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| 1 | Gene mutations in a patient with chronic myelomonocytic leukemia and changes upon progression to acute myeloid leukemia and during treatment显示文摘Objective Chronic myelomonocytic leukemia(CMML) has been categorized as an uncommon hematological malignancy with overlapping features of myelodysplastic syndromes(MDS) and myeloproliferative neoplasms that have an inherent risk of progressing to acute myeloid leukemia(AML). Methods This study presents a case of confirmed CMML combined with M protein, in which the molecular changes upon progression to AML and under decitabine(DAC) plus bortezomib therapy were reported by tracking variant allele frequency(VAF) of mutations in a series of bone marrow samples. Results First, variable sensitivity of clones was observed during DAC treatment, and incomplete mutation clearance may be associated with low overall response rate and unsustained response. Secondly, DAC cannot prevent the new genetic alterations and accumulation of genetic progression on treatment, leading to acute transformation. Finally, autoimmunity was found to have acted as an important pathogenetic factor, increasing the additive mutations that further drive the clonal evolution in CMML. Conclusion Overall, changes in mutations and clonal architecture during CMML progression or treatment are predictive of an early evaluation of therapeutic strategies in CMML. | Jiaming Li Sujiang Zhang | 2019 | Oncology and Translational Medicine2019，5，1： | 2 |
| 2 | Cerium-based conversion coatings as alternatives to hex chrome显示文摘 | O'KEEFE M J SUJIANG G JOSHI S | 2007 | Metal Finishing2007，105，5： | 1 |
| 3 | Effects of modafinil on vestibular function during 24 hour sleep deprivation显示文摘 | Hao Zhan Sujiang Xie Hongbo Jia Sihuang Wei Baisheng Jing | 2007 | Frontiers of Medicine in China2007，，2： | 1 |
| 4 | Universal selenium nanoadjuvant with immunopotentiating and redox-shaping activities inducing high-quality immunity for SARS-CoV-2 vaccine显示文摘Dear Editor,The COVID-19 pandemic still greatly threatens the public health worldwide and novel vaccines to highly effectively combat SARS-CoV-2 remains an unmet clinical need.However,redox imbalance in immune cells under extra stimulation by vaccine or pathogens greatly dampens the quality of the induced immunity.1 In addition,people infected with COVID-19 that characterized by immune system malfunction were also approved to be attributed by the robust oxidative stress. | Haoqiang Lai Ligeng Xu Chang Liu Sujiang Shi Yalin Jiang Yangyang Yu Bo Deng Tianfeng Chen | 2023 | Signal Transduction and Targeted Therapy2023，8，3： | 0 |
| 5 | Decomposition and removal of dental model plaque by using toothpaste containing dextranase显示文摘Objective:The purpose of this study is to demonstrate the decomposition and removal effects of dextranase-containing toothpaste on dental plaque. Method:In the decomposition test,the supernatant of three times diluted toothpaste was applied to a dextran solution (as a dental model plaque),and samples were evaluated by colorimetric reaction with Fehling’s test solution. In the removal test,the supernatant of three times diluted toothpaste was applied to a dental model plaque prepared with Streptococcus mutans and the optical density at 550nm (hereinafter referred to as OD_(550)) was measured as the remaining plaque. Results:In the test solution of toothpaste containing dextranase,a red-brown precipitate was observed. On the other hand,a precipitate was not observed in the test solution of the placebo toothpaste which did not contain dextranase. The plaque removal effect of the test toothpaste was 2. 7 times higher than that of the placebo toothpaste. Conclusion:Our findings suggest that the test toothpaste containing dextranase has a higher plaque removal effect by cuttingα-1,6-linkages inside the plaque. Therefore,the test toothpaste might be helpful to prevent dental caries. | Yuko Aoki Zheng Sujiang Yasuo Nomura Kenichiro Shibasaki Gotaro Iiizumi Liu Jing Li Debao An Fengbao | 2018 | 口腔护理用品工业2018，28，4： | 0 |
| 6 | Tellurium-driven maple leaf-shaped manganese nanotherapeutics reshape tumor microenvironment via chemical transition in situ to achieve highly efficient radioimmunotherapy of triple negative breast cancer显示文摘The therapeutic efficacy of radioimmunotherapy against triple negative breast cancer(TNBC)is largely limited by the complicated tumor microenvironment(TME)and its immunosuppressive state.Thus developing a strategy to reshape TME is expected to achieve highly efficient radioimmunotherapy.Therefore,we designed and synthesized a tellurium(Te)-driven maple leaf manganese carbonate nanotherapeutics(MnCO3@Te)by gas diffusion method,but also provided a chemical catalytic strategy in situ to augment ROS level and activate immune cells for improving cancer radioimmunotherapy.As expected,with the help of H2O2 in TEM,MnCO3@Te heterostructure with reversible Mn3+/Mn2+transition could catalyze the intracellular ROS overproduction to amplify radiotherapy.In addition,by virtue of the ability to scavenge H+in TME by carbonate group,MnCO3@Te directly promote the maturation of dendritic cells and macrophage M1 repolarization by stimulator of interferon genes(STING)pathway activation,resulting in remodeling immuno-microenvironment.As a result,MnCO3@Te synergized with radiotherapy and immune checkpoint blockade therapy effectively inhibited the breast cancer growth and lung metastasis in vivo.Collectively,these findings indicate that MnCO3@Te as an agonist,successfully overcome radioresistance and awaken immune systems,showing promising potential for solid tumor radioimmunotherapy. | Wei Huang Sujiang Shi Haoran Lv Zhenyu Ju Qinghua Liu Tianfeng Chen | 2023 | Bioactive Materials2023，，9： | 0 |
| 7 | DNA crosslinking and recombination-activating genes 1/2(RAG1/2)are required for oncogenic splicing in acute lymphoblastic leukemia显示文摘Background:Abnormal alternative splicing is frequently associated with carcinogenesis.In B-cell acute lymphoblastic leukemia(B-ALL),double homeobox 4 fused with immunoglobulin heavy chain(DUX4/IGH)can lead to the aberrant production of E-26 transformation-specific family related gene abnormal transcript(ERGalt)and other splicing variants.However,the molecular mechanism underpinning this process remains elusive.Here,we aimed to know how DUX4/IGH triggers abnormal splicing in leukemia.Methods:The differential intron retention analysis was conducted to identify novel DUX4/IGH-driven splicing in B-ALL patients.X-ray crystallography,small angle X-ray scattering(SAXS),and analytical ultracentrifugation were used to investigate how DUX4/IGH recognize double DUX4 responsive element(DRE)-DRE sites.The ERGalt biogenesis and B-cell differentiation assays were performed to characterize the DUX4/IGH crosslinking activity.To check whether recombination-activating gene 1/2(RAG1/2)was required for DUX4/IGH-driven splicing,the proximity ligation assay,co-immunoprecipitation,mammalian two hybrid characterizations,in vitro RAG1/2 cleavage,and shRNA knock-down assays were performed.Results:We reported previously unrecognized intron retention events in Ctype lectin domain family 12,member A abnormal transcript(CLEC12Aalt)and chromosome 6 open reading frame 89 abnormal transcript(C6orf89alt),where also harbored repetitive DRE-DRE sites.Supportively,X-ray crystallography and SAXS characterization revealed that DUX4 homeobox domain(HD)1-HD2 might dimerize into a dumbbell-shape trans configuration to crosslink two adjacent DRE sites.Impaired DUX4/IGH-mediated crosslinking abolishes ERGalt,CLEC12Aalt,and C6orf89alt biogenesis,resulting in marked alleviation of its inhibitory effect on B-cell differentiation.Furthermore,we also observed a rare RAG1/2-mediated recombination signal sequence-like DNA edition in DUX4/IGH target genes.Supportively,shRNA knock-down of RAG1/2 in leukemic Reh cells consistently impaired the biogenesis of ERGalt,CLEC12Aalt,and C6orf89alt.Conclusions:All these results suggest that DUX4/IGH-driven DNA crosslinking is required for RAG1/2 recruitment onto the double tandem DRE-DRE sites,catalyzing V(D)J-like recombination and oncogenic splicing in acute lymphoblastic leukemia. | Hao Zhang Nuo Cheng Zhihui Li Ling Bai Chengli Fang Yuwen Li Weina Zhang Xue Dong Minghao Jiang Yang Liang Sujiang Zhang Jianqing Mi Jiang Zhu Yu Zhang Sai-Juan Chen Yajie Zhao Xiang-Qin Weng Weiguo Hu Zhu Chen Jinyan Huang Guoyu Meng | 2021 | Cancer Communications2021，41，11： | 0 |
| 8 | Efficacy and safety of combined decitabine and ruxolitinib in the treatment of chronic myelomonocytic leukemia显示文摘Objective The aim of the study was to evaluate the clinical efficacy of decitabine(DEC)combined with ruxolitinib(RUX)in the treatment of chronic myelomonocytic leukemia(CMML).Methods The clinical characteristics of 12 patients with CMML were analyzed retrospectively and subsequent target sequencing was performed to investigate the efficacy of the combined treatment with DEC and RUX and the molecular signatures therein.Results Among the 12 cases,clinical improvement was observed in all patients(100%),spleen reduction was observed in six patients(67%),and hematologic improvement was observed in four patients(33%).In the CMML-1 group,the overall response was 50%(3/6),one case achieved complete response,one achieved bone marrow remission,and one achieved hematological improvement.In the CMML-2 group,the overall response was 17%(1/6),one case achieved complete response,four showed disease progression(PD),and one exhibited no response.As expected,ASXL1 mutation was predictive for the outcome of CMML(hazard ratio of 2.97,95%confidence interval of 1.21–7.06;P=0.02).Conclusion The use of DEC combined with RUX in the treatment of CMML effectively improved the clinical response and quality of life,especially for CMML-1 patients.Ongoing clinical trials will further evaluate the safety and efficacy of this novel therapeutic approach. | Jiaming Li Sujiang Zhang Yubao Chen Zeying Yan Ying Wang Zhiyin Liu Haimin Sun Yu Chen | 2019 | Oncology and Translational Medicine2019，5，5： | 0 |
| 9 | Effects of modafinil on vestibular function during 24 hour sleep deprivation显示文摘The aim of this research was to investigate the effects of modafinil,a new wake-promoting agent,on vestibular function during 24 h sleep deprivation(SD)so as to provide experimental evidence for the rational use of this drug among air crew.Eight young,healthy male volunteers were exposed to two 24 h periods of continuous wakefulness during the crossover experiment.Initially,200 mg dose of modafinil was given,and one week later,a matching placebo was administered.The SD time started from 08:00 of the first day to 08:00 of the second day.Drugs were given at 0:00 on the second day.Vestibular function was tested at 21:00 on the first day and 1,3,5,7 h after drug administration.The accuracy of saccade tracking and gains in visual-vestibular optokinetic reflex(VVOR)and optokinetic nystagmus(OKN)in the placebo group decreased during 24 h SD,especially at 01:00–05:00 on the second day,while OKN gains in the modafinil group increased significantly.There were no significant differences in the other vestibular functional indices between the modafinil group and placebo group.The 24 h SD can influence vestibular function to a certain degree,but modafinil may improve OKN. | ZHAN Hao XIE Sujiang JIA Hongbo WEI Sihuang JING Baisheng | 2007 | Frontiers of Medicine2007，1，2： | 0 |
| 10 | Clinical manifestation of the SRSF2 gene mutation in Chinese patients with chronic myelomonocytic leukemia显示文摘 | Sun Chao Zhang Sujiang Qiao Chun Yang Xiangchou Li Jianyong | 2014 | Chinese Medical Journal2014，，24： | 0 |
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