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| 1 | Mitochondria-targeting drug conjugates for cytotoxic, anti-oxidizing and sensing purposes:current strategies and future perspectives显示文摘mitochondrial-targeting moieties to anticancer drugs, antioxidants and sensor molecules. Among them, the most widely applied mitochondrial targeting moiety is triphenylphosphonium(TPP), which is a delocalized cationic lipid that readily accumulates and penetrates through the mitochondrial membrane due to the highly negative mitochondrial membrane potential. Other moieties, including short peptides,dequalinium, guanidine, rhodamine, and F16, are also known to be promising mitochondrial targeting agents. Direct conjugation of mitochondrial targeting moieties to anticancer drugs, antioxidants and sensors results in increased cytotoxicity, anti-oxidizing activity and sensing activity, respectively,compared with their non-targeting counterparts, especially in drug-resistant cells. Although many mitochondria-targeted anticancer drug conjugates have been investigated in vitro and in vivo, further clinical studies are still needed. On the other hand, several mitochondria-targeting antioxidants have been analyzed in clinical phases I, II and III trials, and one conjugate has been approved for treating eye disease in Russia. There are numerous ongoing studies of mitochondria-targeted sensors. | Gantumur Battogtokh Yeon Su Choi Dong Seop Kang Sang Jun Park Min Suk Shim Kang Moo Huh Yong-Yeon Cho Joo Young Lee Hye Suk Lee Han Chang Kang | 2018 | Acta Pharmaceutica Sinica B2018，8，6： | 17 |
| 2 | Safety of endoscopic ultrasound-guided ethanol ablation for pancreatic cystic lesions: A single-center experience of 214 patients显示文摘Background:Endoscopic ultrasound-guided ethanol ablation(EUS-EA)for pancreatic cystic lesions(PCLs)has been used in recent years as a feasible treatment modality for low malignant probability PCLs or patients considered high-risk for surgery.The present study aimed to confirm the safety of EUS-EA and to find predictive factors for adverse event(AE).Methods:A retrospective review was performed from the prospectively maintained database of patients who underwent EUS-EA for PCLs from June 2006 to April 2018 at Seoul National University Hospital.The primary outcomes of the study were the rates of AEs and severe AEs by EUS-EA.The secondary outcome was the predictive factors of AEs including acute pancreatitis and abdominal pain.Results:A total of 214 patients were evaluated and the diagnoses of PCLs according to cystic fluid analysis and clinical features were as follows:serous cystic neoplasm(32.2%),mucinous cystic neoplasm(26.6%),branch duct type intraductal papillary mucinous neoplasm(BD-IPMN)(29.4%),and pseudocyst(11.7%).Three patients(1.4%)experienced severe AEs.Overall,AEs occurred in 71(33.2%)patients.BD-IPMN(OR:2.87;95%CI:1.05–7.84;P=0.040),multilocular cysts(OR:3.59;95%CI:1.09–11.85;P=0.036),suspected ethanol leakage during procedure(OR:10.68;95%CI:1.98–57.53;P=0.006),and sticky cystic fluid(OR:3.83;95%CI:1.20–12.24;P=0.024)were predictive factors for post-procedural acute pancreatitis.PCLs of uncinate process(OR:2.99;95%CI:1.22–7.35;P=0.017)and PCLs with exophytic portion(OR:3.70;95%CI:1.96–7.01;P<0.001)were predictive factors for post-procedural abdominal pain.Conclusions:EUS-EA is a safe procedure with a very low rate of severe AEs.It seems possible to predict the AEs according to the features of the procedure and PCLs. | Jin Ho Choi Sang Hyub Lee Young Hoon Choi Min Su You Bang-Sup Shin Woo Hyun Paik Ji Kon Ryu Yong-Tae Kim | 2019 | Hepatobiliary & Pancreatic Diseases International2019，18，6： | 6 |
| 3 | Double layered self-expanding metal stents for malignant esophageal obstruction, especially across the gastroesophageal junction显示文摘AIM: To evaluate the clinical outcomes of double-layered self-expanding metal stents (SEMS) for treatment of malignant esophageal obstruction according to whether SEMS crosses the gastroesophageal junction (GEJ). METHODS: Forty eight patients who underwent the SEMS insertion for malignant esophageal obstruction were enrolled. Patients were classified as GEJ group (SEMS across GEJ, 18 patients) and non-GEJ group (SEMS above GEJ, 30 patients) according to SEMS position. Double layered (outer uncovered and inner covered stent) esophageal stents were placed. RESULTS: The SEMS insertion and the clinical improvement were achieved in all patients in both groups. Stent malfunction occurred in seven patients in the GEJ group and nine patients in the non-GEJ group. Tumor overgrowth occurred in five and eight patients, respectively, food impaction occurred in one patient in each group, and stent migration occurred in one and no patient, respectively. There were no significant differences between the two groups. Reflux esophagitis occurred more frequently in the GEJ group (eight vs five patients, P = 0.036) and was controlled by proton pump inhibitor. Aspiration pneumonia occurred in zero and five patients, respectively, and tracheoesophageal fistula occurred in zero and two patients, respectively. CONCLUSION: Double-layered SEMS are a feasible and effective treatment when placed across the GEJ for malignant esophageal obstruction. Double-layered SEMS provide acceptable complications, especially migration, although reflux esophagitis is more common in the GEJ group. | Min Dae Kim Su Bum Park Dae Hwan Kang Jae Hyung Lee Cheol Woong Choi Hyung Wook Kim Chung Uk Chung Young Il Jeong | 2012 | World Journal of Gastroenterology2012，18，28： | 5 |
| 4 | Shape-controlled Pt nanocubes directly grown on carbon supports and their electrocatalytic activity toward methanol oxidation显示文摘Synthesis of shape-controlled Pt nanocrystals is substantial and important for enhancing chemical and electrochemical reactions.However,the removal of capping agents,shape-controlling chemicals,on Pt surfaces is essential prior to conducting the catalytic reactions.Here we report a facile one-pot synthesis of Pt nanocubes directly grown on carbon supports(Pt nanocubes/C) with modulating the kinetic reaction factors for shaping the nanocrystals,but without adding any capping agents for preserving the clean Pt surfaces.Well-dispersed Pt nanocubes/C shows enhanced activity and long-term stability toward methanol oxidation reaction compared to the commercial Pt/C catalyst. | Hee Jin Kim Bibi Ruqia Mi Sung Kang Su Bin Lim Ran Choi Ki Min Nam Won Seok Seo Gaehang Lee Sang-Il Choi | 2017 | Science Bulletin2017，62，13： | 5 |
| 5 | Inverse correlation between gastroesophageal reflux disease and atrophic gastritis assessed by endoscopy and serology显示文摘BACKGROUND Helicobacter pylori(H.pylori)infection is known to prevent the occurrence of gastroesophageal reflux disease(GERD)by inducing gastric mucosal atrophy.However,little is known about the relationship between atrophic gastritis(AG)and GERD.AIM To confirm the inverse correlation between AG and the occurrence and severity of GERD.METHODS Individuals receiving health checkups who underwent upper gastrointestinal endoscopy at Seoul National University Healthcare System Gangnam Center were included.The grade of reflux esophagitis was evaluated according to the Los Angeles classification.Endoscopic AG(EAG)was categorized into six grades.Serologic AG(SAG)was defined as pepsinogen I≤70 ng/m L and pepsinogen I/II ratio≤3.0.The association between the extent of EAG and SAG and the occurrence and severity of GERD was evaluated using multivariate logistic regression analysis.RESULTS In total,4684 individuals with GERD were compared with 21901 healthy controls.In multivariate logistic regression analysis,advanced age,male sex,body mass index>23 kg/m2,presence of metabolic syndrome,current smoking,and alcohol consumption were associated with an increased risk of GERD.Seropositivity for H.pylori immunoglobulin G antibodies was associated with a decreased risk of GERD.There was an inverse correlation between the extent of EAG and occurrence of GERD:Odds ratio(OR),1.01[95%confidence interval(CI):0.90-1.14]in C1,0.87(0.78-0.97)in C2,0.71(0.62-0.80)in C3,0.52(0.44-0.61)in O1,0.37(0.29-0.48)in O2,and 0.28(0.18-0.43)in O3.Additionally,the extent of EAG showed an inverse correlation with the severity of GERD.The presence of SAG was correlated with a reduced risk of GERD(OR=0.49,95%CI:0.28-0.87,P=0.014).CONCLUSION The extent of EAG and SAG exhibited strong inverse relationships with the occurrence and severity of GERD.AG followed by H.pylori infection may be independently protect against GERD. | Yoo Min Han Su Jin Chung Seokha Yoo Jong In Yang Ji Min Choi Jooyoung Lee Joo Sung Kim | 2022 | World Journal of Gastroenterology2022，28，8： | 3 |
| 6 | Intraductal balloon-guided direct peroral cholangioscopy with an ultraslim upper endoscope (with videos)显示文摘 | Jong Ho Moon Bong Min Ko Hyun Jong Choi Su Jin Hong Young Koog Cheon Young Deok Cho Joon Seong Lee Moon Sung Lee Chan Sup Shim | 2009 | Gastrointestinal Endoscopy2009，，2： | 2 |
| 7 | Overtube-balloon–assisted direct peroral cholangioscopy by using an ultra-slim upper endoscope (with videos)显示文摘 | Hyun Jong Choi Jong Ho Moon Bong Min Ko Su Jin Hong Hyun Cheol Koo Young Koog Cheon Young Deok Cho Joon Seong Lee Moon Sung Lee Chan Sup Shim | 2009 | Gastrointestinal Endoscopy2009，，4： | 2 |
| 8 | Genetic variations in the PRKAA1 and ZBTB20 genes and gastric cancer susceptibility in a Korean population显示文摘 | Hye‐Rim Song Hee Nam Kim Sun‐Seog Kweon Jin‐Su Choi Hyun Jeong Shim Sang Hee Cho Ik Joo Chung Young‐Kyu Park Soo Hyun Kim Yoo‐Duk Choi Kyung Woong Joo Min‐Ho Shin | 2013 | Mol Carcinog2013，，1： | 2 |
| 9 | Changes in Postoperative Recurrence and Prognostic Risk Factors for Patients with Gastric Cancer who Underwent Curative Gastric Resection during Different Time Periods显示文摘 | Dae Hoon Kim Su Mi Kim Jung Kuk Hyun Min Gew Choi Jae Hyung Noh Tae Sung Sohn Jae Moon Bae Sung Kim | 2013 | Annals of Surgical Oncology2013，，7： | 2 |
| 10 | A study of metachronous cancer after endoscopic resection of early gastric cancer显示文摘 | Ji Sun Han Jin Seok Jang Seok Reyol Choi Hyuk Chan Kwon Min Chan Kim Jin Sook Jeong Su Jin Kim You Jung Sohn Eun Joo Lee | 2011 | Scandinavian Journal of Gastroenterology2011，，9： | 2 |
| 11 | Comparison of a 585 nm pulsed dye laser and a 1 064 nm Nd:YAG laser for the treatment of acne scars:A randomized split-face clinical study显示文摘 | Lee DH Choi YS Min SU | 2009 | J Am Acad Dermatol2009，60，5： | 1 |
| 12 | Esculetin suppresses lipopolysaccharide-induced inflammatory mediatorsand cytokines by inhibiting nuclear factor-κB translocation in RAW 264.7 macrophages显示文摘 | Su Hong Hui-Kyung Jeong Min Han Cheol Park Yung Choi | 2014 | Molecular Medicine Reports2014，，： | 1 |
| 13 | Oleanolic acid acetate inhibits osteoclast differentiation by downregulating PLCγ2–Ca 2<ce:hsp sp='0.10'/>+ -NFATc1 signaling, and suppresses bone loss in mice显示文摘 | Ju-Young Kim Yoon-Hee Cheon Hyun Mee Oh Mun Chual Rho Munkhsoyol Erkhembaatar Min Seuk Kim Chang Hoon Lee Jeong Joong Kim Min Kyu Choi Kwon-Ha Yoon Myeung Su Lee Jaemin Oh | 2014 | Bone2014，，： | 1 |
| 14 | The utility of a multibending endoscope for selective cannulation during ERCP in patients with a Billroth II gastrectomy (with video)显示文摘 | Hyun Cheol Koo Jong Ho Moon Hyun Jong Choi Bong Min Ko Su Jin Hong Young Koog Cheon Young Deok Cho Joon Seong Lee Moon Sung Lee Chan Sup Shim | 2009 | Gastrointestinal Endoscopy2009，，4： | 1 |
| 15 | Comparison of a long-pulse Nd:YAG laser and a combined 585/1 064 nm laser for the treat- ment of acne scars : a randomized split-face clinical study 显示文摘 | Min SU Choi YS Lee DH | 2009 | Dermatol Surg2009，35，11： | 1 |
| 16 | Comparison of the efficacy and tolerability of pitavastatin and atorvastatin: An 8-week, multicenter, randomized, open-label, dose-titration study in korean patients with hypercholesterolemia显示文摘 | Sang Hak Lee Namsik Chung Jun Kwan Doo-Il Kim Won Ho Kim Chee Jeong Kim Hyun Seung Kim Si Hoon Park Hong Seog Seo Dong Gu Shin Yung Woo Shin Wan-Joo Shim Tae Hoon Ahn Kyeong Ho Yun Myeong-Ho Yoon Kwang-Soo Cha Si-Wan Choi Seong Wook Han Min Su Hyon | 2007 | Clinical Therapeutics2007，，11： | 1 |
| 17 | Biological characterization of long-term cultured human mesenchymal stem cells显示文摘 | Jiseon Kim Jin Wook Kang Jae Hyun Park Youngju Choi Kyung Suk Choi Ki Dae Park Dae Hyun Baek Su Kyoung Seong Hong-Ki Min Hyung Soo Kim | 2009 | Archives of Pharmacal Research2009，，1： | 1 |
| 18 | I- dentification of Bovine Pregnancy-Specific Whey Proteins u- sing Two-Dimensional Gel Electrophoresis显示文摘 | Rong Xun Han Su Min Choi Myung Youn Kim | 2008 | Reproductive and Developmental Biology2008，32，4： | 1 |
| 19 | The Traditional Herbal Medicine, Dangkwisoo-San, Prevents Cerebral Ischemic Injury through Nitric Oxide-Dependent Mechanisms显示文摘 | Ji Hyun Kim Sun Haeng Park Young Whan Kim Jung Min Ha Sun Sik Bae Guem San Lee Su In Cho Byung Tae Choi Hwa Kyoung Shin | 2011 | Evidence-Based Complementary and Alternative Medicine2011，，： | 1 |
| 20 | Case Report:Congenital atresia of the left main coronary artery in an infant显示文摘Congenital atresia of the left main coronary artery is a rare occurrence, and surgical revascularization-bypass graft is required. We here report a rare case of congenital coronary anomaly in an infant. A 10-month-old male infant was admitted to the hospital with heart failure symptoms. Echocardiographic examinations revealed mitral valve regurgitation and ischemic changes of the anterolateral papillary muscle and chordae. Coronary angiography showed atresia of the left main coronary artery with a severe hypoplastic left anterior descending artery and a circumflex coronary artery. Unfortunately, sudden cardiac arrest occurred after catheterization and the infant did not recover despite of immediate cardiopulmonary resuscitation. Further studies are needed to find a newer diagnostic method to detect coronary anomaly in an infant, and coronary angiography, if necessary, has to be performed very carefully. | Su Ye SOHN Gi Young JANG Byung Min CHOI | 2010 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2010，11，7： | 1 |
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