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| 1 | Existing drugs as broad-spectrum and potent inhibitors for Zika virus by targeting NS2B-NS3 interaction显示文摘Zika 病毒(ZIKV ) 的最近的爆发为治疗学加亮迫切需要。朊酶建筑群 NS2B-NS3 在 flaviviral polyprotein 处理期间起必要作用,并且因此代表一个吸引人的药目标。这里,我们开发了裂口酶识别直接指向 flavivirus NS2B-NS3 相互作用的 orthosteric 禁止者的基于互补的高产量的屏蔽试金。由屏蔽一个总数 2 816 同意了并且 investigational 药,我们识别了三个有势力候选人, temoporfin, niclosamide,和 nitazoxanide,,有 nanomolar 力量的 flavivirus NS2B-NS3 相互作用禁止者。显著地,在老鼠的在人的胎盘、神经的祖先房间的大多数有势力化合物, temoporfin,不是仅仅禁止的 ZIKV 复制,而且阻止的导致 ZIKV 的 viremia 和死亡当模特儿。结构的停靠建议 temoporfin 潜在地绑保持批评 NS2B 残余的 NS3 衣袋,因此禁止以一种非竞争的方式处理的 flaviviral polyprotein。当这些药已经在 USA 或另外的国家在另外的指示任何一个为临床的使用被同意了,他们由 ZIKV 和另外的 flaviviruses 为感染的管理代表有希望、容易开发的治疗。 | Zhong Li Matthew Brecher Yong-Qiang Deng Jing Zhang Srilatha Sakamuru Binbin Liu Ruili Huang Cheri A Koetzner Christina A Allen Susan A Jones Haiying Chen Na-Na Zhang Min Tian Fengshan Gao Qishan Lin Nilesh Banavali Jia Zhou Nathan Boles Menghang Xia Laura D Kramer Cheng-Feng Qin Hongmin Li | 2017 | Cell Research2017，27，8： | 11 |
| 2 | Ron receptor-dependent gene regulation in a mouse model of endotoxin-induced acute liver failure显示文摘BACKGROUND:Prior experimentation has shown that loss of the tyrosine kinase(TK) signaling domain of the Ron receptor leads to marked hepatocyte protection in a model of lipopolysaccharideinduced acute liver failure(ALF) in D-galactosamine(GalN)sensitized mice.The aim of this study was to identify the role of Ron in the regulation of hepatic gene expression.METHODS:Microarray analyses were performed on liver RNA isolated sequentially from wild-type(WT) and TK-/mice during the progression of ALF.Gene array data were validated using Western and immunohistochemistry analyses as well as with ex vivo culture systems.RESULTS:At baseline,101 genes were differentially expressed between WT and TK-/-livers,which regulate processes involved in hypoxia,proliferation,apoptosis and metabolism.One hour after ALF induction,WT livers exhibited increased cytokine expression compared to TK-/-livers,and after 4 hours,an induction of suppressor of cytokine signaling(SOCS) genes as well as JAK-STAT pathway activation were prominent in TK-/livers compared to controls.CONCLUSION:Our studies suggest a novel hepato-protective mechanism in Ron TK-/-mice wherein increased and sustained SOCS production and JAK-STAT activation in the hepatocyte may inhibit the destructive proinflammatory milieu and promote survival factors which blunt hepatic death and the ensuing development of ALF. | Rishikesh M Kulkarni Louis W Kutcher William D Stuart Daniel J Carson Mike A Leonis Susan E Waltz | 2012 | Hepatobiliary & Pancreatic Diseases International2012，11，4： | 3 |
| 3 | Hepatitis B and C infection and liver disease trends among human immunodeficiency virus-infected individuals显示文摘AIM:To examine trends in and correlates of liver disease and viral hepatitis in an human immunodeficiency virus (HIV)-infected cohort. METHODS:The multi-site adult/adolescent spectrum of HIV-related diseases (ASD) followed 29 490 HIVinfected individuals receiving medical care in 11 U.S. metropolitan areas for an average of 2.4 years,and a total of 69 487 person-years,between 1998 and 2004. ASD collected data on the presentation,treatment,and outcomes of HIV,including liver disease,hepatitis screening,and hepatitis diagnoses. RESULTS:Incident liver disease,chronic hepatitis B virus (HBV),and hepatitis C virus (HCV) were diagnosed in 0.9,1.8,and 4.7 per 100 person-years. HBV and HCV screening increased from fewer than 20% to over 60% during this period of observation (P < 0.001). Deaths occurred in 57% of those diagnosed with liver disease relative to 15% overall (P < 0.001). Overall 10% of deaths occurred among individuals with a diagnosis of liver disease. Despite care guidelines promoting screening and vaccination for HBV and screening for HCV,screening and vaccination were not universally conducted or,if conducted,not documented. CONCLUSION:Due to high rates of incident liver disease,viral hepatitis screening,vaccination,and treatment among HIV-infected individuals should be a priority. | Susan E Buskin Elizabeth A Barash John D Scott David M Aboulafia Robert W Wood | 2011 | World Journal of Gastroenterology2011，17，14： | 2 |
| 4 | Propranolol for the prevention of postoperative arrhythmias in general thoracic surgery显示文摘 | Charles D Bayliff David R Massel Richard I Inculet Richard A Malthaner Susan D Quinton Frank S Powell Renee S Kennedy | 1999 | The Annals of Thoracic Surgery1999，，1： | 2 |
| 5 | Genome sequence and analysis of the soil cellulolytic actinomyeete Thermobifidafusca YX 显示文摘 | Athanasios L Konstantinos M Natalia I lain A Miriam L Genevieve D Michele M Alia L Susan L Alex C Paul R David BW Nikos K | 2007 | J Bacteriol2007，189，6： | 1 |
| 6 | Application of the BioMek 2000 laboratory automation workstation and the DNA IQTM system to the extraction of forensic casework samples显示文摘 | Susan A Jeffrey D Karen S | 2004 | J Forensic Sci2004，49，1： | 1 |
| 7 | Reaction synthesis of Ni-Al-based particle composite coatings 显示文摘 | SUSAN D F MISIOLEK W Z MARDER A R | 2001 | Metall Mater Trans2001，32，： | 1 |
| 8 | Dynamic oscillatory rheological measurement and thermal properties of pea protein extracted by salt method:effect of pH and NaCI显示文摘 | XIANG D S SUSAN D A | 2011 | Journal of Food Engineering2011，105，3： | 1 |
| 9 | Overexpression of a stabilized mutant form of the eyclin-dependent kinase inhibitor p27Kip 1 inhibits cell growth显示文摘 | Jean A Hurteau M D Susan A | 2002 | Gynecol Oncol2002，86，1： | 1 |
| 10 | Oxidation of Ni-Al-based electrodeposited composite coatings Ⅰ : Oxidation kinetics and morphglogy at 800 °C 显示文摘 | SUSAN D F MARDER A R | 2002 | Oxid Met2002，57，： | 1 |
| 11 | Diffusion analysis and coating lifetime estimation 显示文摘 | SUSAN D F MARDER A R | 2001 | Acta Materialia2001，49，： | 1 |
| 12 | Oxidation of Ni-Al-based electrodeposited composite coatings Ⅱ: Oxidation kinetics and morphology at 1 000 °C 显示文摘 | SUSAN D F MARDER A R | 2002 | Oxid Met2002，57，15： | 1 |
| 13 | Growth and development Of rat oocytes in vitro 显示文摘 | Susan A J Daniel G Armstrong D T | 1989 | Gamete research1989，24，： | 1 |
| 14 | Behaviour in Lupus Mice:Lessons for Human CNS Lupus显示文摘 | Judah A Denburg Susan D Denburg Boris Sakic | 1998 | Faculty of Health Sciences1998，1，： | 1 |
| 15 | Lipid profiling identifies a triacylglycerol signature of insulin resistance and improves diabetes prediction in humans显示文摘 | Rhee Eugene P Cheng Susan Larson Martin G Walford Geoffrey A Lewis Gregory D McCabe Elizabeth Yang Elaine Farrell Laurie Fox Caroline S O’Donnell Christopher J Carr Steven A Vasan Ramachandran S Florez Jose C Clish Clary B Wang Thomas J Ger | 2011 | Journal of Clinical Investigation2011，，4： | 1 |
| 16 | Not just a grain of rice: the quest for quality显示文摘 | Melissa A F Susan R M Robert D H | 2009 | J Trends in Plant Sci2009，14，3： | 1 |
| 17 | Mutations in filamin 1 Prevent Migration of Cerebral Cortical Neurons in Human Periventricular Heterotopia显示文摘 | Jeremy W Fox Edward D Lamperti Yaman Z Ek?io?lu Susan E Hong Yuanyi Feng Donna A Graham Ingrid E Scheffer William B Dobyns Betsy A Hirsch Rodney A Radtke Samuel F Berkovic Peter R Huttenlocher Christopher A Walsh | 1998 | Neuron1998，，6： | 1 |
| 18 | Crossmodal identification显示文摘 | Calvert Gemma A Brammer Michael J Iversen Susan D | 1998 | Trends in Cognitive Sciences1998，2，7： | 1 |
| 19 | Comparative analysis of the schleicher and schuell iso Code Stix DNA Isolation Device and the Qiagen QIAamp DNA Mini Kit显示文摘 | Susan R Coyne Philip D Craw David A Norwood | 2004 | Journal of Clinical Microbiology2004，42，10： | 1 |
| 20 | An exploratory study of the effects of supplier relationships on new product development outcomes 显示文摘 | Marcos A M P Susan D A | 2002 | Journal of Operations Management2002，20，： | 1 |
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