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| 1 | Histones released by NETosis enhance the infectivity of SARS-CoV-2 by bridging the spike protein subunit 2 and sialic acid on host cells显示文摘Neutrophil extracellular traps(NETs)can capture and kill viruses,such as influenza viruses,human immunodeficiency virus(HIV),and respiratory syncytial virus(RSV),thus contributing to host defense.Contrary to our expectation,we show here that the histones released by NETosis enhance the infectivity of SARS-CoV-2,as found by using live SARS-CoV-2 and two pseudovirus systems as well as a mouse model.The histone H3 or H4 selectively binds to subunit 2 of the spike(S)protein,as shown by a biochemical binding assay,surface plasmon resonance and binding energy calculation as well as the construction of a mutant S protein by replacing four acidic amino acids.Sialic acid on the host cell surface is the key molecule to which histones bridge subunit 2 of the S protein.Moreover,histones enhance cell-cell fusion.Finally,treatment with an inhibitor of NETosis,histone H3 or H4,or sialic acid notably affected the levels of sgRNA copies and the number of apoptotic cells in a mouse model.These findings suggest that SARS-CoV-2 could hijack histones from neutrophil NETosis to promote its host cell attachment and entry process and may be important in exploring pathogenesis and possible strategies to develop new effective therapies for COVID-19. | Weiqi Hong Jingyun Yang Jun Zou Zhenfei Bi Cai He Hong Lei Xuemei He Xue Li Aqu Alu Wenyan Ren Zeng Wang Xiaohua Jiang Kunhong Zhong Guowen Jia Yun Yang Wenhai Yu Qing Huang Mengli Yang Yanan Zhou Yuan Zhao Dexuan Kuang Junbin Wang Haixuan Wang Siyuan Chen Min Luo Ziqi Zhang Tiangi Lu Li Chen Haiying Que Zhiyao He Qiu Sun Wei Wang Guobo Shen Guangwen Lu Zhiwei Zhao Li Yang Jinliang Yang Zhenling Wang Jiong Li Xiangrong Song Lunzhi Dai Chong Chen Jia Geng Maling Gou Lu Chen Haohao Dong Yong Peng Canhua Huang Zhiyong Qian Wei Cheng Changfa Fan Yuquan Wei Zhaoming Su Aiping Tong Shuaiyao Lu Xiaozhong Peng Xiawei Wei | 2022 | Cellular & Molecular Immunology2022，19，5： | 2 |
| 2 | Threshold of Soil pH for Occurrence of Tobacco Bacterial Wilt in Henan Province显示文摘[Objective]The paper was to study the relationship between spatial distribution characteristics of soil p H and bacterial wilt in tobacco-growing area in Henan Province.[Method]The 21 tobacco-growing fields infected by bacterial wilt and 91 tobacco-growing fields with no cases were selected from Henan Province,and the pH of fields was determined.[Result]Bacterial wilt mainly occurred in the tobacco-growing fields in Luoshan,Pingqiao,Queshan,Biyang,Suiping,and Xiping,and the soil pH mainly ranged from 5.5 to 6.5(accounted for 84.75%of total surveyed tobacco fields);bacterial wilt had not been found in tobacco-growing fields in Tanghe,Zhengyang,Shangcai,Sheqi,Wuyang and Chenqu,and the soil pH mainly ranged from 6.5 to 7.0(accounted for 81.25%of total surveyed tobacco fields).There were significant differences in soil pH between the fields with and without bacterial wilt,and soil pH 6.5 could be regarded as the threshold for the occurrence of tobacco bacterial wilt in Henan Province.There was extremely significantly positive linear correlation between soil p H and latitude(y=0.7375 x-17.799,R2=0.386,P<0.01).The geographical boundary of soil pH 6.5 was roughly 33°N,and bacterial wilt was less likely to occur in the north tobacco-growing areas of the boundary.[Conclusion]The study will provide a scientific basis for the prevention and control of tobacco bacterial wilt in Henan. | Haitao Wang Haohao Hao Xiaojing Xu Haitang Huang Xueli Song Lijun Yang | 2021 | Plant Diseases and Pests2021，12，2： | 1 |
| 3 | Contourletbased image adaptive watermarking显示文摘 | Song Haohao Yu Songyu Yang Xiaokang | 2008 | Signal Processing:Image Communication2008，23，3： | 1 |
| 4 | Fusion of multispectral and panchromatic satellite images based on contourlet transform and local average gradient 显示文摘 | Song Haohao Yu Songyu Song Li | 2007 | Optical Engineering(S0091-3286)2007，46，2： | 1 |
| 5 | Nanomaterials-Based Tumor Microenvironment Modulation for Magnifying Sonodynamic Therapy显示文摘CONSPECTUS:Sonodynamic therapy(SDT)is a noninvasive and more preferable therapeutic modality than photodynamic therapy(PDT)due to deeper tissue penetration,which utilizes sonosensitizers to produce reactive oxygen species(ROS)to kill tumor cells and arouse immune responses.However,it still suffers from low ROS production efficiency and insufficient systematic immune activation,which thus has attracted increasing attention and researchers to engage in this field. | Li Song Lu Lu Yinying Pu Haohao Yin Kun Zhang | 2022 | Accounts of Materials Research2022，3，9： | 0 |
| 6 | Spatio-temporal Variation of Water Heat Flux Using MODIS Land Surface Temperature Product over Hulun Lake,China During 2001–2018显示文摘Heat flux is important for studying interactions between atmosphere and lake.The heat exchange between air-water interfaces is one of the important ways to govern the temperature of the water surface.Heat exchange between the air-water interfaces and the surrounding environment is completed by solar radiation,conduction,and evaporation,and all these processes mainly occur at the air-water interface.Hulun Lake was the biggest lake which is also an important link and an indispensable part of the water cycle in Northeast China.This study mapped surface energy budget to better understand spatial and temporal variations in Hulun Lake in China from 2001 to 2018.Descriptive statistics were computed to build a historical time series of mean monthly heat flux at daytime and nighttime from June to September during 2001–2018.Remote sensing estimation methods we used was suitable for Hulun Lake(R2=0.81).At month scale,shortwave radiation and latent heat flux were decrease from June to September.However,the maximum sensible heat flux appeared in September.Net longwave radiation was the largest in August.The effective heat budget showed that Hulun Lake gained heat in the frost-free season with highest value in June(686.31 W/m2),and then steadily decreased to September(439.76 W/m2).At annual scale,net longwave radiation,sensible heat flux and latent heat flux all show significant growth trend from 2001 to 2018(P<0.01).Wind speed had the well correlation on sensible heat flux and latent heat flux.Water surface temperature showed the highest coefficient in sensitivity analysis. | ZHAO Boyu DU Jia SONG Kaishan Pierre-Andre JACINTHE XIANG Xiaoyun ZHOU Haohao YANG Zhichao ZHANG Liyan GUO Pingping | 2020 | Chinese Geographical Science2020，30，6： | 0 |
| 7 | Effects of solid friction modifier on friction and rolling contact fatigue damage of wheel-rail surfaces显示文摘In railway network,friction is an important factor to consider in terms of the service behaviors of wheel-rail system.The objective of this study was to investigate the effect of a solid friction modifier(FM)in a railway environment.This was achieved by studying the friction,wear,and rolling contact fatigue(RCF)damage on the wheel-rail materials at different slip ratios.The results showed that when a solid FM was applied,the friction coefficient decreased.After the solid FM was separated from the wheel-rail interface,the friction coefficient gradually increased to its original level.With the application of the solid FM,the wear rates of the wheel-rail decreased.In addition,the thickness and hardness of the plastic deformation layers of the wheel-rail materials were reduced.The worn surfaces of the wheel-rail were dominated by pits and RCF cracks.Without the FM,RCF cracks ranged from 84 to 120μm,and subsurface cracks were generated.However,with the FM,RCF cracks ranged from 17 to 97μm and no subsurface cracks were generated.These findings indicate possible methods of improving the performance of railway rolling stock by managing friction,and reducing wear and permanent RCF damage affecting both the wheels and rails. | Jingdong SONG Lubing SHI Haohao DING Radovan GALAS Milan OMASTA Wenjian WANG Jun GUO Qiyue LIU Martin HARTL | 2022 | Friction2022，10，4： | 0 |
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