16 | Adoptive regulatory T-eeU therapy protects against cerebral isehemia 显示文摘 | Li P Gan Y Sun BL | 2013 | Ann Neurol2013，74，3： | 1 |
| 17 | AGEs induce Alzheimer-like tau pathology and memory deficit via RAGE-mediated GSK-3 acti- vation显示文摘 | Li XH Lv BL Xie JZ | 2012 | Neurobiol Aging2012，33，7： | 1 |
| 18 | Angiographic follow-up of cerebral aneurysms treated with Guglielmi detachable coils: an analysis of 162 cases with 173 aneurysms 显示文摘 | Li MH Gao BL Fang C | 2006 | Am J Neuroradiol2006，27，5： | 1 |
| 19 | Overexpression of p21-activated klnase 1 promotes endometrial cancer progression 显示文摘 | Lu W Qu JJ Li BL | 2013 | Oncol Rep2013，29，4： | 1 |
| 20 | The origin of the naked grains of maize显示文摘 | Wang H Waglar TN Li BL Zhao Q Vigouroux Y Faller M Bomblies K Lukens L Doebley JF | | 0，，7051： | 1 |
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