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| 1 | Pancreatic cancer: A review of clinical diagnosis, epidemiology, treatment and outcomes显示文摘This review aims to outline the most up-to-date knowledge of pancreatic adenocarcinoma risk, diagnostics, treatment and outcomes, while identifying gaps that aim to stimulate further research in this understudied malignancy. Pancreatic adenocarcinoma is a lethal condition with a rising incidence, predicted to become the second leading cause of cancer death in some regions. It often presents at an advanced stage, which contributes to poor five-year survival rates of 2%-9%, ranking firmly last amongst all cancer sites in terms of prognostic outcomes for patients. Better understanding of the risk factors and symptoms associated with this disease is essential to inform both health professionals and the general population of potential preventive and/or early detection measures. The identification of high-risk patients who could benefit from screening to detect pre-malignant conditions such as pancreatic intraepithelial neoplasia, intraductal papillary mucinous neoplasms and mucinous cystic neoplasms is urgently required, however an acceptable screening test has yet to be identified. The management of pancreatic adenocarcinoma is evolving, with the introduction of new surgical techniques and medical therapies such as laparoscopic techniques and neo-adjuvant chemoradiotherapy, however this has only led to modest improvements in outcomes. The identification of novel biomarkers is desirable to move towards a precision medicine era, where pancreatic cancer therapy can be tailored to the individual patient, while unnecessary treatments that have negative consequences on quality of life could be prevented for others. Research efforts must also focus on the development of new agents and delivery systems. Overall, considerable progress is required to reduce the burden associated with pancreatic cancer. Recent, renewed efforts to fund large consortia and research into pancreatic adenocarcinoma are welcomed, but further streams will be necessary to facilitate the momentum needed to bring breakthroughs seen for other cancer sites. | Andrew McGuigan Paul Kelly Richard C Turkington Claire Jones Helen G Coleman R Stephen McCain | 2018 | World Journal of Gastroenterology2018，24，43： | 140 |
| 2 | Cancer-related inflammation and treatment effectiveness显示文摘 | Connie I Diakos Kellie A Charles Donald C McMillan Stephen J Clarke | 2014 | Lancet Oncology2014，，： | 3 |
| 3 | Th1 cytokines promote T-cell binding to antigen-presenting cells via enhanced hyaluronan production and accumulation at the immune synapse显示文摘Hyaluronan(HA)production by dendritic cells(DCs)is known to promote antigen presentation and to augment T-cell activation and proliferation.We hypothesized that pericellular HA can function as intercellular‘glue’directly mediating T cell–DC binding.Using primary human cells,we observed HA-dependent binding between T cells and DCs,which was abrogated upon pre-treatment of the DCs with 4-methylumbelliferone(4-MU),an agent which blocks HA synthesis.Furthermore,T cells regulate HA production by DCs via T cell-derived cytokines in a T helper(Th)subset-specific manner,as demonstrated by the observation that cell-culture supernatants from Th1 but not Th2 clones promote HA production.Similar effects were seen upon the addition of exogenous Th1 cytokines,IL-2,interferon c(IFN-c)and tumor necrosis factor a(TNF-a).The critical factors which determined the extent of DC–T cell binding in this system were the nature of the pre-treatment the DCs received and their capacity to synthesize HA,as T-cell clones which were pre-treated with monensin,added to block cytokine secretion,bound equivalently irrespective of their Th subset.These data support the existence of a feedforward loop wherein T-cell cytokines influence DC production of HA,which in turn affects the extent of DC–T cell binding.We also document the presence of focal deposits of HA at the immune synapse between T-cells and APC and on dendritic processes thought to be important in antigen presentation.These data point to a pivotal role for HA in DC–T cell interactions at the IS. | Paul L Bollyky Stephen P Evanko Rebecca P Wu Susan Potter-Perigo S Alice Long Brian Kinsella Helena Reijonen Kelly Guebtner Brandon Teng Christina K Chan Kathy R Braun John A Gebe Gerald T Nepom Thomas N Wight | 2010 | Cellular & Molecular Immunology2010，7，3： | 3 |
| 4 | Umbilical Herniorrhapy in Cirrhosis: Improved Outcomes with Elective Repair显示文摘 | Stephen H. Gray Catherine C. Vick Laura A. Graham Kelly R. Finan Leigh A. Neumayer Mary T. Hawn | 2008 | Journal of Gastrointestinal Surgery2008，，4： | 2 |
| 5 | High frequency hearing loss correlated with mutations in the GJB2 gene显示文摘 | Stephen A Wilcox Kerryn Saunders Amelia H Osborn Angela Arnold Julia Wunderlich Therese Kelly Veronica Collins Leah J Wilcox RJ McKinlay Gardner Maria Kamarinos Barbara Cone-Wesson Robert Williamson Hans-Henrik M. Dahl | 2000 | Human Genetics2000，，4： | 1 |
| 6 | Mechanical property measurements of MEMS devices显示文摘 | Stephens L S Kelly K W Simhadri S | 2001 | Micro electro Mechanical Systems2001，10，3： | 1 |
| 7 | Ceramics in dentistry:Historical roots and current perspectives显示文摘 | Kelly J R Nishimura I Stephen D | 1996 | J Prosthet Dent1996，75，1： | 1 |
| 8 | Life cycle assessment of biochar systems:estimating the energetic,economic and climate change potential显示文摘 | Roberts Kelli G Gloy Brent A Joseph Stephen | 2010 | Environmental Science&Technology2010，44，2： | 1 |
| 9 | Observation of superdeformed bands in194Hg显示文摘 | C. W. Beausang E. A. Henry J. A. Becker N. Roy S. W. Yates M. A. Deleplanque R. M. Diamond F. S. Stephens J. E. Draper W. H. Kelly J. Burde R. J. McDonald E. Rubel M. J. Brinkman J. A. Cizewski Y. A. Akovali | 1990 | Zeitschrift für Physik A Atomic Nuclei1990，，3： | 1 |
| 10 | Mesenchymal Stem Cells: Isolation, Characterisation and In Vivo Fluorescent Dye Tracking显示文摘 | Christopher Weir Marie-Christine Morel-Kopp Anthony Gill Kellie Tinworth Leigh Ladd Stephen N. Hunyor Christopher Ward | 2008 | Heart, Lung and Circulation2008，，5： | 1 |
| 11 | pharmacological outcomes in older people with newly diagnosed epilepsy 显示文摘 | Stephen LJ Kelly K Mohanraj R | 2006 | Epilepsy Behav2006，8，2： | 1 |
| 12 | Pharmaco-logical outcomes in older people with newly diagnosedepilepsy 显示文摘 | Stephen LJ Kelly K Mohanraj R | 2006 | Epilepsy Behav2006，8，： | 1 |
| 13 | Mechanical properties evalution and failure analysis of cantilevered LIGA nickel microposts显示文摘 | Stephens L S Kelly K W Simhadri S | 2001 | J Microelectromechanical Systems2001，10，3： | 1 |
| 14 | Purification and characterization of a highly thermostable glucose isomerase produced by the extreme Thermophilic eu- bacterium, Thermotoga maritima 显示文摘 | Stephen H Brown Carsten Sjoholm Robert M Kelly | 1993 | Biotechnology and Bioengineering1993，41，： | 1 |
| 15 | Exploring the perceived influence of safety management practices on project performance in the construction industry显示文摘 | Eddie W.L. Cheng Neal Ryan Stephen Kelly | 2011 | Safety Science2011，，2： | 1 |
| 16 | Spontaneous pneumomediastinum (Hamman’s syndrome)显示文摘 | Steven Kelly Stephanie Hughes Stephen Nixon Simon Paterson-Brown | 2009 | The Surgeon2009，，2： | 1 |
| 17 | Levetiracetam for people with mental retardation and refractory epilepsy显示文摘 | Kelly K Stephen LJ Brodie MJ | 2004 | Epilepsy Behavior2004，6，： | 1 |
| 18 | High frequency hearing loss correlated with mutations in the GJB2 gene显示文摘 | Stephen A Wilcox Kerryn Saunders Amelia H Osborn Angela Arnold Julia Wunderlich Therese Kelly Veronica Collins Leah J Wilcox RJ McKinlay Gardner Maria Kamarinos Barbara Cone-Wesson Robert Williamson Hans-Henrik M. Dahl | 2000 | Human Genetics2000，，4： | 1 |
| 19 | Two-phase seed dispersal: linking the effects of frugivorous birds and seed-caching rodents显示文摘 | Stephen B. Vander Wall Kellie M. Kuhn Jennifer R. Gworek | 2005 | Oecologia2005，，2： | 1 |
| 20 | Silicon imidonitride aerogel exhibiting macro-and meso-dual porosity 显示文摘 | Vincent Rocher Kelly Stephen M Hector Andrew L | 2012 | Microporous and Mesoporous Materials2012，156，： | 1 |
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