|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 体内腺相关病毒-常间回文重复序列丛集及其相关蛋白9介导的基因编辑可改善家族性高胆固醇血症的动脉粥样硬化显示文摘低密度脂蛋白受体(low-density lipoprotein receptor,Ldlr)基因突变是家族性高胆固醇血症的主要原因之一,可导致动脉粥样硬化,并具有很高的终生心血管病风险。常间回文重复序列丛集(clustered regularly interspaced short palindromic repeats,CRISPR)/CRISPR相关蛋白9(CRISPR-related protein 9,Cas9)系统是基因编辑纠正基因突变从而改善疾病的有效工具。该研究的目的是通过腺相关病毒(adeno-associated virus,AAV)携带的CRISPR/Cas9系统进行体内体细胞基因编辑,以确定其能否在小鼠模型中治疗由Ldlr突变体引起的家族性高胆固醇血症。 | 刘青(译) 叶鹏(审校) Zhao H Li Y He L Pu W Yu W Li Y Wu YT Xu C Wei Y Ding Q Song BL Huang H Zhou B | 2020 | 中华高血压杂志2020，28，3： | 22 |
| 2 | 高血压患者血清磷酸盐与新发高尿酸血症风险的关系显示文摘血清磷酸盐与新发高尿酸血症的关系仍不确定。该研究对中国脑卒中一级预防试验(China stroke primary prevention trial,CSPPT)的尿酸亚组研究进行事后分析,旨在评估血清磷酸盐与新发高血尿酸症的风险之间的关系。研究包括基线尿酸水平正常(<357μmol/L)的参与者共10612人。主要观察指标是新发高血尿酸症,其定义为男性血尿酸浓度≥417或女性≥357μmol/L。在中位数为4.4年的随访期间,1663名(15.7%)参与者发生了新发高尿酸血症。 | 刘莉(译) 叶鹏(摘、审校) Cao J Zhang J Li Q Jiang C Song Y Liu C Liu L Wang B Li J Zhang Y Cui Y Huo Y Wang X Tang G Xu X Qin X | 2019 | 中华高血压杂志2019，27，6： | 2 |
| 3 | Terahertz Semiconductor Quantum Well Devices显示文摘For eventually providing terahertz science with compact and convenient devices,terahertz (1~10THz) quantum-well photodetectors and quantum-cascade lasers are investigated.The design and projected detector performance are presented together with experimental results for several test devices,all working at photon energies below and around optical phonons.Background limited infrared performance (BLIP) operations are observed for all samples (three in total),designed for different wavelengths.BLIP temperatures of 17,13,and 12K are achieved for peak detection frequencies of 9.7THz(31μm),5.4THz(56μm),and 3.2THz(93μm),respectively.A set of THz quantum-cascade lasers with identical device parameters except for doping concentration is studied.The δ-doping density for each period varies from 3.2×1010 to 4.8×1010cm-2.We observe that the lasing threshold current density increases monotonically with doping concentration.Moreover,the measurements for devices with different cavity lengths provide evidence that the free carrier absorption causes the waveguide loss also to increase monotonically.Interestingly the observed maximum lasing temperature is best at a doping density of 3.6×1010cm-2. | Liu H C Luo H Ban D Waichter M Song C Y Wasilewski Z R Buchanan M Aers G C SpringThorpe A J Cao J C Feng S L Williams B S Hu Q | 2006 | Journal of Semiconductors2006，27，4： | 2 |
| 4 | 人乳头瘤病毒16型E6通过下调NHERF1基因促进宫颈癌细胞迁移和侵袭显示文摘高危型人乳头瘤病毒(HPV)E6的PDZ结合基序(PBM)在宫颈癌的发生、发展中起重要作用。HPV16 E6通过其PBM区与Na+/H+交换器调节因子1(NHERF1)相互作用,并诱导NHERF1降解。NHERF1通过下调辅肌动蛋白α4(ACTN4)的表达来延缓细胞骨架的组装,从而抑制宫颈癌细胞在细胞和小鼠模型中的迁移和侵袭。HPV16 E6通过下调NHERF1的表达,提高了ACTN4水平,促进了肌动蛋白聚合,增强了宫颈癌细胞的迁移和侵袭能力。宫颈癌标本的基因集富集分析还表明,HPV16 E6与肌动蛋白细胞骨架组装显著相关,而HPV18 E6没有发现此种关联。HPV16 E6下调NHERF1基因促进细胞骨架组装和细胞侵袭,是宫颈癌发生发展的重要原因。 | Wang Q Song R Zhao C 高雯(编译) | 2020 | 中华预防医学杂志2020，54，1： | 2 |
| 5 | Performance improvement of pasted nickel electrodes with an addition of ball-milled nickel hydroxide powder显示文摘 | SONG Q CHILI C CHAN S | 2006 | Eleetroehim Aeta2006，51，： | 1 |
| 6 | Synthesis,characterization and antibacterial activity of quaternized N,O-(2-carboxyethyl) chitosan显示文摘 | CAI Z S SONG Z Q YANG C S | | 0，，： | 1 |
| 7 | 查看详情显示文摘 | Song C Xua J Wang Q B | | 0，，： | 1 |
| 8 | A new integrated genetic linkage map of the soybean显示文摘 | Song Q J Marek L F Shoemaker R C | 2004 | Theoretial and Applied Genetics2004，109，： | 1 |
| 9 | Genome shuffling of hansenula anomala to improve flavour formation of soy sauce 显示文摘 | Can X H Song Q Wang C L | 2012 | World Journal of Microbiology & Biotechnology2012，28，5： | 1 |
| 10 | Mesoporous silica-immobilized aluminum chloride as a new catalyst system for the isopropylation of naphthalene显示文摘 | Zhao X S Lu G Q Song C | 2001 | Chem Commun2001，22，： | 1 |
| 11 | Semi-supervised su&manifold diseriminant analysis显示文摘 | Song Y Q Niea F P Zhang C S | 2008 | Pattern Reeognition Letters2008，29，13： | 1 |
| 12 | A new integrated ge-netic linkage map of the soybean显示文摘 | Song Q J Marek L F Shoemaker R C | 2004 | Theoretical and Applied Ge-netics2004，109，： | 1 |
| 13 | Transient disturbance in a half space under thermo-elasticity with two relaxation times due to moving internal heat source international显示文摘 | SONG Y Q ZHANG Y C | 2003 | Journal of Thermo-physics2003，24，1： | 1 |
| 14 | Comparative analysesof the complete mitochondrial genomes of Ascarislumbricoides and Ascaris suum from humans and pigs显示文摘 | Liu G H Wu C Y Song H Q | 2012 | Gene2012，492，1： | 1 |
| 15 | Green biocomposites from wheat gluten and hydroxyethyl cellulose:processing and properties显示文摘 | Song Y Zheng Q Liu C | 2008 | Industrial Crops and Products2008，28，1： | 1 |
| 16 | Effect of the content of urea groups on the particle size in water-borne polyurethane or polyurethane/polyacrylate dispersions显示文摘 | Song C M Yuan Q L | 2004 | Journal Colloid & Polymer Science2004，282，6： | 1 |
| 17 | Small-signal model-based control strategy for balancing individual DC capacitor voltages in cascaded multilevel inverterbased STATCOM显示文摘 | Liu Y Huang A Q Song W C | | 0，，06： | 1 |
| 18 | Reflection and refraction of micropolar magneto-thermovisco- elastic waves at the inter- face between two micropolar viscoelastic media显示文摘 | Song Y Q Xu H Y Zhang Y C | 2006 | International Journal of Thermophysics2006，27，3： | 1 |
| 19 | Diamondoid hydrocarbons as a molecular proxy for thermal maturity and oil cracking: Geochemical models from hydrous pyrolysis显示文摘 | Wei Z B Moldowan J M Zhang S C Hill R Jarvie D M Wang H T Song F Q Fago F | 2007 | Org Geochem2007，38，2： | 1 |
| 20 | 查看详情显示文摘 | Yan L W Duan X R Ding X T Dong J Q Yang Q W Liu Y Zou X L Liu D Q Xuan W M Chen L Y Rao J Song X M Huang Y Mao W C Wang Q M Li Q Cao Z Li B Cao J Y Lei G J Zhang J H Li X D Chen W Cheng J Cui C H Cui Z Y Deng Z C Dong Y B Feng B B Gao Q D Han X Y Hong W Y | | 0，，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员