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| 1 | Correlation of E-selectin gene polymorphisms with risk of ischemic stroke A meta-analysis显示文摘OBJECTIVE: To investigate the association of E-selectin S128R polymorphisms with ischemic stroke. DATA SOURCES: A computer-based online search was conducted in PubMed, Elsevier, Ovid Database, the China National Knowledge Infrastructure, and Wanfang Database between January 1998 and December 2010. STUDY SELECTION: Case-controlled studies addressing the association of the E-selectin polymorphism and ischemic stroke were included in this review. The genotype distribution complied with the Hardy-Weinberg genetic equilibrium. The included reports were evaluated by two authors for strict quality screening. Meta-analysis software, REVMAN 5.1, was used to investigate heterogeneity, pooled odds ratio (OR) and 95% confidence interval (CI) in individual studies. MAIN OUTCOME MEASURES: Genotype and allele distributions at the E-selectin S128R site. RESULTS: Six case-controlled studies were included after screening and application of inclusion and exclusion criteria. There was no heterogeneity in the genotype and allele frequencies, and no publication bias was found. Meta-analysis of the pooled data showed that the OR value of the (AC+CC)/AA genotype was 1.93 (95% CI: 1.55-2.41, Z = 5.80, P < 0.000 01), and the OR for the C/A allele was 1.80 (95% CI: 1.47-2.22, Z = 5.59, P < 0.000 01) in the ischemic stroke group, compared with control group. Results of pooled data in Chinese subjects showed that the OR value of (AC+CC)/AA was 2.36 (95% CI: 1.68-3.31, Z = 4.99, P < 0.000 01), and the OR value of the C/A allele was 2.25 (95% CI: 1.63-3.12, Z = 4.89, P < 0.000 01). CONCLUSION: Polymorphism of E-selectin S128R was significantly associated with susceptibility to ischemic stroke; the AC and CC genotypes as well as the C allele may be factors associated with susceptibility to ischemic stroke. | Qingli Sun Yu Fu Aping Sun Yanhong Shou Mei Zheng Xiaogang Li Dongsheng Fan | 2011 | Neural Regeneration Research2011，6，22： | 46 |
| 2 | BMAL1 knockout macaque monkeys display reduced sleep and psychiatric disorders显示文摘Circadian disruption is a risk factor for metabolic, psychiatric and age-related disorders, and non-human primate models could help to develop therapeutic treatments. Here, we report the generation of BMAL1 knockout cynomolgus monkeys for circadian-related disorders by CRISPR/Cas9 editing of monkey embryos. These monkeys showed higher nocturnal locomotion and reduced sleep, which was further exacerbated by a constant light regimen. Physiological circadian disruption was reflected by the markedly dampened and arrhythmic blood hormonal levels. Furthermore, BMAL1-deficient monkeys exhibited anxiety and depression, consistent with their stably elevated blood cortisol, and defective sensory processing in auditory oddball tests found in schizophrenia patients. Ablation of BMAL1 up-regulated transcriptional programs toward inflammatory and stress responses, with transcription networks associated with human sleep deprivation, major depressive disorders, and aging. Thus, BMAL1 knockout monkeys are potentially useful for studying the physiological consequences of circadian disturbance, and for developing therapies for circadian and psychiatric disorders. | Peiyuan Qiu Jian Jiang Zhen Liu Yijun Cai Tao Huang Yan Wang Qiming Liu Yanhong Nie Fang Liu Jiumu Cheng Qing Li Yun-Chi Tang Mu-ming Poo Qiang Sun Hung-Chun Chang | 2019 | National Science Review2019，6，1： | 21 |
| 3 | Whole-genome sequencing of 508 patients identifies key molecular features associated with poor prognosis in esophageal squamous cell carcinoma显示文摘Esophageal squamous cell carcinoma(ESCC)is a poor-prognosis cancer type with limited understanding of its molecular etiology.Using 508 ESCC genomes,we identified five novel significantly mutated genes and uncovered mutational signature clusters associated with metastasis and patients’outcomes.Several functional assays implicated that NFE2L2 may act as a tumor suppressor in ESCC and that mutations in NFE2L2 probably impaired its tumor-suppressive function,or even conferred oncogenic activities.Additionally,we found that the NFE2L2 mutations were significantly associated with worse prognosis of ESCC.We also identified potential noncoding driver mutations including hotspot mutations in the promoter region of SLC35E2 that were correlated with worse survival.Approximately 5.9%and 15.2%of patients had high tumor mutation burden or actionable mutations,respectively,and may benefit from immunotherapy or targeted therapies.We found clinically relevant coding and noncoding genomic alterations and revealed three major subtypes that robustly predicted patients’outcomes.Collectively,we report the largest dataset of genomic profiling of ESCC useful for developing ESCC-specific biomarkers for diagnosis and treatment. | Yongping Cui Hongyan Chen Ruibin Xi Heyang Cui Yahui Zhao Enwei Xu Ting Yan Xiaomei Lu Furong Huang Pengzhou Kong Yang Li Xiaolin Zhu Jiawei Wang Wenjie Zhu Jie Wang Yanchun Ma Yong Zhou Shiping Guo Ling Zhang Yiqian Liu Bin Wang Yanfeng Xi Ruifang Sun Xiao Yu Yuanfang Zhai Fang Wang Jian Yang Bin Yang Caixia Cheng Jing Liu Bin Song Hongyi Li Yi Wang Yingchun Zhang Xiaolong Cheng Qimin Zhan Yanhong Li Zhihua Liu-Show | 2020 | Cell Research2020，30，10： | 19 |
| 4 | SHP2 inhibition triggers anti-tumor immunity and synergizes with PD-1 blockade显示文摘Tyrosine phosphatase SHP2 is a promising drug target in cancer immunotherapy due to its bidirectional role in both tumor growth promotion and T-cell inactivation. Its allosteric inhibitor SHP099 is known to inhibit cancer cell growth both in vitro and in vivo. However, whether SHP099-mediated SHP2 inhibition retards tumor growth in vivo via anti-tumor immunity remains elusive. To address this, a CT-26 colon cancer xenograft model was established in mice since this cell line is insensitive to SHP099.Consequently, SHP099 minimally affected CT-26 tumor growth in immuno-deficient nude mice, but significantly decreased the tumor burden in CT-26 tumor-bearing mice with intact immune system.SHP099 augmented anti-tumor immunity, as shown by the elevated proportion of CD8tIFN-γtT cells and the upregulation of cytotoxic T-cell related genes including Granzyme B andPerforin, which decreased the tumor load. In addition, tumor growth in mice with SHP2-deficient T-cells was markedly slowed down because of enhanced anti-tumor responses. Finally, the combination of SHP099 and antiPD-1 antibody showed a higher therapeutic efficacy than either monotherapy in controlling tumor growthin two colon cancer xenograft models, indicating that these agents complement each other. Our study suggests that SHP2 inhibitor SHP099 is a promising candidate drug for cancer immunotherapy. | Mingxia Zhao Wenjie Guo Yuanyuan Wu Chenxi Yang Liang Zhong Guoliang Deng Yuyu Zhu Wen Liu Yanhong Gu Yin Lu Lingdong Kong Xiangbao Meng Qiang Xu Yang Sun | 2019 | Acta Pharmaceutica Sinica B2019，9，2： | 18 |
| 5 | Historical trends of heavy metal contamination and their sources in lacustrine sediment from Xijiu Lake,Taihu Lake Catchment,China显示文摘Concentrations of Cd,Cr,Cu,Pb,Zn and Hg in Xijiu Lake sediment from the Taihu Lake catchment,China,were analyzed.Their contamination state was investigated based on the geoaccumulation index and enrichment factors.Statistical analysis was used to differentiate the anthropogenic versus natural sources of heavy metals (HMs),and the anthropogenic accumulation fluxes were calculated to quantify anthropogenic contribution to HMs.The results indicated that the lake sediment had been heavily contaminated by Cd,enrichment of Zn and Hg was at a relatively high level,while that of Cu and Pb was in the lower-to-moderate level and Cr was in the low enrichment level.Sources of Cr in the sediment were mainly from natural inputs,while other metals,especially Cd,were predominantly derived from anthropogenic sources.In the past century,anthropogenic accumulation fluxes of Pb,Zn and Hg increased by 0.1-47.3 mg/(cm2·yr),2.4-398.1 mg/(cm2·yr),and 3.7-110.3 ng/(m2·yr),respectively,accounting for most inputs of HMs entering the sediment.The contamination state of HMs varied with industrial development of the catchment,which demonstrated that contamination started in the early 20th century,reached the maximal level between the mid-1970s and mid-1990s,and decreased a little after the implementation of constraints on high contamination industries,although the contamination of some HMs,such as Cd,Zn and Hg,is still at high levels. | Haijian Bing Yanhong Wu Zhaobin Sun Shuchun Yao | 2011 | Journal of Environmental Sciences2011，23，10： | 18 |
| 6 | What Happened in the Trans-North China Orogen in the Period 2560-1850 Ma?显示文摘Trans 北方中国造山带(TNCO ) 是东方、西方的块沿着混合了形成一个协调 NorthChina 古地台(NCC ) 的一条 Paleoproterozic continent-continentcollisional 带。最近地质,结构,有在东方块的西方的边缘下面的海洋的岩石圈的东方指导俯冲的 geochemical 和 theorogen 沿着东方块的西方的边缘是大陆人边缘或日本类型弧的同位素的数据表演,由旧海洋与西方的块被分开,。在 2550-2520 妈, deepsubduction 引起了媒介降低的外壳的部分融化,生产被侵入进形成 granitoid plutons 在的外壳的上面的层次的丰富的 granitoid 岩浆低 --tomedium 等级花岗石绿岩岩层。在 2530-2520 妈,海洋的岩石圈的俯冲引起了披风楔的部分融化,它在弧在下地壳和普遍 mafic 和次要的 felsic 火山作用在 mafic 岩浆的 plating 下面导致了,形成绿岩集合的部分。普遍 mafic 驾驶到 felsic 火山作用的扩展在造山带导致了发展 ofback 弧或 intra 弧盆。在 2520-2475 妈,俯冲引起了形成大量 tonalitic-trondhjemitic-granodioritic (TTG ) 的下地壳的进一步偏爱的融化岩浆酌。背弧盆的在这时候后面的进一步的扩展,阵发性的 granitoidmagmatism 发生了,导致 2360 妈,的炮兵阵地~ 2 250 妈 2110-21760 妈和~ 2 在造山带的 050 Magranites。当代的火山沉积的岩石在背弧 orintra 弧盆发展了。在 2150-1920 妈,造山带经历了几前紧张的事件,一条海洋的山脉的可能到期的 tosubduction,导致是的 mafic 女同性恋的炮兵阵地随后变形了到角闪岩和媒介 -- 到高压的 mafic granulites。在 1880-1820 妈,在东方、西方的块之间的海洋被俯冲完全消费,并且关门海洋导致了 continent-arc-continent 碰撞,它引起了大规模推进和等斜褶皱并且搬运了一些岩石进更低的外壳的层次或上地幔形成 granulites 或 eclogites 。山峰变态被 exhumation/uplift 跟随,导致在岩石中的不对称褶皱和 symplectic 质地的普遍开发。 | Guochun ZHAO LIU Shuwen Min SUN LI Sanzhong Simon WILDE Xiaoping XIA Jian ZHANG Yanhong HE | 2006 | Acta Geologica Sinica(English Edition)2006，80，6： | 16 |
| 7 | U-Pb Zircon Dating of the Granitic Conglomerates of the Hutuo Group:Affinities to the Wutai Granitoids and Significance to the Tectonic Evolution of the Trans-North China Orogen显示文摘与在中间的最好、古典的剖面图 Trans 北方 ChinaOrogen 分割的邻近的 Fuping 和 Hengshan Complexesrepresents 联系的 Wutai 建筑群,通常划分了成东方、西方的块。Unconformably overlying Wutai andFuping 建筑群 Hutuo 组在这个区域被看作最年轻的岩石地层单位并且为解释前寒武纪的历史以及 theTrans 北方中国造山带的全面进化重要。在这个组的沉积岩的起源的知识的缺乏妨碍了 depositional 和构造意义的理解。LA-ICP-MS 被使用为花岗石的卵石获得 U-Pb 锆石年龄, Hutuo 组的最低岩石层位学的岩石,它,与结合了以前的岩石层位学, geochronological,结构、变形的数据,在沉积起源和这个区域的构造进化上提供新限制。Hutuo 的顺序从更低的底砾岩 andvolcaniclastic 岩石(Doucun 亚群) 向上组织范围,通过碎屑沉积物,板岩,白云石和云石(Dongye 亚群) ,到在顶(Guojiazhai 亚群) 的沙岩和集团企业。从在 Doucun 亚群底砾岩保存的花岗石的卵石的锆石给加权的mean~( 207 )在 2517 妈和 2566 妈之间的Pb/~( 206 ) Pb 年龄,它与为迟了的 ArcheanWutai Granitoids 的那些一样,显示卵石从 Wutai 花岗石的侵入( 2566-2515 妈)被导出。基于新数据和以前的研究,与在 Hutuo 组为 volcanics 获得的 2087 ±9 妈的火的锆石结晶化年龄结合了, Hutuo 组在在东方块的西方的边缘下面在西方的块的东方指导俯冲期间在 theWutai 弧后面发展了的subduction相关的制动火箭弧低岬盆环境被扔。这盆经历了长寿沉积并且最后在~ 1 期间关上了导致了北方中国古地台的最后的合并的 850 妈 collisional 事件。 | Jian ZHANG Guochun ZHAO LI Sanzhong Min SUN LIU Shuwen Xiaoping XIA Yanhong HE | 2006 | Acta Geologica Sinica(English Edition)2006，80，6： | 15 |
| 8 | Metamorphism of the northern Liaoning Complex:Implications for the tectonic evolution of Neoarchean basement of the Eastern Block,North China Craton显示文摘As one of the areas where typical late Archean crust is exposed in the Eastern Block of the North China Craton,the northern Laioning Complex consists principally of tonalitic-trondhjemitic-granodioritic(TTG) gneisses,massive granitoids and supracrustal rocks.The supracrustal rocks,named the Qingyuan Group, consist of interbedded amphibolite,hornblende granulite,biotite granulite and B1F.Petrological evidence indicates that the amphibolites experienced the early prograde(M1),peak(M2) and post-peak(M3) metamorphism.The early prograde assemblage(M1) is preserved as mineral inclusions,represented by actinotite + hornblende + plagioclase + epidote + quartz + sphene,within garnet porphyroblasts.The peak assemblage(M2) is indicated by garnet + clinopyroxene + hornblende + plagioclase + quartz + ilmenite, which occur as major mineral phases in the rock.The post-peak assemblage(M3) is characterized by the garnet + quartz symplectite.The P—T pseudosections in the NCFMASHTO system constructed by using THERMOCALC define the P-T conditions of Ml,M2 and M3 at 490-550℃/<4.5 kbar,780-810℃/7.65- 8.40 kbar and 630-670℃/8.15-9.40 kbar,respectively.As a result,an anticlockwise P-T path involving isobaric cooling is inferred for the metamorphic evolution of the amphibolites.Such a P-T path suggests that the late Archean metamorphism of the northern Liaoning Complex was related to the intrusion and underplating of mantle-derived magmas.The underplating of voluminous mantle-derived magmas leading to metamorphism with an anticlockwise P-T path involving isobaric cooling may have occurred in continental magmatic arc regions,above hot spots driven by mantle plumes,or in continental rift environments. A mantle plume model is favored because this model can reasonably interpret many other geological features of late Archean basement rocks from the northern Liaoning Complex in the Eastern Block of the North China Craton as well as their anticlockwise P—T paths involving isobaric cooling. | Kam Kuen Wu Guochun Zhao Min Sun Changqing Yin Yanhong He Pui Yuk Tam | 2013 | Geoscience Frontiers2013，4，3： | 14 |
| 9 | Cloning of a gene-edited macaque monkey by somatic cell nuclear transfer显示文摘Cloning of macaque monkeys by somatic cell nucleus transfer(SCNT) allows the generation of monkeys with uniform genetic backgrounds that are useful for the development of non-human primate models of human diseases. Here, we report the feasibility of this approach by SCNT of fibroblasts from a macaque monkey(Macaca fascicularis), in which a core circadian transcription factor BMAL1 was knocked out by clustered regularly interspaced short palindromic repeat/Cas9 gene editing(see accompanying paper).Out of 325 SCNT embryos transferred into 65 surrogate monkeys, we cloned five macaque monkeys with BMAL1 mutations in both alleles without mosaicism, with nuclear genes identical to that of the fibroblast donor monkey. Further peripheral blood m RNA analysis confirmed the complete absence of the wild-type BMAL1 transcript. This study demonstrates that the SCNT approach could be used to generate cloned monkeys from fibroblasts of a young adult monkeys and paves the way for the development of macaque monkey disease models with uniform genetic backgrounds. | Zhen Liu Yijun Cai Zhaodi Liao Yuting Xu Yan Wang Zhanyang Wang Xiaoyu Jiang Yuzhuo Li Yong Lu Yanhong Nie Xiaotong Zhang Chunyang Li Xinyan Bian Mu-ming Poo Hung-Chun Chang Qiang Sun | 2019 | National Science Review2019，6，1： | 14 |
| 10 | U-Pb Age and Hf Isotope Study of Detrital Zircons from the Wanzi Supracrustals:Constraints on the Tectonic Setting and Evolution of the Fuping Complex,Trans-North China Orogen显示文摘在 Trans 北方中国造山带的中间的片断定位了, FupingComplex 在理解北方 ChinaCraton (NCC ) 的进化历史被看作一个批评区域。建筑群由各种各样的高级、多样地使变形的岩石组成,包括灰色的片麻岩,基本 granulite,角闪岩,有细密纹理的片麻岩和大理石,变形了到上面的角闪岩或 granulite 外形。它能被划分成四个岩石单位:Fuping TTG 片麻岩, Longquanguan augen, Wanzi 在上 crustals,和 Nanying 花岗石的片麻岩。从 FupingComplex 的 Wanzi 在上 crustals 的大约 200 由岩屑形成的锆石的 U-Pb 年龄和 Hfisotope 作文被分析了。边界给的变形锆石上的数据 1.82-1.84 Ga 变老,相应于 NCC 的最后的合并事件为在~ 2 .10 和~ 2 .51 Ga 的火的锆石核心产量二年龄人口的数据,与在第 2.5a 2.9 Ga 之间散布的一些继承年龄。这些结果建议 Wanzi 在上 crustals 从 Fuping TTGgneisses (~ 2 .5 Ga ) 和 Nanying 花岗石的片麻岩(2.0-2.1 Ga ) 被导出并且在 2.10 and1.84 Ga 之间扔了。有~ 2 .51 Ga 年龄的所有锆石有起始的ε _(Hf ) 从 +1.4 珍视到 +10.9 的 positive,建议在通过从披风的少年材料的增加的~ 2 .5 Ga 的一个重要外壳的生长事件。为由岩屑形成的锆石的 Hf 同位素数据进一步暗示 2.8 Ga 岩石是在下地壳的重要部件,它与从为东方块的 Nd 同位素数据的一个建议一致。 2.10 Ga 人口的锆石有起始的ε_( Hf ) -4.9 to+6.1 的价值,作为在 2.1 Ga.These 结果与次要的少年材料贡献外壳的再融化混合解释了为西方的块从那是不同的,支持 Fuping 建筑群是在在东方块的西方的边缘的构造活跃环境的 emplaced 。 | Xiaoping XIA Min SUN Guochun ZHAO WU Fuyuan XU Ping Jian ZHANG Yanhong HE ZHANG Jiheng | 2006 | Acta Geologica Sinica(English Edition)2006，80，6： | 12 |
| 11 | Hydrogen bubble fiotation of fine minerals containing calcium显示文摘One characteristic of electro-flotation is the presence of micro bubbles that are well known for improving the fiotation performance of fine particles.An electro-flotation method was studied with fine scheelite and fluorite particles sized into three different fractions.Experiments were performed in a modified Hallimond tube.We investigated the effects of gas holdup,particle size,and different mesh electrode apertures on mineral recovery.Flotation results show that two size fractions show increased flotation recovery as the gas holdup increases.For the sized scheelite and fluorite,the flotation effect is diverse for different sizes of the cathode aperture.Pictures of the bubbles taken by a high speed CCD were used to determine the hydrogen bubble size distribution generated as a function of collector,current density,and electrode size.The diameters of the hydrogen bubbles ranged from 12 to 117 lm in alkaline conditions. | Sun Wei Ma Liang Hu Yuehua Dong Yanhong Zhang Gang | 2011 | Mining Science and Technology2011，21，4： | 10 |
| 12 | Emission Trading Based Optimal Scheduling Strategy of Energy Hub with Energy Storage and Integrated Electric Vehicles显示文摘This paper focuses on the optimal scheduling of the district energy system with multiple energy supply modes and flexible loads.For multi-energy system(MES),the energy hub(EH)model including energy storage system and integrated electric vehicle(EV)is established.Based on the model,the influence of pollutant trading market on total operation cost is analyzed,and the optimal scheduling strategy is further put forward to realize the minimum purchase cost and emission tax cost of the MES.Finally,this paper compares the economic benefit of the fixed mode and the response mode,and discusses the contribution of the energy storage device and the multi-energy complementary mode to energy utilization efficiency.The simulation results indicate that optimal scheduling strategy of the EH can coordinate various energy complementary modes reasonably.Meanwhile,the proposed strategy is able to improve the operation economy of the EH,and ensure the better response effect of the demand side.The sensitivity analysis demonstrates the impact of pollutant emission price change on emission reduction. | Yanhong Luo Xinwen Zhang Dongsheng Yang Qiuye Sun | 2020 | Journal of Modern Power Systems and Clean Energy2020，8，2： | 8 |
| 13 | Multi-Stage Hydrocarbon Accumulation and Formation Pressure Evolution in Sinian Dengying FormationCambrian Longwangmiao Formation, Gaoshiti-Moxi Structure, Sichuan Basin显示文摘Sichuan Basin is a typical superimposed basin, which experienced multi-phase tectonic movements, meanwhile Sinian–Cambrian underwent complex hydrocarbon accumulation processes, causing exploration difficulties in the past 60 years. Based on the microscopic evidence of fluid inclusions, combined with basin-modelling, this paper determines stages and time of hydrocarbon accumulation, reconstructs evolution of formation pressure and dynamic processes of hydrocarbon accumulation in Sinian Dengying Formation-Cambrian Longwangmiao Formation of Gaoshiti-Moxi structure. Three stages of inclusions are detected, including a stage of yellow-yellowgreen fluorescent oil inclusions, a stage of blue fluorescent oil-gas inclusions and a stage of non-fluorescent gas inclusions, reflecting the study area has experienced a series of complex hydrocarbon accumulation processes, such as formation of paleo-oil reservoirs, cracking of crude oil, formation of paleo-gas reservoirs and adjustment to present gas reservoirs, which occurred during 219–188, 192–146 and 168–0 Ma respectively. During the period of crude oil cracking, Dengying Formation-Longwangmiao Formation showed weak overpressure to overpressure characteristics, then after adjustment of paleo-gas reservoirs to present gas reservoirs, the pressure in Dengying Formation changed into overpressure but finally reduced to normal pressure system. However, due to excellent preservation conditions, the overpressure strength in Longwangmiao Formation only slightly decreased and was still kept to this day. | Juan Wu Shugen Liu Guozhi Wang Yihua Zhao Wei Sun Jinming Song Yanhong Tian | 2016 | Journal of Earth Science2016，27，5： | 8 |
| 14 | Anti-β2 glycoprotein I antibodies in complex with β2 glycoprotein I induce platelet activation via two receptors: apolipoprotein E receptor 2' and glycoprotein I ba显示文摘 | Wenjing Zhang Fei Gao Donghe Lu Na Sun Xiaoxue Yin Meili Jin Yanhong Liu | 2016 | Frontiers of Medicine2016，10，1： | 8 |
| 15 | The enrichment characteristics of mercury in the sediments of Dongjiu and Xijiu, Taihu Lake catchment, in the past century显示文摘The concentration and the enrichment factors of mercury (Hg) in the sediment cores of Dongjiu and Xijiu, Taihu Lake catchment, were studied. The accumulation fluxes, anthropogenic input concentration and anthropogenic accumulation fluxes of Hg in recent 100 years were also analyzed based on the 210Pb dating. The results indicate that the increasing concentrations of Hg in the sediments are influ-enced by natural factors and anthropogenic input simultaneously. Generally, about 2/3 of the Hg in the sediment was from anthropogenic sources. In the early 20th century, the anthropogenic input was owing to the urban development and fossil fuel consumptions surrounding the Taihu Lake and the worldwide atmospheric deposition of Hg since the industrial revolution. The concentration and an-thropogenic fluxes of Hg increased with the industrial development in the catchment since the 1930s. It reached the maximum during the middle 1970s and middle 1990s, and decreased since the middle 1990s with constraints on high pollution industries. | WU YanHong JIANG XueZhong LIU EnFeng YAO ShuChun ZHU YuXin SUN ZhaoBin | 2008 | Science China Earth Sciences2008，51，6： | 8 |
| 16 | Enhanced resistance of marine shrimp Exopalamon carincauda Holthuis to WSSV by injecting live VP28-recombinant bacteria显示文摘Recombinant bacteria secreting the transmembrane-truncated region of white spot syndrome virus (WSSV) envelope protein VP28 named DhpVB were constructed, using live Escherichia coli as a deliverer and a constitutive secretory expression plasmid as the expression vector. With the ability to deliver recombinant protein products outside, DhpVB could make VP28 directly interact with the shrimp when injected into shrimp. In order to test the protection potential, live DhpVB were injected into the marine shrimp Exopalamon carincauda Holthuis for three times and WSSV challenge was performed twice simultaneously at the last two injections of the bacteria. The results showed that DhpVB displayed statistically significant advantage over bacteria without VP28 after the second challenge with an average RI (Resistance index) of 0.67 ± 0.08, compared with 0.41 ± 0.09 of bacteria without VP28 (P <0.05). The data suggested that a quasi-immune response may exist in E. carincauda and live bacteria carrying VP28 could enhance the shrimp resistance against WSSV. | SUN Yumiao LI Fuhua CHI Yanhong XIANG Jianhai | 2013 | Acta Oceanologica Sinica2013，32，2： | 7 |
| 17 | Protonation induced high-T_c phases in iron-based superconductors evidenced by NMR and magnetization measurements显示文摘Chemical substitution during growth is a well-established method to manipulate electronic states of quantum materials, and leads to rich spectra of phase diagrams in cuprate and iron-based superconductors. Here we report a novel and generic strategy to achieve nonvolatile electron doping in series of(i.e.11 and 122 structures) Fe-based superconductors by ionic liquid gating induced protonation at room temperature. Accumulation of protons in bulk compounds induces superconductivity in the parent compounds, and enhances the Tclargely in some superconducting ones. Furthermore, the existence of proton in the lattice enables the first proton nuclear magnetic resonance(NMR) study to probe directly superconductivity. Using Fe S as a model system, our NMR study reveals an emergent high-Tcphase with no coherence peak which is hard to measure by NMR with other isotopes. This novel electric-fieldinduced proton evolution opens up an avenue for manipulation of competing electronic states(e.g.Mott insulators), and may provide an innovative way for a broad perspective of NMR measurements with greatly enhanced detecting resolution. | Yi Cui Gehui Zhang Haobo Li Hai Lin Xiyu Zhu Hai-Hu Wen Guoqing Wang Jinzhao Sun Mingwei Ma Yuan Li Dongliang Gong Tao Xie Yanhong Gu Shiliang Lie Huiqian Luo Pu Yu Weiqiang Yu | 2018 | Science Bulletin2018，63，1： | 7 |
| 18 | ADVANCE SELLING IN THE PRESENCE OF PRODUCT DIFFUSION EFFECT显示文摘产品散开指以后的需求依赖于早出售的现象。调查卖策略的公司进展怎么被产品散开的效果影响,我们考虑一个独占者卖主在在二个时期上近视、战略的消费者包括的一个市场卖一个时髦产品(即,卖季节的进展和常规卖季节) 。为我们发现那的线性产品散开效果,当产品散开的效果是积极的时,卖主可以设置一个极其高的进展售价劝诱战略消费者在常规卖季节购买,它是违反直觉的。而且,为卖主的最佳的获得数量可以在战略消费者的数量在产品散开和减少的否定效果增加。当我们扩大我们的模型认为凹面二次时产品散开效果然而,最佳的获得数量是在战略消费者的数量的凹面。数字研究进一步被介绍讨论经理的卓见。 | Xiaoyan Xu Xuemei Li Yiwen Bian Yanhong Sun | 2017 | Journal of Systems Science and Systems Engineering2017，26，1： | 7 |
| 19 | Soil phosphorus bioavailability assessed by XANES and Hedley sequential fractionation technique in a glacier foreland chronosequence in Gongga Mountain, Southwestern China显示文摘The primary productivity of terrestrial ecosystems is influenced by soil phosphorus bioavailability, which depends largely on chemical fractions of phosphorus. The sequential fractionation technique developed by Hedley et al. or its subsequent modification is a well-known method to determine soil phosphorus forms. Hedley sequential fractionation technique separates the phosphorus into fractions based on their different chemical solubilities in extractants with certain chemical properties. Recently, synchrotron-based X-ray absorption near edge structure(XANES) spectroscopy has been employed to measure soil phosphorus species directly and non-invasively. The XANES method provides information concerning local structure and chemical information of target elements at a molecular level. Thus, it can distinguish phosphorus fractions bound by metal oxides or hydroxides(such as Fe, Al, and Ca). In this present work, the phosphorus speciation of topsoil along a glacial foreland chronosequence in Gongga Mountain is determined using these two methods. The changes in soil phosphorus bioavailability along the 120-year-old chronosequence are assessed based on comparisons of the results obtained by these two methods. The results indicate that Hedley sequential fractionation technique shows a greater ability to determine soil bioavailable phosphorus(Resin-P and NaCHO3-P), while XANES is effective in distinguishing phosphorus bound by metal compounds. In the chronosequence, Ca- and Al-bound phosphorus were derived mainly from primary minerals, whose phosphorus contents decreased within 120 years of moraine weathering and soil development. The content of soil bioavailable phosphorus increased rapidly after 30 years since deglaciation. The increasing phosphorus bioavailability promoted the colonizing and primary succession vegetation. | WU YanHong Jrg PRIETZEL ZHOU Jun BING HaiJian LUO Ji YU Dong SUN ShouQin LIANG JianHong SUN HongYang | 2014 | Science China Earth Sciences2014，57，8： | 6 |
| 20 | Hepatitis C Virus Infection Downregulates the Ligands of the Activating Receptor NKG2D显示文摘Natural killer (NK) cells are a major component of the host innate immune defense against various pathogens. Several viruses, including hepatitis C virus (HCV), have developed strategies to evade the NK-cell response. In our study, we found HCV infection could trigger DNA damage response by both ataxia telangiectasia mutated (ATM) and ATM- and Rad3-related (ATR) pathways. Recent reports had revealed that NKG2D ligands (NK cell-activating ligands) were upregulated when a major DNA damage checkpoint pathway was activated. However, here we found that DNA damage response was activated but NKG2D ligands were downregulated upon HCV infection. Further studies showed that the protease NS3/4A of HCV which had been shown relation with immune invasion contributed to the reduced expression of NKG2D ligands. These findings provide a novel insight into the mechanisms evolved by HCV to escape from the NK cell response. | Chaoyang Wen Xiang He Hongfang Ma Ningbo Hou Congwen Wei Ting Song Yanhong Zhang Liping Sun Qingjun Ma Hui Zhong | 2008 | Cellular & Molecular Immunology2008，5，6： | 6 |
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