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| 1 | Oil & Gas Drilling Technology in China:Past and Present显示文摘Drilling is a prerequisite for oil and gas exploration. As one of the core upstream business of oil and gas exploration and development, it mainly includes | Su Yinao Huang Hongchun Zhou Yuhui Gao Wenkai Zeng Qiang | 2009 | China Oil & Gas2009，16，4： | 9 |
| 2 | Efficacy and safety of low-dose interleukin-2 in combination with methotrexate in patients with active rheumatoid arthritis:a randomized,double-blind,placebo-controlled phase 2 trial显示文摘Rheumatoid arthritis(RA)is an aggressive autoimmune arthritis,and current therapies remain unsatisfactory due to low remission rate and substantially adverse effects.Low-dose interleukin-2(Ld-IL2)is potentially a therapeutic approach to further improve the disease.This randomized,double-blind,placebo-controlled trial was undertaken to evaluate the efficacy and safety of Ld-IL2 in patients with active RA.Patients were randomly assigned(1:1)to receive Ld-IL2,defined as a dose of 1 million IU,or placebo in a 12-week trial with a 12-week follow-up.Three cycles of Ld-IL2 or placebo were administered subcutaneously every other day for 2 weeks(a total of 7 doses),followed by a 2-week break.All patients received a stable dose of methotrexate(MTX).The primary outcomes were the proportion of patients achieving the ACR20,DAS28-ESR<2.6,and the change from baseline in CDAI or SDAI at week 24.Secondary endpoints included other clinical responses and safety.The primary outcomes were achieved in the perprotocol population.The improvements from baseline in CDAI and SDAI were significantly greater across time points for the LdIL2+MTX group(n=17)than for the placebo+MTX group(n=23)(P=0.018 and P=0.015,respectively).More patients achieved ACR20 response in the Ld-IL2+MTX group than those in the placebo+MTX group at week 12(70.6%vs 43.5%)and at week 24(76.5%vs 56.5%)(P=0.014).In addition,low Treg and high IL-21 were associated with good responses to Ld-IL2.Ld-IL-2 treatment was well-tolerated in this study.These results suggested that Ld-IL2 was effective and safe in RA.ClinicalTrials.gov number:NCT 02467504. | Xiaoying Zhang Miao Miao Ruijun Zhang Xu Liu Xiaozhen Zhao Miao Shao Tian Liu Yuebo Jin Jiali Chen Huixin Liu Xia Zhang Yun Li Yunshan Zhou Yue Yang Ru Li Haihong Yao Yanying Liu Chun Li Yuhui Li Limin Ren Yin Su Xiaolin Sun Jing He Zhanguo Li | 2022 | Signal Transduction and Targeted Therapy2022，7，4： | 7 |
| 3 | Hollow cobalt oxide nanoparticles embedded in nitrogen-doped carbon nanosheets as an efficient bifunctional catalyst for Zn–air battery显示文摘Rational design of low-cost, highly electrocatalytic activity, and stable bifunctional electrocatalysts for oxygen reduction reaction(ORR) and oxygen evolution reaction(OER) has been a great significant for metal–air batteries. Herein, an efficient bifunctional electrocatalyst based on hollow cobalt oxide nanoparticles embedded in nitrogen-doped carbon nanosheets(Co/N-Pg) is fabricated for Zn–air batteries. A lowcost biomass peach gum, consisting of carbon, oxygen, and hydrogen without other heteroatoms, was used as carbon source to form carbon matrix hosting hollow cobalt oxide nanoparticles. Meanwhile, the melamine was applied as nitrogen source and template precursor, which can convert to carbon-based template graphitic carbon nitride by polycondensation process. Owing to the unique structure and synergistic effect between hollow cobalt oxide nanoparticles and Co-N-C species, the proposal Co/N-Pg catalyst displays not only prominent bifunctional electrocatalytic activities for ORR and OER, but also excellent durability. Remarkably, the assembled Zn–air battery with Co/N-Pg air electrode exhibited a low discharge-charge voltage gap(0.81 V at 50 mA cm^-2) and high peak power density(119 mW cm^-2) with long-term cycling stability. This work presents an effective approach for engineering transition metal oxides and nitrogen modified carbon nanosheets to boost the performance of bifunctional electrocatalysts for Zn–air battery. | Yuhui Tian Li Xu Jian Bao Junchao Qian Huaneng Su Huaming Li Haidong Gu Cheng Yan Henan Li | 2019 | Journal of Energy Chemistry2019，28，6： | 4 |
| 4 | Development and identification of a dwarf wheat-Leymus mollis double substitution line with resistance to yellow rust and Fusarium head blight显示文摘Leymus mollis (Trin.) Pilger (2n = 4x = 28, NsNsXmXm,), a wild relative of common wheat, possesses many potentially valuable traits for genetic improvement of wheat, including strong, short stems, long spikes with numerous spikelets, tolerance to drought and cold stresses, and resistance to many fungal and bacterial diseases. In the present study, a wheat-L. mollis double substitution line DM96 was selected from a F6 progeny of a cross between M842-16 (an octoploid Tritileymus line) and D4286 (a Triticum durum line) using genomic in situ hybridization (GISH), simple sequence repeat (SSR) markers, and expressed sequence tagged sequence site (EST-STS) markers. Chromosome analysis at mitosis and meiosis showed that DM96 had a chromosome constitution of 2n = 42 = 21II. GISH analysis indicated that DM96 carried 38 chromosomes from wheat and two homologous pairs of Ns chromosomes from L. mollis. Fluorescent in situ hybridization (FISH) showed that chromosomes 2Ns and 3Ns from L. mollis had replaced wheat chromosomes 2D and 3D in DM96, which was confirmed by SSR and STS markers. The newly developed substitution line DM96 has shorter height, longer spikes and more kernels than its parents and showed high resistance to stripe rust and Fusarium head blight (FHB). Thus, this line is a new bridge material for the production of useful translocation lines for wheat genetic research and genetic improvement of wheat yield and disease resistance in breeding programs. | Jixin Zhao Yang Liu Xueni Cheng Yuhui Pang Jiachuang Li Zhenqi Su Jun Wu Qunhui Yang Guihua Bai Xinhong Chen | 2019 | The Crop Journal2019，7，4： | 2 |
| 5 | Ultimate control and expropriation of minority shareholders:new evidence from Taiwan显示文摘 | Yeh Y H Ko C E Su Yuhui | 2003 | Academic Economic Papers2003，31，： | 1 |
| 6 | PD0325901, an ERK inhibitor, enhances the efficacy of PD-1 inhibitor in non-small cell lung carcinoma显示文摘ERK pathway regulated the programmed death ligand-1(PD-L1)expression which was linked to the response of programmed death-1(PD-1)/PD-L1 blockade therapy.So it is deducible that ERK inhibitor could enhance the efficacy of PD-1 inhibitor in cancer immunotherapy.In this study,PD0325901,an oral potent ERK inhibitor,strongly enhanced the efficacy of PD-1 antibody in vitro and in vivo models in non-small cell lung carcinoma(NSCLC)cells.Mechanistically,PD0325901 or shRNA-ERK1/2 significantly downregulated the PD-L1 expression in NSCLC cells and increased the CD3+T cells infiltration and functions in tumor tissue.There was a positive correlation between the p-ERK1/2 expression and PD-L1 expression in patients with NSCLC.And the patients with low p-ERK1/2 expression were observed a high response rate of PD-1/PD-L1 blockage therapy.Our results demonstrate that PD0325901,an ERK inhibitor,can enhance the efficacy of PD-1 blockage against NSCLC in vitro and in vivo models.And the combination of ERK inhibitor such as PD0325901 and PD-1/PD-L1 blockage is a promising regimen and encouraged to be further confirmed in the treatment of patients with NSCLC. | Min Luo Yuhui Xia Fang Wang Hong Zhang Danting Su Chaoyue Su Chuan Yang Shaocong Wu Sainan An Suxia Lin Liwu Fu | 2021 | Acta Pharmaceutica Sinica B2021，11，10： | 1 |
| 7 | Discharge and disposal of coking residue and distribution characteristics of PAHs in it显示文摘 | Ma Yuhui Su Wei Wang Qunhui | 2014 | Applied Mechanics and Materials2014，2，： | 1 |
| 8 | Web usage mining with intentional browsing data显示文摘 | Tao Yuhui Hong Tzungpei Su Yuming | 2008 | Expert Systems with Applications2008，4，： | 1 |
| 9 | A non-human primate derived anti-P-selectin glycoprotein ligand-1 antibody curtails acute pancreatitis by alleviating the inflammatory responses显示文摘Acute pancreatitis(AP)is a devastating disease characterized by an inflammatory disorder of the pancreas.P-selectin glycoprotein ligand-1(PSGL-1)plays a crucial role in the initial steps of the adhesive at process to inflammatory sites,blockade of PSGL-1 might confer potent anti-inflammatory effects.In this study,we generated two non-human primate derived monoclonal antibodies capable of efficiently targeting human PSGL-1,RH001-6 and RH001-22,which were screened from immunized rhesus macaques.We found that RH001-6,can effectively block the binding of P-selectin to PSGL-1,and abolish the adhesion of leukocytes to endothelial cells in vitro.In vivo,we verified that RH001-6 relieved inflammatory responses and pancreatic injury in both caerulein and L-arginine induced AP models.We also evaluated the safety profile after RH001-6 treatment in mice,and verified that RH001-6 did not cause any significant pathological damages in vivo.Taken together,we developed a novel non-human primate derived PSGL-1 blocking antibody with high-specificity,named RH001-6,which can interrupt the binding of PSGL-1 and P-selectin and attenuate inflammatory responses during AP.Therefore,RH001-6 is highly potential to be further developed into therapeutics against acute inflammatory diseases,such as AP. | Yuhan Li Xiangqing Ding Xianxian Wu Longfei Ding Yuhui Yang Xiaoliang Jiang Xing Liu Xu Zhang Jianrong Su Jianqing Xu Zhiwei Yang | 2023 | Acta Pharmaceutica Sinica B2023，13，11： | 0 |
| 10 | VvWRKY5 enhances white rot resistance in grape by promoting the jasmonic acid pathway显示文摘Grape white rot is a disease caused by Coniella diplodiella(Speg.)Sacc.(Cd)can drastically reduce the production and quality of grape(Vitis vinifera).WRKY transcription factors play a vital role in the regulation of plant resistance to pathogens,but their functions in grape white rot need to be further explored.Here,we found that the expression of the WRKY IIe subfamily member VvWRKY5 was highly induced by Cd infection and jasmonic acid(JA)treatment.Transient injection and stable overexpression(in grape calli and Arabidopsis)demonstrated that VvWRKY5 positively regulated grape resistance to white rot.We also determined that VvWRKY5 regulated the JA response by directly binding to the promoters of VvJAZ2(a JA signaling suppressor)and VvMYC2(a JA signaling activator),thereby inhibiting and activating the transcription of VvJAZ2 and VvMYC2,respectively.Furthermore,the interaction between VvJAZ2 and VvWRKY5 enhanced the suppression and promotion of VvJAZ2 and VvMYC2 activities by VvWRKY5,respectively.When VvWRKY5 was overexpressed in grape,JA content was also increased.Overall,our results suggested that VvWRKY5 played a key role in regulating JA biosynthesis and signal transduction as well as enhancing white rot resistance in grape.Our results also provide theoretical guidance for the development of elite grape cultivars with enhanced pathogen resistance. | Zhen Zhang Changyue Jiang Cui Chen Kai Su Hong Lin Yuhui Zhao Yinshan Guo | 2023 | Horticulture Research2023，10，10： | 0 |
| 11 | Polyoxometallate Intercalated MgAI Layered Double Hydroxide and Its Photocatalytic Performance显示文摘 | Yuhui Zhang Jixin Su Xiaopeng Wang Qi Pan Wen Qu | 2012 | 材料科学与工程(中英文B版)2012，2，1： | 0 |
| 12 | Ar^(39)离子源控制软件研究与设计显示文摘According to the content of Ar^(39) in the sample to be tested,the age of the sample can be accurately calculated.This method is used in the measurement of glacial age,the measurement of ancient fossils,etc.So the Ar39 ion source has been established to meet the requirement of ice age survey and fossil survey.The software of the Ar^(39) ion source control system is based on EPICS(Experimental Physics and Industrial Control System)architecture.It mainly consists of two layers:IOC layer and an layer.The OPI layer also includes two layers:Channel Access(CA)client interface and application software.The IOC layer includes six layers:Channel Access(CA)server interface,database access interface,dynamic database,record support module,device support module and device driver. | Li Yunjie Guo Yuhui Zhang Jianchuan Wu Qi Jia Zhehua Su Jianjun Wang Yanyu Sun Liangting | 2018 | IMP & HIRFL Annual Report2018，，1： | 0 |
| 13 | Numerical analysis of a double interlocking padded finger seal performance based on thermo-fluid-structure coupling method显示文摘Non-contacting finger seals represent an advanced non-contacting and compliant seal in gas turbine sealing technology.This paper proposes a new structure of noncontacting finger seals with double interlocking pads.The numerical analysis model based on the thermo-fluid-structure coupling method for the new type finger seal was established.The influence of working conditions on leakage of the seal was studied and compared with the single padded non-contacting finger seal.The results show that the interface between the bottom of the finger pad and rotor surface is the main leakage path that forms the gas film with obvious variations of pressure and flow velocity.Under high temperature and high pressure operating conditions,the hydrodynamic effect of the gas film is enhanced,and lifting force is significantly improved.The deformation of fingers is composed of elastic deformation and thermal deformation.At room temperature,the deformation of fingers is mainly elastic deformation and points to the center of the rotor,which reduces the gas film clearance.The deformation of fingers at high temperature and high pressure creates a circumferentially convergent gap between the bottom of the pad and the rotor,which is beneficial to improve the loading capacity and to reduce leakage of the seal.Compared with the typical single padded noncontacting finger seal,the double interlocking padded finger seal proposed in this paper reduces the leakage factor by about 37%,which provides an advanced seal concept with the potential to improve sealing performance under high temperature and high pressure working conditions. | Hua Su Yuhui Huang Chao Wu | 2023 | Propulsion and Power Research2023，12，2： | 0 |
| 14 | Poly(thiourea triethylene glycol) as a multifunctional binder for enhanced performance in lithium-sulfur batteries显示文摘A mechanically strong binder with polar functional groups could overcome the dilemma of the large volume change during charge/discharge processes and poor cyclability of lithium-sulfur batteries(LSBs).In this work,for the first time,we report the use of poly(thiourea triethylene glycol)(PTTG)as a multifunctional binder for sulfur cathodes to enhance the performance of LSBs.As expected,the PTTG binder facilitates the high performance and stability delivered by the Sulfur-PTTG cathode,including a higher reversible capacity of 825 mAh g^(-1) at 0.2 C after 80 cycles,a lower capacity fading(0.123%per cycle)over 350 cycles at 0.5 C,a higher areal capacity of 2.5 mAh cm^(-2) at 0.25 mA cm^(-2),and better rate capability of 587 mAh g^(-1) at 2 C.Such superior electrochemical performances could be attributed to PTTG's strong chemical adsorption towards polysulfides which may avoid the lithium polysulfide shuttle effect and excellent mechanical characteristics which prevents electrode collapse during cycling and allows the Sulfur-PTTG electrode to maintain robust electron and ion migration pathways for accelerated redox reaction kinetics. | Luke Hencz Hao Chen Zhenzhen Wu Xingxing Gu Meng Li Yuhui Tian Su Chen Cheng Yan Abdulaziz S.R.Bati Joseph G.Shapter Milton Kiefel Dong-Sheng Li Shanqing Zhang | 2022 | Green Energy & Environment2022，7，6： | 0 |
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