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| 1 | Differences in lithospheric structures between two sides of Taihang Mountain obtained from the Zhucheng-Yichuan deep seismic sounding profile显示文摘A 2-D model of lithospheric velocity structures in the southern part of the North China Craton was obtained using data from the Zhucheng-Yichuan deep seismic sounding profile.Results show that there are great differences in lithospheric structures between two sides of Taihang Mountain.In the eastern region,the lithosphere is thinner,with a thickness of about 70-80 km,while in the western region,the thickness is 85-120 km.There is a jump of the lithospheric thickness across Taihang Mountain gravity anomaly belt with a magnitude of about 30 km.P wave velocities of the lithospheric mantle and lower crust are lower in the eastern region and higher in the western region.In the eastern region,there are low velocity bodies in the middle and lower crust,while none were found in the western region.These differences indicate that the Taihang Mountain gravity anomaly belt is a belt with a abrupt change of lithospheric thickness and lithological composition.According to the Pm waveform,it can be deduced that the Moho in the eastern region is not a sharp discontinuity,but a complex transitional zone.From a preliminary analysis,it is found that the geothermal mechanical-chemical erosion could be the main mechanism causing the thinning and destruction of the lithosphere beneath the eastern side of Taihang Mountain.In addition,subduction of the Pacific Plate is an important factor which changes the properties of the lithospheric mantle of the North China Craton. | LI SongLin LAI XiaoLing LIU BaoFeng WANG ZhiSuo HE JiaYong SUN Yi | 2011 | Science China Earth Sciences2011，54，6： | 27 |
| 2 | Cloning and Characterization of miRNAs and Their Targets, Including a Novel miRNA-Targeted NBS-LRR Protein Class Gene in Apple (Golden Delicious)显示文摘MicroRNA (miRNA ) 在植物作为基因表示的一个重要管理者出现了。146 miRNAs 从苹果被识别(Malus domestica cv。金色美味) 由定序的生物信息的分析和 RNA 图书馆。从这些, 135 被保存, 11 是新奇 miRNAs。目标分析预言了新奇 miRNAs 之一, Md-miRLn11 (Malus domestica microRNA Ln11 ) ,指向了一个苹果核苷酸绑定地点(NBS ) 充满白氨酸的重复(LRR ) 班蛋白质编码基因(Md-NBS ) 。5 赛跑试金证实了 Md-miRLn11 的能力在 1112-nt 位置劈开 Md-NBS。Md-miRLn11 和 Md-NBS 的表示的分析在在 40 个苹果变化的最佳侵略时期期间证明在抵抗变化的 Md-NBS 基因的表示比在易受影响的变化高,与为 Md-miRLn11 的一个反的模式。从抵抗苹果变化 JiGuan 的幼苗被用来执行 Agrobacterium 渗入试金,然后与苹果叶点疾病接种。结果在 JiGuan 苹果显示出疾病抵抗的清楚的衰落。相反,与 Md-NBS 基因渗入的易受影响的变化富士在疾病抵抗显示出重要增加。基于上述结果,我们建议 Md-miRLn11 特别地在病原体感染的条件下面调整 Md-NBS 基因表示,并且指向 P 环地点的 Md-miRLn11 可以在木质的植物调整许多 NBSLRR 蛋白质类基因。 | Chao Ma You Lu Songlin Bai Wennan Zhang Xuwei Duan Dong Meng Zhigang Wang Aide Wang Zongshan Zhou Tianzhong Li | 2014 | Molecular Plant2014，7，1： | 19 |
| 3 | Lightweight Design of Automobile Drive Shaft Based on the Characteristics of Low Amplitude Load Strengthening显示文摘There are two kinds of internationally recognized approaches in terms of lightweight design.One is based on fatigue accumulated damage theory to achieve better reliability by optimal structural design;another is to use high performance lightweight materials.The former method takes very few considerations on the structural strengthening effects caused by the massive small loads in service.In order to ensure safety,the design is usually conservative,but the strength potential of the component is not fully exerted.In the latter method,cost is the biggest obstacle to lightweight materials in automotive applications.For the purpose of light weighting design on a fuel cell vehicle,the new design method is applied on drive shafts.The method is based on the low amplitude load strengthening characteristics of the material,and allows the stress,corresponding to test load,to enter into the strengthened range of the material.Under this condition,the light weighting design should assure that the reliability of the shaft is not impaired,even maximizes the strength potential of machine part in order to achieve the weight reduction and eventually to reduce the cost.At last,the feasibility of the design is verified by means of strength analysis and modal analysis based on the CAD model of light weighted shaft.The design applies to the load case of half shaft in independent axle,also provides technological reference for the structural lightweight design of vehicles and other machineries. | ZHENG Songlin XU Honghui FENG Jinzhi ZHENG Zuanxi WANG Youtao LU Leilei | 2011 | Chinese Journal of Mechanical Engineering2011，24，6： | 16 |
| 4 | Broadband achromatic metalens in terahertz regime显示文摘Achromatic focusing is essential for broadband operation, which has recently been realised from visible to infrared wavelengths using a metasurface. Similarly, multi-terahertz functional devices can be encoded in a desired metasurface phase profile. However, metalenses suffer from larger chromatic aberrations because of the intrinsic dispersion of each unit element. Here, we propose an achromatic metalens with C-shaped unit elements working from 0.3 to 0.8 THz with a bandwidth of approximately 91% over the centre frequency. The designed metalens possesses a high working efficiency of more than 68% at the peak and a relatively high numerical aperture of 0.385. We further demonstrate the robustness of our Cshaped metalens, considering lateral shape deformations and deviations in the etching depth. Our metalens design opens an avenue for future applications of terahertz meta-devices in spectroscopy, time-offlight tomography and hyperspectral imaging systems. | Qingqing Cheng Meilin Ma Dong Yu Zhixiong Shen Jingya Xie Juncheng Wang Nianxi Xu Hanming Guo Wei Hu Shuming Wang Tao Li Songlin Zhuang | 2019 | Science Bulletin2019，64，20： | 16 |
| 5 | Development of real-time laser-scanning system to detect tree canopy characteristics for variable-rate pesticide application显示文摘Improving pesticide application efficiency is increasingly important in orchard spraying.In this study,a laser-scanning system was designed to acquire gridding volumes of a tree to quantify the geometry characteristics of the tree canopy in real-time.A laser-scanning sensor mounted on a linear guide was utilized to measure the structure of a target tree canopy.A computer was used to receive measurement data from the laser scanner and obtain the movement distance of the laser-scanning sensor from a controller.An algorithm written with VC#program was designed to calculate gridding volumes of trees by recognizing valid measurement data from the laser scanner.Laboratory evaluations were conducted on three kinds of regular objects,and the maximum relative errors of section volumes of the cuboid,triangular prism and cylinder objects were 3.3%,7.9%and 9.4%,respectively,which illustrated that the algorithm could calculate the section volumes in different parts of the objects with high accuracy.A conifer tree and an apple tree were chosen to verify detecting accuracy of the laser-scanning system at variable speeds and grid sizes.The variation coefficients of total volumes for each kind of the tree were 0.078 and 0.041,respectively,which indicated that the laser-scanning system could be applied to provide the gridding volumes of different canopy densities in real-time with good reliability for guiding a variable-rate sprayer. | Cai Jichen Wang Xiu Song Jian Wang Songlin Yang Shuo Zhao Chunjiang | 2017 | International Journal of Agricultural and Biological Engineering2017，10，6： | 14 |
| 6 | Research and Practice of Blending Teaching Based on “MOOC + SPOC + Flipped Classroom” for Software Engineering显示文摘Based on 'MOOC + SPOC + Flipped Classroom', a particular blending teaching pattern adapting to MOOC teaching is proposed to strengthen software engineering students' abilities to study themselves and practice innovatively. Firstly, the process of MOOC development in China is introduced. The distinguishing feature and effect of MOOC teaching are analyzed, followed by the comparison with traditional class. The online Plus offline blending teaching pattern is the combination of online self-study on MOOC before class, seminar study of flipped classroom in class and the summary after class. With the demonstration of a typical case, a progressive strategy is given to implement blending teaching. Finally, the blending teaching pattern is assessed from multiple perspectives, of which both advantages and disadvantages are dissected. Through primary exploration, introducing online study and flipped classroom, blending teaching plays a positive role in software engineering teaching, which means traditional teaching pattern is changed. Meanwhile, students' innovative consciousness and practical ability are inspired. Nevertheless, new problems arise, so that intensive practice and improvement are necessary. | Ce Zhang Dianhui Chu Songlin Gu Xiaofei Xu Jianan Jiang Zheng Wang Hua Zhang | 2018 | 计算机教育2018，，12： | 14 |
| 7 | Anlotinib has good efficacy and low toxicity: a phase Ⅱ study of anlotinib in pre-treated HER-2 negative metastatic breast cancer显示文摘Objective:Anlotinib is a novel tyrosine kinase inhibitor blocking angiogenesis.This study was performed to assess the efficacy and safety of anlotinib in patients with metastatic breast cancer.Methods:Patients with HER2-negative breast cancer,who were pre-treated with anthracycline or taxanes in a neoadjuvant,adjuvant,or metastatic setting,and had treatment failure after at least one prior chemotherapy regimen in the metastatic setting were enrolled.Anlotinib was administered at 12 mg daily for 14 days in a 21-day cycle until disease progression or unacceptable toxicity occurred.Simultaneously,5–10 m L of venous blood was collected to perform circulating tumor DNA(ct DNA)testing every 2 treatment cycles.The primary endpoint was the objective response rate(ORR).Secondary endpoints included the disease control rate(DCR),progression-free survival(PFS),overall survival,safety,and biomarkers.Results:Twenty-six eligible patients were enrolled,with a median age of 56(30–75)years.The median follow-up time was 10.5 months.The ORR was 15.4%,the DCR was 80.8%,and the median PFS was 5.22 months(95%confidence interval 2.86–6.24).Fourteen(53.8%)patients survived for more than 10 months.The changes in the detectable ct DNA variant allele frequency were consistent with the tumor response.The most common treatment-related adverse events were hypertension(57.7%),thyroidstimulating hormone elevation(34.6%),and hand-foot syndrome(23.1%).Conclusion:Anlotinib showed objective efficacy with tolerable toxicity in heavily pre-treated,metastatic HER2-negative breast cancer.The dynamic changes in the ct DNA variant allele fraction may be predictive of the tumor response. | Nanlin Hu Yiran Si Jian Yue Tingting Sun Xue Wang Zhuqing Jia Songlin Gao Qiao Li Yang Shao Jiayu Wang Yang Luo Fei Ma Binghe Xu Peng Yuan | 2021 | Cancer Biology & Medicine2021，18，3： | 11 |
| 8 | Altered microRNA expression following sciatic nerve resection in dorsal root ganglia of rats显示文摘MicroRNAs (miRNAs ) 是否定地 post-transcriptionally 调整基因表示的小、非编码的 RNA (22 核苷酸) 的一个类,通过目标 mRNAs 的翻译抑制或降级的任何一个。我们揭开了在在在在在用 microarray 分析的老鼠的臀部的神经的切除术以后的 1, 4, 7,和 14 天的背面的根 ganglia (DRG ) 的 miRNAs 的表示的以前未知的改变。32 显著地, upregulated 和 18 downregulated miRNAs 在跟随臀部的神经损害的四个次点在 DRG 被识别。四的表示连续地 deregulated miRNAs,由即时 Taqman 聚合酶链反应分析了,与 microarray 数据一致(upregulated:miR-21, miR-221;downregulated:miR-500, miR-551b ) 。为这些 miRNAs 的潜在的目标,在臀部的神经切除术以后改变了,主要涉及细胞的进程的神经系统开发,多细胞的 organismal 开发,和规定。这研究在一只老鼠在臀部的神经的切除术以后在 DRG 表明了 miRNAs 的不同参与模型,和它可以也在说明为神经新生负责的分子的机制作出贡献。 | Bin Yu Songlin Zhou Tianmei Qian Yongjun Wang Fei Ding Xiaosong Gu | 2011 | Acta Biochimica et Biophysica Sinica2011，43，11： | 9 |
| 9 | Microstructure, porosity and mechanical properties of selective laser melted AlSi10Mg显示文摘Finite element modeling(FEM),microscopy,X-ray computed tomography(CT)and mechanical property tests were used to study the microstructure,porosity and mechanical properties of an AlSi10Mg alloy produced by selective laser melting(SLM).The simulation of the melt pool and thermal history under different energy densities produced an optimized result with an energy density of 44.5 J·mm-3.The high cooling rate during the SLM process significantly refined the previous a-Al dendrites.The growth direction of the network-like Al-Si eutectic structure at different orientations confirmed the anisotropic nature of the microstructure.Furthermore,the microhardness,tensile testing and fracture analysis results proved that there were no obvious distinctions in the strength between the transverse and longitudinal directions,and that the ductility was anisotropic,possibly due to the shape and distribution of the pores.The pores measured by X-ray CT at different energy densities confirmed that the sphericity of the pores was inversely related to pores volumes.With optimized processing conditions,the porosity of the selective laser melted sample decreased leading to the improved fabricated fuel system component via SLM. | Jing CHEN Wei HOU Xiuzhuan WANG Songlin CHU Zhiyi YANG | 2020 | Chinese Journal of Aeronautics2020，33，7： | 9 |
| 10 | Chinese Stroke Association guidelines for clinical management of cerebrovascular disorders: executive summary and 2019 update of clinical management of intracerebral haemorrhage显示文摘Aim This evidence-based guideline aims to present current and comprehensive recommendations for the diagnosis and management of spontaneous intracerebral haemorrhage(ICH).Methods A formal literature search was conducted on MEDLINE(1 January 1990 to 30 June 2019).Data were synthesised using evidence tables.The members of the working group met by teleconference to update and formulate data-based recommendations.The recommendations are graded according to levels of evidence grading algorithm of the Chinese Stroke Association.The guideline draft has been reviewed by Chinese Stroke Association Stroke Council Guideline Writing Committee.Results Evidence-based guideline is proposed for the management of patients with ICH.The focus of the guideline is divided into the diagnosis and aetiology of ICH,management of ICH in emergency department,surgical treatment for removal of hematoma,management of complications and prevention of secondary ICH.Conclusions This guideline provides a framework for ICH management.Early active and reasonable treatment may improve the clinical outcome of patients. | Yong Cao Songlin Yu Qian Zhang Tao Yu Yanfang Liu Zhenghui Sun Meng Zhao Wen Wang Ji Zong Zhao | 2020 | Stroke & Vascular Neurology2020，5，4： | 8 |
| 11 | Zircon Hf Isotopes and Geochemistry of the Early Paleoproterozoic High-Sr Low-Y Quartz-Diorite in the Quanji Massif,NW China:Crustal Growth and Tectonic Implications显示文摘The metamorphosed Early Paleoproterozoic granitoids in the Quanji massif,Northwestern China provide constraints for relationship between the Tarim Craton and North China Craton.Among granitoids batholiths,rocks of the Mohe quartz-diorite show typically adakitic geochemical characteristics,with medium K2O/Na2O ratios(0.56–1.17)and high Sr(519–619 ppm)low Y(9.37–20.40 ppm)and Yb(0.97–1.77 ppm)concentrations.The rocks haveεNd(t)values between+2.4and+4.4 and depleted mantle Nd model ages of 2.43–2.59 Ga.The magmatic zircons have positiveεHf(t)values ranging from+0.40 to+7.60 and depleted mantle Hf model ages of 2.43–2.70 Ga,with major peaks at^2.54 and^2.65 Ga.The geochemical and Nd-Hf isotopic characteristics indicate that the Mohe quartz-dioritic rocks might be formed by partial melting of high-pressure metamorphosed juvenile crustal rocks in post-orogenic extensional regime in the Early Paleoproterozoic.It suggests that important crustal growth occurred in the Quanji massif and the Tarim Craton at^2.4 and 2.5–2.7 Ga.The Quanji massif and Tarim Craton might share a similar crustal evolution history with the North China Craton in the Neoarchean. | Songlin Gong Nengsong Chen Hongyan Geng Min Sun Lu Zhang Qinyan Wang | 2014 | Journal of Earth Science2014，25，1： | 8 |
| 12 | Circular RNA circStag1 promotes bone regeneration by interacting with HuR显示文摘Postmenopausal osteoporosis is a common bone metabolic disorder characterized by deterioration of the bone microarchitecture,leading to an increased risk of fractures.Recently,circular RNAs(circ RNAs)have been demonstrated to play pivotal roles in regulating bone metabolism.However,the underlying functions of circ RNAs in bone metabolism in postmenopausal osteoporosis remain obscure.Here,we report that circ Stag1 is a critical osteoporosis-related circ RNA that shows significantly downregulated expression in osteoporotic bone marrow mesenchymal stem cells(BMSCs)and clinical bone tissue samples from patients with osteoporosis.Overexpression of circ Stag1 significantly promoted the osteogenic capability of BMSCs.Mechanistically,we found that circ Stag1 interacts with human antigen R(Hu R),an RNA-binding protein,and promotes the translocation of Hu R into the cytoplasm.A high cytoplasmic level of Hu R led to the activation of the Wnt signaling pathway by stabilizing and enhancing low-density lipoprotein receptor-related protein 5/6(Lrp5/6)andβ-catenin expression,thereby stimulating the osteogenic differentiation of BMSCs.Furthermore,overexpression of circ Stag1 in vivo by circ Stag1-loaded adeno-associated virus(circ Stag1-AAV)promoted new bone formation,thereby preventing bone loss in ovariectomized rats.Collectively,we show that circ Stag1 plays a pivotal role in promoting the regeneration of bone tissue via Hu R/Wnt signaling,which may provide new strategies to prevent bone metabolic disorders such as postmenopausal osteoporosis. | Gaoyang Chen Canling Long Shang Wang Zhenmin Wang Xin Chen Wanze Tang Xiaoqin He Zhiteng Bao Baoyu Tan Jin Zhao Yongheng Xie Zhizhong Li Dazhi Yang Guozhi Xiao Songlin Peng | 2022 | Bone Research2022，10，3： | 7 |
| 13 | Development and characterization of a cell line from the embryos of half smooth tongue sole (Cynoglossus semilaevis)显示文摘A new cell line,CSEC,has been successfully established from embryos at gastrula stage of a cultured marine fish,half smooth tongue sole(Cynoglossus semilaevis).CSEC cells grow actively and stably more than 50 passages for over 200 d in DMEM medium supplemented with 15% FBS(fetal bovine serum),2.5 ng/cm 3 bFGF(basic fibroblast growth factor),1 ng/cm 3 LIF(leukemia inhibitory factor) and 50 mmol/dm 3 2-ME(2-mecaptoethanol).The cells grew well in the temperature range of 24-30 ℃ and the optimal growth temperature was 24℃.FBS and bFGF concentrations are the two key components for CSEC cells proliferation.Chromosome analysis reveals that CSEC cells have a normal diploid karyotype with 2n=42t.The significant fluorescent signals were observed in CSEC after transfection with the GFP reporter gene,suggesting that the CSEC cell line can be used as a useful tool for transgenic and genetic manipulation studies.CSEC cells showed the cytopathic effect(CPE) after infection with lymphosystis disease virus(LCDV) in 2 d.Moreover,the LCDV particles can be observed in the cytoplasm of virus-infected cells by electron microscopy.It suggests that CSEC could be potentially used for the study of aquatic virus. | SHA Zhenxia REN Guocheng WANG Xianli WANG Na CHEN Songlin | 2010 | Acta Oceanologica Sinica2010，29，2： | 7 |
| 14 | Progress on design and related R&D activities for the water-cooled breeder blanket for CFETR显示文摘The water-cooled ceramic breeder (WCCB) blanket is one of the blanket candidates for Chinese fusion engineering testing reactor (CFETR) and is being developed at the Institute of Plasma Physics, Chinese Academy of Sciences (ASIPP). This paper reviews design and evolution of the WCCB blanket for CFETR, and presents a new WCCB blanket design according to the latest CFETR core parameters (major and minor radii are R = 7.2 m and a = 2.2 m, respectively) and missions. This new design is expected to satisfy multiple CFETR operation modes of 0.2, 0.5, 1.0, and 1.5 GW fusion power and achieve tritium self-sufficiency. The feasibility of the updated blanket design is evaluated from the aspects of neutronics and thermo-hydraulics. Furthermore, the research and development (R&D) activities supporting to the WCCB blanket for CFETR are reported, including the design code, the water loop experiments, the pebble bed modeling and experiments, and the components fabrication technology. | Songlin Liu Xiaoman Cheng Xuebin Ma Lei Chen Kecheng Jiang Xia Li Hui Bao Jichao Wang Wanjing Wang Changhong Peng Peng Lu Min Li Kai Huang | 2019 | Theoretical & Applied Mechanics Letters2019，9，3： | 6 |
| 15 | Adjuvant radiotherapy in central hepatocellular carcinoma after narrow-margin hepatectomy:A 10-year real-world evidence显示文摘Objective:A prospective randomized control study investigated the feasibility and efficacy of adjuvant radiotherapy on patients with central hepatocellular carcinoma(HCC)after narrow-margin hepatectomy(<1 cm).This study presents an updated 10-year real-world evidence to further characterize the role of adjuvant radiotherapy.Methods:Patients with central HCC after narrow-margin hepatectomy(<1 cm)were prospectively assigned to adjuvant radiotherapy group and control group.Patients'outcome,adverse events,long-term recurrence and survival rates were investigated.Results:The 1-,5-,and 10-year recurrence-free survival(RFS)rates were 81.0%,43.9%,and 38.7%,respectively in adjuvant radiotherapy group and 71.7%,35.8%,and 24.2%,respectively in control group(log-rank test,P=0.09).The 1-,5-,and 10-year overall survival(OS)rates were 96.6%,54.7%,and 42.8%,respectively in adjuvant radiotherapy group and 90.2%,55.1%,and 30.0%,respectively in control group(log-rank test,P=0.20).The 1-,5-,and 10-year RFS rates for patients with small HCC(≤5 cm)were 91.1%,51.6%,and 48.4%,respectively in adjuvant radiotherapy group and 80.0%,36.6%,and 26.6%,respectively in control group(log-rank test,P=0.03).Landmark analysis demonstrated that patients with small HCC in adjuvant radiotherapy group had a significantly improved OS in second five years after treatment in comparison to patients in control group(log-rank test,P=0.05).Conclusions:Our updated results showed a sustained clinical benefit on reducing recurrence,improving longterm survival for small central HCC by adjuvant radiotherapy after narrow-margin hepatectomy.Long-term survival data also indicated that hepatectomy is an optimal treatment for selected patients with central HCC. | Weiqi Rong Weibo Yu Liming Wang Fan Wu Kai Zhang Bo Chen Chengli Miao Liguo Liu Songlin An Changcheng Tao Weihu Wang Jianxiong Wu | 2020 | Chinese Journal of Cancer Research2020，32，5： | 6 |
| 16 | Effect of reinforcing kidney-essence, removing phlegm, and promoting mental therapy on treating Alzheimer's disease显示文摘OBJECTIVE: To explore the mechanism of reinforcing kidney-essence, removing phlegm, and promoting mental therapy in treating Alzheimer's disease (AD). METHODS: Sixty patients with AD in Wuhan No.1 Hospital of Traditional Chinese Medicine for Geriatrics from May 2009 to April 2011 were randomly divided into two groups, with 30 in each group. Patients in Bushenhuatanyizhi group (BHY group) took BHY instant granules (6 g, twice per day). Patients in the control group took piracetam (0.8 g, 3 times per day). There were twelve weeks in a course. Changes in the mini-mental state examination (MMSE) score and Activity of Daily Living Scale (ADL) score were analyzed before and after treatment. RESULTS: MMSE scores in the two groups in-creased and ADL scores decreased after treatment, compared with those before treatment (both P< 0.05).The total effective rate was 86.67% in the BHY group (10 very effective, 13 effective, 7 non-responsive). The control group was 57.69% (5 very effective, 16 effective, 9 non-responsive) (P<0.05). Superoxide dismutase levels were increased, lipid peroxide and triglyceride levels decreased after treatment in the BHY group as compared with the control group. CONCLUSION: Reinforcing kidney-essence, removing phlegm, and promoting mental therapy can improve cognitive function and daily life of AD patients. The mechanism of the therapy might be related to improving blood fat, scavenging free radicals, and inhibiting lipid peroxides. | Ping Liu Mingwang Kong Songlin Liu Gang Chen Ping Wang | 2013 | Journal of Traditional Chinese Medicine2013，33，4： | 5 |
| 17 | Comparative Proteomic Analysis of Arabidopsis Mature Pollen and Germinated Pollen显示文摘Proteomic analysis was applied to generating the map of Arabidopsis mature pollen proteins and analyzing the differentially expressed proteins that are potentially involved in the regulation of Arabidopsis pollen germination.By applying 2-D electrophoresis and silver staining,we resolved 499 and 494 protein spots from protein samples extracted from pollen grains and pollen tubes,respectively.Using the matrix-assisted laser desorption ionization time-of-flight mass spectrometry method,we identified 189 distinct proteins from 213 protein spots expressed in mature pollen or pollen tubes,and 75 new identified proteins that had not been reported before in research into the Arabidopsis pollen proteome.Comparative analysis revealed that 40 protein spots exhibit reproducible significant changes between mature pollen and pollen tubes.And 21 proteins from 17 downregulated and six upregulated protein spots were identified.Functional category analysis indicated that these differentially expressed proteins mainly involved in signaling,cellular structure,transport,defense/stress responses,transcription,metabolism,and energy production.The patterns of changes at protein level suggested the important roles for energy metabolism-related proteins in pollen tube growth,accompanied by the activation of the stress response pathway and modifications to the cell wall. | Junjie Zou Lianfen Song Wenzheng Zhang Yi Wang Songlin Ruan Wei-Hua Wu | 2009 | Journal of Integrative Plant Biology2009，51，5： | 5 |
| 18 | Mandible exosomal ssc-mir-133b regulates tooth development in miniature swine via endogenous apoptosis显示文摘Signal transduction between different organs is crucial in the normal development of the human body. As an important medium for signal communication, exosomes can transfer important information, such as microRNAs(miRNAs), from donors to receptors.MiRNAs are known to fine-tune a variety of biological processes, including maxillofacial development; however, the underlying mechanism remains largely unknown. In the present study, transient apoptosis was found to be due to the expression of a miniature swine maxillofacial-specific miRNA, ssc-mir-133b. Upregulation of ssc-mir-133b resulted in robust apoptosis in primary dental mesenchymal cells in the maxillofacial region. Cell leukemia myeloid 1(Mcl-1) was verified as the functional target, which triggered further downstream activation of endogenous mitochondria-related apoptotic processes during tooth development.More importantly, mandible exosomes were responsible for the initial apoptosis signal. An animal study demonstrated that ectopic expression of ssc-mir-133 b resulted in failed tooth formation after 12 weeks of subcutaneous transplantation in nude mice. The tooth germ developed abnormally without the indispensable exosomal signals from the mandible. | Ye Li Xinxin Wang Jiali Ren Xiaoshan Wu Guoqing Li Zhipeng Fan Chunmei Zhang Ang Li Songlin Wang | 2018 | Bone Research2018，6，4： | 5 |
| 19 | Facile fabrication of MoP nanodots embedded in porous carbon as excellent anode material for potassium-ion batteries显示文摘Molybdenum phosphide(MoP),owing to its abundant reserve and high theoretical capacity,is regarded as a promising anode material for potassium-ion batteries.However,it still suffers from the problems of acute volume expansion and weak diffusion kinetics.This study reports a simple method to synthesize a composite of molybdenum phosphide and porous carbon(MoP@PC)through simple mixing and annealing treatment.In the MoP@PC,lots of MoP nanodots with an average diameter of about 4 nm uniformly embedded in the petal-like porous carbon.The MoP@PC shows reversible capacities of 330 mAh g^(-1) at100 mA g^(-1) after 100 cycles,and ultra-long cycling stability with a capacity of 240 mAh g^(-1) after 1000 cycles at 1 A g^(-1) and 161 mAh g^(-1) after 1000 cycles at 5 A g^(-1).The structure of MoP@PC after charging-discharging cycles is also investigated by high resolution transmission electron microscope(HRTEM)and the result shows that MoP can still maintain the nanodot morphology without any agglomeration after 1000 cycles at 5 A g^(-1).The storage mechanism of potassium ions was studied as well,which reveals that MoP and potassium ion have a conversion reaction. | Zhanheng Yan Zhongyuan Huang Haihui Zhou Xinxin Yang Songlin Li Wenlong Zhang Fei Wang Yafei Kuang | 2021 | Journal of Energy Chemistry2021，30，3： | 5 |
| 20 | Inorganic nitrate alleviates the senescence-related decline in liver function显示文摘Senescence-related decline in liver function is a common complication in the elderly that can lead to impaired health in older individuals.Dietary nitrate supplements have physiological and therapeutic effects on organ function by nitrate(NO_3^-)-nitrite(NO_2^-)-nitric oxide(NO)pathway.However,the role of dietary nitrate on the senescence-related decline in liver function is unclear.The findings of the present study showed that nitrate levels in the serum and liver decreased,whereas the levels of alanine aminotransferase(ALT)and aspartate aminotransferase(AST)in serum increased in ageing mice.Consistently,cell senescence,decreased glycogen levels and increased lipid deposition were found in the liver of aged mice,both glucokinase(GCK)and phosphoenolpyruvate carboxykinase(PCK)were down-regulated(n=10).Daily nitrate intake(0.5 mmol L^(-1))restored nitrate levels,decreased ALT and AST levels,and prevented cell senescence and structural and glucose and lipid metabolism degeneration in liver tissue both in D-galactose(D-gal)-induced ageing mice(n=10)and in natural aged mice(n=10).In conclusion,the present study demonstrated that the reduction of nitrate levels was correlated with liver degeneration in ageing individuals and that dietary supplement of nitrate could restore the nitrate levels in serum and the liver and prevent ageing-related liver degeneration. | Haifeng Wang Lei Hu Le Li Xiaoshan Wu Zhipeng Fan Chunmei Zhang Jinsong Wang Jidong Jia Songlin Wang | 2018 | Science China(Life Sciences)2018，61，1： | 5 |
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